Title: Santiago Vacation Packages 2026 from $536 | Expedia.com

[Hotels in Santiago](https://expedia.com/Santiago-Puebla-Hotels.0-n892336686902599680-0.Travel-Guide-Filter-Hotels)[Flights to Puebla](https://expedia.com/Cheap-Flights-To-Puebla.d2738.Travel-Guide-Flights)[Things to do in Puebla](https://expedia.com/Things-To-Do-In-Puebla.d2738.Travel-Guide-Activities)[Car Rentals in Santiago](https://expedia.com/Car-Rentals-In-Santiago.d892336686902599680.Car-Rental-Guide)

![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_packages.jpeg?impolicy=fcrop&w=1200&h=300&q=medium)

# Santiago Vacations from $536

## Book a Hotel + Flight or Car together to unlock savings

## The Latest Santiago Vacation Packages

Price found within the past 48 hours. Click for updated prices.

![Xoxula by Inmense](https://images.trvl-media.com/lodging/13000000/12430000/12425500/12425496/7ce69349_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Xoxula by Inmense

Cholula

$536

per person

Apr 23 - Apr 27

found 1 day ago

Roundtrip non-stop flight included

Los Angeles (LAX) to Puebla (PBC)

9/10 Wonderful! (184 reviews)

Great and friendly staff.

Reviewed on Jan 19, 2026

![Grand Fiesta Americana Puebla Angelópolis](https://images.trvl-media.com/lodging/14000000/13210000/13205900/13205808/6f40138f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Grand Fiesta Americana Puebla Angelópolis

Angelópolis

Save 100% on your flight

$1,060

per person

May 24 - May 31

found 6 hours ago

Roundtrip flight included

Houston (HOU) to Puebla (PBC)

9.6/10 Exceptional! (1,004 reviews)

Clean and convenient

Reviewed on Mar 2, 2026

![Molino de los Reyes ](https://images.trvl-media.com/lodging/82000000/81070000/81065700/81065697/c3f1d63f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Molino de los Reyes 

Save 100% on your flight

$674

per person

Apr 23 - Apr 27

found 1 day ago

Roundtrip non-stop flight included

Los Angeles (LAX) to Puebla (PBC)

8.8/10 Excellent! (8 reviews)

![Hotel Andante](https://images.trvl-media.com/lodging/9000000/8170000/8165800/8165755/1d25961f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Hotel Andante

Puebla Historic Center

Save 100% on your flight

$592

per person

May 24 - May 31

found 6 hours ago

Roundtrip flight included

Houston (HOU) to Puebla (PBC)

9.2/10 Wonderful! (249 reviews)

Cleanliness great staff

Reviewed on Oct 10, 2025

![Collection O Al otro lado del rio, Puebla](https://images.trvl-media.com/lodging/10000000/9590000/9583900/9583840/097717ba_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Collection O Al otro lado del rio, Puebla

Puebla Historic Center

$571

per person

Apr 10 - Apr 16

found 4 hours ago

Roundtrip flight included

Houston (HOU) to Puebla (PBC)

9/10 Wonderful! (199 reviews)

Not great for holiday, just fine for quick stay. Parking is not in the property, it is close but it is need it to the staff to open the gate, at night is not ideal. Hotel have several not hotel restaurantes inside the hotel and they are too loud. Again, not for holiday only for quick stay.

Reviewed on Oct 14, 2025

## Where to stay in Santiago

Find the best Santiago areas and neighborhoods for the activities you enjoy most. [Learn more about Santiago](https://expedia.com/Puebla-Santiago.dx892336686902599680)

![Zocalo Square featuring heritage elements](https://images.trvl-media.com/place/6171841/5ffde135-894d-43fa-aabe-cacd797adb65.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Puebla Historic Center

4 out of top 10 points of interest in this area

4.5/5(361 area reviews)

 Discover a World Heritage Site filled with colonial buildings in the Historic Monuments Zone, where you can explore Barrio de los Sapos, Barrio del Artista, and the stunning Puebla Cathedral. 

