Title: Seneca Vacation Rentals from $120: Search Short-Term Rentals | Expedia.com

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![Lake Keowee South Carolina](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-03-20&endDate=2026-03-22&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[May 1 - May 3](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-05-01&endDate=2026-05-03&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[May 29 - May 31](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-05-29&endDate=2026-05-31&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jun 26 - Jun 28](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-06-26&endDate=2026-06-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Seneca vacation rentals

![View from property](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/d7c06df6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/cf119645.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/ec2a8fca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/53271cae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

[](https://www.expedia.com/Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information)

Seneca

9.8/10

Exceptional

(64 reviews)

"Excellent stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Beonca

$109 nightly

$120 total

Mar 9 - Mar 10

Total with taxes and fees

[](https://www.expedia.com/Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information)

![Private kitchen](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/40d3b059.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/ec808a43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/89ea8ad4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/45872750.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Clemson Cottage - 3.6 mi. to Memorial Stadium

[](https://www.expedia.com/Seneca-Hotels-The-Clemson-Cottage-36-Mi-To-Memorial-Stadium.h96153668.Hotel-Information)

Seneca

10/10

Exceptional

(15 reviews)

"Adorable and clean home convenient to Clemson’s campus. We enjoyed our stay and Tyler was an exceptional host! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mandy H.

$360 nightly

$396 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-The-Clemson-Cottage-36-Mi-To-Memorial-Stadium.h96153668.Hotel-Information)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/118000000/117650000/117644500/117644416/c0b82041.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/118000000/117650000/117644500/117644416/c2f5c321.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Microwave, oven, stovetop](https://images.trvl-media.com/lodging/118000000/117650000/117644500/117644416/b1844261.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/118000000/117650000/117644500/117644416/5fc6414e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

###  Enjoy one of our RV units son less of a headache for you this vacation!

[](https://www.expedia.com/Seneca-Hotels-Cozy-Campground-In-Enchanting-Seneca-With-AC.h117644416.Hotel-Information)

Seneca

8.0/10

Very Good

(4 reviews)

"My partner and I stayed 5 nights and we enjoyed it so much. It's such a convenient place to reside for a get away. If you're looking for that "outback" feeling but want to be cozy; look no further. Communication was always qick with responses and was more than willing to help with anything we needed! We would definitely stay again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Denise s.

$149 nightly

$164 total

Apr 6 - Apr 7

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Cozy-Campground-In-Enchanting-Seneca-With-AC.h117644416.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/123000000/122340000/122332400/122332322/w1536h2048x0y0-6998e207.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/123000000/122340000/122332400/122332322/ad885ebc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/123000000/122340000/122332400/122332322/511c9b4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/123000000/122340000/122332400/122332322/c9812bb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy Clemson TIny House Cabin

[](https://www.expedia.com/Seneca-Hotels-Cozy-Clemson-TIny-House-Cabin.h122332322.Hotel-Information)

Seneca

$195 nightly

$215 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Cozy-Clemson-TIny-House-Cabin.h122332322.Hotel-Information)

![Smart TV, fireplace, books](https://images.trvl-media.com/lodging/106000000/105770000/105769700/105769612/9e2b77c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, travel crib, free WiFi, bed sheets](https://images.trvl-media.com/lodging/106000000/105770000/105769700/105769612/bd51a502.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/106000000/105770000/105769700/105769612/651434b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/106000000/105770000/105769700/105769612/d1bcfdf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

[](https://www.expedia.com/Seneca-Hotels-Renovated-Bungalow-1-Block-From-Downtown-Seneca-8-Miles-From-Clemson.h105769612.Hotel-Information)

Downtown

10/10

Exceptional

(16 reviews)

"Great home base for a Clemson game. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Karen A.

