Sikeston Vacations from $330

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Your Sikeston Vacation

There's tons to like about Sikeston, from its rich history to its rural countryside. When you're ready to say hi to this captivating city, our Sikeston vacation packages will be perfect for you. Fill your spare time with visits to Sikeston Depot Museum, The Book Bug and Central Park, some of the top attractions you just have to see during your trip to Sikeston. That dream Sikeston vacation is clicks away. Browse hotels, flights and more on Expedia for a getaway that's tailored to suit your travel style.

The Latest Sikeston vacation packages

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Price was $658, price is now $330 per person
$330
per person
Sep 24 - Sep 28
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,650 reviews)
The staff was wonderful

Reviewed on Jul 25, 2026

Remodeled and Inviting Free EV

Remodeled and Inviting Free EV

2 out of 5
Save 100% on your flight
Price was $916, price is now $558 per person
$558
per person
Sep 17 - Sep 22
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
10/10 Exceptional! (1 review)
The property was excellent, and the home was very warm and welcoming.

Reviewed on Jun 25, 2026

The Cheshire

The Cheshire

4 out of 5
Save 100% on your flight
Price was $681, price is now $433 per person
$433
per person
Sep 24 - Sep 28
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,010 reviews)
The Cheshire is our home away from home in St Louis. We’ve stayed here at least seven times in the last thirteen years and have never been disappointed. The location is so central with great highway access that it’s hard to be more than twenty minutes from most places to visit.

Reviewed on Jul 25, 2026

Residence Inn by Marriott St Louis Downtown

Residence Inn by Marriott St Louis Downtown

3 out of 5
Midtown
Save 100% on your flight
Price was $573, price is now $374 per person
$374
per person
Sep 24 - Sep 28
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
7.8/10 Good! (1,000 reviews)
Has to wait and request the room I booked. The hotel smelled like weed.

Reviewed on Jul 24, 2026

The Knight Center at Washington University

The Knight Center at Washington University

2.5 out of 5
Save 100% on your flight
Price was $605, price is now $426 per person
$426
per person
Sep 24 - Sep 28
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.4/10 Exceptional! (627 reviews)

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Stay near popular Sikeston attractions

Sikeston Depot Museum

7.6/10 (57 reviews)
Housed in a restored 1916 train depot, this museum showcases Sikeston's cotton-growing heritage and local art. Explore regional history through rotating exhibits while admiring the building's National Register status.
See properties

Sikeston Hotel Deals

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $125 total per night from Aug 16 to Aug 17
$125 total
Aug 16 - Aug 17
Total with taxes and fees
9.6/10 Exceptional! (1,007 reviews)
"Wonderful staff. Pet friendly"

Reviewed on Jul 24, 2026

Drury Inn & Suites Sikeston, MO
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $104 total per night from Jul 26 to Jul 27
$104 total
Jul 26 - Jul 27
Total with taxes and fees
8.4/10 Very Good! (1,003 reviews)
"Everything was well but the actual property was a little winding getting there (but i wasarriving at night) and there is not another business next to it, just a small lake, If you like that. Overall clean, nice and quiet. Nice breakfast room!"

Reviewed on Jul 25, 2026

Best Western Plus Sikeston I-55
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $77 total per night from Aug 4 to Aug 5
$77 total
Aug 4 - Aug 5
Total with taxes and fees
7.2/10 Good! (1,004 reviews)
"Poor location -- far from restaurants or grocery. The parking lot was dirty (cigarette butts, broken asphalt, weeds untrimmed). Stair rubber treads are broken (a customer easy to trip and fall). Shower floor was dirty. The room had stain couch fabric, a lamp broken, and the TV reception was poor. ..."

Reviewed on Jul 24, 2026

Days Inn and Suites by Wyndham Sikeston
See all 319 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Sikeston Vacation Packages

Sikeston Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Cape Girardeau Municipal Airport (CGI)
Population
16,400
Max Temp Winter
45ºF
Max Temp Summer
85ºF
Top Sights
Sikeston Depot Museum, Central Park and The Book Bug

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Frequently asked questions

How much does a Sikeston vacation package cost?
You'll find cheap prices from $330 on Expedia for your Sikeston getaway. However, a range of factors like the season, length of stay and your choice of hotel will determine how much your vacation to Sikeston costs.
What are the cheapest months to go to Sikeston?
If you're hoping to score a cheap Sikeston vacation package, consider planning a trip in November, December and January. You'll typically find lower rates on hotels and flights during these months — ideal for travelers wishing to save money.
How many days is enough for Sikeston?
Usually, a handful of days is great for a Sikeston vacation. With a well-planned itinerary, you can go to all the popular sights such as The Book Bug, as well as explore some hidden treasures along the way.
Is it worth booking a vacation package to Sikeston?
Sikeston offers everything you need for an unforgettable getaway. Get your Sikeston vacation off to a flying start by visiting major attractions like Sikeston Depot Museum.
How to find the best Sikeston package deals?
Use Expedia's filters to find some great Sikeston package deals. When you start your search, just set your maximum budget and then order the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or look for Sikeston package deals in the off-season. Play around with your travel dates and you may land even better discounts. As a rule of thumb, it's usually best to lock in your vacation package as soon as possible.
Is it cheaper to book a Sikeston vacation as a package?
An Expedia vacation package could land you significant savings when compared to booking stays and flights separately. Better still, you can tailor your Sikeston escape to fit your exact style. Pick your preferred flight time, select the hotel type and add a car rental. Browse our bundle deals and find out how much you can save.
When to book a vacation package to Sikeston?
Enjoy incredible bargains by booking your flights in advance with Expedia. If spontaneity is more your thing, snap up one of our last-minute deals for a spur-of-the-moment Sikeston trip.
Does Expedia offer Book Now, Pay Later Sikeston vacation packages?
If you're like us, you love traveling the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With the help of online lender Affirm, you can spread the total cost of your Sikeston vacation over 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can secure great vacation packages with payment plans as soon as you see them.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.