Santana Vacations from $5,174

Book a Hotel + Flight or Car together to unlock savings

Photo by Fabrice Récalt

Your Santana Vacation

Art, food, entertainment and more … There's so much to experience with a Santana vacation package. And with the ability to easily customize your city adventure, it's guaranteed to be one you won't forget. When it's time to venture out and explore, be sure to put Cathedral of São Tomé and Estadio Nacional 12 de Julho on the to-do list for your trip to Santana. Your ideal Santana vacation is a couple of clicks away. Explore accommodations, flights and more on Expedia for a getaway that's tailored just for you.

The Latest Santana vacation packages

Price found within the past 48 hours. Click for updated prices.
Miramar São Tomé

Miramar São Tomé

3 out of 5
Price was $5,304, price is now $5,174 per person
$5,174
per person
Aug 2 - Aug 8
found 1 day ago
Roundtrip flight included
Sacramento (SMF) to São Tomé Island (TMS)
7.2/10 Good! (46 reviews)
Very helpful and accommodating staff

Reviewed on Jun 7, 2024

Pestana São Tomé

Pestana São Tomé

5 out of 5
Vila Maria
Price was $5,715, price is now $5,472 per person
$5,472
per person
Aug 2 - Aug 8
found 1 day ago
Roundtrip flight included
Sacramento (SMF) to São Tomé Island (TMS)
8.2/10 Very Good! (82 reviews)
Wonderful stay, great staff, easy, relaxing delightful.

Reviewed on Dec 9, 2025

Alojamento Santos Silva

Alojamento Santos Silva

3 out of 5
Price was $9,595, price is now $9,393 per person
$9,393
per person
Aug 23 - Aug 29
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to São Tomé Island (TMS)
No reviews
Omali São Tomé – Principe Collection

Omali São Tomé – Principe Collection

4 out of 5
Price was $9,369, price is now $9,179 per person
$9,179
per person
Aug 23 - Aug 29
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to São Tomé Island (TMS)
9.4/10 Exceptional! (64 reviews)
The employees really make the property a superstar.

Reviewed on Feb 21, 2025

Hotel Kenito

Hotel Kenito

2.5 out of 5
Price was $8,799, price is now $8,650 per person
$8,650
per person
Aug 23 - Aug 29
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to São Tomé Island (TMS)
10/10 Exceptional! (4 reviews)
Don't see what you're looking for?
See all available trips from Columbus to Santana
View all trips

Santana Hotel Deals

Sea House

Sea House

Santana Cantagalo
Get rates
Sea House
Roça Santo António Ecolodge Hotel

Roça Santo António Ecolodge Hotel

3.5 out of 5
Roça Santo Antonio Santana
8.4/10 Very Good! (15 reviews)
"This is a wonderful place to stay. I loved room #1!"

Reviewed on Apr 23, 2022

Get rates
Roça Santo António Ecolodge Hotel
Pool and Beach Villa in Santana

Pool and Beach Villa in Santana

3 out of 5
Estrada brasil Roca Uba Budo Praia Santana São Tomé
Get rates
Pool and Beach Villa in Santana
See all 52 properties in Santana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santana Vacation Packages

Santana Essential Information

Language
Portuguese
Currency
São Tomé and Príncipe dobras
Local Welcome
Olá
Local Goodbye
Adeus
Closest Airport
Sao Tome Intl. Airport (TMS)
Top Sights
Cathedral of São Tomé, Estadio Nacional 12 de Julho and Fort de Sao Sebastiao

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a Santana vacation package cost?
You can grab a vacation package to this popular destination from $5,174 on Expedia. However, how much your vacation to Santana costs will depend on factors like your hotel choice, season and length of stay.
What are the cheapest months to go to Santana?
February, October and December are the best times to search for cheap Santana vacation packages. Traveling in quieter periods means you'll typically find reduced prices on flights and hotels.
How many days is enough for Santana?
Typically, a handful of days is enough to tick off the top sights during your Santana vacation. But if you'd like to have some time to kick back or take day trips, consider extending your trip.
How to find the best Santana package deals?
Finding a cheap Santana package deal is a cinch with Expedia. Once you've entered your travel dates and destination under our "Packages" tab, set your maximum budget, add some filters and browse what's available. You can tailor your search by "Popular locations," "Property type," "Guest rating" and more. Order the results by "Price: low to high" to discover the most economical Santana package deals. Want a simple trick to get the biggest savings? Be flexible with your departure dates and consider traveling on a weekday, when prices are generally lower.
Is it cheaper to book a Santana vacation as a package?
An Expedia vacation package could land you significant savings when compared to arranging flights and accommodations separately. Better still, you can customize your Santana trip to fit your exact needs. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
When to book a vacation package to Santana?
Enjoy incredible discounts by reserving your flights ahead of time with Expedia. If being spontaneous is more your thing, take advantage of our last-minute deals for an impromptu Santana escape.
How to plan a trip to Santana?

  1. Choose when to go: Check your schedule and get your bags packed. Your preferred season and the available activities will also help you decide when to escape to Santana.
  2. Set a budget: Factor in expenses such as flights, food and transportation when working out how much to set aside for your trip to Santana. Then, pick a hotel that fits your budget, whether that's a low-cost stay or a deluxe getaway.
  3. Organize your Santana getaway with Expedia's trip planning tool: Look for and book stays and experiences all in one place. You can also collaborate with family and friends to plan an unforgettable trip to Santana together.
  4. Decide how long to go away for: Now that you're more familiar with Santana, you can figure out the perfect length of your vacation. Create a draft itinerary and give yourself enough time for all the things you want to do.
  5. Bundle your bookings: With your travel dates in place, you can combine your hotels, flights, car rental and more into a customized Santana vacation package.
  6. Book activities and experiences in advance: Whether it's a ticket to a big attraction or a walking tour, you won't have to worry about missing out on Santana's highlights. Find all the exciting things to do in Santana with our dedicated activity guide.

Does Expedia offer Book Now, Pay Later Santana vacation packages?
If you're anything like us, you love traveling the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With the help of online lender Affirm, you can break down the overall cost of your Santana vacation across 3, 6 or 12 months. There are also no hidden or late payment fees, so you can secure cheap vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.