
Southeast Iowa Vacations
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $1,045 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Southeast Iowa Vacation
Enjoy the flexibility to travel wherever your wanderlust takes you when you book a Southeast Iowa vacation package. From its rich history to a whole lot more, you can experience it all at your own speed. A carefully planned itinerary is a must for your trip to Southeast Iowa. Burlington, Mount Pleasant and Keokuk are a few of the most well-known cities here. Whether you're traveling for a few days or a few weeks, Expedia are here to help you organize your next dream Southeast Iowa vacation.
Discover the most popular places to visit in Southeast Iowa

Joseph Smith Historic Site
You can learn about the history of Nauvoo when you stop by Joseph Smith Historic Site. While you're in the area, stroll along the riverfront.
FunCity
Enjoy an outing to FunCity during your stay in Burlington. Visit the area's casinos, or simply enjoy its bars.
Historic Nauvoo
Find out about the history of Nauvoo when you spend time at Historic Nauvoo. While you're in the area, stroll along the riverfront.
Southeast Iowa Hotel Deals

Comfort Suites Burlington
The pool was warm so you can step right in, the beds were comfy, rooms were clean, hotel was clean, very nice!
Reviewed on Jan 12, 2026

The Catfish Bend Inn & Spa
Clean and lots of room
Reviewed on Jan 18, 2026

Fun City Resort Hotel
Room was great — Every staff member we came in contact with was extremely courteous & helpful.
Reviewed on Dec 14, 2025
Find the Best Southeast Iowa Vacation Packages
Southeast Iowa Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Des Moines Intl. Airport (DSM) |



