$305 nightly

$330 total

Apr 1 - Apr 2

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Renovated-Bungalow-1-Block-From-Downtown-Seneca-8-Miles-From-Clemson.h105769612.Hotel-Information)

![Smart TV](https://images.trvl-media.com/lodging/121000000/120090000/120082600/120082534/0834ba3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/121000000/120090000/120082600/120082534/51bdec15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/121000000/120090000/120082600/120082534/ab96edf9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/121000000/120090000/120082600/120082534/c941d493.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock

[](https://www.expedia.com/Seneca-Hotels-Lakefront-Tiny-Home-Retreat-On-Hartwell-Near-CU.h120082534.Hotel-Information)

Seneca

8.8/10

Excellent

(5 reviews)

"Everything was in great condition! Items provided were good quality. You can tell a lot of time and thought has been put into this property. We would love to stay again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Alisa W.

$265 nightly

$292 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Lakefront-Tiny-Home-Retreat-On-Hartwell-Near-CU.h120082534.Hotel-Information)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/101000000/100790000/100784300/100784243/67979a9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/101000000/100790000/100784300/100784243/424e1883.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/101000000/100790000/100784300/100784243/c5a2afe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/101000000/100790000/100784300/100784243/e2588273.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

[](https://www.expedia.com/Seneca-Hotels-Cozy-Camper-In-Clemson-Hills-5-Minutes-From-Clemson-University-Pet-Friendly.h100784243.Hotel-Information)

Seneca

10/10

Exceptional

(12 reviews)

"Very clean and comfortable - very close to Clemson and easy access. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jim A.

$180 nightly

$198 total

Mar 9 - Mar 10

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Cozy-Camper-In-Clemson-Hills-5-Minutes-From-Clemson-University-Pet-Friendly.h100784243.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/115000000/114550000/114542100/114542071/e032590e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/115000000/114550000/114542100/114542071/8a811318.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/115000000/114550000/114542100/114542071/518d0c67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/115000000/114550000/114542100/114542071/9b29fdfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming 3-bedroom house with WiFi and AC in serene Seneca on Lake Hartwell

[](https://www.expedia.com/Charming-3-Bedroom-House-With-WiFi-And-AC-In-Serene-Seneca-On-Lake-Hartwell.h114542071.Hotel-Information)

Seneca

10/10

Exceptional

(9 reviews)

"We enjoyed our stay. Had everything we needed. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Diane S.

$480 nightly

$528 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Charming-3-Bedroom-House-With-WiFi-And-AC-In-Serene-Seneca-On-Lake-Hartwell.h114542071.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/7bfcd263.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/bf812e86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/8d32bcc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, table tennis](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/1692b12e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 3-bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

[](https://www.expedia.com/Seneca-Hotels-3-Bedroom-2-Bath-Home-Located-Minutes-From-Keowee-Mariana.h118704946.Hotel-Information)

Seneca

10/10

Exceptional

(5 reviews)

"Great place with a lot close by"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Aldor D.

$288 nightly

$316 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-3-Bedroom-2-Bath-Home-Located-Minutes-From-Keowee-Mariana.h118704946.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/126000000/125630000/125624500/125624500/891c0bf4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/126000000/125630000/125624500/125624500/2d71c6c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/126000000/125630000/125624500/125624500/a6445e2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/126000000/125630000/125624500/125624500/fbb953e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

###  bedroom available in my house in lovely Seneca. 5 miles from Clemson University

[](https://www.expedia.com/Seneca-Hotels-Charming-1-Bedroom-House-In-Lovely-Seneca-5-Miles-From-Clemson-University.h125624500.Hotel-Information)

Seneca

$77 nightly

$85 total

Mar 13 - Mar 14

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Charming-1-Bedroom-House-In-Lovely-Seneca-5-Miles-From-Clemson-University.h125624500.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/fc891652.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, video games](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/f0fe695d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/d37b415d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![4 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/d33a6537.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

[](https://www.expedia.com/Seneca-Hotels-Beautiful-Updated-Clemson-Lake-House-5-Mins-From-Downtown-Clemson-And-The-Stadium.h107517282.Hotel-Information)

Seneca

9.6/10

Exceptional

(8 reviews)

"Very accommodating host. Property is a great location and very clean. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Craig F.

