Title: TOP 10 Hotels in Seneca, SC (from $59) - COMPETITIVE PRICES | Expedia.com ![Lake Keowee South Carolina](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Seneca Pool [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-04-12&d1=2026-04-12&endDate=2026-04-14&d2=2026-04-14&amenities=POOL) Pet friendly [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-04-12&d1=2026-04-12&endDate=2026-04-14&d2=2026-04-14&amenities=PETS) Family friendly [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-04-12&d1=2026-04-12&endDate=2026-04-14&d2=2026-04-14&travelerType=family_friendly) Cabin [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-04-12&d1=2026-04-12&endDate=2026-04-14&d2=2026-04-14&lodging=CABIN) Hot tub [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-04-12&d1=2026-04-12&endDate=2026-04-14&d2=2026-04-14&amenities=HOT_TUB) Apart­ment [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-04-12&d1=2026-04-12&endDate=2026-04-14&d2=2026-04-14&lodging=APARTMENT) Cottage [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-04-12&d1=2026-04-12&endDate=2026-04-14&d2=2026-04-14&lodging=COTTAGE) Condo [](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-04-12&d1=2026-04-12&endDate=2026-04-14&d2=2026-04-14&lodging=CONDO) ## Check prices for these dates Tonight [Mar 29 - Mar 30](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-03-29&endDate=2026-03-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 30 - Mar 31](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-03-30&endDate=2026-03-31&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Seneca hotels ![View from property](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/d7c06df6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/cf119645.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/f29b16c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin, 1 Queen Bed (View) | Private kitchen | Mini-fridge, stovetop, cookware/dishes/utensils, paper towels](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/60991646.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy [](https://www.expedia.com/Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) Seneca 9.8/10 Exceptional (66 reviews) "Excellent stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Beonca $124 nightly $137 total Apr 6 - Apr 7 Total with taxes and fees [](https://www.expedia.com/Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/f6f7c8c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business center](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/16b3def6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/eab53b27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Seneca Clemson Area US-123 [](https://www.expedia.com/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) Downtown 8.0/10 Very Good (689 reviews) "Room was very clean, the grounds was in well taken care of, was safe. Overall a good place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Billy $84 nightly $92 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/w4000h2662x0y0-18bf21d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/e45ab30f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/cc35e730.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/2c84c92f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites Seneca Clemson Univ Area [](https://www.expedia.com/Seneca-Hotels-Fairfield-Inn-Suites-By-Marriott-Seneca.h71594655.Hotel-Information) Seneca 9.4/10 Exceptional (214 reviews) "Hotel and room were super clean. Hotel is fairly new and it shows. Nice view of Lake Keowee. Breakfast was quite good & excellent coffee. Would definitely stay there again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Matthew $120 nightly $132 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Seneca-Hotels-Fairfield-Inn-Suites-By-Marriott-Seneca.h71594655.Hotel-Information) ![Aerial view](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/db449d90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/91e6d418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/589bd84f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/6abd26aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lakeside Lodge Clemson [](https://www.expedia.com/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) Seneca 9.0/10 Wonderful (1,002 reviews) "Great place and location, great mattress, " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeffrey $123 nightly $135 total Mar 31 - Apr 1 Total with taxes and fees [](https://www.expedia.com/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/83732283.