Seneca Vacation Rentals from $146: Search Short-Term Rentals

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Our top choices for Seneca vacation rentals

A cabin with a cozy interior, a wooden exterior, and a view of the forest.

1. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

Winston

$133 nightly

Dec 3 - Dec 4

Total with taxes and fees

A modern bedroom with a large bed, bedside tables, a desk, and a sliding door with a sign.

2. Enjoyable 1-bedroom hotel suites with AC in Seneca

Downtown

$196 nightly

Nov 5 - Nov 6

Total with taxes and fees

A blue building with a wooden deck and two Adirondack chairs.

3. Cozy Clemson TIny House Cabin

Seneca

Rebecca J.

$189 nightly

Nov 5 - Nov 6

Total with taxes and fees

A spacious living room with a high ceiling and a ceiling fan, a kitchen with modern appliances, and a dining area with a table and chairs.

4. Peaceful 3-bedroom home 4 miles from Clemson.

Seneca

Justin K.

$247 nightly

Nov 11 - Nov 12

Total with taxes and fees

A living room with a sofa, a coffee table, and a TV mounted on the wall.

5. Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms

Seneca

Brandon P.

$319 nightly

Nov 30 - Dec 1

Total with taxes and fees

A modern kitchen with wooden cabinets, stainless steel appliances, granite countertops, and pendant lighting.

6. Walk to Boat Ramp Lake Keowee w/ Parking + Firepit

Seneca

Stacey W.

$426 nightly

Nov 8 - Nov 9

Total with taxes and fees

A bedroom with a wooden headboard, white bedding, and a dark blue throw blanket.

7. Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

Seneca

Josie G.

$174 nightly

Nov 9 - Nov 10

Total with taxes and fees

A living room with a large tiger mural, a fireplace, a sofa, and a coffee table.

8. Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

Downtown

Krystine F.

$333 nightly

Nov 8 - Nov 9

Total with taxes and fees

A dining area with a wooden table and metal chairs, a ceiling fan, and a view of the outdoors through large windows.

9. Renovated 3BR near Lake Keowee & Clemson

Seneca

Brenda B.

$334 nightly

Nov 5 - Nov 6

Total with taxes and fees

A modern kitchen with a central island, wooden cabinets, and a built-in refrigerator.

10. 3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

Seneca

Jason M.

$331 nightly

Nov 5 - Nov 6

Total with taxes and fees

A compact living space with a sofa, a chair, a coffee table, and a kitchenette area.

11. Camping on Fancy-Perfect for small family getaway or couples retreat!

Seneca

Regina J.

$214 nightly

Dec 1 - Dec 2

Total with taxes and fees

A cozy bedroom with a bed, a nightstand, a lamp, a small table, a window, and a Christmas tree.

12. 8 Mi to Clemson: Peaceful Family Home w/ Yard

Seneca

Jason

$563 nightly

Nov 27 - Nov 28

Total with taxes and fees

A spacious living room with a sofa, chairs, a wooden coffee table, and a fireplace.

13. Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock

Seneca

Diana H.

$273 nightly

Nov 8 - Nov 9

Total with taxes and fees

A wooden deck with a bench, table, and chairs, surrounded by a wooden railing and trees.

14. Lakefront Retreat l Near Clemson, Hot Tub, Game Room, Kayaks, Private Dock

Seneca

Scott M.

$754 nightly

Nov 17 - Nov 18

Total with taxes and fees

A modern kitchen with white cabinetry, a central island, and a large window.

15. The Big Golf House- 10 miles to Clemson

Seneca

David E.

$547 nightly

Nov 5 - Nov 6

Total with taxes and fees

A wooden deck with a railing overlooking a forested area during sunset.

16. Waterfront 3br home on Lake Hartwell near Clemson

Seneca

Diane S.

$469 nightly

Nov 8 - Nov 9

Total with taxes and fees

A covered porch with wicker furniture, a wooden table, and a ceiling fan.

17. Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

Seneca

Allison C.

$625 nightly

Nov 5 - Nov 6

Total with taxes and fees

A staircase with wooden steps and a brick wall on one side.

18. The Nest Above - Finch Suite

Downtown

$614 nightly

Nov 13 - Nov 14

Total with taxes and fees

A small, white, cave-like structure with a wooden pathway leading to it, surrounded by lush greenery.

19. Earth Dome @ Seneca Treehouse Project

Seneca

$280 nightly

Nov 5 - Nov 6

Total with taxes and fees

A modern living room with a sofa, ottoman, and a TV on a stand.

