Sikeston Vacations from $275
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Your Sikeston Vacation
There's tons to like about Sikeston, from its rich history to its rural countryside. When you're ready to say hi to this captivating city, our Sikeston vacation packages will be perfect for you. Fill your spare time with visits to Sikeston Depot Museum, The Book Bug and Central Park, some of the top attractions you just have to see during your trip to Sikeston. That dream Sikeston vacation is clicks away. Browse hotels, flights and more on Expedia for a getaway that's tailored to suit your travel style.
The Latest Sikeston vacation packages
Price found within the past 48 hours. Click for updated prices.
Osage Village Inn Near Lake Ozarks US 54
Save 100% on your flight
Price was $388, price is now $275 per person
$275
per person
Jul 15 - Jul 20
found 8 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
6.6/10 (1,000 reviews)
I thought it could have been cleaner and did find a bug under covers. It was dead and checked the rest of the bed including under mattress and found nothing. Staff just kinda shrugged it off.
Reviewed on Jun 10, 2026
The Wildwood Hotel
Save 100% on your flight
Price was $647, price is now $351 per person
$351
per person
Aug 21 - Aug 24
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9.2/10 Wonderful! (1,657 reviews)
Everything was good, except the air conditioning was so loud,we couldn't sleep at all.
Reviewed on Jun 11, 2026
Lodge Of Four Seasons Golf Resort, Marina & Spa
Save 100% on your flight
Price was $541, price is now $362 per person
$362
per person
Jul 15 - Jul 20
found 8 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
7.4/10 Good! (1,149 reviews)
3 pools, great views of the lake, nice outdoor bar
Reviewed on Jun 12, 2026
Moonrise Hotel
Delmar Loop
Save 100% on your flight
Price was $542, price is now $390 per person
$390
per person
Aug 21 - Aug 24
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9/10 Wonderful! (1,957 reviews)
The guys at the front desk were all super nice and helpful. The rooftop bar is chill and the food is pretty good.
Reviewed on Jun 13, 2026
The Cheshire
Save 100% on your flight
Price was $601, price is now $442 per person
$442
per person
Aug 21 - Aug 24
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
8.8/10 Excellent! (1,007 reviews)
The Cheshire is an interesting experience. It is definitely one-of-a-kind. The problem is that the rooms are outdated. The a/c in my room was very loud. The ceiling tiles were dirty. The walls are very thin and I could hear everything the neighbor was saying. The pool is nice but is loud if your room faces it. Parking is convenience. Breakfast is average hotel continental breakfast - nothing special. The pub is cool. The place needs a refresh and an update, which can be accomplished while maintaining its cool medieval throwback vibe.
Reviewed on Jun 10, 2026
Sikeston Hotel Deals
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $125 total per night from Jun 18 to Jun 19
$125 total
Jun 18 - Jun 19
Total with taxes and fees
9.6/10 Exceptional! (1,011 reviews)
"Evening drinks and meal were included. Breakfast was also included and very good"
Reviewed on Jun 11, 2026
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from Jun 16 to Jun 17
$79 total
Jun 16 - Jun 17
Total with taxes and fees
7.2/10 Good! (1,008 reviews)
"Lobby reeked like pot and cigarettes, room was not the cleanest and smelled like wet dog, water only got lukewarm, and milk for breakfast was days expired. Pics on Expedia definitely don’t look like the room we had."
Reviewed on Jun 8, 2026
Hampton Inn Sikeston
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $115 total per night from Jul 12 to Jul 13
$115 total
Jul 12 - Jul 13
Total with taxes and fees
9/10 Wonderful! (576 reviews)
"I was very impressed with this Hampton Inn. From the moment I walked in at 10PM, I was greeted warmly. The floor was quiet - a plus. The room was so cool and I love that for sleeping. I slept like a baby."
Reviewed on Jun 10, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Sikeston Vacation Packages
Sikeston Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Cape Girardeau Municipal Airport (CGI) |
Population | 16,400 |
Max Temp Winter | 45ºF |
Max Temp Summer | 85ºF |
Top Sights | Sikeston Depot Museum, Central Park and The Book Bug |
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
