Find hotels in East Prairie, MO from $57

  • Upfront pricing

    Our total price for your stay includes taxes and fees
  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for East Prairie hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,000 reviews)
"Great travel hotel from Texas to Chicago."
United States
Sally
$111 nightly
The price is $128
May 18 - May 19
Total with taxes and fees
Drury Inn & Suites Sikeston, MO

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (387 reviews)
"Great stay. "
United States
Paul
$87 nightly
The price is $104
Jun 7 - Jun 8
Total with taxes and fees
Sleep Inn at Discovery Park of America

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1,008 reviews)
"Very nice folks who manage the hotel!!"
United States
Jane
$86 nightly
The price is $97
May 17 - May 18
Total with taxes and fees
Best Western Plus Sikeston I-55

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (559 reviews)
"Perfect nights stay!! "
United States
Amanda
$102 nightly
The price is $115
May 31 - Jun 1
Total with taxes and fees
Hampton Inn Sikeston

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (412 reviews)
"All very just okay "
United States
Sherry
$75 nightly
The price is $83
May 15 - May 16
Total with taxes and fees
The Riverstone Hotel Charleston-Sikeston

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (77 reviews)
"The breakfast was good, the service was good, and the staff was very friendly"
United States
Angela
$110 nightly
The price is $125
May 21 - May 22
Total with taxes and fees
Fairfield Inn & Suites by Marriott Sikeston

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (325 reviews)
"Great hotel. Well worth it"
United States
Shannon
$110 nightly
The price is $131
May 17 - May 18
Total with taxes and fees
Holiday Inn Express & Suites Union City by IHG

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (182 reviews)
"Spotless , friendly staff."
United States
Gail
$107 nightly
The price is $127
May 24 - May 25
Total with taxes and fees
Hampton Inn Union City

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (777 reviews)
"Breakfast was adequate room was clean."
United States
Daniel
$63 nightly
The price is $72
May 21 - May 22
Total with taxes and fees
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.4 out of 10, Good, (1,000 reviews)
"Business friendly, clean room staff very friendly, accommodating."
United States
Janice
$61 nightly
The price is $70
May 17 - May 18
Total with taxes and fees
Days Inn and Suites by Wyndham Sikeston

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very Good, (764 reviews)
"The staff was great very helpful and friendly "
United States
Javier
$53 nightly
The price is $57
Jun 14 - Jun 15
Total with taxes and fees
New Orleans Inn Portageville

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very Good, (510 reviews)
"Bathroom walls were dirty and bathroom ceiling had mold on it"
United States
Emily
$62 nightly
The price is $74
Jun 3 - Jun 4
Total with taxes and fees
Quality Inn Union City US 51

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (462 reviews)
"Clean rooms, friendly staff and convenient location."
United States
Mark
$101 nightly
The price is $114
Jun 14 - Jun 15
Total with taxes and fees
Holiday Inn Express & Suites Sikeston Southwest by IHG

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (17 reviews)
"Room was very nice and in very clean condition and hotel staff was very helpful and polite. The breakfast was very delicious and coffee served all day. The hotel smelled very nice and had a very welcoming feeling. Will definitely book with them again"
United States
Joseph
$127 nightly
The price is $144
May 21 - May 22
Total with taxes and fees
TownePlace Suites by Marriott Sikeston

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.8 out of 10, (625 reviews)
"Staff is great rooms clean no bugs and bed was comfortable "
United States
James
$63 nightly
The price is $72
May 17 - May 18
Total with taxes and fees
Super 8 by Wyndham Sikeston/Miner Area

Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, (391 reviews)
"Easy to check in.. Clean Room..Lots of food options near by.. "
United States
Pooran
$57 nightly
The price is $68
May 17 - May 18
Total with taxes and fees
Hospitality House Union City I 69 / US 51

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (571 reviews)
"Very clean nice staff and well run "
United States
zach
$66 nightly
The price is $79
Jun 8 - Jun 9
Total with taxes and fees
Country Hearth Inn & Suites Union City

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (485 reviews)
"The lake view was beautiful and staff was amazing"
United States
Richard
$68 nightly
The price is $78
Jun 1 - Jun 2
Total with taxes and fees
Reelfoot Lake Inn

Great location just across the street from Reelfoot Lake close to boat ramps

Great location just across the street from Reelfoot Lake close to boat ramps
Hornbeak
9.8 out of 10, Exceptional, (85 reviews)
"Very welcoming, great amenities and accomodations. "
United States
Allan K.
$160 nightly
The price is $179
May 18 - May 19
Total with taxes and fees
Great location just across the street from Reelfoot Lake close to boat ramps
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Where to stay in and around East Prairie

Discover the charm of East Prairie, Missouri, where outdoor adventures and scenic beauty await. Experience family-friendly excursions, explore local parks, and indulge in the area's culinary delights as a foodie destination. Enjoy a relaxing atmosphere and connect with friendly locals for an unforgettable vacation.