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/590fd43d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds | Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/62fa3a56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/ac7a917f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Seneca Clemson [](https://www.expedia.com/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information) Seneca 9.2/10 Wonderful (818 reviews) "The hotel was very clean staff was amazing " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Clifford $112 nightly $123 total Apr 26 - Apr 27 Total with taxes and fees [](https://www.expedia.com/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/8f736b3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/aca2d330.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, down comforters, desk, laptop workspace](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/52f82f37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Seneca-Clemson Area [](https://www.expedia.com/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) Seneca 9.2/10 Wonderful (687 reviews) "Rooms good for the night. No issues with rooms" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sofia $131 nightly $144 total Apr 1 - Apr 2 Total with taxes and fees [](https://www.expedia.com/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) ![Standard Room, 1 King Bed, Non Smoking, Jetted Tub | Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/520000/517600/517561/eaa8fc9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/520000/517600/517561/65f927f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/520000/517600/517561/d223eeb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/520000/517600/517561/83901eb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Seneca-Clemson [](https://www.expedia.com/Anderson-Hotels-Best-Western-Seneca-Clemson.h517561.Hotel-Information) Seneca 8.4/10 Very Good (653 reviews) "Clean room! Great staff! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joshua $99 nightly $109 total Apr 13 - Apr 14 Total with taxes and fees [](https://www.expedia.com/Anderson-Hotels-Best-Western-Seneca-Clemson.h517561.Hotel-Information) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/20000/14900/14854/56ab80ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/14900/14854/79b68f69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free cribs/infant beds, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/14900/14854/0d1cab6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/14900/14854/dac98c3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Seneca / Clemson Area [](https://www.expedia.com/Anderson-Hotels-Days-Inn-By-Wyndham-Seneca-Clemson-Area.h14854.Hotel-Information) Seneca 6.8/10 (734 reviews) "Our stay was ok..the bathroom was in need of renovation " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) clyde $70 nightly $77 total Apr 2 - Apr 3 Total with taxes and fees [](https://www.expedia.com/Anderson-Hotels-Days-Inn-By-Wyndham-Seneca-Clemson-Area.h14854.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/30000/24700/24698/94758a40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/24700/24698/a55e2333.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24700/24698/19b6ad64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/24700/24698/895359d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites Easley - Greenville [](https://www.expedia.com/Easley-Hotels-Quality-Inn-Suites.h24698.Hotel-Information) Easley 7.0/10 Good (418 reviews) "Clean room Friendly Staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrina $56 nightly $62 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Easley-Hotels-Quality-Inn-Suites.h24698.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/570000/569400/569381/f18cfd05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/570000/569400/569381/816f82a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/570000/569400/569381/8ea6d425.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/570000/569400/569381/acae25f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Easley/Greenville [](https://www.expedia.com/Easley-Hotels-Baymont-By-Wyndham-EasleyGreenville.h569381.Hotel-Information) Easley 7.4/10 Good (795 reviews) "Spotless room, comfortable bed, friendly and attentive staff, breakfast was quite nice" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Teresa $63 nightly $70 total Apr 10 - Apr 11 Total with taxes and fees [](https://www.expedia.com/Easley-Hotels-Baymont-By-Wyndham-EasleyGreenville.h569381.Hotel-Information) ![Free breakfast](https://images.trvl-media.com/lodging/4000000/3630000/3629900/3629858/e417f297.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business center](https://images.trvl-media.com/lodging/4000000/3630000/3629900/3629858/70604dbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3630000/3629900/3629858/60389240.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Two queens | In-room safe, blackout drapes, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/4000000/3630000/3629900/3629858/91fb1400.