$657 nightly

$695 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Beautiful-Updated-Clemson-Lake-House-5-Mins-From-Downtown-Clemson-And-The-Stadium.h107517282.Hotel-Information)

![4 bedrooms, desk, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/115000000/114850000/114843800/114843702/41018e46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/115000000/114850000/114843800/114843702/3ef9dbf2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/115000000/114850000/114843800/114843702/aad65738.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/115000000/114850000/114843800/114843702/50a9d9d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Johnsons Cove - Lakefront Retreat With EV Charger

[](https://www.expedia.com/Seneca-Hotels-Johnsons-Cove-Lakefront-Retreat-With-EV-Charger-Family-And-Pet-Friendly.h114843702.Hotel-Information)

Seneca

10/10

Exceptional

(1 review)

"We truly enjoyed our stay at Johnson’s Cove. The property was super clean. The kitchen was one of the best stocked rentals I have stayed in. The mattress we slept on was better than our mattress at home. The communication with the owner was fast and she was quick to respond. We rented a pontoon for the day and the dock was easy to use for loading and unloading/restroom. We will surely rent there again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rebecca G.

$749 nightly

$795 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Johnsons-Cove-Lakefront-Retreat-With-EV-Charger-Family-And-Pet-Friendly.h114843702.Hotel-Information)

![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/c027128d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/84d2a4cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/9e13146e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/5ddade10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Big Golf House- 10 miles to Clemson

[](https://www.expedia.com/Seneca-Hotels-The-Big-Seneca-Golf-House-7-Miles-To-Death-Valley.h119746321.Hotel-Information)

Seneca

10/10

Exceptional

(2 reviews)

"Absolutely! Perfect space for our needs, so for accommodating for our family & pet. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gennifer Q.

$586 nightly

$636 total

Apr 6 - Apr 7

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-The-Big-Seneca-Golf-House-7-Miles-To-Death-Valley.h119746321.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/825f9309.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/644a4539.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, video games, stereo](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/735219a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/ce0e5825.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger

[](https://www.expedia.com/Seneca-Hotels-Deepwater-Cove-On-Lake-Keowee-Complete-With-Dock-And-Kayaks-EV-Charger.h24155990.Hotel-Information)

Serenity Bay

9.8/10

Exceptional

(130 reviews)

"A wonderful stay! The house offered many different spaces and the lake access/dock was perfect!!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

stacy s.

$651 nightly

$716 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Deepwater-Cove-On-Lake-Keowee-Complete-With-Dock-And-Kayaks-EV-Charger.h24155990.Hotel-Information)

![Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining](https://images.trvl-media.com/lodging/10000000/9130000/9126600/9126575/e62d89db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/10000000/9130000/9126600/9126575/44e61f9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room](https://images.trvl-media.com/lodging/10000000/9130000/9126600/9126575/6f5c7f95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | Living room | TV](https://images.trvl-media.com/lodging/10000000/9130000/9126600/9126575/1853a44e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Carolina Landing RV Resort - Caravan Park

[](https://www.expedia.com/Fair-Play-Hotels-Carolina-Landing-RV-Resort-Caravan-Park.h9126575.Hotel-Information)

Fair Play

7.6/10

Good

(47 reviews)

"Lake "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Milton

$130 nightly

$143 total

Mar 29 - Mar 30

Total with taxes and fees

[](https://www.expedia.com/Fair-Play-Hotels-Carolina-Landing-RV-Resort-Caravan-Park.h9126575.Hotel-Information)

![Full-size fridge, microwave, oven, coffee/tea maker](https://images.trvl-media.com/lodging/88000000/87140000/87136100/87136049/31949138.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/88000000/87140000/87136100/87136049/28889e9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/88000000/87140000/87136100/87136049/0073b890.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/88000000/87140000/87136100/87136049/5c042fbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Pendle-Tin

[](https://www.expedia.com/Pendleton-Hotels-The-Pendle-Tin.h87136049.Hotel-Information)

Pendleton

9.8/10

Exceptional

(9 reviews)

"Property was cute, cozy and perfect for our short 2 night stay! Clean and distance to campus was great! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Cindy L.

