Santuario Vacations from $433

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Santuario Vacation

Your next great escape is calling your name with a vacation package to Santuario. Excitement, fun and nonstop good times — you're bound to find it in this neighborhood. What to tick off your to-do list first? Nearby Grayhawk Golf Club is a must-see during your trip to Santuario. No matter your travel plans or budget, booking your dream Santuario vacation is easy with Expedia.

The Latest Santuario Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Raintree at Phoenix South Mountain Preserve

Raintree at Phoenix South Mountain Preserve

3.5 out of 5
South Mountain
Price was $949, price is now $433 per person
$433
per person
Feb 18 - Feb 21
found 1 day ago
Roundtrip flight included
Minneapolis (MSP) to Phoenix (PHX)
8.4/10 Very Good! (130 reviews)
Spacious condo in timeshare resort. Staff was efficient and friendly. Grounds were clean. Units themselves are pretty dated and look like they were furnished in the 70s. Better than staying at a mid range hotel in the area for the money.

Reviewed on Nov 9, 2025

Marriott Phoenix Chandler

Marriott Phoenix Chandler

4 out of 5
Save 100% on your flight
Price was $774, price is now $464 per person
$464
per person
Feb 27 - Mar 3
found 1 day ago
Roundtrip flight included
Chicago (CHI) to Phoenix (PHX)
9.4/10 Exceptional! (974 reviews)
My bed sheets had blood all over it and dark spots but the restroom was clean

Reviewed on Nov 29, 2025

Scottsdale Plaza Resort

Scottsdale Plaza Resort

4 out of 5
Save 100% on your flight
Price was $805, price is now $491 per person
$491
per person
Jan 21 - Jan 25
found 1 day ago
Roundtrip flight included
Chicago (CHI) to Phoenix (PHX)
8.8/10 Excellent! (2,207 reviews)
The room was great, however on the day of our artival we were notified that the entire resort would be out of power until 3am. After check in, we had to use our flashlights on phone to attempt to find room. There was no heat and the room was freezing. The temperature in our room was 55 degrees at night and no way to heat. This is not ok to expect your guests ti pay for a room that did not have heat or electricity.

Reviewed on Dec 7, 2025

Holiday Inn Club Vacations Scottsdale Resort by IHG

Holiday Inn Club Vacations Scottsdale Resort by IHG

4 out of 5
Save 100% on your flight
Price was $865, price is now $561 per person
$561
per person
Feb 19 - Feb 22
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to Phoenix (PHX)
9/10 Wonderful! (1,005 reviews)
The restaurant on site was a huge disappointment the two burgers we ordered were completely burnt not eatable The front desk staff was super nice and the resort really had alot for the kids to do which I appreciate. I think they need to remind people when they check in that its a cash only place, cause when we went to the restaurant and i tried paying cash the lady was super rude about it.

Reviewed on Dec 7, 2025

Residence Inn Phoenix Glendale/Peoria

Residence Inn Phoenix Glendale/Peoria

3 out of 5
Save 100% on your flight
Price was $1,487, price is now $991 per person
$991
per person
Feb 12 - Feb 17
found 7 hours ago
Roundtrip flight included
Minneapolis (MSP) to Phoenix (PHX)
9/10 Wonderful! (397 reviews)
Very clean, room with kitchen and wonderful staff.

Reviewed on Oct 8, 2025

Where to stay in Santuario

Find the best Santuario areas and neighborhoods for the activities you enjoy most. Learn more about Santuario
Downtown Phoenix which includes signage and night scenes

Downtown Phoenix

2 out of top 10 points of interest in this area
3.5/5(2,458 area reviews)

A true urban neighborhood, Downtown Phoenix boasts major sports venues like Chase Field and Footprint Center, as well as cultural attractions such as the Arizona Science Center and Phoenix Art Museum. Easily accessible via Valley Metro Light Rail, enjoy walkable streets, friendly cafes, and local businesses.

Find hotels in Downtown Phoenix

Santuario Hotel Deals

Talking Stick Resort

Talking Stick Resort

4 out of 5
9800 E. Talking Stick Way Scottsdale AZ
Fully refundableReserve now, pay when you stay
$184 nightly
The price is $210 total per night from Dec 14 to Dec 15
$210 total
Dec 14 - Dec 15
Total with taxes and fees
9.2/10 Wonderful! (4,167 reviews)
The room was clean, and the shower was amazing.

Reviewed on Dec 12, 2025

Talking Stick Resort
Hilton Phoenix Tapatio Cliffs Resort

Hilton Phoenix Tapatio Cliffs Resort

4 out of 5
11111 N 7th St Phoenix AZ
Fully refundableReserve now, pay when you stay
$145 nightly
The price is $164 total per night from Dec 21 to Dec 22
$164 total
Dec 21 - Dec 22
Total with taxes and fees
8.4/10 Very Good! (2,203 reviews)
I fell off

Reviewed on Dec 7, 2025

Hilton Phoenix Tapatio Cliffs Resort
Hilton Garden Inn Phoenix Airport North

Hilton Garden Inn Phoenix Airport North

3 out of 5
3838 E Van Buren St Phoenix AZ
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $95 total per night from Dec 21 to Dec 22
$95 total
Dec 21 - Dec 22
Total with taxes and fees
8.6/10 Excellent! (2,282 reviews)
Desk was friendly. Server at dinner was the absolute worst! Extremely rude. Room was clean. Shower door doesn't seal and water goes everywhere. Beds very hard. Great pillows!

Reviewed on Dec 12, 2025

Hilton Garden Inn Phoenix Airport North
See all 11,078 properties in Santuario
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santuario

Grady Gammage Memorial Auditorium

Arizona State University

4.5/5(1,877 reviews)

Explore the campus of Arizona State University, a top college in Tempe. Amble around the area's lakeside or seek out the jogging trails.

Arizona State University
Phoenix Convention Center

Phoenix Convention Center

4/5(959 reviews)

During your trip, find out what's happening at Phoenix Convention Center, a top convention center in Phoenix. Experience the acclaimed art scene and fascinating museums in this vibrant area.

Phoenix Convention Center
Gameday in Glendale, AZ.

State Farm Stadium

4.5/5(934 reviews)

Catch an event at State Farm Stadium during your trip to Glendale. Experience the lively festivals or attend a football game in this culturally rich area.

State Farm Stadium

Things to do

Phoenix: Historic Walking Tour

Phoenix: Historic Walking Tour

$25
per adult
Phoenix: Historic Walking Tour
See all activities in Phoenix
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.