[Find hotel + flight trips in Puebla Historic Center](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Puebla%20Historic%20Center&DestID=6320710&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![When in Puebla you must visit La Estrella de Puebla where you will enjoy views from this City #patterns #WeLoveOurMarkets #LifeAtExpedia #Puebla #TLoTravel ](https://images.trvl-media.com/place/6085110/ef31c741-e146-42d4-8d92-0307c7fa10fe.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Angelópolis

2 out of top 10 points of interest in this area

4.5/5(81 area reviews)

 The neighborhood boasts luxurious residential developments, cultural spaces, and parks. Explore attractions like La Estrella de Puebla, The Art Park, and the Baroque Museum, or shop at Centro Comercial Angelópolis. 

[Find hotel + flight trips in Angelópolis](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Angel%C3%B3polis&DestID=553248633981743959&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![La Virgen de los Remedios Sanctuary showing heritage elements and mountains](https://images.trvl-media.com/place/6302832/07824718-e7b5-4e47-b507-f01aa10455e4.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Cholula

1 out of top 10 points of interest in this area

 Best known for its Great Pyramid and numerous churches, Cholula features the Iglesia de Nuestra Señora de los Remedios sanctuary atop the pyramid. Explore the city's eighteen distinct barrios, each with a patron saint. 

[Find hotel + flight trips in Cholula](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Cholula&DestID=182169&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![#lifeatexpedia #weloveourmarkets #latam #Mexico #Puebla #Cholula 
It was founded before 1529 on the land where it was located in a temple dedicated to Quetzalcoatl. Located in the Plaza de la Concordia, the magnificent construction has Gothic and Plateresque elements, and was carried out entirely by indigenous hands](https://images.trvl-media.com/place/182169/c6b21c32-aca5-4aa6-93a2-638804bd6551.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Cholula Centro

4.5/5(14 area reviews)

 While visiting Cholula Centro, you might make a stop by sights like Zócalo and San Gabriel Convent. 

[Find hotel + flight trips in Cholula Centro](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Cholula%20Centro&DestID=553248635976400020&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![La Paz Jesus Christ  Mosaic Facade Outside Catholic Church Puebla Mexico](https://images.trvl-media.com/place/553248635976008553/20a6e007-9ab1-4040-ab20-48bc18cdf296.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### La Paz

5/5(2 area reviews)

 While La Paz isn't home to many top sights, Galerías Serdán and Triangulo Las Animas Shopping Center are some notable places to visit nearby. 

[Find hotel + flight trips in La Paz](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=La%20Paz&DestID=553248635976008553&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

## Santiago Hotel Deals

![NH Puebla Centro Histórico](https://images.trvl-media.com/lodging/2000000/1280000/1277300/1277213/9811b629_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

NH Puebla Centro Histórico

Calle 5 Sur #105, Col. Centro Puebla PUE

Fully refundableReserve now, pay when you stay

$59 nightly

$70 total

Mar 8 - Mar 9

Total with taxes and fees

8.6/10 Excellent! (1,546 reviews)

The staff was great. But we got all sorts of problems with the water system. The shower head was not functioning properly (urgently needed to be decalcified). Terrible noise in the pipes each time we were using the tap to wash our hands.

Reviewed on Mar 1, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F8%2F2026&endDate=3%2F9%2F2026&selected=1277213&PinnedHotelID=1277213&HadPinnedHotel=true&regionId=892336686902599680)

![Holiday Inn Express Hotel & Suites Puebla Angelopolis by IHG](https://images.trvl-media.com/lodging/8000000/7670000/7662000/7661913/a98b83a8_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Holiday Inn Express Hotel & Suites Puebla Angelopolis by IHG

Perseo N. 2502, Col.San Martinito San Andrés Cholula PUE

Fully refundable

$61 nightly

$72 total

Mar 29 - Mar 30

Total with taxes and fees

9.4/10 Exceptional! (1,041 reviews)

Some things inside the bathroom were not well placed. Looks like it is not having proper maintenance. Swimming pool not working. Breakfast good.