$177 nightly

$196 total

Mar 30 - Mar 31

Total with taxes and fees

[](https://www.expedia.com/Pendleton-Hotels-The-Pendle-Tin.h87136049.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/60000000/59210000/59201300/59201223/8a43d27a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/60000000/59210000/59201300/59201223/95150ab1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/60000000/59210000/59201300/59201223/fc180d72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/60000000/59210000/59201300/59201223/1c990bc8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lake Hartwell Rental w/Dock

[](https://www.expedia.com/Fair-Play-Hotels-Lake-Hartwell-Rental-WDock.h59201223.Hotel-Information)

Fair Play

10/10

Exceptional

(55 reviews)

"Michelle and the crew were awesome. I’d recommend staying there to anyone!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Christopher L.

$352 nightly

$390 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Fair-Play-Hotels-Lake-Hartwell-Rental-WDock.h59201223.Hotel-Information)

![Premium bedding, in-room safe, individually furnished, laptop workspace](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/afe0f510.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cabin, 1 Bedroom, Courtyard View | Front of property](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/f825207a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Seasonal outdoor pool, open 7:00 AM to 10:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/b26b87ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cabin, 1 Bedroom, Courtyard View | Living area | 55-inch Smart TV with digital channels, streaming services](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/3f2de599.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Carolina Camp Cedar

[](https://www.expedia.com/Pickens-Hotels-Carolina-Camp-Cedar.h122099740.Hotel-Information)

Pickens

10/10

Exceptional

(2 reviews)

"The cottage was clean, staff was so friendly, our stay was quiet and peaceful… it was perfect! Definitely planning to stay there again!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Katlynn

$170 nightly

$189 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Pickens-Hotels-Carolina-Camp-Cedar.h122099740.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/125000000/124170000/124162600/124162529/e8b6e199.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/125000000/124170000/124162600/124162529/9fa8d902.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/125000000/124170000/124162600/124162529/bb572974.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/125000000/124170000/124162600/124162529/66229e2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The sweetest Spot is your cozy and convenient Northeast, GA getaway,

[](https://www.expedia.com/Toccoa-Hotels-The-Sweetest-Spot-Is-Your-Cozy-And-Convenient-Northeast.h124162529.Hotel-Information)

Toccoa

10/10

Exceptional

(2 reviews)

"Everything is good thanks"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

MariaIsabel

$99 nightly

$114 total

Mar 16 - Mar 17

Total with taxes and fees

[](https://www.expedia.com/Toccoa-Hotels-The-Sweetest-Spot-Is-Your-Cozy-And-Convenient-Northeast.h124162529.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/36000000/35050000/35040900/35040802/w1018h758x6y0-627f3154.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, coffee/tea maker, blender](https://images.trvl-media.com/lodging/36000000/35050000/35040900/35040802/666180c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/36000000/35050000/35040900/35040802/dd70088e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/36000000/35050000/35040900/35040802/8ed4ee03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy Cabin 1/LAKE HARTWELL/Green Pond & Broyles Lndgs/Lockable Boat Shelter

[](https://www.expedia.com/Townville-Hotels-14-Mi-LAKE-HARTWELL-Broyles5mi-Green-Pond15-To-ClemsonLockable-Boat-Shelter.h35040802.Hotel-Information)

Townville

10/10

Exceptional

(113 reviews)

"All information sent in a timelyanner and everything was great with the tiny house."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Alison P.

