Vanduser Vacations from $348

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The Latest Vanduser vacation packages

Price found within the past 48 hours. Click for updated prices.
EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel

3 out of 5
Price was $463, price is now $348 per person
$348
per person
Apr 24 - Apr 29
found 1 day ago
Roundtrip flight included
Chicago (CHI) to Cape Girardeau (CGI)
9.6/10 Exceptional! (84 reviews)
Clean rooms, great value.

Reviewed on Nov 28, 2025

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
Price was $550, price is now $448 per person
$448
per person
Apr 24 - Apr 29
found 1 day ago
Roundtrip flight included
Chicago (CHI) to Cape Girardeau (CGI)
9.6/10 Exceptional! (1,001 reviews)
Great breakfast, location right off the freeway, pleasant staff

Reviewed on Mar 17, 2026

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
Price was $546, price is now $464 per person
$464
per person
Apr 24 - Apr 29
found 1 day ago
Roundtrip flight included
Chicago (CHI) to Cape Girardeau (CGI)
9.4/10 Exceptional! (1,007 reviews)
Always the friendliest staff, like they love their job and feel respected. Always a clean room. Had a suite for this day, and ver spacious, felt like an apartment.

Reviewed on Mar 17, 2026

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3 out of 5
Price was $439, price is now $380 per person
$380
per person
Apr 24 - Apr 29
found 1 day ago
Roundtrip flight included
Chicago (CHI) to Cape Girardeau (CGI)
9.6/10 Exceptional! (1,009 reviews)
Stayed there for 10 years when we leave the Gulf to head home. Great place to stop. Meals for supper and breakfast.

Reviewed on Mar 4, 2026

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 out of 5
Price was $538, price is now $469 per person
$469
per person
Apr 24 - Apr 29
found 1 day ago
Roundtrip flight included
Chicago (CHI) to Cape Girardeau (CGI)
9.4/10 Exceptional! (1,007 reviews)
I was amazed to find out this place is 20+ years old. It is in great shape. Room was wonderful. Breakfast was great; very lovely stay.

Reviewed on Mar 13, 2026

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Vanduser Hotel Deals

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from Mar 26 to Mar 27
$108 total
Mar 26 - Mar 27
Total with taxes and fees
9.4/10 Exceptional! (1,003 reviews)
Pool not too cold and it was even snowing at one point. Staff was very friendly and helpful. Never had to wait for elevator. Breakfast waffles were excellent. Room was spacious. I’ve stayed in a lot of hotels, and this is one of the best. They get a 100/10 for amenities!

Reviewed on Mar 18, 2026

Drury Inn & Suites Sikeston, MO
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $110 total per night from Apr 12 to Apr 13
$110 total
Apr 12 - Apr 13
Total with taxes and fees
9/10 Wonderful! (506 reviews)
We wished we could have stayed longer.

Reviewed on Mar 17, 2026

Hampton Inn Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $104 total per night from Mar 24 to Mar 25
$104 total
Mar 24 - Mar 25
Total with taxes and fees
8.4/10 Very Good! (1,006 reviews)
Room was clean, the bathroom had a good vent and nice lighting which we've had a problem with with other hotels. Very satisfied with our stay and breakfast was gold.

Reviewed on Mar 19, 2026

Best Western Plus Sikeston I-55
See all 21 properties in Vanduser
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Vanduser Vacation Packages

Vanduser Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Cape Girardeau Municipal Airport (CGI)
Top Sights
Sikeston Depot Museum, Central Park and The Book Bug

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Frequently asked questions

How much does a Vanduser vacation package cost?
You'll find cheap prices from $348 on Expedia for your Vanduser break. However, factors like the length of stay, hotel choice and season will influence how much your vacation to Vanduser costs.
What are the cheapest months to go to Vanduser?
January, October and December are the best times to look for cheap Vanduser vacation packages. Traveling in less busy months means you can generally find reduced prices on accommodations and flights.
How many days is enough for Vanduser?
The ideal duration of your Vanduser vacation depends on what you'd like to do and see. Generally, a handful of days to a week will give you enough time to tick off all the major sights and discover some hidden spots along the way.
How to find the best Vanduser package deals?
Start your search for a Vanduser package deal by entering your travel dates and destination under our "Packages" tab. Then add some filters, like "Popular locations" and "Property type," to fine-tune the results to your exact style. You can also sort by "Package discount" and discover offers that come with irresistible savings. If you don't find the ideal Vanduser package deal straight away, simply tweak your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Vanduser escape off to a flying start.
Is it cheaper to book a Vanduser vacation as a package?
You can enjoy significant savings on your next Vanduser break by booking a tailored vacation package. Click on the "Package" heading, then enter your destination and travel dates to view some great flight and hotel prices. Bundling can save travelers hundreds of dollars. Consider adding a rental car and you may land a better deal.
When to book a vacation package to Vanduser?
If you've got your Vanduser vacation dates locked in, book as soon as you can to score some fantastic deals. With Expedia, you can often reserve some flights up to a year in advance. Prefer spur-of-the-moment trips? Our last-minute deals are perfect for impromptu escapes.
Does Expedia offer Book Now, Pay Later Vanduser vacation packages?
Your Vanduser break is meant to be a relaxing escape from your daily routine, not a source of money-related stress. So to give you extra flexibility, we've partnered with online lender Affirm to offer you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and break down the cost over 3, 6 or 12 months. Plus, there aren't any late payment fees or hidden costs to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.