Sikeston Vacations from $235

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Your Sikeston Vacation

There's tons to like about Sikeston, from its rich history to its rural countryside. When you're ready to say hi to this captivating city, our Sikeston vacation packages will be perfect for you. Fill your spare time with visits to Sikeston Depot Museum, The Book Bug and Central Park, some of the top attractions you just have to see during your trip to Sikeston. That dream Sikeston vacation is clicks away. Browse hotels, flights and more on Expedia for a getaway that's tailored to suit your travel style.

The Latest Sikeston vacation packages

Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield

3 out of 5
Price was $343, price is now $235 per person
$235
per person
Feb 6 - Feb 9
found 8 hours ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
8.2/10 Very Good! (779 reviews)
Just a really nice hotel tucked away from everything, but still close to get whereevre you need to go!

Reviewed on Oct 26, 2025

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Save 100% on your flight
Price was $510, price is now $254 per person
$254
per person
Feb 6 - Feb 9
found 8 hours ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
9.2/10 Wonderful! (1,600 reviews)
Very clean very safe

Reviewed on Dec 9, 2025

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
Grand Center
Price was $388, price is now $281 per person
$281
per person
Feb 6 - Feb 9
found 8 hours ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
8.8/10 Excellent! (1,022 reviews)
Fabulous location for catching a show at the FOX Theater. We ate at the bar which had wonderful drinks and food.

Reviewed on Dec 10, 2025

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
Price was $360, price is now $265 per person
$265
per person
Feb 6 - Feb 9
found 8 hours ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
8.4/10 Very Good! (2,194 reviews)
Everything was great. Keep up the good work!

Reviewed on Dec 10, 2025

Hampton Inn By Hilton St Louis Airport

Hampton Inn By Hilton St Louis Airport

2.5 out of 5
Woodson Terrace
Price was $347, price is now $256 per person
$256
per person
Feb 6 - Feb 9
found 8 hours ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
8.8/10 Excellent! (96 reviews)
Booked this hotel to catch a flight the next day. The hotel was clean and the breakfast was decent. The long term parking was confusing to find when I pulled in and cost more than was noted on Expedia. The shuttle driver was very nice and prompt and the shuttle was easy to find.

Reviewed on Dec 10, 2025

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Discover the most popular places to visit in Sikeston

Central Park

4/5(25 reviews)

Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this relaxing area, you can savor the top-notch restaurants.

Central Park

Sikeston Depot Museum

4/5(15 reviews)

You can spend time exploring the galleries in Sikeston Depot Museum in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants.

Sikeston Depot Museum

Sikeston Hotel Deals

Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $108 total per night from Dec 21 to Dec 22
$108 total
Dec 21 - Dec 22
Total with taxes and fees
8.8/10 Excellent! (437 reviews)
Nice quiet night

Reviewed on Nov 28, 2025

Hampton Inn Sikeston
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $103 total per night from Dec 14 to Dec 15
$103 total
Dec 14 - Dec 15
Total with taxes and fees
9.4/10 Exceptional! (1,003 reviews)
Clean room and spacious

Reviewed on Dec 8, 2025

Drury Inn & Suites Sikeston, MO
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
Fully refundableReserve now, pay when you stay
$55 nightly
The price is $63 total per night from Dec 11 to Dec 12
$63 total
Dec 11 - Dec 12
Total with taxes and fees
8.4/10 Very Good! (716 reviews)
Travel friendly accommodations at a good price. Facility was clean and functional as a halfway stopping point on the way home after Thanksgiving. Pet friendly option is a big plus for us. Recommended!

Reviewed on Nov 30, 2025

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
See all 286 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Sikeston Vacation Packages

Sikeston Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Cape Girardeau Municipal Airport (CGI)
Population
16,400
Max Temp Winter
45ºF
Max Temp Summer
85ºF
Top Sights
Sikeston Depot Museum, Central Park and The Book Bug

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Frequently asked questions

How much does a Sikeston vacation package cost?
You'll find cheap prices from $235 on Expedia for your Sikeston getaway. However, a range of factors like the season, length of stay and your choice of hotel will determine how much your vacation to Sikeston costs.
What are the cheapest months to go to Sikeston?
If you're hoping to score a cheap Sikeston vacation package, consider planning a trip in November, December and January. You'll typically find lower rates on hotels and flights during these months — ideal for travelers wishing to save money.
How many days is enough for Sikeston?
Usually, a handful of days is great for a Sikeston vacation. With a well-planned itinerary, you can go to all the popular sights such as The Book Bug, as well as explore some hidden treasures along the way.
Is it worth booking a vacation package to Sikeston?
Sikeston offers everything you need for an unforgettable getaway. Get your Sikeston vacation off to a flying start by visiting major attractions like Sikeston Depot Museum.
How to find the best Sikeston package deals?
Use Expedia's filters to find some great Sikeston package deals. When you start your search, just set your maximum budget and then order the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or look for Sikeston package deals in the off-season. Play around with your travel dates and you may land even better discounts. As a rule of thumb, it's usually best to lock in your vacation package as soon as possible.
Is it cheaper to book a Sikeston vacation as a package?
An Expedia vacation package could land you significant savings when compared to booking stays and flights separately. Better still, you can tailor your Sikeston escape to fit your exact style. Pick your preferred flight time, select the hotel type and add a car rental. Browse our bundle deals and find out how much you can save.
When to book a vacation package to Sikeston?
Enjoy incredible bargains by booking your flights in advance with Expedia. If spontaneity is more your thing, snap up one of our last-minute deals for a spur-of-the-moment Sikeston trip.
Does Expedia offer Book Now, Pay Later Sikeston vacation packages?
If you're like us, you love traveling the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With the help of online lender Affirm, you can spread the total cost of your Sikeston vacation over 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can secure great vacation packages with payment plans as soon as you see them.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.