Seneca Vacations from $543

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

The Latest Seneca vacation packages

Price found within the past 48 hours. Click for updated prices.
Park Place Apartments by Landing

Park Place Apartments by Landing

4 out of 5
Price was $722, price is now $543 per person
$543
per person
Feb 18 - Feb 23
found 1 day ago
Roundtrip flight included
New York (LGA) to Greenville (GSP)
7.6/10 Good! (41 reviews)
The concept is nice, but the execution/completion would make it nicer. Power went out for over 32 hrs (not sure if it was longer because I left for better accomodations), alarms went off, there is no alternative to the steep stairs due to the elevators not being complete. It was cool for the few hours I had power.

Reviewed on Jul 30, 2025

Hilton Greenville

Hilton Greenville

3.5 out of 5
Price was $813, price is now $636 per person
$636
per person
Feb 13 - Feb 18
found 23 hours ago
Roundtrip non-stop flight included
Chicago (CHI) to Greenville (GSP)
8.2/10 Very Good! (1,004 reviews)
Awesome and super clean

Reviewed on Dec 19, 2025

Comfort Inn Greenville - Haywood Mall

Comfort Inn Greenville - Haywood Mall

2.5 out of 5
Price was $693, price is now $551 per person
$551
per person
Feb 13 - Feb 18
found 23 hours ago
Roundtrip non-stop flight included
Chicago (CHI) to Greenville (GSP)
8/10 Very Good! (1,004 reviews)
The room was clean, the breakfast was delicious, awesome spread. Staff was friendly. Seamless and smooth.

Reviewed on Dec 30, 2025

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

3.5 out of 5
Price was $688, price is now $557 per person
$557
per person
Feb 13 - Feb 18
found 23 hours ago
Roundtrip non-stop flight included
Chicago (CHI) to Greenville (GSP)
8.6/10 Excellent! (1,005 reviews)
No, the room was not spotless, but it was clean. The staff was very cooperative.

Reviewed on Dec 21, 2025

Hotel Hartness

Hotel Hartness

4 out of 5
Price was $1,170, price is now $947 per person
$947
per person
Feb 13 - Feb 18
found 23 hours ago
Roundtrip non-stop flight included
Chicago (CHI) to Greenville (GSP)
9.8/10 Exceptional! (613 reviews)
Wonderful, up to date, clean property. Dining options were great. Close to the airport but far enough to be quiet.

Reviewed on Dec 28, 2025

Don't see what you're looking for?
See all available trips from Columbus to Seneca
View all trips

Where to stay in Seneca

Find the best Seneca areas and neighborhoods for the activities you enjoy most. Learn more about Seneca
Default Image

Serenity Bay

Though Serenity Bay might not have many top sights, you can venture to the surrounding area to see attractions like Keowee Key Golf Course and Lake Keowee.

Find hotels in Serenity Bay

Seneca Hotel Deals

Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd Seneca SC
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $135 total per night from Jan 1 to Jan 2
$135 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
8.8/10 Excellent! (1,000 reviews)
Enjoyed our stay.

Reviewed on Dec 15, 2025

Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

2.5 out of 5
13050 Clemson Blvd Seneca SC
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $111 total per night from Jan 11 to Jan 12
$111 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
9.2/10 Wonderful! (799 reviews)
Staff is amazing, hotel and amenities are great.

Reviewed on Dec 24, 2025

Tru by Hilton Seneca Clemson
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 out of 5
226 Hi Tech Rd Seneca SC
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $87 total per night from Jan 11 to Jan 12
$87 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
7.8/10 Good! (665 reviews)
Property, room, and front desk were all very nice. Safety strips in the bathtub would be my only suggestion.

Reviewed on Nov 28, 2025

Quality Inn Seneca Clemson Area US-123
See all 1,655 properties in Seneca
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Seneca Vacation Packages

Seneca Essential Information

Language
English
Currency
U.S dollars
Population
8,300
Max Temp Winter
50ºF
Max Temp Summer
90ºF

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a Seneca vacation package cost?
You'll find cheap prices from $543 on Expedia for your Seneca break. However, factors like the season, choice of hotel and length of stay will determine how much your vacation to Seneca costs.
What are the cheapest months to go to Seneca?
You can typically find lower rates and better availability in September, October and December. Browse our cheap Seneca vacation packages and you could land some great off-season discounts.
How many days is enough for Seneca?
Usually, a handful of days is enough to tick off the top attractions during your Seneca vacation. But if you prefer to have more time to rest or go on day tours, consider extending your itinerary.
How to find the best Seneca package deals?
Start your search for a Seneca package deal by entering your destination and travel dates under our "Packages" tab. Then add some filters, like "Guest rating" and "Property type," to tailor the results to your exact style. You can also sort by "Package discount" and browse offers that come with irresistible savings. If you don't find the perfect Seneca package deal right away, simply tweak your dates and search again. Keep in mind that deals are only available for a limited time, so book early and get your Seneca escape underway.
Is it cheaper to book a Seneca vacation as a package?
Expedia vacation packages are designed to give you more bang for your buck. Bundle your hotel, car rental and flight into one great-value price and you could save hundreds of dollars. You'll generally get a better deal than booking each component separately. And you'll still enjoy the freedom to create a personalized Seneca vacation by choosing your preferred type of stay, airline and car class.
When to book a vacation package to Seneca?
If you've got your Seneca travel dates locked in, book as early as you can to grab some fantastic deals. With Expedia, you can typically reserve some flights up to one year ahead of time. Prefer spur-of-the-moment getaways? Our last-minute deals are great for traveling on a whim.
Does Expedia offer Book Now, Pay Later Seneca vacation packages?
Set off on your perfect escape to Seneca with help from our Book Now, Pay Later vacations. There's no need to scrimp and save or wait until your next payday — we've joined forces with online lender Affirm to give you financial flexibility. Our vacation packages with payment plans allow you to spread the total cost over 3, 6 or 12 months. With no hidden charges or late payment fees, you can easily stay on budget and snap up cheap deals before they disappear.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.