St. Mary's Vacations from $144
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $2,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your St. Marys Vacation
Our St. Marys vacation packages are a fast and practical way to plan and reserve your next break. Discover the heart and soul of this unique neighborhood without the burden of having to plan everything yourself. Wondering what to see and do during your trip to St. Marys? Nearby attractions like University of California, San Francisco, Twin Peaks and Louise Davies Symphony Hall are great places to start. Don't just dream it — turn it into reality! Reserve your perfect St. Marys vacation with Expedia and get to where you're going your way.
The Latest St. Mary's Vacation Packages
Cathedral Hill Hotel
Reviewed on Oct 4, 2026
Merritt House Hotel
Reviewed on Oct 5, 2026
1 Hotel San Francisco
Reviewed on Oct 2, 2026
Where to stay in St. Mary's
Fisherman's Wharf
Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.
Union Square
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.
Downtown San Francisco
Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.
South of Market
From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.
Nob Hill
Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.
St. Mary's Hotel Deals
Holiday Inn Golden Gateway by IHG
"Property is well located and the amenities on site were very good. Nice bar and decent restaurant. Negative is always parking. Expensive and our vehicle was actually too tall for the garage that is only 5’8”"
Reviewed on Oct 6, 2026
Hotel Riu Plaza Fisherman's Wharf
"Location good . WiFi dreadful . Some elevators always out of action. So called resort fee a complete rip off"
Reviewed on Oct 6, 2026
Hilton San Francisco Financial District
Things to do
Alcatraz Inside tour with Round trip ferry & Audio App Packages
California Academy of Sciences Daytime Admission