20. Perfect 1-bedroom hotel suites with AC in fabulous Seneca- ROOM 2

Downtown

$206 nightly

Nov 5 - Nov 6

Total with taxes and fees

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Top Seneca Hotel Reviews

Jan/March 2027, 800 dollars/week, 2800/month, 2 week minimum. 4/3 Waterfront

8/10 Good

"Great location.Very clean."

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

8/10 Good

"This is a very interesting camping/glamping experience. It's off the beaten path to some degree. We were familiar with area already.The cabins/tiny homes are very clean inside. And well put together. Very quiet area/ property grounds. We enjoyed the stay. Thought that it was closer to the lake but that was ok."

New to VRBO! Big water views, private dock, pool table, 15 min Clemson!

10/10 Excellent

"We enjoyed our stay very much. The home was very clean and well stocked; we felt comfortable, had room to spread out, and loved the front and back views. The property owners provided timely responses. Our group agreed we would stay here again. Depending on traffic, it took 17 to 20 minutes to get to the university on Homecoming weekend, which wasn't a problem for us. Thank you for sharing your home!"

Charming and Entertaining Lake House Retreat for Large Groups!

10/10 Excellent

"This is an amazing property -- that won't disappoint. I was sold on the pics but this home and surroundings are even better in person. The layout of the home, beds/baths, and all the games/amenities -- so much more than we expected. The enclosed porch was a perfect adult hangout for Mahjong while the kids played skeet-ball and video games. My nephew was even able to fish in the lake. There is nothing more that could be done to make our visit any better -- it was perfect!!. Check in and check out super easy and host was very responsive. We loved our family time together and this home was definitely a highlight. Beyond 5 stars!!"

Find out more about Seneca

Everything you need to know about Seneca vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Seneca vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Seneca vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Seneca vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Seneca. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Seneca in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $146 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Seneca rentals

At Expedia, we put the best Seneca vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Seneca rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Seneca vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Seneca. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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Frequently asked questions

Are there vacation rentals in Seneca?

Yes, there are vacation rentals in Seneca close to Blue Ridge Arts Center, or you can go with a more secluded option if you'd like a relaxing place to stay. Discover why Seneca is known for its marina and lakeside. While you're here, grab a bite or have a drink at the coffeehouses.

What's the top vacation rental in Seneca?

Lake House Near Clemson Private Boat Dock WiFi 65" TV Grill Kayaks Deep Water: This highly rated vacation home rental in Seneca is located on a lake and has a fireplace, a patio, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. You can relax into your vacation with a garden and a selection of games. Some other homes for rent in Seneca include Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub and New to VRBO! Big water views, private dock, pool table, 15 min Clemson!.

How many vacation rentals are there in Seneca?

Choose from 217 Expedia vacation rentals in Seneca for a memorable vacation.

What’s there to see and do in Seneca?

Cultural attractions include The Gauntlet and Oconee Community Theatre, whereas Lake Keowee and Lake Hartwell are a couple of picturesque spots to enjoy the outdoors. While here, Keowee Key Golf Course and Oconee County Library Seneca Branch are other places worth a visit.

What’s a vacation rental in Seneca like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Seneca. Vacation rentals offer amenities such as WiFi and washers and dryers so you'll have all the conveniences of home. If you're concerned about cleanliness, vacation rentals can provide a sense of security away from shared hotel elevators and busy concierge desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a standard hotel, which makes a vacation rental an attractive choice for family trips.

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Check prices for these dates

Our top choices for Seneca vacation rentals

1. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

2. Enjoyable 1-bedroom hotel suites with AC in Seneca

3. Cozy Clemson TIny House Cabin

4. Peaceful 3-bedroom home 4 miles from Clemson.

5. Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms

6. Walk to Boat Ramp Lake Keowee w/ Parking + Firepit

7. Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

8. Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

9. Renovated 3BR near Lake Keowee & Clemson

10. 3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

11. Camping on Fancy-Perfect for small family getaway or couples retreat!

12. 8 Mi to Clemson: Peaceful Family Home w/ Yard

13. Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock

14. Lakefront Retreat l Near Clemson, Hot Tub, Game Room, Kayaks, Private Dock

15. The Big Golf House- 10 miles to Clemson

16. Waterfront 3br home on Lake Hartwell near Clemson

17. Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

18. The Nest Above - Finch Suite

19. Earth Dome @ Seneca Treehouse Project

20. Perfect 1-bedroom hotel suites with AC in fabulous Seneca- ROOM 2

Find vacation rentals that suit your style

Top Seneca Hotel Reviews

Jan/March 2027, 800 dollars/week, 2800/month, 2 week minimum. 4/3 Waterfront

Find out more about Seneca

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