South Main Vacations from $428

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Your South Main Vacation

Book your vacation package to South Main and get ready to explore its nightlife and plenty more. Whether you're looking for adventure or relaxation, you'll discover it in this sought-after neighborhood. Can't wait to head out and see the sights during your trip to South Main? Don't miss nearby attractions like Orpheum Theatre, Sun Studio and Stax Museum of American Soul Music. Expedia will help you turn your dream South Main vacation into reality, whatever your travel plans or budget.

The Latest South Main Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Memphis East Germantown, TN

Hilton Garden Inn Memphis East Germantown, TN

3 out of 5
Price was $532, price is now $428 per person
$428
per person
Dec 5 - Dec 8
found 23 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Memphis (MEM)
8.8/10 Excellent! (421 reviews)
Pet friendly, kind staff, clean and quiet rooms!

Reviewed on Oct 5, 2025

Sheraton Memphis Downtown Hotel

Sheraton Memphis Downtown Hotel

4 out of 5
Downtown Memphis
Price was $676, price is now $465 per person
$465
per person
Dec 5 - Dec 8
found 23 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Memphis (MEM)
7.6/10 Good! (1,011 reviews)
Very nice. Clean . Elegant . Staff is prompt . Professional. Valet staff is lovely and quick. Front desk staff got us check in/out with no mishaps Housekeeping did not disappoint at all. dinning Staff very polite &attentive we had William as our server and he made us feel like home away from home very catering and down to earth. Made our experience even greater it’s a must we visit again overall hotel experience 10/10

Reviewed on Sep 29, 2025

The Rambler

The Rambler

4 out of 5
Downtown Memphis
Save 100% on your flight
Price was $1,006, price is now $731 per person
$731
per person
Dec 5 - Dec 8
found 23 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Memphis (MEM)
9.2/10 Wonderful! (490 reviews)
just terrible parking and you can get towed if you park in the wrong area

Reviewed on Sep 29, 2025

ARRIVE Memphis

ARRIVE Memphis

4 out of 5
Downtown Memphis
Price was $1,655, price is now $1,250 per person
$1,250
per person
Nov 5 - Nov 9
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Memphis (MEM)
9.6/10 Exceptional! (1,003 reviews)
Close to everything. Very eclectic building

Reviewed on Sep 28, 2025

Hampton Inn Collierville

Hampton Inn Collierville

2.5 out of 5
Price was $983, price is now $789 per person
$789
per person
Nov 5 - Nov 9
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Memphis (MEM)
9/10 Wonderful! (972 reviews)
Clean room and excellent staff

Reviewed on Sep 17, 2025

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most. Learn more about South Main
Beale Street showing nightlife, night scenes and street scenes

Downtown Memphis

5 out of top 10 points of interest in this area
4/5(1,782 area reviews)

Home to the Memphis Redbirds and Grizzlies NBA team, this central business district offers entertainment, dining, and attractions like Beale Street, FedExForum, and AutoZone Park. Easily accessible via major highways and public transit options.

Find hotels in Downtown Memphis

South Main Hotel Deals

ARRIVE Memphis

ARRIVE Memphis

4 out of 5
477 S Main St, Memphis, TN
Fully refundableReserve now, pay when you stay
$180 nightly
The price is $216 total per night from Nov 1 to Nov 2
$216 total
Nov 1 - Nov 2
Total with taxes and fees
9.6/10 Exceptional! (1,000 reviews)
"Le valet et le personnel sont très gentil! À 10 minutes à pied de Beale street. Le lobby et le bar sont très bien."

Reviewed on Oct 1, 2025

ARRIVE Memphis
The Central Station Memphis, Curio Collection by Hilton

The Central Station Memphis, Curio Collection by Hilton

4 out of 5
545 South Main, Memphis, TN
Fully refundableReserve now, pay when you stay
$144 nightly
The price is $173 total per night from Oct 19 to Oct 20
$173 total
Oct 19 - Oct 20
Total with taxes and fees
8.8/10 Excellent! (1,006 reviews)
"Everything was fantastic. Highly recommend. The staff amazing. Room was clean. Only thing needed is more lights in room."

Reviewed on Sep 29, 2025

The Central Station Memphis, Curio Collection by Hilton
The Rambler

The Rambler

4 out of 5
400 S Main St, Memphis, TN
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $160 total per night from Oct 12 to Oct 13
$160 total
Oct 12 - Oct 13
Total with taxes and fees
9/10 Wonderful! (502 reviews)
"It was amazing. Very clean, mostly quiet, decent area"

Reviewed on Oct 2, 2025

The Rambler
See all 1,572 properties in South Main
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in South Main

Graceland showing a house and a pool

Graceland

Step into the lavish mansion where Elvis relaxed, entertained guests and recorded music for a fascinating glimpse into his private life and career.

Graceland
Beale Street which includes nightlife, street scenes and a city

Beale Street

With iconic landmarks, historic buildings and live music venues, Beale Street, "the Home of the Blues" is Memphis as it was at the turn of the 20th century.

Beale Street
University of Memphis

University of Memphis

Explore the campus of University of Memphis during your stay in Memphis. Make time to visit the area's shops, or simply enjoy its top-notch restaurants.

University of Memphis

Things to do

Memphis Haunted History Bus Tour

Memphis Haunted History Bus Tour

$33
per adult
90% of travellers recommend
Memphis Haunted History Bus Tour
Memphis City Tour with Sun Studio Admission

Memphis City Tour with Sun Studio Admission

$75
per adult
84% of travellers recommend
Memphis City Tour with Sun Studio Admission
Woodruff-Fontaine House Museum Admission Ticket in Memphis

Woodruff-Fontaine House Museum Admission Ticket in Memphis

$15
per adult
Woodruff-Fontaine House Museum Admission Ticket in Memphis
See all activities in Memphis
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.