$180 nightly

$200 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Townville-Hotels-14-Mi-LAKE-HARTWELL-Broyles5mi-Green-Pond15-To-ClemsonLockable-Boat-Shelter.h35040802.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-21&endDate=2026-03-22&regionId=6548&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

[Book now](https://expedia.com/deals?rfrr=VR_SPRING_PROMO_6548)

## Find vacation rentals that suit your style

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-04&d1=2026-06-04&endDate=2026-06-07&d2=2026-06-07&lodging=CABIN)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-04&d1=2026-06-04&endDate=2026-06-07&d2=2026-06-07&lodging=COTTAGE)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-04&d1=2026-06-04&endDate=2026-06-07&d2=2026-06-07&lodging=VACATION_HOME)

Condos

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-04&d1=2026-06-04&endDate=2026-06-07&d2=2026-06-07&lodging=CONDO)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-04&d1=2026-06-04&endDate=2026-06-07&d2=2026-06-07&lodging=APARTMENT)

Aparthotels

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-04&d1=2026-06-04&endDate=2026-06-07&d2=2026-06-07&lodging=APART_HOTEL)

Villas

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-04&d1=2026-06-04&endDate=2026-06-07&d2=2026-06-07&lodging=VILLA)

Chalets

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-04&d1=2026-06-04&endDate=2026-06-07&d2=2026-06-07&lodging=CHALET)

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## Top Seneca Hotel Reviews

![Fairfield Inn & Suites Seneca Clemson Univ Area    ](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/w4000h2662x0y0-18bf21d5_y.jpg)

### Fairfield Inn & Suites Seneca Clemson Univ Area 

10/10 Excellent

"Very clean & comfortable."

[](https://expedia.com/Seneca-Hotels-Fairfield-Inn-Suites-By-Marriott-Seneca.h71594655.Hotel-Information)

![Hampton Inn & Suites Seneca-Clemson Area](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/8f736b3a_y.jpg)

### Hampton Inn & Suites Seneca-Clemson Area

10/10 Excellent

"Clean"

[](https://expedia.com/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information)

![The Shepherd Hotel Downtown Clemson](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/bd45b45c_y.jpg)

### The Shepherd Hotel Downtown Clemson

10/10 Excellent

"Top notch hotel. Staff is amazing. If you visit, be sure to check out the outdoor space on the 7th floor. Excellent views and areas to sit and chat or work. Room was clean and the bed was wonderfully comfortable. "

[](https://expedia.com/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information)

![Lakeside Lodge Clemson](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/db449d90_y.jpg)

### Lakeside Lodge Clemson

8/10 Good

"I got a great corner room this time. Just wish the hottub was open at night. Very weird that it's not. "

[](https://expedia.com/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information)

![Tru by Hilton Seneca Clemson](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/83732283_y.jpg)

### Tru by Hilton Seneca Clemson

10/10 Excellent

"was great "

[](https://expedia.com/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information)

![Days Inn by Wyndham Seneca / Clemson Area](https://images.trvl-media.com/lodging/1000000/20000/14900/14854/56ab80ce_y.jpg)

### Days Inn by Wyndham Seneca / Clemson Area

2/10 Terrible

"Don't get a chance to park "

[](https://expedia.com/Anderson-Hotels-Days-Inn-By-Wyndham-Seneca-Clemson-Area.h14854.Hotel-Information)

![Best Western Seneca-Clemson](https://images.trvl-media.com/lodging/1000000/520000/517600/517561/eaa8fc9a_y.jpg)

### Best Western Seneca-Clemson

10/10 Excellent

"Room was clean and staff was very efficient. "

[](https://expedia.com/Anderson-Hotels-Best-Western-Seneca-Clemson.h517561.Hotel-Information)

![Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/d7c06df6_y.jpg)

### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"Very simple, but really unique touches. We enjoyed it."

