South Main Vacations from $406

Book a Hotel + Flight or Car together to unlock savings

Your South Main Vacation

Book your vacation package to South Main and get ready to explore its nightlife and plenty more. Whether you're looking for adventure or relaxation, you'll discover it in this sought-after neighborhood. Can't wait to head out and see the sights during your trip to South Main? Don't miss nearby attractions like Orpheum Theatre, Sun Studio and Stax Museum of American Soul Music. Expedia will help you turn your dream South Main vacation into reality, whatever your travel plans or budget.

The Latest South Main Vacation Packages

Price found within the past 48 hours. Click for updated prices.
The Moose

The Moose

4 out of 5
Victorian Village Historic District
Price was $560, price is now $406 per person
$406
per person
Nov 10 - Nov 15
found 1 day ago
Roundtrip flight included
New York (JFK) to Memphis (MEM)
10/10 Exceptional! (150 reviews)
The bed and pillows were very comfortable. A short uber or 20 minute walk into downtown… the place was amazing with more amenities than I could use and a very nice kitchen

Reviewed on Aug 8, 2025

Hotel Napoleon Memphis

Hotel Napoleon Memphis

4 out of 5
Downtown Memphis
Price was $841, price is now $570 per person
$570
per person
Nov 8 - Nov 11
found 11 hours ago
Roundtrip non-stop flight included
Charlotte (CLT) to Memphis (MEM)
8.6/10 Excellent! (941 reviews)
The staff was very friendly and professional. The room was clean and nicely decorated. The location of the hotel was great!

Reviewed on Aug 26, 2025

The Stallion

The Stallion

4 out of 5
Downtown Memphis
Price was $846, price is now $606 per person
$606
per person
Nov 8 - Nov 11
found 11 hours ago
Roundtrip non-stop flight included
Charlotte (CLT) to Memphis (MEM)
9.8/10 Exceptional! (88 reviews)
Super clean and a heck of a bargain. Just make sure to tidy up after yourself…there is also a washer and dryer on site which is awesome. You get a whole loft and all the amenities included which was awesome. Plenty of garage parking and the location was awesome, right in the middle of everything. We will do business again!

Reviewed on Aug 25, 2025

Sheraton Memphis Downtown Hotel

Sheraton Memphis Downtown Hotel

4 out of 5
Downtown Memphis
Save 100% on your flight
Price was $817, price is now $604 per person
$604
per person
Nov 10 - Nov 15
found 1 day ago
Roundtrip flight included
New York (JFK) to Memphis (MEM)
7.6/10 Good! (1,005 reviews)
The quick weekend staycation I needed 🌖

Reviewed on Aug 11, 2025

The Rambler

The Rambler

4 out of 5
Downtown Memphis
Price was $873, price is now $648 per person
$648
per person
Nov 8 - Nov 11
found 11 hours ago
Roundtrip non-stop flight included
Charlotte (CLT) to Memphis (MEM)
9.2/10 Wonderful! (481 reviews)
Absolutely beautiful and spacious. What a unique property with a full kitchen two separate baths and big large, beautiful bedrooms it was like being in our own condo.

Reviewed on Aug 27, 2025

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most. Learn more about South Main
Beale Street showing nightlife, night scenes and street scenes

Downtown Memphis

5 out of top 10 points of interest in this area
4/5(1,782 area reviews)

Home to the Memphis Redbirds and Grizzlies NBA team, this central business district offers entertainment, dining, and attractions like Beale Street, FedExForum, and AutoZone Park. Easily accessible via major highways and public transit options.

Find hotels in Downtown Memphis

South Main Hotel Deals

ARRIVE Memphis

ARRIVE Memphis

4 out of 5
477 S Main St, Memphis, TN
Fully refundableReserve now, pay when you stay
$160 nightly
The price is $192 total per night from Sep 1 to Sep 2
$192 total
Sep 1 - Sep 2
Total with taxes and fees
9.6/10 Exceptional! (1,005 reviews)
Best place to stay in Memphis
"We love this hotel for the location and comfort."

Reviewed on Aug 24, 2025

ARRIVE Memphis
The Central Station Memphis, Curio Collection by Hilton

The Central Station Memphis, Curio Collection by Hilton

4 out of 5
545 South Main, Memphis, TN
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $179 total per night from Aug 31 to Sep 1
$179 total
Aug 31 - Sep 1
Total with taxes and fees
The Central Station Memphis, Curio Collection by Hilton
The Rambler

The Rambler

4 out of 5
400 S Main St, Memphis, TN
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $160 total per night from Sep 2 to Sep 3
$160 total
Sep 2 - Sep 3
Total with taxes and fees
9/10 Wonderful! (482 reviews)
"Nice stay room floor and couch was not clean.Also shower drain was a little backed up .Besides that great stay"

Reviewed on Aug 24, 2025

The Rambler
See all 1,514 properties in South Main
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in South Main

Graceland showing a house and a pool

Graceland

4.5/5(1,408 reviews)

Step into the lavish mansion where Elvis relaxed, entertained guests and recorded music for a fascinating glimpse into his private life and career.

Graceland
Beale Street which includes nightlife, street scenes and a city

Beale Street

4/5(1,985 reviews)

With iconic landmarks, historic buildings and live music venues, Beale Street, "the Home of the Blues" is Memphis as it was at the turn of the 20th century.

Beale Street
University of Memphis

University of Memphis

4/5(391 reviews)

Explore the campus of University of Memphis during your stay in Memphis. Make time to visit the area's shops, or simply enjoy its top-notch restaurants.

University of Memphis

Things to do

A Self Guided Walking Tour of Brews, Blues and BBQ in Memphis

A Self Guided Walking Tour of Brews, Blues and BBQ in Memphis

$15
per adult
A Self Guided Walking Tour of Brews, Blues and BBQ in Memphis
Downtown Memphis: History and Must-See Sites with Self-Guided Audio Tour

Downtown Memphis: History and Must-See Sites with Self-Guided Audio Tour

$10
per traveler
Downtown Memphis: History and Must-See Sites with Self-Guided Audio Tour
Elvis' Birthplace

Elvis Presley Birthplace Park in Tupelo with Transport from Memphis

$215
per adult
100% of travellers recommend
Elvis Presley Birthplace Park in Tupelo with Transport from Memphis
See all activities in Memphis
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.