Title: Sikeston Vacation Packages 2026 from $395 | Expedia.com [Sikeston Travel Guide](https://expedia.com/Sikeston.dx6058766)[Hotels in Sikeston](https://expedia.com/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)[Vacation Rentals in Sikeston](https://expedia.com/Sikeston-Vacation-Rentals.d6058766.Travel-Guide-VacationRentals)[Flights to Sikeston](https://expedia.com/Cheap-Flights-To-Sikeston.d6058766.Travel-Guide-Flights)[Car Rentals in Sikeston](https://expedia.com/Car-Rentals-In-Sikeston.d6058766.Car-Rental-Guide) ![](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Sikeston Vacations from $395 ## Book a Hotel + Flight or Car together to unlock savings ## Your Sikeston Vacation There's tons to like about Sikeston, from its rich history to its rural countryside. When you're ready to say hi to this captivating city, our Sikeston vacation packages will be perfect for you. Fill your spare time with visits to [Sikeston Depot Museum](https://www.expedia.com/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction), [The Book Bug](https://www.expedia.com/The-Book-Bug-Sikeston.d553248621532655751.Vacation-Attraction) and [Central Park](https://www.expedia.com/Central-Park-Sikeston.d6305608.Vacation-Attraction), some of the top attractions you just have to see during your trip to Sikeston. That dream Sikeston vacation is clicks away. Browse hotels, flights and more on Expedia for a getaway that's tailored to suit your travel style. ## The Latest Sikeston vacation packages Price found within the past 48 hours. Click for updated prices. ![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/800a6847_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Wildwood Hotel $395 per person Mar 27 - Mar 29 found 1 day ago Roundtrip flight included Atlanta (ATL) to St. Louis (STL) 9.2/10 Wonderful! (1,600 reviews) Everything was great Reviewed on Feb 23, 2026 ![Angad Arts Hotel St. Louis, Tapestry Collection by Hilton](https://images.trvl-media.com/lodging/28000000/27620000/27617000/27616925/25bc97a8_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Angad Arts Hotel St. Louis, Tapestry Collection by Hilton Grand Center $495 per person Apr 27 - Apr 30 found 14 hours ago Roundtrip flight included Las Vegas (LAS) to St. Louis (STL) 8.8/10 Excellent! (1,022 reviews) Great customer service. The locals there are friendly as well as the staff members Reviewed on Feb 23, 2026 ![Home2 Suites by Hilton St. Louis Downtown](https://images.trvl-media.com/lodging/77000000/76520000/76510800/76510729/104b5741_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Home2 Suites by Hilton St. Louis Downtown Downtown West $464 per person Apr 27 - Apr 30 found 14 hours ago Roundtrip flight included Las Vegas (LAS) to St. Louis (STL) 8/10 Very Good! (567 reviews) Our room was clean and very comfortable. Warm water was very slow to arrive in the shower (5 minutes) and then it was lukewarm. The elevators were a problem. Only one working with a full hotel. Breakfast was decent . Reviewed on Feb 17, 2026 ![DoubleTree by Hilton St. Louis Forest Park](https://images.trvl-media.com/lodging/2000000/1090000/1082400/1082373/3f93ad2e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### DoubleTree by Hilton St. Louis Forest Park Central West End $490 per person Apr 27 - Apr 30 found 14 hours ago Roundtrip flight included Las Vegas (LAS) to St. Louis (STL) 8.2/10 Very Good! (1,003 reviews) The room was clean and comfortable, the staff was friendly and accommodating. Perfect for our stay! Reviewed on Feb 24, 2026 ![Hampton Inn By Hilton St Louis Airport](https://images.trvl-media.com/lodging/111000000/110650000/110648500/110648496/acc96ed2_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hampton Inn By Hilton St Louis Airport Woodson Terrace $466 per person Apr 27 - Apr 30 found 14 hours ago Roundtrip flight included Las Vegas (LAS) to St. Louis (STL) 8.8/10 Excellent! (96 reviews) The staff does not tell you that they only clean rooms every other day. I had to send for more towels and tissue. Otherwise the stay was fine. Also there is no laundry. Reviewed on Feb 24, 2026 