Sikeston Vacations from $370

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Your Sikeston Vacation

There's tons to like about Sikeston, from its rich history to its rural countryside. When you're ready to say hi to this captivating city, our Sikeston vacation packages will be perfect for you. Fill your spare time with visits to Sikeston Depot Museum, The Book Bug and Central Park, some of the top attractions you just have to see during your trip to Sikeston. That dream Sikeston vacation is clicks away. Browse hotels, flights and more on Expedia for a getaway that's tailored to suit your travel style.

The Latest Sikeston vacation packages

Price found within the past 48 hours. Click for updated prices.
Alhonna Resort LLC

Alhonna Resort LLC

3 out of 5
Price was $513, price is now $370 per person
$370
per person
Sep 8 - Sep 11
just found
Roundtrip flight included
Philadelphia (PHL) to St. Louis (STL)
8.8/10 Excellent! (289 reviews)
Easy to find, close to lake, easy check in and check out

Reviewed on Jun 26, 2026

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Save 100% on your flight
Price was $861, price is now $500 per person
$500
per person
Sep 9 - Sep 13
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9.2/10 Wonderful! (1,663 reviews)
Very clean & pleasant staff. Breakfast had a very good selection even though they say it is Continental style.

Reviewed on Jun 24, 2026

Moonrise Hotel

Moonrise Hotel

4 out of 5
Delmar Loop
Price was $773, price is now $585 per person
$585
per person
Sep 9 - Sep 13
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9/10 Wonderful! (1,981 reviews)
Great hotel, on the Loop, staff is always helpful. On-site parking. Nice little workout room. Restaurant. Coffee shops and food nearby.

Reviewed on Jun 25, 2026

Hilton Pennywell St. Louis at the Arch

Hilton Pennywell St. Louis at the Arch

4 out of 5
Downtown St. Louis
Price was $660, price is now $524 per person
$524
per person
Sep 8 - Sep 11
just found
Roundtrip flight included
Philadelphia (PHL) to St. Louis (STL)
8.8/10 Excellent! (1,088 reviews)
It was a nic hotel. Room was very clean and everything in order. The guys that checked us in was awesome

Reviewed on Jun 26, 2026

Lodge Of Four Seasons Golf Resort, Marina & Spa

Lodge Of Four Seasons Golf Resort, Marina & Spa

4 out of 5
Price was $501, price is now $404 per person
$404
per person
Sep 8 - Sep 11
just found
Roundtrip flight included
Philadelphia (PHL) to St. Louis (STL)
7.4/10 Good! (1,186 reviews)
Needs serious updating. Door window frame to our room is broken. Blinds are broken/malfunctioning. Room and lobby smell musty. Check in staff did not explain how to get to location of our room—we were told to “go to the three buildings” for your room. That part was correct, we found the three buildings. However, we were on the bottom of three floors and parking around the back side was where we should’ve parked. We had to figure out which building and which floor without any signage to help us. Will never recommend to anyone. Will never return.

Reviewed on Jun 25, 2026

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Stay near popular Sikeston attractions

Sikeston Depot Museum

7.6/5 (57 reviews)
Housed in a restored 1916 train depot, this museum showcases Sikeston's cotton-growing heritage and local art. Explore regional history through rotating exhibits while admiring the building's National Register status.
See properties

Sikeston Hotel Deals

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $122 total per night from Jul 2 to Jul 3
$122 total
Jul 2 - Jul 3
Total with taxes and fees
9.6/10 Exceptional! (1,003 reviews)
"This was a wonderful stay for the night while traveling. Thankful for the recommendation from the front desk to eat at Lamberts restaurant 3 minutes down the road. So fun!"

Reviewed on Jun 15, 2026

Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Fully refundableReserve now, pay when you stay
$68 nightly
The price is $78 total per night from Jun 30 to Jul 1
$78 total
Jun 30 - Jul 1
Total with taxes and fees
7.2/10 Good! (1,001 reviews)
"Rooms are nice and clean although fixtures could be updated. There is no central air and heat, room is cooled by a wall unit. Room was extremely hot when I first entered."

Reviewed on Jun 24, 2026

Days Inn and Suites by Wyndham Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $97 total per night from Jul 26 to Jul 27
$97 total
Jul 26 - Jul 27
Total with taxes and fees
8.4/10 Very Good! (1,001 reviews)
"I could not stay the night the room smelled of mold. I checked in at 1045 and left before 230 am. I cldnt breathe in the room, terrible experience. I booked the room for a bike event but went home instead."

Reviewed on Jun 27, 2026

Best Western Plus Sikeston I-55
See all 314 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Sikeston Vacation Packages

Sikeston Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Cape Girardeau Municipal Airport (CGI)
Population
16,400
Max Temp Winter
45ºF
Max Temp Summer
85ºF
Top Sights
Sikeston Depot Museum, Central Park and The Book Bug

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Frequently asked questions

How much does a Sikeston vacation package cost?
You'll find cheap prices from $370 on Expedia for your Sikeston getaway. However, a range of factors like the season, length of stay and your choice of hotel will determine how much your vacation to Sikeston costs.
What are the cheapest months to go to Sikeston?
If you're hoping to score a cheap Sikeston vacation package, consider planning a trip in November, December and January. You'll typically find lower rates on hotels and flights during these months — ideal for travelers wishing to save money.
How many days is enough for Sikeston?
Usually, a handful of days is great for a Sikeston vacation. With a well-planned itinerary, you can go to all the popular sights such as The Book Bug, as well as explore some hidden treasures along the way.
Is it worth booking a vacation package to Sikeston?
Sikeston offers everything you need for an unforgettable getaway. Get your Sikeston vacation off to a flying start by visiting major attractions like Sikeston Depot Museum.
How to find the best Sikeston package deals?
Use Expedia's filters to find some great Sikeston package deals. When you start your search, just set your maximum budget and then order the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or look for Sikeston package deals in the off-season. Play around with your travel dates and you may land even better discounts. As a rule of thumb, it's usually best to lock in your vacation package as soon as possible.
Is it cheaper to book a Sikeston vacation as a package?
An Expedia vacation package could land you significant savings when compared to booking stays and flights separately. Better still, you can tailor your Sikeston escape to fit your exact style. Pick your preferred flight time, select the hotel type and add a car rental. Browse our bundle deals and find out how much you can save.
When to book a vacation package to Sikeston?
Enjoy incredible bargains by booking your flights in advance with Expedia. If spontaneity is more your thing, snap up one of our last-minute deals for a spur-of-the-moment Sikeston trip.
Does Expedia offer Book Now, Pay Later Sikeston vacation packages?
If you're like us, you love traveling the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With the help of online lender Affirm, you can spread the total cost of your Sikeston vacation over 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can secure great vacation packages with payment plans as soon as you see them.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.