Sikeston

For travelers looking for a memorable trip, Sikeston offers a delightful blend of outdoor adventures and cultural experiences. Just a short drive from East Prairie, this city features attractions like the Sikeston Depot Museum and Central Park, perfect for exploring art and nature. With options for family fun, business gatherings, or romantic getaways, Sikeston's recreational area and nearby national state park cater to a variety of interests. Choosing Sikeston as your home base ensures easy access to these experiences and a welcoming atmosphere for all visitors.

Pinhook

Experience the charm of Pinhook, a wonderful hub for families and nature enthusiasts seeking an affordable getaway. This quaint village in East Prairie offers easy access to attractions like Big Oak Tree State Park, where outdoor adventures await, as well as the New Madrid Historical Museum, perfect for history buffs. Be sure to check out the City of Miner Convention Center for local events. With its strategic location, Pinhook is a smart choice for your next vacation stay.

Anniston

Make the most of your visit by staying in Anniston, a haven for families and nature enthusiasts thanks to its variety of outdoor activities and historic sites. Travelers will enjoy exploring the urban park and the nearby Columbus-Belmont State Park, while also having access to shopping and the City of Miner Convention Center for events. Located about 5 miles from East Prairie, Anniston offers a great blend of city life and natural beauty, making it an excellent choice for your stay.

Charleston

Charleston stands out as a prime spot for travelers seeking a blend of business and family-friendly experiences. Nestled about 10 miles from East Prairie, this charming city offers access to a national state park, a scenic lake, and a historic venue, making it perfect for outdoor adventures. Visitors can explore the City of Miner Convention Center, the Front Street Studio & Art Gallery, and the Sikeston Depot Museum. Charleston is a smart choice for your next getaway.

Bertrand

Travelers visiting the area often choose Bertrand, especially families and nature enthusiasts seeking close proximity to various outdoor activities. With its stunning scenery, Bertrand offers access to a beautiful national state park, a tranquil lake, and lush forests for exploration. Visitors can enjoy local attractions like the City of Miner Convention Center, Sikeston Depot Museum, and Central Park. Located about 10 miles from East Prairie, Bertrand is a smart hotel booking choice for those looking to immerse themselves in the great outdoors.

Stay near popular attractions in and around East Prairie

East Prairie offers a perfect blend of outdoor adventure and cultural experiences. Explore scenic parks, engage with local art, and discover vibrant event venues. Whether you're seeking tranquility or excitement, the area promises memorable moments for every traveler. Enjoy the natural beauty and rich culture that awaits!

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

The Mississippi River near Hannibal, Missouri, USA

Top East Prairie Hotel Reviews

More cheap stays in East Prairie

Hotels in East Prairie with star-rating

Find out more about East Prairie

Top reasons to visit East Prairie

  • Outdoor Adventures: East Prairie is perfect for hiking, camping, and exploring scenic recreational areas, making it an ideal destination for nature lovers.
  • Dog Park Fun: Enjoy quality time with your furry friends at local dog parks, providing a great space for pets and their owners to relax and socialize.
  • Cultural Experiences: Delve into local history through museums and art galleries, offering a glimpse into the region's rich heritage.
  • Family-Friendly Activities: Enjoy a welcoming atmosphere with various excursions suitable for all ages, ensuring fun for the whole family.
  • Comfortable Accommodations: Choose from a range of pet-friendly hotels and motels that cater to both business and leisure travelers.

Find great hotels near East Prairie

Discover a range of comfortable accommodations in East Prairie, Missouri, perfect for every type of traveler. From pet-friendly hotels to welcoming motels, you'll find options that cater to business travelers and those seeking an inclusive experience. Whether you're looking for hotels near East Prairie or the best motels in the area, you can enjoy a relaxing stay surrounded by Southern hospitality.