Don't see what you're looking for? See all available trips from Columbus to Sikeston [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-25/2026-04-01/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=STL&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_6058766) ### Discover the most popular places to visit in Sikeston #### Central Park 4/5(25 reviews) Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants. [](https://expedia.com/Central-Park-Sikeston.d6305608.Vacation-Attraction) #### Sikeston Depot Museum 4/5(15 reviews) You can spend time exploring the galleries in Sikeston Depot Museum in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants. [](https://expedia.com/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction) ## Sikeston Hotel Deals ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Sikeston, MO 2608 East Malone Ave, Miner Sikeston MO Fully refundableReserve now, pay when you stay $94 nightly $108 total Mar 2 - Mar 3 Total with taxes and fees 9.4/10 Exceptional! (1,001 reviews) Yes Reviewed on Feb 25, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F2%2F2026&endDate=3%2F3%2F2026&selected=24210&PinnedHotelID=24210&HadPinnedHotel=true®ionId=6058766) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hampton Inn Sikeston 1240 Commerce Drive Sikeston MO Fully refundableReserve now, pay when you stay $100 nightly $113 total Mar 8 - Mar 9 Total with taxes and fees 9/10 Wonderful! (485 reviews) CLEAN ROOM, CLEAN FACILITY, FREINDLY STAFF Reviewed on Feb 23, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F8%2F2026&endDate=3%2F9%2F2026&selected=25178175&PinnedHotelID=25178175&HadPinnedHotel=true®ionId=6058766) ![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 100 Matthews Lane Sikeston MO Fully refundableReserve now, pay when you stay $65 nightly $75 total Feb 26 - Feb 27 Total with taxes and fees 8.4/10 Very Good! (740 reviews) Very friendly and had an amazing stay so peaceful Reviewed on Feb 18, 2026 [](https://expedia.com/Hotel-Search?startDate=2%2F26%2F2026&endDate=2%2F27%2F2026&selected=34745&PinnedHotelID=34745&HadPinnedHotel=true®ionId=6058766) [See all 288 properties in Sikeston](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=2%2F26%2F2026&endDate=2%2F27%2F2026®ionId=6058766) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best Sikeston Vacation Packages ## Sikeston Essential Information | Language | English | | --------------- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ | | Currency | U.S dollars | | Closest Airport | Cape Girardeau Municipal Airport (CGI) | | Population | 16,400 | | Max Temp Winter | 45ºF | | Max Temp Summer | 85ºF | | Top Sights | [Sikeston Depot Museum](https://www.expedia.com/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction), [Central Park](https://www.expedia.com/Central-Park-Sikeston.d6305608.Vacation-Attraction) and [The Book Bug](https://www.expedia.com/The-Book-Bug-Sikeston.d553248621532655751.Vacation-Attraction) | ## More vacations you might like 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Bloomfield ](https://www.expedia.com/Cheap-Flights-To-Bloomfield.d6351829.Travel-Guide-Flights) - [Flights from Stoddard County ](https://www.expedia.com/lp/flights/553248635976432323/flights-from-stoddard-county) - [Sikeston Depot Museum ](https://www.expedia.com/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction) - [Central Park ](https://www.expedia.com/Central-Park-Sikeston.d6305608.Vacation-Attraction) - [Boot Heel Golf Club ](https://www.expedia.com/Boot-Heel-Golf-Club-Sikeston.d6305606.Vacation-Attraction) - [Bertrand Vacations ](https://www.expedia.com/Bertrand.d3000349285.Destination-Travel-Guides) - [Visit Bertrand ](https://www.expedia.com/Bertrand.dx3000349285) - [Visit Blodgett ](https://www.expedia.com/Blodgett.dx3000349291) - [Visit Canalou ](https://www.expedia.com/Canalou.dx3000349311) - [Visit East Prairie ](https://www.expedia.com/East-Prairie.dx3000349349) - [Charleston Vacations ](https://www.expedia.com/Charleston.d7182.Destination-Travel-Guides) - [Visit 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