Southampton Vacations from $160

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Your Southampton Vacation

Take the stress out of planning your next getaway with a Southampton vacation package. Take in the sounds and sights of this captivating neighborhood and experience what it has to offer. Your trip to Southampton wouldn't be complete without exploring top attractions nearby such as Houston Zoo, Houston Natural Science Museum and Childrens Museum of Houston. Expedia is here to help put your plans into action. Book your dream Southampton vacation today.

The Latest Southampton Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Holiday Inn Houston Downtown by IHG

Holiday Inn Houston Downtown by IHG

3 out of 5
Downtown Houston
Save 100% on your flight
Price was $245, price is now $160 per person
$160
per person
Jan 17 - Jan 20
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.8/10 Excellent! (1,519 reviews)
Friendly staff, clean room

Reviewed on Dec 8, 2025

Palace Inn Blue Edgebrook

Palace Inn Blue Edgebrook

3 out of 5
Southeast Houston
Save 100% on your flight
Price was $564, price is now $315 per person
$315
per person
Mar 4 - Mar 9
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Houston (IAH)
9.4/10 Exceptional! (142 reviews)
Such a great place to stay! Absolutely amazing!

Reviewed on Oct 13, 2025

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
Greater Uptown
Save 100% on your flight
Price was $290, price is now $187 per person
$187
per person
Feb 13 - Feb 15
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.2/10 Very Good! (2,889 reviews)
10/10! Courtney handled us at the front desk and her service was phenomenal. Our room was huge with a great balcony view & full kitchen! Loved this stay would definitely recommend!

Reviewed on Dec 11, 2025

Margaritaville Lake Resort, Lake Conroe/Houston

Margaritaville Lake Resort, Lake Conroe/Houston

3.5 out of 5
Save 100% on your flight
Price was $466, price is now $302 per person
$302
per person
Feb 5 - Feb 8
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.2/10 Very Good! (1,006 reviews)
No free breakfast, no microwave (rediculous), very hard to find light switches for lamps, no wifii, parking far from entrance altho shuttle was helpful. Beautiful sunrise and sunset…..oh wait…God made those.

Reviewed on Dec 4, 2025

Capital O Parker Motel Clute Jackson Tx 332

Capital O Parker Motel Clute Jackson Tx 332

2.5 out of 5
Save 100% on your flight
Price was $275, price is now $180 per person
$180
per person
Feb 21 - Feb 28
found 6 hours ago
Roundtrip flight included
Chicago (ORD) to Houston (IAH)
5.8/10 (8 reviews)
Yes when I stayed there I my 2 best friends were with me. My wife and my dog.

Reviewed on Nov 4, 2025

Where to stay in Southampton

Find the best Southampton areas and neighborhoods for the activities you enjoy most. Learn more about Southampton
Discovery Green which includes a city, central business district and a high rise building

Downtown Houston

3 out of top 10 points of interest in this area
4.5/5(2,300 area reviews)

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

Find hotels in Downtown Houston

Southampton Hotel Deals

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $135 total per night from Jan 11 to Jan 12
$135 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
8.2/10 Very Good! (3,052 reviews)
For the most part it was a great Stay

Reviewed on Dec 9, 2025

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $105 total per night from Dec 22 to Dec 23
$105 total
Dec 22 - Dec 23
Total with taxes and fees
8.2/10 Very Good! (1,730 reviews)
If the room had a microwave our stay would have been perfect.

Reviewed on Dec 9, 2025

Hilton Houston Plaza/Medical Center
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $101 total per night from Jan 12 to Jan 13
$101 total
Jan 12 - Jan 13, 2026
Total with taxes and fees
8.4/10 Very Good! (3,924 reviews)
Room was clean, wish they could have explained the parking in more detail but it was a nice stay

Reviewed on Dec 8, 2025

Club Quarters Hotel Downtown, Houston
See all 6,844 properties in Southampton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Southampton

Close to the entrance of convention center.

George R. Brown Convention Center

4/5(961 reviews)

During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the acclaimed theater scene and entertainment choices in this vibrant area.

George R. Brown Convention Center
NASA Johnson Space Center

NASA Johnson Space Center

4.5/5(1,214 reviews)

After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.

NASA Johnson Space Center
Rice University

Rice University

4.5/5(356 reviews)

Enjoy the collegiate vibe around Rice University, a top university in Houston. Experience the area's lively festivals and fascinating museums.

Rice University

Things to do

Houston Space Center

Space Center Houston Admission Ticket

$33
per adult
88% of travellers recommend
Space Center Houston Admission Ticket
Houston: Houston Botanic Garden Entry Ticket

Houston: Houston Botanic Garden Entry Ticket

$12
per adult
80% of travellers recommend
Houston: Houston Botanic Garden Entry Ticket
Houston Museum of Natural Science: Cockrell Butterfly Center

Houston Museum of Natural Science: Cockrell Butterfly Center

$15
per adult
100% of travellers recommend
Houston Museum of Natural Science: Cockrell Butterfly Center
See all activities in Houston
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.