[](https://expedia.com/Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information)

![Best Western Plus Clemson Hotel & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3837h2558x3y3-4efd29d6_y.jpg)

### Best Western Plus Clemson Hotel & Conference Center

10/10 Excellent

"The room was very clean, it was a room with a king bed and a sofa bed plus a microwave, mini fridge, coffee machine. The reception desk was very helpful when I had to do a late check in."

[](https://expedia.com/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information)

## Find out more about Seneca

**Everything you need to know about Seneca vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Seneca vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Seneca vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Seneca vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Seneca. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Seneca in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $120 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Seneca rentals**

At Expedia, we put the best Seneca vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Seneca rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Seneca vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Seneca. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

## Explore a world of travel with Expedia

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- [Michigan Vacation Rentals ](https://www.expedia.com/Destinations-In-Michigan.d224.Vacation-Rental-Destinations)

- [Vacation Homes in Seneca ](https://expedia.com/Seneca-Private-Vacation-Homes.d6548-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Cottages in Seneca ](https://expedia.com/Seneca-Cottages.d6548-aaCottages.Travel-Guide-Accommodation)
- [Cabin Rentals in Seneca ](https://expedia.com/Seneca-Cabins.d6548-aaCabins.Travel-Guide-Accommodation)
- [Apartments in Seneca ](https://expedia.com/Seneca-Apartments.d6548-aaApartments.Travel-Guide-Accommodation)
- [Condo Rentals in Seneca ](https://expedia.com/Seneca-Condos.d6548-aaCondos.Travel-Guide-Accommodation)
- [Villas in Seneca ](https://expedia.com/Seneca-Villas.d6548-aaVillas.Travel-Guide-Accommodation)
- [Motels in Seneca ](https://expedia.com/Seneca-Motels.d6548-aaMotels.Travel-Guide-Accommodation)
- [Farmstay in Seneca ](https://expedia.com/Seneca-Agritourism.d6548-aaAgritourism.Travel-Guide-Accommodation)
- [Lodges in Seneca ](https://expedia.com/Seneca-Lodges.d6548-aaLodges.Travel-Guide-Accommodation)
- [RV Parks in Seneca ](https://expedia.com/Seneca-RV-Parks.d6548-aaRVParks.Travel-Guide-Accommodation)
- [B&B in Seneca ](https://expedia.com/Seneca-Bed-And-Breakfast.d6548-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Guest Houses in Seneca ](https://expedia.com/Seneca-Guest-Houses.d6548-aaGuestHouses.Travel-Guide-Accommodation)
- [Chalets in Seneca ](https://expedia.com/Seneca-Chalets.d6548-aaChalets.Travel-Guide-Accommodation)
- [Houseboats in Seneca ](https://expedia.com/Seneca-Houseboats.d6548-aaHouseboats.Travel-Guide-Accommodation)
- [Condo Resorts in Seneca ](https://expedia.com/Seneca-Condominium-Resort.d6548-aaCondominiumResort.Travel-Guide-Accommodation)

