Seneca Vacation Rentals from $153: Search Short-Term Rentals

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Our top choices for Seneca vacation rentals

1. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

laysha

$139 nightly

Aug 17 - Aug 18

Total with taxes and fees

2. Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms

Seneca

Brandon P.

$307 nightly

Aug 24 - Aug 25

Total with taxes and fees

3. Cozy Clemson TIny House Cabin

Seneca

Charlotte C.

$199 nightly

Aug 9 - Aug 10

Total with taxes and fees

4. Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

Seneca

Jim A.

$183 nightly

Aug 10 - Aug 11

Total with taxes and fees

5. Iroquois Crossroads - 10 min from Clemson & lakes

Seneca

$305 nightly

Aug 25 - Aug 26

Total with taxes and fees

6. Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

Downtown

David E.

$353 nightly

Aug 25 - Aug 26

Total with taxes and fees

Coffee/tea maker, fridge, microwave, oven

7. Carolina Cottage Retreat-12 Minutes from Clemson University

Seneca

Karen S.

$305 nightly

Aug 16 - Aug 17

Total with taxes and fees

8. Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University

Seneca

Brenda

$315 nightly

Aug 23 - Aug 24

Total with taxes and fees

9. 3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

Seneca

Jason M.

$320 nightly

Aug 16 - Aug 17

Total with taxes and fees

10. Tucker Farm Cottage on Century Farm

Seneca

Crystal N.

$364 nightly

Aug 11 - Aug 12

Total with taxes and fees

11. South Cove Cottage 5 bedroom

Indian Oaks

Richard M.

12. Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock

Seneca

Diana H.

$313 nightly

Aug 7 - Aug 8

Total with taxes and fees

13. Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!

Seneca

Felicia L.

$480 nightly

Aug 27 - Aug 28

Total with taxes and fees

14. The Big Golf House- 10 miles to Clemson

Seneca

David E.

$572 nightly

Sep 1 - Sep 2

Total with taxes and fees

15. Waterfront 3br home on Lake Hartwell near Clemson

Seneca

Diane S.

$480 nightly

Aug 8 - Aug 9

Total with taxes and fees

4 bedrooms, desk, iron/ironing board, WiFi (surcharge)

16. Johnsons Cove - Lakefront Retreat With EV Charger

Seneca

"We truly enjoyed our stay at Johnson’s Cove. The property was super clean. The kitchen was one of the best stocked rentals I have stayed in. The mattress we slept on was better than our mattress at home. The communication with the owner was fast and she was quick to respond. We rented a pontoon for the day and the dock was easy to use for loading and unloading/restroom. We will surely rent there again."

Rebecca G.

$751 nightly

Sep 3 - Sep 4

Total with taxes and fees

17. Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

Seneca

Allison C.

$723 nightly

Aug 24 - Aug 25

Total with taxes and fees

18. Renovated 3BR near Lake Keowee & Clemson

Seneca

$305 nightly

Aug 23 - Aug 24

Total with taxes and fees

19. The Pendle-Tin

Pendleton

INGRID S.

$183 nightly

Aug 10 - Aug 11

Total with taxes and fees

20. Glamping with a partial lake view, 30 minutes to Clemson University

Westminster

Scott S.

$186 nightly

Aug 10 - Aug 11

Total with taxes and fees

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Top Seneca Hotel Reviews

Lakefront home with private beach & unbelievable sunsets on Lake Keowee

10/10 Excellent

"We had a fantastic stay! The house was clean, comfortable, and the dock was perfect for fishing, kayaking, and paddleboarding. Our boys had an absolute blast tubing on the lake and exploring the nearby island was one of the highlights of the trip. We made so many great family memories and would definitely stay here again. Highly recommend!"

Tranquil Lakefront Setting near Clemson SC with Private, Covered Dock

10/10 Excellent

"Our family of 6 really enjoyed our time at Robby's place. The house was clean and comfortable. The kitchen was well stocked with about anything you might need. Lovely back deck to enjoy the mornings and evenings. The proximity to the water was good and the dock worked out great for our 24' boat. This was our first time visiting Lake Keowee and it was beautiful!"