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Anderson/ Alliance Business Park [](https://www.expedia.com/Anderson-Hotels-Hampton-Inn-Anderson-North.h3629858.Hotel-Information) Anderson 9.2/10 Wonderful (832 reviews) "Staff were so helpful , place was clean and food spots near by" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) osiry $109 nightly $121 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Anderson-Hotels-Hampton-Inn-Anderson-North.h3629858.Hotel-Information) ![Premium bedding, in-room safe, individually furnished, laptop workspace](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/afe0f510.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin, 1 Bedroom, Courtyard View | Front of property](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/f825207a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, individually furnished, laptop workspace](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/4d5d913d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin, 1 Bedroom, Courtyard View | Living area | 55-inch Smart TV with digital channels, streaming services](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/3f2de599.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Carolina Camp Cedar [](https://www.expedia.com/Pickens-Hotels-Carolina-Camp-Cedar.h122099740.Hotel-Information) Pickens 10/10 Exceptional (3 reviews) "The cottage was clean, staff was so friendly, our stay was quiet and peaceful… it was perfect! Definitely planning to stay there again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Katlynn $173 nightly $193 total Mar 31 - Apr 1 Total with taxes and fees [](https://www.expedia.com/Pickens-Hotels-Carolina-Camp-Cedar.h122099740.Hotel-Information) ![Room, 1 King Bed, Non Smoking, Refrigerator & Microwave (Jetted Tub) | Bathroom | Shower, towels](https://images.trvl-media.com/lodging/2000000/1130000/1122900/1122844/cca88344.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1130000/1122900/1122844/2620d800.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1130000/1122900/1122844/b21c888a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/2000000/1130000/1122900/1122844/be5a333d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Hartwell [](https://www.expedia.com/Hartwell-Hotels-Hampton-Inn-Hartwell.h1122844.Hotel-Information) Hartwell 9.0/10 Wonderful (365 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Annmargaret $107 nightly $128 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Hartwell-Hotels-Hampton-Inn-Hartwell.h1122844.Hotel-Information) ![Signature Cottage, 2 Bedrooms | Living room | 43-inch Smart TV with cable channels, TV, Netflix](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/a4df93b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Cottage, 2 Bedrooms | Private kitchen | Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/w775h924x3y0-5b08ac43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Cottage, 2 Bedrooms | Private kitchen | Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/0d77f138.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/b86441f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Clemson Memorabilia House [](https://www.expedia.com/Clemson-Hotels-Clemson-Memorabilia-House.h89502605.Hotel-Information) Clemson 9.8/10 Exceptional (9 reviews) "We enjoyed our stay, it was the perfect size for our family of four. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ashley $224 nightly $249 total Apr 2 - Apr 3 Total with taxes and fees [](https://www.expedia.com/Clemson-Hotels-Clemson-Memorabilia-House.h89502605.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/115000000/114350000/114348700/114348655/220e9886.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/115000000/114350000/114348700/114348655/9b603c5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/115000000/114350000/114348700/114348655/d68f179a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/115000000/114350000/114348700/114348655/31f33137.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Woodspring Suites Anderson North I-85 [](https://www.expedia.com/Anderson-Hotels-Woodspring-Suites-Anderson-North-I-85.h114348655.Hotel-Information) Anderson 7.8/10 Good (109 reviews) "Home away from home, great staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Selena $74 nightly $82 total Mar 31 - Apr 1 Total with taxes and fees [](https://www.expedia.com/Anderson-Hotels-Woodspring-Suites-Anderson-North-I-85.h114348655.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1350000/1340700/1340606/5902a5ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast served](https://images.trvl-media.com/lodging/2000000/1350000/1340700/1340606/27046188.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1350000/1340700/1340606/7711c34b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1350000/1340700/1340606/78e2a715.