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Seneca Vacation Rentals

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Our top choices for Seneca vacation rentals

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (79 reviews)
"Awesome place "
United States
Jason
$133 nightly
The price is $146
Jun 29 - Jun 30
Total with taxes and fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Cozy Clemson TIny House Cabin

Cozy Clemson TIny House Cabin
Seneca
$198 nightly
The price is $218
Jun 23 - Jun 24
Total with taxes and fees
Cozy Clemson TIny House Cabin

Camping on Fancy-Perfect for small family getaway or couples retreat!

Camping on Fancy-Perfect for small family getaway or couples retreat!
Seneca
$152 nightly
The price is $167
Jun 22 - Jun 23
Total with taxes and fees
Camping on Fancy-Perfect for small family getaway or couples retreat!

Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
Seneca
10.0 out of 10, Exceptional, (13 reviews)
"Very clean and comfortable - very close to Clemson and easy access. "
United States
Jim A.
$182 nightly
The price is $200
Jun 22 - Jun 23
Total with taxes and fees
Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

Waterfront 3br home on Lake Hartwell near Clemson

Waterfront 3br home on Lake Hartwell near Clemson
Seneca
9.8 out of 10, Exceptional, (10 reviews)
"We enjoyed our stay. Had everything we needed. "
United States
Diane S.
$479 nightly
The price is $527
Jun 21 - Jun 22
Total with taxes and fees
Waterfront 3br home on Lake Hartwell near Clemson

Carolina Cottage Retreat-12 Minutes from Clemson University

Carolina Cottage Retreat-12 Minutes from Clemson University
Seneca
$350 nightly
The price is $385
Jun 29 - Jun 30
Total with taxes and fees
Carolina Cottage Retreat-12 Minutes from Clemson University

Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University

Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University
Seneca
$330 nightly
The price is $363
Jul 12 - Jul 13
Total with taxes and fees
Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University

Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium
Seneca
9.4 out of 10, Exceptional, (10 reviews)
"Very accommodating host. Property is a great location and very clean. "
United States
Craig F.
$657 nightly
The price is $695
Jun 23 - Jun 24
Total with taxes and fees
Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms

Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms
Seneca
10.0 out of 10, Exceptional, (25 reviews)
"Very nice accommodations and great location for stay in Clemson. "
United States
Marisa G.
$350 nightly
The price is $385
Jun 24 - Jun 25
Total with taxes and fees
Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms

3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
Seneca
9.6 out of 10, Exceptional, (9 reviews)
"Great place with a lot close by"
United States
Aldor D.
$312 nightly
The price is $343
Jun 21 - Jun 22
Total with taxes and fees
3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!
Downtown
10.0 out of 10, Exceptional, (20 reviews)
"Great home base for a Clemson game. "
United States
Karen A.
Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

The Big Golf House- 10 miles to Clemson

The Big Golf House- 10 miles to Clemson
Seneca
10.0 out of 10, Exceptional, (3 reviews)
"Great house and host!"
United States
David E.
$573 nightly
The price is $621
Jun 23 - Jun 24
Total with taxes and fees
The Big Golf House- 10 miles to Clemson

Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger

Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger
Serenity Bay
9.8 out of 10, Exceptional, (135 reviews)
"Beautiful home, well furnished, very clean, easy TV"
United States
Alan
$730 nightly
The price is $803
Jun 25 - Jun 26
Total with taxes and fees
Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger

Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!

Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!
Seneca
9.8 out of 10, Exceptional, (62 reviews)
"We had a beautiful stay over Thanksgiving in this very cozy lake house. "
United States
Felicia L.
$477 nightly
The price is $525
Jun 21 - Jun 22
Total with taxes and fees
Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!