4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit, Pet Friendly!

10/10 Excellent

"Jim and Gail’s place was absolutely wonderful! From the moment we arrived, we felt right at home. We spent most of our time outdoors because the property is so beautiful. The landscaping is meticulously maintained, and the outdoor living spaces are perfect for relaxing, gathering, and making memories with a large family. The private dock sits in a peaceful, quiet cove, which made it an ideal spot for swimming, floating, and enjoying the crystal-clear water of Lake Keowee. The calm water was perfect for both kids and adults, and we loved spending our days on the lake. We brought our fishing boat and also rented a pontoon so the entire family could explore the lake together. There was plenty of room at the dock, and being able to enjoy one of the cleanest and most beautiful lakes in America made our stay even more special. The home itself was clean, comfortable, and well equipped with everything we needed for a relaxing vacation. Jim and Gail were fantastic hosts friendly, welcoming, and easy to communicate with throughout our stay. We were welcomed with fresh flowers, such a nice touch. This was one of our favorite family vacations, and we created memories we cherish. We would absolutely stay here again and recommend this property to anyone looking for a peaceful, beautiful getaway on Lake Keowee at a great price !"

Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub

10/10 Excellent

"Perfect property. Nice dock on a quiet cove, close to a boat launch and a few water toys are included. . Beautiful neighborhood and great home. Very well stocked and comfortable. Our host was amazing."

Find out more about Seneca

Everything you need to know about Seneca vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Seneca vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Seneca vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Seneca vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Seneca. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Seneca in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $153 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Seneca rentals

At Expedia, we put the best Seneca vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Seneca rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Seneca vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Seneca. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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Frequently asked questions

Are there vacation rentals in Seneca?

Yes, there are vacation rentals in Seneca close to Blue Ridge Arts Center, or you can go with a more secluded option if you'd like a relaxing place to stay. Discover why Seneca is known for its marina and lakeside. While you're here, grab a bite or have a drink at the coffeehouses.

What's the top vacation rental in Seneca?

Lakefront home with private beach & unbelievable sunsets on Lake Keowee: This highly rated vacation home rental in Seneca is located on a lake and has a patio, a selection of games, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Some other homes for rent in Seneca include 4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit, Pet Friendly! and Lake House with Dock, Pool, and Pet Friendly. 8 Minutes from Clemson..

How many vacation rentals are there in Seneca?

Choose from 210 Expedia vacation rentals in Seneca for a memorable vacation.

What’s there to see and do in Seneca?

Cultural attractions include The Gauntlet and Oconee Community Theatre, whereas Keowee Reservoir and Lake Keowee are a couple of picturesque spots to enjoy the outdoors. While here, Keowee Key Golf Course and Lake Hartwell are other places worth a visit.

What’s a vacation rental in Seneca like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Seneca. Vacation rentals offer amenities such as WiFi and washers and dryers so you'll have all the conveniences of home. If you're concerned about cleanliness, vacation rentals can provide a sense of security away from shared hotel elevators and busy concierge desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a standard hotel, which makes a vacation rental an attractive choice for family trips.

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Check prices for these dates

Our top choices for Seneca vacation rentals

1. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

2. Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms

3. Cozy Clemson TIny House Cabin

4. Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

5. Iroquois Crossroads - 10 min from Clemson & lakes

6. Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

7. Carolina Cottage Retreat-12 Minutes from Clemson University

8. Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University

9. 3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

10. Tucker Farm Cottage on Century Farm

11. South Cove Cottage 5 bedroom

12. Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock

13. Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!

14. The Big Golf House- 10 miles to Clemson

15. Waterfront 3br home on Lake Hartwell near Clemson

16. Johnsons Cove - Lakefront Retreat With EV Charger

17. Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

18. Renovated 3BR near Lake Keowee & Clemson

19. The Pendle-Tin

20. Glamping with a partial lake view, 30 minutes to Clemson University

Find vacation rentals that suit your style

Top Seneca Hotel Reviews

Lakefront home with private beach & unbelievable sunsets on Lake Keowee

Find out more about Seneca

Explore a world of travel with Expedia

Frequently asked questions

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