## Frequently asked questions

### Are there vacation rentals in Seneca?

### What's the top vacation rental in Seneca?

### How many vacation rentals are there in Seneca?

### What’s there to see and do in Seneca?

### What’s a vacation rental in Seneca like?

### Expedia's Latest Trends

Hotels

- [Charleston Oceanfront Hotels](https://expedia.com/Charleston-Hotels-Oceanfront-Hotels.0-0-d179997-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
- [Best Hotels in Mount Pleasant](https://expedia.com/Mount-Pleasant-Hotels.d8675.Travel-Guide-Hotels)
- [Charleston Cheap Hotels](https://expedia.com/Charleston-Hotels-Cheap-Hotels.0-0-d179997-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Best Hotels in Summerville](https://expedia.com/Summerville-Hotels.d6992.Travel-Guide-Hotels)
- [Best Hotels in Myrtle Beach](https://expedia.com/Myrtle-Beach-Hotels.d601685.Travel-Guide-Hotels)
- [Myrtle Beach All-inclusive Resorts](https://expedia.com/Myrtle-Beach-Hotels-All-Inclusive-Hotel.0-0-d601685-tAllinclusiveHotel.Travel-Guide-Filter-Hotels)
- [Best Hotels in North Myrtle Beach](https://expedia.com/North-Myrtle-Beach-Hotels.d8929.Travel-Guide-Hotels)
- [Best Hotels in Greenville](https://expedia.com/Greenville-Hotels.d1388.Travel-Guide-Hotels)
- [Myrtle Beach Oceanfront Hotels](https://expedia.com/Myrtle-Beach-Hotels-Oceanfront-Hotels.0-0-d601685-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
- [Best Hotels in Hilton Head Island](https://expedia.com/Hilton-Head-Island-Hotels.d601684.Travel-Guide-Hotels)
- [Hilton Head Island Oceanfront Hotels](https://expedia.com/Hilton-Head-Island-Hotels-Oceanfront-Hotels.0-0-d601684-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
- [Best Hotels in Columbia](https://expedia.com/Columbia-Hotels.d764.Travel-Guide-Hotels)
- [Best Hotels in Florence](https://expedia.com/Florence-Hotels.d1221.Travel-Guide-Hotels)
- [Myrtle Beach Cheap Hotels](https://expedia.com/Myrtle-Beach-Hotels-Cheap-Hotels.0-0-d601685-tCheapHotels.Travel-Guide-Filter-Hotels)
- [North Myrtle Beach Oceanfront Hotels](https://expedia.com/North-Myrtle-Beach-Hotels-Oceanfront-Hotels.0-0-d8929-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
- [Best Hotels in Charleston](https://expedia.com/Charleston-Hotels.d179997.Travel-Guide-Hotels)
- [Myrtle Beach Pet-friendly Hotels](https://expedia.com/Myrtle-Beach-Hotels-Pet-Friendly-Hotel.0-0-d601685-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
- [Folly Beach Oceanfront Hotels](https://expedia.com/Folly-Beach-Hotels-Oceanfront-Hotels.0-0-d7217-tOceanfrontHotels.Travel-Guide-Filter-Hotels)

Flights

- [Flights to CAE](https://expedia.com/Cheap-Flights-To-Columbia.d764.Travel-Guide-Flights)
- [Flights to CHS](https://expedia.com/Cheap-Flights-To-Charleston.d179997.Travel-Guide-Flights)
- [Flights to SAV](https://expedia.com/Cheap-Flights-To-Hilton-Head-Island.d601684.Travel-Guide-Flights)
- [Flights to MYR](https://expedia.com/Cheap-Flights-To-Myrtle-Beach.d601685.Travel-Guide-Flights)

Cars

- [Car rentals in Columbia](https://expedia.com/Car-Rentals-In-Columbia.d764.Car-Rental-Guide)
- [Car rentals in Charleston](https://expedia.com/Car-Rentals-In-Charleston.d179997.Car-Rental-Guide)
- [Car rentals in Myrtle Beach](https://expedia.com/Car-Rentals-In-Myrtle-Beach.d601685.Car-Rental-Guide)
- [Car rentals in Greenville](https://expedia.com/Car-Rentals-In-Greenville.d1388.Car-Rental-Guide)

Cruises

- [Cruises from Charleston](https://expedia.com/Cruises-from-Charleston.d179997.Cruise-Departure-Port)

Activities

- [Things to do in Myrtle Beach](https://expedia.com/Things-To-Do-In-Myrtle-Beach.d601685.Travel-Guide-Activities)

Packages

- [Myrtle Beach Vacation Packages](https://expedia.com/Myrtle-Beach.d601685.Destination-Travel-Guides)

Vacation Rentals

- [Vacation Rentals Myrtle Beach](https://expedia.com/Myrtle-Beach-Vacation-Rentals.d601685.Travel-Guide-VacationRentals)

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