Reviewed on Mar 2, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F29%2F2026&endDate=3%2F30%2F2026&selected=7661913&PinnedHotelID=7661913&HadPinnedHotel=true&regionId=892336686902599680)

![Fiesta Inn Puebla Las Animas](https://images.trvl-media.com/lodging/5000000/4960000/4956200/4956147/48ab4eb7_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Fiesta Inn Puebla Las Animas

39 Poniente 3515 Col Las Animas Puebla PUE

Fully refundableReserve now, pay when you stay

$70 nightly

$83 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://expedia.com/Hotel-Search?startDate=3%2F8%2F2026&endDate=3%2F9%2F2026&selected=4956147&PinnedHotelID=4956147&HadPinnedHotel=true&regionId=892336686902599680)

[See all 649 properties in Santiago](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F4%2F2026&endDate=3%2F5%2F2026&regionId=892336686902599680)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

All Inclusive Vacations

[](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Beach Vacations

[](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Kid Friendly Vacations

[](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Golf Vacations

[](https://expedia.com/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Luxury Vacations

[](https://expedia.com/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Romantic Vacations

[](https://expedia.com/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Ski Vacations

[](https://expedia.com/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click)

![Gay Friendly Vacations](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

LGBTQ Friendly Vacations

[](https://expedia.com/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2017/07/05/170615_Adventure_1320_2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adventure Vacations

[](https://expedia.com/lp/theme-vacations/adventure-vacations?rfrr=editorial.Adventure_Vacations.click)

![Vacations in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Where to go when

[](https://expedia.com/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/honeymoon_hawaii.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Honeymoon Vacations

[](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Mountain Vacations

[](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Fishing Vacations

[](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adults Only Vacations

[](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Waterpark Vacations

[](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Scuba Diving Vacations

[](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Yoga Vacations

[](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Cheap Vacations

[](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Solo Vacations

[](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click)

### Discover the most popular places to visit in Santiago

![Africam Safari showing land animals and zoo animals](https://images.trvl-media.com/place/6167153/76e41001-2599-4604-9162-5802a3ee2139.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Africam Safari

Bring the whole family for an entertaining day out. In the car or on foot, spot lions, giraffes, elephants and more roaming together.

[](https://expedia.com/Africam-Safari-Puebla.d6167153.Vacation-Attraction)

![Zocalo Square featuring heritage elements](https://images.trvl-media.com/place/6171841/ea7e42c4-14b7-458b-b271-74c9497b1866.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Zócalo de Puebla

View the public works of art, relax in one of the cafés and get a sense of the culture in this central plaza.

[](https://expedia.com/Zocalo-De-Puebla-Puebla-Historic-Center.d6171841.Vacation-Attraction)

![Great Pyramid of Cholula featuring a garden and heritage elements](https://images.trvl-media.com/place/6165713/887fe9b3-b11c-48dd-9ece-5a91391b56fb.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Great Pyramid of Cholula

Presiding over the city of Cholula is one of the world’s largest pyramids, with an immense slope built up over centuries of religious devotion.

[](https://expedia.com/Great-Pyramid-Of-Cholula-Cholula.d6165713.Vacation-Attraction)

### Things to do

![Turitour Discover Cholula and Atlixco Magical Towns](https://mediaim.expedia.com/localexpert/3897996/91f19e19-57a5-459a-ac13-7190ce72da4e.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Discover Cholula and Atlixco Magical Towns

$35

per adult

**84%** of travellers recommend

[](https://expedia.com/things-to-do/discover-cholula-and-atlixco-magical-towns.a3897996.activity-details)

![Elephants at the African Safari Zoo in Puebla ](https://mediaim.expedia.com/localexpert/274411/816ceacd-7f96-4143-bfe2-caf3b87df19c.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Africam Safari Park

$29

per adult

**100%** of travellers recommend

[](https://expedia.com/things-to-do/africam-safari-park.a274411.activity-details)

![From Puebla: Cholula and Atlixco Puebla ́s Magical Towns](https://mediaim.expedia.com/localexpert/47764364/ec3d845a-438c-4507-a474-e7dd525fb78c.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### From Puebla: Cholula and Atlixco Magical Towns Tour

$35

per adult

**92%** of travellers recommend

[](https://expedia.com/things-to-do/from-puebla-cholula-and-atlixco-magical-towns-tour.a47764364.activity-details)

[See all activities in Puebla](https://expedia.com/things-to-do/search?rid=892336686902599680)

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.