Plan your trip

Find hotels in Lilbourn, MO from $57

  • Upfront pricing

    Our total price for your stay includes taxes and fees

  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices

    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

  • Go beyond your typical stay in Lilbourn

    Pet friendly

    Pool

    Hot tub

    Cabin

    Apart­ment

    Family friendly

    Condo

    Waterpark

    Check prices for these dates

    Check prices for these dates, December 12 – 13, 2026

    View in a map

    Our top choices for Lilbourn hotels

    1. Super 8 By Wyndham Marston

    A modern kitchen with a stone backsplash, a dining area with red chairs, and a red accent wall with a framed picture.

    2. Drury Inn & Suites Sikeston, MO

    A Drury Inn & Suites building with a covered entrance, multiple windows, and a parking lot.

    3. Hampton Inn Sikeston

    A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

    4. Holiday Inn Express & Suites Sikeston Southwest by IHG

    A buffet with labeled containers of turkey sausage and cookies.

    5. Fairfield Inn & Suites by Marriott Sikeston

    A modern restaurant with a wooden ceiling, large windows, and a central bar area.

    6. Best Western Plus Sikeston I-55

    A hotel room with a bed, a desk with a computer, a television, a microwave, and a refrigerator.

    7. TownePlace Suites by Marriott Sikeston

    Property amenity

    8. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

    A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

    9. Days Inn and Suites by Wyndham Sikeston

    A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

    10. Comfort Inn & Suites Sikeston I-55

    A modern building with a flat roof and large windows.

    11. Travel Inn Marston I-55 by Hotel O

    A hotel lobby with a glass table and checkered chairs, an exit door, and a vending machine.

    12. Drury Inn & Suites Hayti Caruthersville

    A spacious lobby with a modern design, featuring a seating area with patterned armchairs and a round table, a large window, and a fireplace with decorative wall art.

    13. Super 8 by Wyndham Sikeston/Miner Area

    A hotel room with a TV, microwave, desk, chair, two beds, and a window with curtains.

    14. Hampton Inn By Hilton Dexter

    A Hampton Inn hotel with a modern design, featuring a flat roof and a prominent signage.

    15. Reelfoot Lake Inn

    A hotel room with a wooden cabinet, a television, a lamp, a chair, and a desk.

    16. Country Yard Inn and Suite

    A hotel room with a bed, bedside table, desk, chair, telephone, television, and a bathroom with a mirror and sink.

    17. Quality Inn Hayti North

    A hotel entrance with a covered driveway, stone pillars, and a sign indicating a clearance of 12 feet.

    18. Econo Lodge Dexter

    A hotel room with a bed, a desk, a chair, a bathroom with a bathtub, and a patterned floor.

    19. Dexter Inn

    A restaurant with a counter, seating area, and a television.

    20. Travelodge by Wyndham Dexter

    A reception area with a marble counter, potted plants, a clock, and a TV on the wall.

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

    View all properties

    Top Lilbourn Hotel Reviews

    Drury Inn & Suites Sikeston, MO

    A Drury Inn & Suites building with a covered entrance, multiple windows, and a parking lot.

    Hampton Inn Sikeston

    A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

    Drury Inn & Suites Hayti Caruthersville

    A spacious lobby with a modern design, featuring a seating area with patterned armchairs and a round table, a large window, and a fireplace with decorative wall art.

    Holiday Inn Express & Suites Sikeston Southwest by IHG

    A buffet with labeled containers of turkey sausage and cookies.

    Best Western Plus Sikeston I-55

    A hotel room with a bed, a desk with a computer, a television, a microwave, and a refrigerator.

    Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

    A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

    Comfort Inn & Suites Sikeston I-55

    A modern building with a flat roof and large windows.

    Days Inn and Suites by Wyndham Sikeston

    A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

    Reelfoot Lake Inn

    A hotel room with a wooden cabinet, a television, a lamp, a chair, and a desk.

    Dexter Inn

    A restaurant with a counter, seating area, and a television.

    Frequently Asked Questions

    What is the best area to stay in Lilbourn?

    The best area to stay in Lilbourn is near the intersection of US-61 and US-62, as this is where you'll find the most amenities and convenient access to the surrounding region.

    This central area of Lilbourn is primarily characterized by its easy access to major roadways, making it ideal for travelers passing through or using Lilbourn as a base for exploring southeastern Missouri. While it's a smaller town, this intersection offers the most concentration of services, including dining options and local businesses.

    For travelers seeking convenience, especially those on a road trip, this area is a practical choice. The proximity to US-61 and US-62 means less time navigating local streets and more time on your journey or at your destination.

    When is the best time to go to Lilbourn?

    The best time to go to Lilbourn is during the spring (April to May) and fall (September to October) months.

    These seasons offer pleasant weather, with moderate temperatures and lower humidity, making it comfortable for outdoor activities and exploring the local area. Spring brings blooming dogwood trees and azaleas, while fall showcases colorful foliage, providing a scenic backdrop for your visit.

    Families often find these times ideal for visiting, as the mild weather is superb for enjoying local parks or taking day trips to nearby natural attractions without the extreme heat of summer or the chill of winter.

    Can I cancel my hotel reservation on Expedia?

    You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Lilbourn.

    How much is the nightly rate at a Lilbourn hotel?

    Prices for hotels in Lilbourn often vary, but you can find a great deal from $57 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

    Explore a world of travel with Expedia