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Anderson [](https://www.expedia.com/Anderson-Hotels-Hilton-Garden-Inn-Anderson.h1340606.Hotel-Information) Anderson 9.0/10 Wonderful (707 reviews) "Rooms were clean, staff were friendly, and we had 2 good night’s sleep." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sadie $99 nightly $110 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Anderson-Hotels-Hilton-Garden-Inn-Anderson.h1340606.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/2600/2544/269fcec4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast](https://images.trvl-media.com/lodging/1000000/10000/2600/2544/5926289d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/10000/2600/2544/c069e415.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking | Desk, iron/ironing board, cribs/infant beds, rollaway beds](https://images.trvl-media.com/lodging/1000000/10000/2600/2544/d03a9275.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Clemson near University [](https://www.expedia.com/Anderson-Hotels-Quality-Inn-Clemson-Near-University.h2544.Hotel-Information) Anderson 7.0/10 Good (907 reviews) "Staff was great and our beds were very comfortable!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laurie $53 nightly $59 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Anderson-Hotels-Quality-Inn-Clemson-Near-University.h2544.Hotel-Information) ![Suite, 1 King Bed with Sofa bed, Smoking | Iron/ironing board, free cribs/infant beds, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/1000000/120000/119400/119303/5de5724d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Accessible, Non Smoking | Bathroom | Combined shower/tub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/120000/119400/119303/dbcabb39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/120000/119400/119303/29f7d83c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/120000/119400/119303/bad127ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Royston [](https://www.expedia.com/Hartwell-Hotels-Days-Inn-By-Wyndham-Royston.h119303.Hotel-Information) Royston 7.2/10 Good (237 reviews) "They are still doing renovations to the lobby, but the rooms were great" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Theodore $94 nightly $108 total Apr 10 - Apr 11 Total with taxes and fees [](https://www.expedia.com/Hartwell-Hotels-Days-Inn-By-Wyndham-Royston.h119303.Hotel-Information) ![Hartwell Suites - Suite 1 | 1 bedroom, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/103000000/102310000/102308500/102308495/d251378e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/103000000/102310000/102308500/102308495/w3597h2400x2y0-6da1bac9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hartwell Suites - Suite 1 | 1 bedroom, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/103000000/102310000/102308500/102308495/3c48d6cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/103000000/102310000/102308500/102308495/7150f3ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hartwell Suites [](https://www.expedia.com/Hartwell-Hotels-Hartwell-Suites.h102308495.Hotel-Information) Hartwell 9.2/10 Wonderful (24 reviews) "Beautiful area" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Duane $187 nightly $221 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Hartwell-Hotels-Hartwell-Suites.h102308495.Hotel-Information) ![Business center](https://images.trvl-media.com/lodging/1000000/540000/533900/533878/813e9213.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/540000/533900/533878/971b0081.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/540000/533900/533878/5a22cd65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/540000/533900/533878/b60fead8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Anderson Clemson [](https://www.expedia.com/Anderson-Hotels-Baymont-By-Wyndham-Anderson-Clemson.h533878.Hotel-Information) Anderson 7.0/10 Good (868 reviews) "Very pleasant as usual. Best bang for your buck and would recommend to anyone. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) A. Marc $68 nightly $76 total Apr 24 - Apr 25 Total with taxes and fees [](https://www.expedia.com/Anderson-Hotels-Baymont-By-Wyndham-Anderson-Clemson.h533878.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-13&endDate=2026-04-14®ionId=6548&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSeneca-Hotels.d6548.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSeneca-Hotels.d6548.Travel-Guide-Hotels) ## Where to stay in Seneca Find the best Seneca areas and neighborhoods for the activities you enjoy most. [Learn more about Seneca](https://www.expedia.com/Seneca.dx6548) - Downtown - Serenity Bay - Pine Ridge Point - Indian Oaks ![Boat Ride on Lake Hartwell](https://images.trvl-media.com/place/944725335916802048/1c54d8c1-0e1b-42ce-868f-a52d696b915a.