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Compare 71 Vacation Homes in Seneca with updated reviews, rates, and availability. Most hotels are fully refundable.

Perfect Lake Hartwell Getaway - Gorgeous Lake Views!
Seneca, SC
5/5 Exceptional! (48 reviews)
Perfect Family Weekend Getaway
"My family and I had such a wonderful weekend together! This home is gorgeous with beautiful views! It is well stocked with anything I could have possibly needed! The kids (and my husband) had so much fun in the game room! The only disappointment... was having to leave this home! We will most definitely ..."

Reviewed on Dec 23, 2022

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Perfect Lake Hartwell Getaway - Gorgeous Lake Views!
Well Appointed Bungalow on Beautiful Horse Farm w/boat parking, close to Clemson
Seneca, SC
4.9/5 Exceptional! (39 reviews)
Micro house
"Very nice lay out, nice room. Owner is the most reasonable person you can talk with and plan a get away. Very cozy"

Reviewed on Dec 12, 2022

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Well Appointed Bungalow on Beautiful Horse Farm w/boat parking, close to Clemson
The Clemson Cottage | 3.6mi to Football Stadium
Seneca, SC
The price is $110 per night from Feb 7 to Feb 8
$110
per night
Feb 7 - Feb 8
4.7/5 Exceptional! (3 reviews)
Amazing place
"The Clemson Cottage was a perfect spot for my family to enjoy a Clemson Football weekend, super clean, comfortable beds, great location and easy great communication from Logan."

Reviewed on Dec 13, 2022

The Clemson Cottage | 3.6mi to Football Stadium

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Beautiful 4 Bedroom Lake Keowee Waterfront Home With Dock In Tranquil Cove
seneca, SC
5/5 Exceptional! (10 reviews)
Lovely property
"We really enjoyed our stay here. The home is well-appointed, clean, and comfortable. The neighborhood is quiet. We really enjoyed the game room!"

Reviewed on Nov 16, 2021

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Beautiful 4 Bedroom Lake Keowee Waterfront Home With Dock In Tranquil Cove
Lake front house near Clemson University
Seneca, SC
5/5 Exceptional! (21 reviews)
Perfect Clemson Getaway
"We had an outstanding time! We had 3 families come together to celebrate Christmas/ New Year’s and each family had their own space. There are enough king size beds for 3 family units to be there comfortably- maybe even 4th family/couple- as there is another king and queen for older kids. Also, a ..."

Reviewed on Jan 3, 2023

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Lake front house near Clemson University
Cozy Bungalow on Beautiful Horse Farm w/boat parking, close to Clemson Univ
Seneca, SC
5/5 Exceptional! (17 reviews)
Peaceful and Cozy
"I needed a place to stay while visiting to see my child play in Tiger Band at a Clemson football game. I don’t like crowds or traffic, and this was the perfect peaceful getaway, only 20 min. from campus. It was fun to have a “tiny home” experience, and wake up to horses just past the front porch. ..."

Reviewed on Nov 21, 2022

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Cozy Bungalow on Beautiful Horse Farm w/boat parking, close to Clemson Univ
North Forty Rd - Family Friendly Home Overlooking Lake Keowee
Seneca, SC
5/5 Exceptional! (2 reviews)
Clemson Football
"We have a yearly trip for Clemson every year and this house was perfect !! 25 minutes to Clemson and light traffic."

Reviewed on Dec 6, 2022

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North Forty Rd - Family Friendly Home Overlooking Lake Keowee
Spacious Log Cabin on Point Lot, Private Beach, Boat Rental Available
Seneca, SC
4.8/5 Exceptional! (51 reviews)
Beautiful views with so much to explore!
"We stayed over New Year's and this property is a perfect spot for a getaway. The views are undeniably gorgeous and there are some fun things to do in the area if you need to get out for the day. Carter was extremely responsive and I would highly recommend renting this home."

Reviewed on Jan 4, 2023

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Spacious Log Cabin on Point Lot, Private Beach, Boat Rental Available
Sunset Cove * Lake Keowee * Waterfront * 13 miles to Clemson
Seneca, SC
4/5 Very Good! (1 review)
Perfect floor plan
"The open common area us perfect for gathering. Perfect location. We will definitely try to book this again soon."

Reviewed on Dec 12, 2022

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Sunset Cove * Lake Keowee * Waterfront * 13 miles to Clemson
Seneca Townhome on Lake Hartwell < 4 Mi to Clemson
Seneca, SC
5/5 Exceptional! (11 reviews)
Weekend Escape
"We had a great time in Clemson and spent all day Saturday on the lake. The place is right next to the Clemson Marina where you can rent a boat. The house is “lived-in” and very comfy. You can’t beat the proximity to Clemson while staying on the lake!"

Reviewed on Jul 25, 2022

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Seneca Townhome on Lake Hartwell < 4 Mi to Clemson
1940's Bungalow located one block from Ram Cat Alley (Main St.) in Seneca, SC
Seneca, SC
5/5 Exceptional! (5 reviews)
Clemson Game
"The home was great- clean & close to campus."

Reviewed on Dec 9, 2022

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1940's Bungalow located one block from Ram Cat Alley (Main St.) in Seneca, SC
New! Peaceful Lakefront Home on Keowee! Only 7 Miles from Clemson!
Seneca, SC
5/5 Exceptional! (5 reviews)
Perfect location for a Clemson game, and gorgeous!
"Traveling with my wife, getting away from the kids for a change, this was a beautiful, quiet place that exceeded all of our expectations. We came for the Clemson Carolina ball game, and it couldn't have been any more convenient. It was only 10 minutes from the school, without traffic, and we were ..."

