Title: Santana Vacation Packages 2026 | Expedia.com [Hotels in Santana](https://expedia.com/Santana-Hotels.d553248635974903086.Travel-Guide-Hotels)[Vacation Rentals in Santana](https://expedia.com/Santana-Vacation-Rentals.d553248635974903086.Travel-Guide-VacationRentals)[Car Rentals in Santana](https://expedia.com/Car-Rentals-In-Santana.d553248635974903086.Car-Rental-Guide) ![](https://images.trvl-media.com/place/553248635974903086/d35e79ad-6d17-4482-90bd-71db9c6c2017.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Santana Vacations ## Book a Hotel + Flight or Car together to unlock savings Photo by Fabrice Récalt ## Your Santana Vacation Art, food, entertainment and more … There's so much to experience with a Santana vacation package. And with the ability to easily customize your city adventure, it's guaranteed to be one you won't forget. When it's time to venture out and explore, be sure to put [Cathedral of São Tomé](https://www.expedia.com/Cathedral-Of-Sao-Tome-Sao-Tome-Island.d553248621565341574.Vacation-Attraction) and [Estadio Nacional 12 de Julho](https://www.expedia.com/Estadio-Nacional-12-De-Julho-Sao-Tome.d6118168.Vacation-Attraction) on the to-do list for your trip to Santana. Your ideal Santana vacation is a couple of clicks away. Explore accommodations, flights and more on Expedia for a getaway that's tailored just for you. ## Santana Hotel Deals ![Jo's Nature Cabin Santana](https://images.trvl-media.com/lodging/40000000/39140000/39137900/39137854/f41761e2_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Jo's Nature Cabin Santana Santana São Tomé [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F6%2F2026&endDate=4%2F7%2F2026&selected=39137854&PinnedHotelID=39137854&HadPinnedHotel=true®ionId=553248635974903086) [](https://expedia.com/Hotel-Search?startDate=4%2F6%2F2026&endDate=4%2F7%2F2026&selected=39137854&PinnedHotelID=39137854&HadPinnedHotel=true®ionId=553248635974903086) ![Roça Santo António Ecolodge Hotel](https://images.trvl-media.com/lodging/21000000/20430000/20423300/20423214/3deed7de_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Roça Santo António Ecolodge Hotel Roça Santo Antonio Santana 8.4/10 Very Good! (15 reviews) This is a wonderful place to stay. I loved room #1! Reviewed on Apr 23, 2022 [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F6%2F2026&endDate=4%2F7%2F2026&selected=20423214&PinnedHotelID=20423214&HadPinnedHotel=true®ionId=553248635974903086) [](https://expedia.com/Hotel-Search?startDate=4%2F6%2F2026&endDate=4%2F7%2F2026&selected=20423214&PinnedHotelID=20423214&HadPinnedHotel=true®ionId=553248635974903086) ![Sea House](https://images.trvl-media.com/lodging/111000000/110860000/110857500/110857426/622f9ead_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Sea House Santana Cantagalo [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F6%2F2026&endDate=4%2F7%2F2026&selected=110857426&PinnedHotelID=110857426&HadPinnedHotel=true®ionId=553248635974903086) [](https://expedia.com/Hotel-Search?startDate=4%2F6%2F2026&endDate=4%2F7%2F2026&selected=110857426&PinnedHotelID=110857426&HadPinnedHotel=true®ionId=553248635974903086) [See all 50 properties in Santana](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F24%2F2026&endDate=3%2F25%2F2026®ionId=553248635974903086) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best Santana Vacation Packages ## Santana Essential Information | Language | Portuguese | | --------------- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Currency | São Tomé and Príncipe dobras | | Local Welcome | Olá | | Local Goodbye | Adeus | | Closest Airport | Sao Tome Intl. Airport (TMS) | | Top Sights | [Cathedral of São Tomé](https://www.expedia.com/Cathedral-Of-Sao-Tome-Sao-Tome-Island.d553248621565341574.Vacation-Attraction), [Estadio Nacional 12 de Julho](https://www.expedia.com/Estadio-Nacional-12-De-Julho-Sao-Tome.d6118168.Vacation-Attraction) and [Fort de Sao Sebastiao](https://www.expedia.com/Fort-De-Sao-Sebastiao-Sao-Tome.d6118166.Vacation-Attraction) | ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) 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Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Where to go when [](https://expedia.com/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/honeymoon_hawaii.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Honeymoon Vacations [](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Mountain Vacations [](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Fishing Vacations [](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Adults Only Vacations [](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Waterpark Vacations [](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Scuba Diving Vacations [](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Yoga Vacations [](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Cheap Vacations [](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Solo Vacations [](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click) ## Frequently asked questions ### How much does a Santana vacation package cost? ### What are the cheapest months to go to Santana? ### How many days is enough for Santana? ### How to find the best Santana package deals? ### Is it cheaper to book a Santana vacation as a package? ### When to book a vacation package to Santana? ### How to plan a trip to Santana? > 1. Choose when to go: Check your schedule and get your bags packed. Your preferred season and the available activities will also help you decide when to escape to Santana. > 2. Set a budget: Factor in expenses such as flights, food and transportation when working out how much to set aside for your trip to Santana. Then, pick a hotel that fits your budget, whether that's a low-cost stay or a deluxe getaway. > 3. Organize your Santana getaway with Expedia's [trip planning tool](https://www.expedia.com/why/trip-planning): Look for and book stays and experiences all in one place. You can also collaborate with family and friends to plan an unforgettable trip to Santana together. > 4. Decide how long to go away for: Now that you're more familiar with Santana, you can figure out the perfect length of your vacation. Create a draft itinerary and give yourself enough time for all the things you want to do. > 5. Bundle your bookings: With your travel dates in place, you can combine your hotels, flights, car rental and more into a customized Santana vacation package. > 6. Book activities and experiences in advance: Whether it's a ticket to a big attraction or a walking tour, you won't have to worry about missing out on Santana's highlights. Find all the exciting [things to do in Santana](https://www.expedia.com/Things-To-Do-In-Santana.d553248635974903086.Travel-Guide-Activities) with our dedicated activity guide. ### Does Expedia offer Book Now, Pay Later Santana vacation packages? \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.