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Sunset along the shoreline of Lake Keowee, SC.](https://images.trvl-media.com/place/944725335916802048/90313c7f-a667-4e9c-9126-626952e93c3f.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.com/Hotel-Search?pwaOverlay=map®ionId=944725335916802048) ![Downtown map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:uctrE%7CnjyNkAmSco%40tHaFFw%40sG%7DDq%7E%40rhAaLzEbgADdTmNlA&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=W0Bl9iLKssG7Dfgw2px-gKD4lJc=) ### Downtown Downtown Seneca captures the essence of small-town Southern charm with its well-preserved railroad heritage and historic brick buildings. Tree-lined streets lead to charming shops and local eateries housed in structures dating back to the 1800s. Ram Cat Alley's colorful murals tell stories of local history while the old courthouse square hosts community gatherings. This walkable district offers a peaceful retreat from big city life. Visitors can browse antique stores for railroad memorabilia, sample authentic Southern comfort food, or explore the cultural exhibits at the Bertha Lee Strickland Museum. The nearby Lake Keowee provides outdoor recreation just minutes away. [See properties](https://www.expedia.com/Hotel-Search?regionId=944725335916802048) [](https://www.expedia.com/Hotel-Search?pwaOverlay=map®ionId=553248635976468572) ![Serenity Bay map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:gzfsEj%7BmyNoOuOmDuXn%5EwOWpa%40yGpW&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=8pP_LE48Ao4j6S-mrEGIMKeSvt4=) ### Serenity Bay Serenity Bay offers a peaceful retreat within Saxony Forest's coastal embrace. The quiet residential streets wind through mature trees, creating a tranquil atmosphere away from tourist crowds. Nature lovers can explore nearby Lake Keowee or enjoy the neighborhood's forest trails. The area perfectly balances woodland serenity with beach proximity. Visitors should plan for self-contained vacation rentals rather than hotels. While dining options are limited within the neighborhood, the natural surroundings provide ideal conditions for relaxation and outdoor recreation. [See properties](https://www.expedia.com/Hotel-Search?regionId=553248635976468572) ![Female Kayaker on Lake Keowee at Sunset](https://images.trvl-media.com/place/553248635976472456/3b558c58-c920-447c-ab12-ddbbcf97f799.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.com/Hotel-Search?pwaOverlay=map®ionId=553248635976472456) ![Pine Ridge Point map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7BalsEhndyNwOsU%7BHgHcDeNnS%7BErOdYfAfUsFnD&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=XLaSweFr5Wdz_LaNTr-TqlSNujY=) ### Pine Ridge Point Lake Keowee's serene waters lap against the shores of Pine Ridge Point, a tranquil residential haven in Seneca. Private docks stretch into crystal-clear waters where boats gently bob. Towering pines create natural privacy between lakefront homes. Visitors enjoy peaceful mornings watching mist rise over the water. This neighborhood offers an authentic lakeside living experience without tourist crowds. Vacation rentals range from cozy cabins to luxury estates with private boat slips. Days revolve around swimming, fishing, and water sports on Lake Keowee. Nature trails wind through mature forests for hiking and birdwatching. [See properties](https://www.expedia.com/Hotel-Search?regionId=553248635976472456) [](https://www.expedia.com/Hotel-Search?pwaOverlay=map®ionId=553248635976482027) ![Indian Oaks map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7BxzrEj%7CnyNyH%7DNhDyY%60RgU%7EJNrClNmGdXwUzV&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=PEwl89Df4b_h_205oaRH2JFAjNI=) ### Indian Oaks Indian Oaks offers a tranquil retreat in suburban Seneca where mature oak trees create natural canopies over peaceful residential streets. This family-oriented community provides an authentic glimpse into American suburban living without tourist crowds. Landscaped yards and community green spaces showcase South Carolina's native beauty. Visitors can enjoy quiet morning walks on spacious sidewalks while listening to birdsong. Lake Keowee lies just beyond the neighborhood boundaries for those seeking water activities. With minimal commercial presence, Indian Oaks delivers a genuinely restful experience away from urban bustle. [See properties](https://www.expedia.com/Hotel-Search?regionId=553248635976482027) ## Stay near popular Seneca attractions ![High Shoals Falls in South Mountains State Park](https://images.trvl-media.com/place/911207525238796288/011afcd2-7d3a-43bc-9cd9-d478be9a614c.jpg) ### High Falls County Park Nestled along Lake Keowee with the Blue Ridge Mountains as backdrop, High Falls County Park offers pristine swimming and camping spots. Reserve waterfront campsites early to enjoy the park's serene natural setting. