Title: First Car Rental Car Rentals in Isla Canas - Expedia.com ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_car.jpeg?impolicy=fcrop&w=1200&h=300&q=medium) # First Car Rental Car Rentals in Isla Canas - ![protection illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__protection.svg) ### Change your mind Penalty-free cancellation on many/select car rentals - ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Treat yourself One Key members save 10% or more on over 1 million car rentals [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![package illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__package.svg) ### Shop smart Compare car suppliers and package your flight, hotel, and car to save ## Find Cheap First Car Rental Rental Deals in Isla Canas \* Price found within the past 6 days. Click for updated prices. ### Don't see what you're looking for? See all car rentals in Isla Canas [View all cars](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Isla%20Canas,%20Los%20Santos,%20Panama&dpln=6286066&date1=2/23/2026&date2=2/25/2026&crfrr=defaultFlex&SearchType=Place&selVen=[%221107%22]) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=CTG_SPRING_PROMO_6286066) At Expedia, we are proud to work with First Car Rental due to their history of superior customer service as well their large fleet of premier vehicles. Start browsing through the great selection of rental cars by entering your search preferences into our online booking wizard and sorting through everything from spacious SUVs to compact luxury cars. Meaning, whether you need an economy car for a quick business trip or a roomy vehicle to fit the entire family on a long road trip, we’ve got you covered. And, what’s more, we always offer First Car Rental Isla Canas cars at the lowest possible prices. Our prices on First Car Rental rentals in Isla Canas can’t be beat. Get started and peruse our myriad of cheap deals and discounts on rental cars for your time in Isla Canas today. ## First Car Rental Car Rental Information | Car Supplier: | First Car Rental | | ------------------------------------------------- | ------------------------------------------------------------------------------------------------------- | | Price: | | | From the airport to your hotel: | [Airport Transportation](https://www.expedia.com/ground-transfers?rfrr=car.table.AirportTransportation) | | From popular domestic and international airports: | [Airport Car Rentals](https://www.expedia.com/lp/b/car-rental/airport) | ## Frequently asked questions ### What type of car can I rent on Isla Canas with First Car Rental? ### How can I get a cheap First Car Rental rental car on Isla Canas with Expedia? ### How much does it cost to rent a car with First Car Rental on Isla Canas? ### Why should I rent a First Car Rental vehicle through Expedia? ### What happens if I need to cancel my First Car Rental rental car reservation? 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Explore Isla Canas with Expedia's Travel Guides to find the best hotels, vacation packages, car rental deals and more! [Flights to Isla Canas ](https://expedia.com/Cheap-Flights-To-Isla-Canas.d6286066.Travel-Guide-Flights)[ Isla Canas Hotels ](https://expedia.com/Isla-Canas-Hotels.d6286066.Travel-Guide-Hotels)[ Vacation Rentals in Isla Canas ](https://expedia.com/Isla-Canas-Vacation-Rentals.d6286066.Travel-Guide-VacationRentals)[ Car Rentals in Isla Canas ](https://expedia.com/Car-Rentals-In-Isla-Canas.d6286066.Car-Rental-Guide)[ Isla Canas Vacations ](https://expedia.com/Isla-Canas.d6286066.Destination-Travel-Guides)