Lake Keowee Retreat! Swim, Boat, Kayak & Relax on Dock Just Steps from the Water

Lake Keowee Retreat! Swim, Boat, Kayak & Relax on Dock Just Steps from the Water
Seneca
10.0 out of 10, Exceptional, (87 reviews)
"Nice location and functionality for family. "
United States
T P.
$857 nightly
The price is $943
Jun 28 - Jun 29
Total with taxes and fees
Lake Keowee Retreat! Swim, Boat, Kayak & Relax on Dock Just Steps from the Water

Lakefront + Quiet Cove + Dock + Fire Pit + 4 Kings + Bunks

Lakefront + Quiet Cove + Dock + Fire Pit + 4 Kings + Bunks
Seneca
$1,392 nightly
The price is $1,406
Jun 29 - Jun 30
Total with taxes and fees
Lakefront + Quiet Cove + Dock + Fire Pit + 4 Kings + Bunks

Sunset Ridge on Lake Keowee!

Sunset Ridge on Lake Keowee!
Seneca
10.0 out of 10, Exceptional, (1 review)
"Very nice. Everything seems brand new. "
United States
Heather P.
$2,832 nightly
The price is $3,115
Jun 27 - Jun 28
Total with taxes and fees
Sunset Ridge on Lake Keowee!

The Pendle-Tin

The Pendle-Tin
Pendleton
9.8 out of 10, Exceptional, (12 reviews)
"This property was private, in a safe neighborhood so walking was wonderful. It's location was perfect for the event I was attending, It's a short walk to downtown - drive 3-4 minutes"
United States
Karla
$197 nightly
The price is $219
Jun 22 - Jun 23
Total with taxes and fees
The Pendle-Tin

Lake Hartwell 2 bedroom w/ deck & dock! Plenty of parking for boats on trailers

Lake Hartwell 2 bedroom w/ deck & dock! Plenty of parking for boats on trailers
Anderson
$256 nightly
The price is $284
Jun 21 - Jun 22
Total with taxes and fees
Lake Hartwell 2 bedroom w/ deck & dock! Plenty of parking for boats on trailers

Glamping with a partial lake view, 30 minutes to Clemson University

Glamping with a partial lake view, 30 minutes to Clemson University
Westminster
9.4 out of 10, Exceptional, (15 reviews)
"The camper was very clean and the set up was very nice. Didn’t have a view of the lake, but all in all had a very nice stay. "
United States
Scott S.
$182 nightly
The price is $200
Jun 22 - Jun 23
Total with taxes and fees
Glamping with a partial lake view, 30 minutes to Clemson University
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Seneca Hotel Reviews

Find out more about Seneca

Everything you need to know about Seneca vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Seneca vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Seneca vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Seneca vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Seneca. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Seneca in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $146 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Seneca rentals

At Expedia, we put the best Seneca vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Seneca rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Seneca vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Seneca. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Are there vacation rentals in Seneca?

Yes, there are vacation rentals in Seneca close to Blue Ridge Arts Center, or you can go with a more secluded option if you'd like a relaxing place to stay. Discover why Seneca is known for its marina and lakeside. While you're here, grab a bite or have a drink at the coffeehouses.

What's the top vacation rental in Seneca?

Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock: This highly rated vacation home rental in Seneca is located on a lake and has a patio, a private yard, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. Some other homes for rent in Seneca include 4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit, Pet Friendly! and Lakefront Treehouse Retreat Minutes from Clemson University!.

How many vacation rentals are there in Seneca?

Choose from 206 Expedia vacation rentals in Seneca for a memorable vacation.

What’s there to see and do in Seneca?

Cultural attractions include The Gauntlet and Oconee Community Theatre, whereas Lake Keowee and Lake Hartwell are a couple of picturesque spots to enjoy the outdoors. While here, Keowee Key Golf Course and Seneca Historic District are other places worth a visit.

What’s a vacation rental in Seneca like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Seneca. Vacation rentals offer amenities such as WiFi and washers and dryers so you'll have all the conveniences of home. If you're concerned about cleanliness, vacation rentals can provide a sense of security away from shared hotel elevators and busy concierge desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a standard hotel, which makes a vacation rental an attractive choice for family trips.