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=911207525238796288) ![Lovely shot of the Blue Ridge Mountains in the distance, with a rural pasture in the foreground, in late summer when the grass is starting to turn yellow and brown. Upstate South Carolina scene.](https://images.trvl-media.com/place/911210239066738688/b5610b10-5820-4595-a405-0078e7ecb5fe.jpg) ### Blue Ridge Field This historic park honors African-American education in Oconee County on the former Blue Ridge High School football grounds. Stroll the paved loop trail and explore community gardens in this peaceful green space. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=911210239066738688) ### South Cove Park This lakeside retreat on Lake Keowee offers pristine beaches, boat ramps, and scenic picnic spots. Enjoy fishing, swimming, or simply relaxing amid the natural beauty of upstate South Carolina. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=911207021295271936) ### Oconee County Library Seneca Branch This welcoming community hub offers reading materials, digital resources, and programs for all ages. Explore seasonal events like storytimes, trivia contests, and craft workshops in a tranquil learning environment. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=911209801458212864) ### Friendship Recreaction Area After visiting Friendship Recreaction Area, make a plan to see the other sights and activities in Seneca. Stroll along the lakeside or attend a sporting event in this family-friendly area. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=911208996019736576) ### Blue Ridge Arts Center Enjoy an outing to Blue Ridge Arts Center during your stay in Seneca. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=1003030878039134208) ### Highpointe Lower Field Highpointe Lower Field is just one of the places to see in Seneca, so why not enjoy the other things to explore during your travels? Stroll along the lakeside or attend a sporting event in this family-friendly area. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=911207501962506240) ### Cross Creek Plantation Golf Enjoy a round of golf in Seneca at Cross Creek Plantation Golf. Stroll along the lakeside or attend a sporting event in this family-friendly area. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=911208069724479488) ## Top Seneca Hotel Reviews ## More cheap stays in Seneca ![Quality Inn Clemson near University](https://images.trvl-media.com/lodging/1000000/10000/2600/2544/269fcec4_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Quality Inn Clemson near University 3430 Clemson Blvd Anderson SC $53 nightly $59 total Apr 12 - Apr 13 Total with taxes and fees 7/10 Good! (907 reviews) [](https://expedia.com/Anderson-Hotels-Quality-Inn-Clemson-Near-University.h2544.Hotel-Information) ![Days Inn by Wyndham Anderson](https://images.trvl-media.com/lodging/1000000/10000/6400/6344/bea0c9d1_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Days Inn by Wyndham Anderson 1007 George Smith Mill Rd Anderson SC $59 nightly $65 total Apr 12 - Apr 13 Total with taxes and fees 8/10 Very Good! (1,007 reviews) [](https://expedia.com/Anderson-Hotels-Days-Inn-By-Wyndham-Anderson.h6344.Hotel-Information) ![Inn @ Clemson](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/d257793d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Inn @ Clemson 1303 Tiger Blvd Clemson SC $87 nightly $97 total Mar 31 - Apr 1 Total with taxes and fees 8.2/10 Very Good! (1,001 reviews) [](https://expedia.com/Anderson-Hotels-Inn-Clemson.h84636.Hotel-Information) ![Comfort Inn & Suites Clemson - University Area](https://images.trvl-media.com/lodging/1000000/20000/19100/19019/60d71ae1_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Comfort Inn & Suites Clemson - University Area 1305 Tiger Blvd Clemson SC $97 nightly $108 total Apr 26 - Apr 27 Total with taxes and fees 8.2/10 Very Good! (1,002 reviews) [](https://expedia.com/Anderson-Hotels-Comfort-Inn-Suites-Clemson-University-Area.h19019.Hotel-Information) ![Best Western Plus Clemson Hotel & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3837h2558x3y3-4efd29d6_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Best Western Plus Clemson Hotel & Conference Center 1310 Tiger Blvd Clemson SC $104 nightly $115 total Apr 3 - Apr 4 Total with taxes and fees 8.2/10 Very Good! (1,007 reviews) [](https://expedia.com/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) ![Lakeside Lodge Clemson](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/db449d90_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Lakeside Lodge Clemson 13500 Clemson Blvd Seneca SC $123 nightly $135 total Mar 31 - Apr 1 Total with taxes and fees 9/10 Wonderful! 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