Protected from development, Guana Tolomato Matanzas National Estuarine Research Reserve attracts an impressive range of birds and other fauna. Understand how the local community has collaborated to preserve the natural habitat here.

To visit this nature reserve, find your way to South Ponte Vedra Beach. You'll find lots of other things to see and do in the area, including Palencia Club, Castle Otttis, and Usina Beach.

Plan a trip to see Guana Tolomato Matanzas National Estuarine Research Reserve

Price found within the past 48 hours. Click for updated prices.

Florida Hotel & Conference Center in the Florida Mall

$285

per person

Jan 8 - Jan 13

found 1 day ago

Roundtrip flight included

Boston (BOS) to Orlando (MCO)

18.4/10 Exceptional! (2,232 reviews)

We had a great time.

Reviewed on Nov 20, 2025

Residence Inn by Marriott Daytona Beach Oceanfront

$621

per person

Jan 27 - Feb 3

found 1 day ago

Roundtrip flight included

Boston (BOS) to Orlando (MCO)

17.2/10 Exceptional! (1,002 reviews)

Clean room expected amenities

Reviewed on Nov 12, 2025

The Shores Resort & Spa

$387

per person

Jan 27 - Feb 3

found 1 day ago

Roundtrip flight included

Boston (BOS) to Orlando (MCO)

18/10 Exceptional! (1,681 reviews)

From the minute we checked in and Michelle greeted us, we knew we picked the right spot! Since it’s quiet season, they were able to upgrade our room to double balcony oceanfront. It felt like we were right over the beach! Very clean rooms and facilities. We were visiting my nephew who goes to school at DSC and the valet guys were so accommodating, allowing us to leave the car out front for a few hours here and there without charging us the parking fee. Sore isl shout out to Dom from valet. The pool area was great and we loved the tiki bar (shout out to Doug the bartender!) he even gave me a special drink for my bday!!! They give s’mores kits at night to use at the pool side fire pits too! When we come back to visit, we will definitely rebook at the Shores!!!

Reviewed on Nov 16, 2025

Browse tours and tickets to explore Guana Tolomato Matanzas National Estuarine Research Reserve

Tours & day trips

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St Augustine Old Town Trolley Hop-on Hop-off City Tour

Free cancellation available

Holiday & seasonal tours

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St Augustine: Nights of Lights Tour by Electric Cart

Free cancellation available

Private & custom tours

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: Step back in time with pastime private historical tours

Free cancellation available

Water activities

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St Augustine: Nights of Lights Sunset Sail with Live Music

Free cancellation available

Wildlife & nature

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St. Augustine: Dolphin and Wildlife Historical Boat Tour

Free cancellation available

Popular places to visit

Fort Mose Historic State Park

Learn about the local history of St. Augustine with a stop at Fort Mose Historic State Park. Stroll along the area's seaside or experience its fascinating museums.

Vilano Beach

Why not spend a carefree afternoon at Vilano Beach during your travels in St. Augustine? Amble around this family-friendly area's seaside and enjoy its top-notch restaurants.

Guana Pine State Park and Wildlife Management Area

Explore the lovely green spaces of Guana Pine State Park and Wildlife Management Area and enjoy the golf courses in Ponte Vedra Beach. Wander the beautiful beaches and seaside in the area.

South Ponte Vedra Beach

Why not spend a lazy afternoon at South Ponte Vedra Beach during your trip to Ponte Vedra Beach?

Guana River Wildlife Management Area

You can take time to visit Guana River Wildlife Management Area during your travels to Ponte Vedra Beach.

Water + Stone Gallery

You can browse the exhibits at Water + Stone Gallery, a museum with a storied past, during your trip to St. Augustine. Wander the beautiful beaches and seaside in the area.