Sikeston Vacations from $368

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Your Sikeston Vacation

There's tons to like about Sikeston, from its rich history to its rural countryside. When you're ready to say hi to this captivating city, our Sikeston vacation packages will be perfect for you. Fill your spare time with visits to Sikeston Depot Museum, The Book Bug and Central Park, some of the top attractions you just have to see during your trip to Sikeston. That dream Sikeston vacation is clicks away. Browse hotels, flights and more on Expedia for a getaway that's tailored to suit your travel style.

The Latest Sikeston vacation packages

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Save 100% on your flight
Price was $655, price is now $368 per person
$368
per person
Oct 27 - Oct 31
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,571 reviews)
The Wildwood Inn was just perfect for a good nights sleep after a full day of driving and checking out some sights.

Reviewed on Sep 18, 2025

Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield

3 out of 5
Price was $517, price is now $374 per person
$374
per person
Oct 27 - Oct 31
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to St. Louis (STL)
8.2/10 Very Good! (763 reviews)
I booked online and paid via the app. When I arrived on site they explained they had overbooked and had no rooms available. The staff was amazing and went above and beyond and secured a room at another location. Thank you to the staff for taking care of us.

Reviewed on Jul 26, 2025

The Principal Hotel

The Principal Hotel

3.5 out of 5
Price was $593, price is now $434 per person
$434
per person
Nov 6 - Nov 10
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9.8/10 Exceptional! (126 reviews)
Everything was good. It is very clean. We had a couple of issues but the young lady at the front desk went above and beyond to take care of it. When really it wasn’t a big enough issue to worry about we just wanted to let her know for the next person in line. They have amazing staff and an amazing hotel. We will go back

Reviewed on Sep 17, 2025

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
Grand Center
Price was $536, price is now $398 per person
$398
per person
Oct 27 - Oct 31
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,017 reviews)
Very convenient to awesome arts area. Housekeeping never came during 3 night stay, despite us being out by 10 am the second day. They dropped off towels after a second request but didn’t take the old ones. Not sure what was going on this weekend because this is usually a great place to stay for us.

Reviewed on Sep 16, 2025

Hampton Inn By Hilton St Louis Airport

Hampton Inn By Hilton St Louis Airport

2.5 out of 5
Woodson Terrace
Price was $532, price is now $397 per person
$397
per person
Nov 6 - Nov 10
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
8.8/10 Excellent! (62 reviews)
Hallways clean and very well lit. Clean smell, courteous staff with great hospitality.

Reviewed on Sep 8, 2025

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Discover the most popular places to visit in Sikeston

Sikeston Depot Museum

4/5(15 reviews)

You can spend time exploring the galleries in Sikeston Depot Museum in Sikeston. While in this relaxing area, you can savor the top-notch restaurants.

Sikeston Depot Museum

Central Park

4/5(25 reviews)

Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants.

Central Park

Sikeston Hotel Deals

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $103 total per night from Sep 25 to Sep 26
$103 total
Sep 25 - Sep 26
Total with taxes and fees
9.4/10 Exceptional! (1,003 reviews)
"The bed was comfy. Food was delicious. Hot tub was relaxing. Staff was nice and helpful. Overall the hotel was very nice."

Reviewed on Sep 16, 2025

Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr, Sikeston, MO
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $72 total per night from Sep 21 to Sep 22
$72 total
Sep 21 - Sep 22
Total with taxes and fees
7.2/10 Good! (1,003 reviews)
"Spacious room"

Reviewed on Sep 13, 2025

Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $89 total per night from Sep 23 to Sep 24
$89 total
Sep 23 - Sep 24
Total with taxes and fees
9.2/10 Wonderful! (1,002 reviews)
"Staff, clean room, quiet environment"

Reviewed on Sep 16, 2025

Pear Tree Inn Sikeston
See all 277 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

How much does a Sikeston vacation package cost?
You'll find cheap prices from $368 on Expedia for your Sikeston getaway. However, a range of factors like the season, length of stay and your choice of hotel will determine how much your vacation to Sikeston costs.
What are the cheapest months to go to Sikeston?
If you're hoping to score a cheap Sikeston vacation package, consider planning a trip in November, December and January. You'll typically find lower rates on hotels and flights during these months — ideal for travelers wishing to save money.
How many days is enough for Sikeston?
Usually, a handful of days is great for a Sikeston vacation. With a well-planned itinerary, you can go to all the popular sights such as The Book Bug, as well as explore some hidden treasures along the way.
Is it worth booking a vacation package to Sikeston?
Sikeston offers everything you need for an unforgettable getaway. Get your Sikeston vacation off to a flying start by visiting major attractions like Sikeston Depot Museum.
How to find the best Sikeston package deals?
Use Expedia's filters to find some great Sikeston package deals. When you start your search, just set your maximum budget and then order the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or look for Sikeston package deals in the off-season. Play around with your travel dates and you may land even better discounts. As a rule of thumb, it's usually best to lock in your vacation package as soon as possible.
Is it cheaper to book a Sikeston vacation as a package?
An Expedia vacation package could land you significant savings when compared to booking stays and flights separately. Better still, you can tailor your Sikeston escape to fit your exact style. Pick your preferred flight time, select the hotel type and add a car rental. Browse our bundle deals and find out how much you can save.
When to book a vacation package to Sikeston?
Enjoy incredible bargains by booking your flights in advance with Expedia. If spontaneity is more your thing, snap up one of our last-minute deals for a spur-of-the-moment Sikeston trip.
Does Expedia offer Book Now, Pay Later Sikeston vacation packages?
If you're like us, you love traveling the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With the help of online lender Affirm, you can spread the total cost of your Sikeston vacation over 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can secure great vacation packages with payment plans as soon as you see them.

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Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.