  • Days Inn and Suites by Wyndham Sikeston: Located 11 miles from East Prairie, Days Inn and Suites by Wyndham Sikeston is the perfect budget-friendly option for travelers seeking a comfortable stay without breaking the bank. This hotel caters to both business and leisure guests, allowing pets on-site, making it an excellent choice for pet owners. With amenities such as free Wi-Fi, complimentary breakfast, and a pool, guests can enjoy a pleasant stay. The hotel’s pet policy includes specific restrictions, ensuring a welcoming environment for all furry companions.
  • Drury Inn & Suites Sikeston, MO: With a stellar guest rating of 9.4 out of 10, Drury Inn & Suites Sikeston, MO is a 3-star hotel that stands out for families and business travelers alike. Situated 11 miles from East Prairie, this hotel offers a range of child-friendly amenities, including free cribs. Its pet-friendly policy allows for furry family members to join the fun, with certain restrictions in place. Guests can indulge in complimentary breakfast, evening snacks, and a welcoming atmosphere that makes every stay memorable.
  • Best Western Plus Sikeston I-55: Rated 8.4 out of 10, Best Western Plus Sikeston I-55 is another excellent budget-friendly choice located 11 miles from East Prairie. This hotel ensures a cozy stay for pet owners, with specific pet policies that allow pets on the property. Guests can enjoy amenities like free Wi-Fi, hot breakfast, and a fitness center. Ideal for travelers looking for convenience and comfort, this hotel combines quality service with excellent facilities, ensuring a pleasant experience for all who stay.

Where to stay near East Prairie

East Prairie, Missouri, is a hidden gem for outdoor enthusiasts and adventure seekers alike. Nestled in a serene landscape, this charming city offers family-friendly excursions and a welcoming atmosphere. Explore the beautiful prairies and enjoy the friendly local culture. Nearby destinations provide additional opportunities for relaxation and exploration, making East Prairie an ideal base for discovering the scenic wonders of the region. Get ready for an unforgettable vacation experience.

  • Sikeston: Located 13 miles from East Prairie, Sikeston is a vibrant city that offers a mix of outdoor and family-friendly activities. Visitors often flock here for its recreational areas and arena entertainment facilities. The city’s appeal peaks during the summer months, making it a great spot for those looking to enjoy warm-weather adventures. Sikeston is also home to a shopping center that caters to various tastes. Nature enthusiasts will appreciate the nearby lake and national state park, providing ample opportunities for hiking, fishing, and relaxation in picturesque surroundings.
  • Anniston: Just 5 miles from East Prairie, Anniston is a charming city that invites families and outdoor lovers alike. While its visitor numbers remain steady year-round, the summer months see the most activity. Here, you can explore educational venues, enjoy shopping at local centers, and take advantage of the city's urban parks. Anniston's attractions also include a museum that showcases the area’s rich history, making it an excellent destination for those interested in culture and exploration. Its welcoming atmosphere and convenient amenities ensure a pleasant travel experience.
  • Charleston: Situated 10 miles away from East Prairie, Charleston is an adventurous city that captivates visitors with its stunning scenery. Popular for outdoor enthusiasts, the city offers a variety of recreational areas and a lively shopping center. Travelers are drawn to Charleston for its outdoor adventures, particularly in the spring and summer months. The nearby national state park and lake provide a beautiful backdrop for hiking and water activities, while historic sites highlight the region's past. Whether you're seeking adventure or relaxation, Charleston has something for everyone.

Things to do in East Prairie

East Prairie, Missouri, is perfect for an outdoor adventure getaway, offering a range of activities such as exploring scenic recreational areas, enjoying time at a dog park, or hitting the links at a local golf course. Whether you're looking for weekend camping options or simply a relaxing trip, East Prairie provides the ideal backdrop for memorable outdoor experiences and fun weekend trips.

Shopping

In East Prairie, visit local shops for unique gifts and souvenirs. If you're up for a drive, check out the Sikeston Factory Outlet Stores, about 12 miles away, offering a variety of brand-name merchandise at discounted prices, perfect for finding that special item.

Recreation

In East Prairie, rejuvenate at the Healing Touch Wellness Center, where you can indulge in holistic therapies and massage treatments tailored to your needs. For outdoor fun, explore local parks for hiking and fishing, embracing nature's tranquility while enjoying the area's serene landscapes.

Adventure

East Prairie offers thrilling outdoor activities, including fishing at Lake Coutra, where you can reel in bass and catfish. Explore the nearby Mississippi River for kayaking adventures, or take a scenic hike in the surrounding woodlands, perfect for spotting local wildlife and enjoying the natural beauty.

Nightlife

In East Prairie, you can enjoy a laid-back nightlife atmosphere with local bars and eateries offering live music and friendly vibes. The Prairie Dog Saloon is popular for its casual setting and drinks, while nearby events often showcase regional talent, creating a charming community feel.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for East Prairie

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in East Prairie are December to February, where the prices are slightly lower. This is in comparison to April, June and August, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in East Prairie is Sunday. The most expensive day to stay in East Prairie is Saturday.
  • Find cheap hotels on Expedia: Certainly. Here's a paraphrased version of the text in a trusted and attentive tone:Expedia's user-friendly search tool enables you to set your budget, choose your desired location, and much more. You can easily arrange your results to display hotels from the most affordable to the higher-priced options, ensuring you find the best deals first. Additionally, you have the option to refine your search by hotel type. For instance, by selecting the Eco-certified filter, you'll be shown a selection of sustainable and environmentally-friendly hotels that are available for booking.
  • Consider bundling your trip: You can save money by combining your hotel stay in East Prairie with your flights and activities through an Expedia package deal.

