Title: Sikeston Vacation Packages 2026 from $491 | Expedia.com [Sikeston Travel Guide](https://expedia.com/Sikeston.dx6058766)[Hotels in Sikeston](https://expedia.com/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)[Vacation Rentals in Sikeston](https://expedia.com/Sikeston-Vacation-Rentals.d6058766.Travel-Guide-VacationRentals)[Flights to Sikeston](https://expedia.com/Cheap-Flights-To-Sikeston.d6058766.Travel-Guide-Flights)[Car Rentals in Sikeston](https://expedia.com/Car-Rentals-In-Sikeston.d6058766.Car-Rental-Guide) ![](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Sikeston Vacations from $491 ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Your Sikeston Vacation There's tons to like about Sikeston, from its rich history to its rural countryside. When you're ready to say hi to this captivating city, our Sikeston vacation packages will be perfect for you. Fill your spare time with visits to [Sikeston Depot Museum](https://www.expedia.com/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction), [The Book Bug](https://www.expedia.com/The-Book-Bug-Sikeston.d553248621532655751.Vacation-Attraction) and [Central Park](https://www.expedia.com/Central-Park-Sikeston.d6305608.Vacation-Attraction), some of the top attractions you just have to see during your trip to Sikeston. That dream Sikeston vacation is clicks away. Browse hotels, flights and more on Expedia for a getaway that's tailored to suit your travel style. ## The Latest Sikeston vacation packages Price found within the past 48 hours. Click for updated prices. ![Crowne Plaza St. Louis Airport by IHG](https://images.trvl-media.com/lodging/1000000/10000/3100/3010/90ecdcdc_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Crowne Plaza St. Louis Airport by IHG Save 100% on your flight $491 per person Apr 20 - Apr 27 found 1 day ago Roundtrip flight included Atlanta (ATL) to St. Louis (STL) 8/10 Very Good! (1,004 reviews) Centrally located, great park and fly, breakfast is great. The only thing I do not like is for police officers to park outside and go to eat breakfast. It appears that there is trouble at the hotel. Reviewed on Mar 9, 2026 ![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/035dee6c_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Wildwood Hotel $884 per person Apr 20 - Apr 27 found 1 day ago Roundtrip flight included Atlanta (ATL) to St. Louis (STL) 9.2/10 Wonderful! (1,626 reviews) Great space for a couple Reviewed on Mar 11, 2026 ![Angad Arts Hotel St. Louis, Tapestry Collection by Hilton](https://images.trvl-media.com/lodging/28000000/27620000/27617000/27616925/25bc97a8_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Angad Arts Hotel St. Louis, Tapestry Collection by Hilton Grand Center Save 100% on your flight $765 per person Apr 20 - Apr 27 found 1 day ago Roundtrip flight included Atlanta (ATL) to St. Louis (STL) 8.8/10 Excellent! (1,060 reviews) The property was beautiful and unique. The food was a disappointment. Unfortunately it was just too greasy for us. Reviewed on Mar 6, 2026 ![The Cheshire](https://images.trvl-media.com/lodging/1000000/30000/26100/26061/24983857_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Cheshire Save 100% on your flight $714 per person Apr 20 - Apr 27 found 1 day ago Roundtrip flight included Atlanta (ATL) to St. Louis (STL) 8.6/10 Excellent! (1,001 reviews) Bar and restaurant were both great! Reviewed on Mar 9, 2026 ![The Knight Center at Washington University](https://images.trvl-media.com/lodging/39000000/38720000/38711900/38711810/a9bf89ab_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Knight Center at Washington University Save 100% on your flight $666 per person Apr 20 - Apr 27 found 1 day ago Roundtrip flight included Atlanta (ATL) to St. Louis (STL) 9.4/10 Exceptional! (486 reviews) The property locates on campus, convenient location. Newly renovated, quiet and clean. It would be great if the hotel can provide day time hot coffee in the lobby. Reviewed on Mar 9, 2026 Don't see what you're looking for? See all available trips from Columbus to Sikeston [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-04-11/2026-04-18/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=STL&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_6058766) ### Discover the most popular places to visit in Sikeston #### Central Park 4/5(25 reviews) Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this relaxing area, you can savor the top-notch restaurants. [](https://expedia.com/Central-Park-Sikeston.d6305608.Vacation-Attraction) #### Sikeston Depot Museum 4/5(15 reviews) You can spend time exploring the galleries in Sikeston Depot Museum in Sikeston. While in this relaxing area, you can savor the top-notch restaurants. [](https://expedia.com/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction) ## Sikeston Hotel Deals ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Sikeston, MO 2608 East Malone Ave, Miner Sikeston MO Fully refundableReserve now, pay when you stay $94 nightly $108 total Mar 15 - Mar 16 Total with taxes and fees 9.4/10 Exceptional! (1,000 reviews) Everything and everyone were wonderful at this Drury Inn! Very clean rooms and common areas, helpful, positive staff, fun indoor/outdoor pool area with towels, and breakfast and evening snacks and drinks all included in a great price! What a deal! Reviewed on Mar 10, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F15%2F2026&endDate=3%2F16%2F2026&selected=24210&PinnedHotelID=24210&HadPinnedHotel=true®ionId=6058766) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hampton Inn Sikeston 1240 Commerce Drive Sikeston MO Fully refundableReserve now, pay when you stay $95 nightly $108 total Mar 22 - Mar 23 Total with taxes and fees 9/10 Wonderful! (498 reviews) East, friendly check in. Beautiful, large room. Reviewed on Mar 9, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F22%2F2026&endDate=3%2F23%2F2026&selected=25178175&PinnedHotelID=25178175&HadPinnedHotel=true®ionId=6058766) ![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Best Western Plus Sikeston I-55 120 S Interstate Drive Sikeston MO Fully refundableReserve now, pay when you stay $82 nightly $93 total Mar 26 - Mar 27 Total with taxes and fees 8.4/10 Very Good! (1,007 reviews) nice and covenant have stay here a few times, staff always has a smile. Reviewed on Mar 10, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F26%2F2026&endDate=3%2F27%2F2026&selected=8420572&PinnedHotelID=8420572&HadPinnedHotel=true®ionId=6058766) [See all 290 properties in Sikeston](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F12%2F2026&endDate=3%2F13%2F2026®ionId=6058766) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best Sikeston Vacation Packages ## Sikeston Essential Information | Language | English | | --------------- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ | | Currency | U.S dollars | | Closest Airport | Cape Girardeau Municipal Airport (CGI) | | Population | 16,400 | | Max Temp Winter | 45ºF | | Max Temp Summer | 85ºF | | Top Sights | [Sikeston Depot Museum](https://www.expedia.com/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction), [Central Park](https://www.expedia.com/Central-Park-Sikeston.d6305608.Vacation-Attraction) and [The Book Bug](https://www.expedia.com/The-Book-Bug-Sikeston.d553248621532655751.Vacation-Attraction) | ## More vacations you might like 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