Reviewed on Nov 28, 2022

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New! Peaceful Lakefront Home on Keowee! Only 7 Miles from Clemson!
Keowee Hideout at Lake Keowee
Seneca, SC
5/5 Exceptional! (1 review)
Lake house.
"It was nic I wish we could have used the boats but we had a great time."

Reviewed on Nov 17, 2022

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Keowee Hideout at Lake Keowee
PRICES REDUCED! Lakehouse with Private Dock!
Seneca, SC
4.3/5 Excellent! (3 reviews)
Perfect spot
"We had a wonderful weekend with friends and family at this adorable house. We were there to visit our son at Clemson and to see a game. Great location for a Clemson weekend. The lake and yard are beautiful. We enjoyed the grill and fire pit."

Reviewed on Nov 15, 2022

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PRICES REDUCED! Lakehouse with Private Dock!
Lake House Near Clemson, Priv. Dock, WiFi, 60" TV, Grill, Kayaks, Deep Water
Seneca, SC
4.9/5 Exceptional! (105 reviews)
Great Property and a great host
"This property was exactly as listed. Spacious and comfortable with a beautiful view of the private dock and the lake. Unfortunately, we didn’t have good weather to fully take advantage of it. As advertised, the location was only 10 minutes from the Clemson campus. We would definitely stay here again ..."

Reviewed on Nov 15, 2022

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Lake House Near Clemson, Priv. Dock, WiFi, 60" TV, Grill, Kayaks, Deep Water
Harber's Way in Keowee Haven
Seneca, South Carolina
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Harber's Way in Keowee Haven
Lake Hartwell Home w/ Dock < 10 Miles to Clemson!
Seneca, SC
4.8/5 Exceptional! (40 reviews)
Fantastic!
"Awesome place and will be back !!!"

Reviewed on Dec 9, 2022

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Lake Hartwell Home w/ Dock < 10 Miles to Clemson!
Lakefront Keowee Retreat w/ Dock ~14 Mi to Clemson
Seneca, South Carolina
4.9/5 Exceptional! (37 reviews)
New favorite hide away!
"So happily surprised! Absolutely loved it. Owners went above and beyond in providing necessary items. Came for a funeral, will come again for vacation!"

Reviewed on Jan 3, 2023

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Lakefront Keowee Retreat w/ Dock ~14 Mi to Clemson
Brand New Construction!! Very close to Clemson, Flat Lot, 50 feet to the Water!
Seneca, SC
5/5 Exceptional! (10 reviews)
Beautiful!
"This home is beautiful and was the perfect fit for our large family over the holidays!"

Reviewed on Jan 22, 2023

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Brand New Construction!! Very close to Clemson, Flat Lot, 50 feet to the Water!
Completely Remodeled Lake Keowee Waterfront Home
Seneca, SC
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Completely Remodeled Lake Keowee Waterfront Home
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other property types in Seneca

Boutique hotel in historic downtown Seneca (Room #5)
Seneca, SC
5/5 Exceptional! (4 reviews)
Fantastic location with a great sleep!
"Steps from local shops and restaurants. Short drive to all the major hits—Lake Keowee, Clemson, hikes! Kids and adults all happy."

Reviewed on Jan 20, 2023

Boutique hotel in historic downtown Seneca (Room #5)
Perfect Lake Hartwell Getaway - Gorgeous Lake Views!
Seneca, SC
5/5 Exceptional! (48 reviews)
Perfect Family Weekend Getaway
"My family and I had such a wonderful weekend together! This home is gorgeous with beautiful views! It is well stocked with anything I could have possibly needed! The kids (and my husband) had so much fun in the game room! The only disappointment... was having to leave this home! We will most definitely ..."

Reviewed on Dec 23, 2022

Perfect Lake Hartwell Getaway - Gorgeous Lake Views!
Fall fun at the cabin! Convenient to Lake Keowee and Clemson
Seneca, SC
4.6/5 Wonderful! (63 reviews)
Would definitely book again
"We thoroughly enjoyed our stay. While the weather was not in our favor, we enjoyed every minute during our stay. We enjoyed many hours of family time playing cards, board games or just relaxing. Very quiet and tranquil surroundings. Best part…we were able to bring along our 4-legged friends. We would ..."

Reviewed on Jun 13, 2022

Fall fun at the cabin! Convenient to Lake Keowee and Clemson
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Seneca Vacation Homes information

Number of reviews409
Accommodation71 Vacation Homes
Lowest Price$110
Highest Price$130

Recent reviews of Seneca hotels
Expedia verified reviews

  • Boutique hotel in historic downtown Seneca (Room #4)

    Boutique hotel in historic downtown Seneca (Room #4)

    5/5 Excellent
    Great stay in Seneca
    "This was a great stay in Seneca. Walking distance to many restaurants and shops. Easy to get in and out of property. Room and common area was gorgeous and modern. There weren't any windows in our room, but that was fine with us. We love to sleep in. Really enjoyed our stay."
    A verified traveler stayed at Boutique hotel in historic downtown Seneca (Room #4)
    Posted 2 days ago
    Boutique hotel in historic downtown Seneca (Room #4)

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