Find the best attractions near East Prairie

East Prairie, Missouri, offers an exciting blend of outdoor adventures and cultural experiences for tourists. Visitors can explore nearby national and state parks, delve into local history at museums, and appreciate art at nearby galleries. Whether you're seeking scenic landscapes or rich cultural insights, East Prairie provides a variety of attractions that cater to every traveler's interests, ensuring a memorable vacation.

  • Columbus-Belmont State Park: Discover stunning landscapes and outdoor adventures at this beautiful state park, located 15 miles from East Prairie. Enjoy hiking, picnicking, and exploring the rich history of the area, including its Civil War significance.
  • Central Park: This urban gem, situated 13 miles away, is perfect for families looking to relax and enjoy the outdoors. Stroll through lush green spaces, partake in recreational activities, and soak in the vibrant city atmosphere.
  • Sikeston Depot Museum: Located 13 miles from East Prairie, this art museum offers a glimpse into local culture and history. Explore fascinating exhibits that showcase the region's heritage and artistic talent.

Best time to go to East Prairie

The best time to visit East Prairie is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are moderately high and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are moderately high and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January36.3°F (2.4°C)Light RainMostly SunnyModerately HighSlightly Low
February39.4°F (4.1°C)Light RainMostly SunnyAverageSlightly Low
March49.5°F (9.7°C)Light RainMostly SunnyAverageAverage
April58.5°F (14.7°C)Light RainMostly SunnyAverageSlightly High
May68.2°F (20.1°C)Light RainMostly SunnyAverageAverage
June77.0°F (25.0°C)Light RainMostly SunnyModerately HighSlightly High
July79.5°F (26.4°C)Light RainMostly SunnyModerately HighAverage
August77.5°F (25.3°C)Light RainMostly SunnyAverageSlightly High
September72.1°F (22.3°C)Light RainMostly SunnyAverageAverage
October60.8°F (16.0°C)Light RainMostly SunnyModerately LowAverage
November48.6°F (9.2°C)Light RainMostly SunnyModerately LowAverage
December41.2°F (5.1°C)Light RainMostly SunnyModerately LowSlightly Low

The nearest major airports for your trip to East Prairie

Traveling to East Prairie, Missouri, can be conveniently done via several nearby airports. Jackson, TN (MKL-McKellar-Sipes Regional) is 85 miles away, with excellent hotel options such as the 4-star DoubleTree by Hilton Hotel Jackson and the 3-star Hilton Garden Inn, both 5 miles from the airport. The Cape Girardeau, MO (CGI-Cape Girardeau Municipal) airport is a closer option at 32 miles, featuring hotels like the Drury Plaza Hotel and Drury Inn & Suites, both within 6 miles. Additionally, Marion, IL (MWA-Williamson County Regional) is 70 miles away, offering the Drury Inn & Suites Marion just 2 miles from the airport for easy access.

Why book with Expedia?

  • Flexible booking

    On Expedia, you can find plenty of hotels with flexible cancellation in East Prairie using the “Fully refundable property” search filter. Just be sure to always double-check each hotel's cancellation policy before booking.

  • Book now and pay later

    With countless book now, pay later options, there's no need to wait till payday to grab a deal. Use the “Reserve now, pay later” search filter to view all properties available with this payment option in East Prairie.

  • Hotel comparison

    Thanks to the handy “Compare properties” tool on Expedia, you can compare hotels in East Prairie side by side with just a few clicks.

  • Member prices

    Join Expedia's loyalty program, One Key, for free and unlock Member Prices and rewards on select hotels worldwide. Simply log in when you search and look out for the blue savings label.

Frequently asked questions

When is the best time to go to East Prairie?
The best time to visit East Prairie, Missouri, is during the spring (April to May) and fall (September to October) when the weather is most pleasant.

Spring brings mild temperatures and blooming flora, making it ideal for outdoor activities like exploring the nearby floodplains or attending local community events. The average high temperatures range from the low 60s to mid-70s Fahrenheit, providing comfortable conditions for sightseeing.

Fall offers cooler, crisp air and often clear skies, great for enjoying the changing leaves in the surrounding rural landscapes. Temperatures typically range from the mid-70s in September to the mid-50s in October, making it comfortable for strolls or day trips.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in East Prairie.
How can I save on a East Prairie hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible East Prairie hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a East Prairie hotel?
Prices for hotels in East Prairie often vary, but you can find a great deal from $57 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

Explore a world of travel with Expedia