Sucusari Vacations from $172

This is probably one of the better business-class hotels in Iquitos, from what I could see. It is not overly fancy, but the rooms are clean, comfortable and air-conditioned. The staff is helpful and speak English. The attached restaurant serves delicious food.

My trip to the Amazon was one of the highlights of a three-week vacation to Latin America, and I owe it in large part to Amazon Nativo Lodge. Please note that you should contact them independently soon after. They will arrange your transportation from the airport to the lodge. They also have plenty of tour and activity options, which I highly recommend. Although I'm not one for guided tours, I'm thankful they have guides so familiar with the jungle because it would have been hard to find my way back, and I also would have missed some animals and unique plant life they pointed out, including ice cream beans and a troop of monkeys passing through the trees overhead. They really put out the welcome mat for me and ensured that I was comfortable. You will also get all three meals provided, though I recommend bringing snacks just in case as you'll be far from the city. I slept great while I was here. It's far enough removed from the river that you won't hear passing motorboats, rather you'll get soothing sounds from the jungle. And living in a large city, I also forgot how many stars there are in the sky without light pollution until I saw the clear night sky here. I loved my time at the lodge and can't recommend them enough.