Title: TOP 10 Hotels in East Prairie, MO (from $58) - COMPETITIVE PRICES | Expedia.com [East Prairie Travel Guide](https://expedia.com/East-Prairie.dx3000349349)[Vacation Rentals in East Prairie](https://expedia.com/East-Prairie-Vacation-Rentals.d3000349349.Travel-Guide-VacationRentals)[Car Rentals in East Prairie](https://expedia.com/Car-Rentals-In-East-Prairie.d3000349349.Car-Rental-Guide)[East Prairie Vacation Packages](https://expedia.com/East-Prairie.d3000349349.Destination-Travel-Guides) ![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in East Prairie Family friendly [](https://www.expedia.com/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America®ionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2026-04-12&d1=2026-04-12&endDate=2026-04-14&d2=2026-04-14&travelerType=family_friendly) Pet friendly [](https://www.expedia.com/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America®ionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2026-04-12&d1=2026-04-12&endDate=2026-04-14&d2=2026-04-14&amenities=PETS) Pool [](https://www.expedia.com/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America®ionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2026-04-12&d1=2026-04-12&endDate=2026-04-14&d2=2026-04-14&amenities=POOL) ## Check prices for these dates Tonight [Mar 29 - Mar 30](https://www.expedia.com/Hotel-Search?regionId=3000349349&startDate=2026-03-29&endDate=2026-03-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 30 - Mar 31](https://www.expedia.com/Hotel-Search?regionId=3000349349&startDate=2026-03-30&endDate=2026-03-31&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=3000349349&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=3000349349&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for East Prairie hotels ![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/432f7137.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, free WiFi, bed sheets](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/cbe2898d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Sikeston [](https://www.expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) Sikeston 9.0/10 Wonderful (517 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) grant $98 nightly $111 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/2a51d3d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/57e73ffd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/55808580.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/54eabc09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn at Discovery Park of America [](https://www.expedia.com/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information) Union City 9.2/10 Wonderful (369 reviews) "Great stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paul $76 nightly $90 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/978331d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/95135562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Sikeston, MO [](https://www.expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) Sikeston 9.4/10 Exceptional (1,003 reviews) "Very nice for overnight stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Scott $94 nightly $108 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, down comforters, desk, iron/ironing board](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/4b95ba78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/58cb82c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/3aa729da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Sikeston Southwest by IHG [](https://www.expedia.com/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information) Sikeston 8.6/10 Excellent (451 reviews) "Clean rooms, friendly staff and convenient location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mark $93 nightly $105 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information) ![Room, 1 Queen Bed, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/5b4d84d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/ef46b494.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/e6403655.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/7d06bc03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 By Wyndham Marston [](https://www.expedia.com/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information) Marston 8.2/10 Very Good (53 reviews) "The property is beautiful! The rooms are terrific! Staff is amazing! Totally recommend!! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sue $65 nightly $74 total Apr 3 - Apr 4 Total with taxes and fees [](https://www.expedia.com/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/a42cb957.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/08c2ace2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/7fdae22d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/15abbdc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Riverstone Hotel Charleston-Sikeston [](https://www.expedia.com/Charleston-Hotels-The-Riverstone-Hotel.h20594.Hotel-Information) Charleston 6.8/10 (410 reviews) "Clean " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chris $61 nightly $68 total Mar 30 - Mar 31 Total with taxes and fees [](https://www.expedia.com/Charleston-Hotels-The-Riverstone-Hotel.h20594.Hotel-Information) ![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/c1609da5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/bfe56101.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking | Iron/ironing board, free cribs/infant beds, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/ba65d6e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/97ce04e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Union City US 51 [](https://www.expedia.com/Union-City-Hotels-Quality-Inn-Union-City-US-51.h14571.Hotel-Information) Union City 8.4/10 Very Good (500 reviews) "Overall, a decent stay. No fancy bells or whistles, exactly what was advertised and delivered. Only issue of note was that the room smelled of body odder when we stayed. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John $69 nightly $82 total Apr 19 - Apr 20 Total with taxes and fees [](https://www.expedia.com/Union-City-Hotels-Quality-Inn-Union-City-US-51.h14571.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/42667f54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking, Refrigerator & Microwave (with Sofabed) | Laptop workspace, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/b775798e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/13d95c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Sikeston I-55 [](https://www.expedia.com/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) Sikeston 8.4/10 Very Good (1,000 reviews) "nice and covenant have stay here a few times, staff always has a smile. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Roger $93 nightly $106 total Apr 2 - Apr 3 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/7bc13d14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/d5184d02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Accessible, Non Smoking | Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/c5b64e33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/3fa32ded.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Hearth Inn & Suites Union City [](https://www.expedia.com/Union-City-Hotels-Country-Hearth-Inn-Suites-Union-City.h969839.Hotel-Information) Union City 8.6/10 Excellent (558 reviews) "Very clean nice staff and well run " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) zach $63 nightly $75 total Mar 30 - Mar 31 Total with taxes and fees [](https://www.expedia.com/Union-City-Hotels-Country-Hearth-Inn-Suites-Union-City.h969839.Hotel-Information) ![Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/679acee6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/bbf96e9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/a5038447.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Charleston/Sikeston East MO [](https://www.expedia.com/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) Charleston 6.8/10 (627 reviews) "Affordable for a quick one night stay. Restaurant and gas station next to hotel." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Annette $62 nightly $69 total Mar 30 - Mar 31 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) ![Individually decorated, individually furnished, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/bf40a512.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/594efec2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/d5d0cfa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) [](https://www.expedia.com/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) Sikeston 8.4/10 Very Good (755 reviews) "Very nice place, very nice stay! They were out of cream cheese for the bagels at breakfast though.:-)" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mark $65 nightly $75 total Mar 30 - Mar 31 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/7d2010d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/27c728aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/e959f8b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Sikeston [](https://www.expedia.com/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) Sikeston 9.4/10 Exceptional (65 reviews) "Nice quiet hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steven $101 nightly $114 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) ![1 bedroom, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/be0d2e33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/8fe9a2cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/717baff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/3d86dbb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn and Suites by Wyndham Sikeston [](https://www.expedia.com/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) Sikeston 7.2/10 Good (1,000 reviews) "Business friendly, clean room staff very friendly, accommodating." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janice $68 nightly $78 total Mar 31 - Apr 1 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ![Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premier Room, 1 Bedroom, Non Smoking | Bathroom | Combined shower/tub, free toiletries, towels, soap](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/5fa7b845.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/91bb8871.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking | Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/a77daa89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### New Orleans Inn Portageville [](https://www.expedia.com/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information) Portageville 8.0/10 Very Good (755 reviews) "The staff was great very helpful and friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Javier $53 nightly $58 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/40000000/39580000/39579100/39579081/c970f53d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/40000000/39580000/39579100/39579081/6140f4df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/40000000/39580000/39579100/39579081/832ea567.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/40000000/39580000/39579100/39579081/aadd65c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Union City by IHG [](https://www.expedia.com/Union-City-Hotels-Holiday-Inn-Express-Suites-Union-City.h39579081.Hotel-Information) Union City 9.4/10 Exceptional (317 reviews) "The room was spacious & clean. The complimentary breakfast was nice. Very quiet place and next to a unique tourist attraction." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Angela $104 nightly $124 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Union-City-Hotels-Holiday-Inn-Express-Suites-Union-City.h39579081.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/f1c41457.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/9d3e181d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/74187a0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking | Iron/ironing board, free cribs/infant beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/e2b2c624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Cairo I-57 [](https://www.expedia.com/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information) Cairo 6.6/10 (282 reviews) "Amenities, microwave, refrigerator,iron and iron board,Shower soap options " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maurice $78 nightly $87 total Mar 30 - Mar 31 Total with taxes and fees [](https://www.expedia.com/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/22000000/21830000/21826900/21826840/e1e1641a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/22000000/21830000/21826900/21826840/5a28b168.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite, 1 King Bed, Non Smoking, Microwave | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/22000000/21830000/21826900/21826840/c064d51d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite, 1 King Bed, Non Smoking, Microwave | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/22000000/21830000/21826900/21826840/73298be5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hospitality House Union City I 69 / US 51 [](https://www.expedia.com/Union-City-Hotels-Hospitality-House.h21826840.Hotel-Information) Union City 6.8/10 (388 reviews) "Easy to check in.. Clean Room..Lots of food options near by.. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Pooran $66 nightly $78 total Apr 28 - Apr 29 Total with taxes and fees [](https://www.expedia.com/Union-City-Hotels-Hospitality-House.h21826840.Hotel-Information) ![Standard Room, 2 Double Beds, Non Smoking | Blackout drapes, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/543bd231.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/e0fa396b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Handicap Room | Blackout drapes, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/6128b6d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/45782657.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Reelfoot Lake Inn [](https://www.expedia.com/Union-City-Hotels-Reelfoot-Lake-Inn.h16769945.Hotel-Information) Tiptonville 7.2/10 Good (476 reviews) "Ok one night stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David $70 nightly $80 total Mar 30 - Mar 31 Total with taxes and fees [](https://www.expedia.com/Union-City-Hotels-Reelfoot-Lake-Inn.h16769945.Hotel-Information) ![Desk, free WiFi, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/4da73ae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/7a78d337.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/7657c6fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/07d69819.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Sikeston I-55 [](https://www.expedia.com/Sikeston-Hotels-Comfort-Inn-Suites-Sikeston-I-55.h1804447.Hotel-Information) Sikeston 8.4/10 Very Good (290 reviews) "nice room, clean. breakfast was great and lady keeping it full, hot, and clean!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Fred $93 nightly $106 total Apr 19 - Apr 20 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Comfort-Inn-Suites-Sikeston-I-55.h1804447.Hotel-Information) ![Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/d9ee28fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/97dfc357.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/55187aa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/715f35ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Sikeston/Miner Area [](https://www.expedia.com/Sikeston-Hotels-Super-8-By-Wyndham-SikestonMiner-Area.h855478.Hotel-Information) Sikeston 6.8/10 (603 reviews) "The room was spotless, the staff was very good and helpful. I loved my stay. I recommend Drury Inn to all my family and friends. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kandy $63 nightly $72 total Mar 31 - Apr 1 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Super-8-By-Wyndham-SikestonMiner-Area.h855478.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-12&endDate=2026-04-13®ionId=3000349349&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FEast-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FEast-Prairie-Hotels.d3000349349.Travel-Guide-Hotels) ## Stay near popular East Prairie attractions ### Big Oak Tree State Park 3.8/5 (8 reviews) You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532655754) ## Learn more about East Prairie Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing. [See all hotels in East Prairie](https://www.expedia.com/Hotel-Search?startDate=2026-04-12&endDate=2026-04-13&adults=2®ionId=3000349349) ![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=395&h=400&p=1&q=high) ## Top East Prairie Hotel Reviews ![Sleep Inn at Discovery Park of America](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/2a51d3d0_y.jpg) ### Sleep Inn at Discovery Park of America 10/10 Excellent "Everything was great. " [](https://expedia.com/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg) ### Hampton Inn Sikeston 8/10 Good "The hotel was very clean and nice. The staff were friendly. It was the other people staying in the hotel that they did not control my 6 year old daughter almost got hit in the face with a volleyball and they were running through the halls and screaming all night. " [](https://expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![New Orleans Inn Portageville ](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936_y.jpg) ### New Orleans Inn Portageville 10/10 Excellent "Room was clean. Appeared to have been freshly painted and carpeted. Bathroom walls were a little rough, but nothing that affected our stay. Parking lot was bright and we were able to pull our truck right up to our door. We just needed a place to rest our heads for 7 or 8 hours. This was perfect for the price. The woman who checked us in was very sweet. " [](https://expedia.com/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information) ![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7_y.jpg) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 8/10 Good "Stayed here as we were just passing through the area. Room was clean. Pillows were not very soft. Breakfast was very limited. Was as expected for the price." [](https://expedia.com/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "We will definitely be back! We travel from Wisconsin to Texas at least 2 times a year to visit family and we like to break our trip up with an overnight stay. This Drury Inn in Siikeston, Missouri will be our home away from " [](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Reelfoot Lake Inn](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/543bd231_y.jpg) ### Reelfoot Lake Inn 10/10 Excellent "The view of the lake is beautiful. It's right across the road. The manager and staff were very kind and set me up in the kind of room I requested. It had a microwave, refrigerator and coffee pot with the coffee. The bed was very comfortable and the air worked great. I would stay there again. " [](https://expedia.com/Union-City-Hotels-Reelfoot-Lake-Inn.h16769945.Hotel-Information) ![Fairfield Inn & Suites by Marriott Sikeston](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54_y.jpg) ### Fairfield Inn & Suites by Marriott Sikeston 10/10 Excellent "Perfect" [](https://expedia.com/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) ![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg) ### Best Western Plus Sikeston I-55 10/10 Excellent "Room was clean, breakfast was good, staff was friendly " [](https://expedia.com/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) ![Country Yard Inn and Suite](https://images.trvl-media.com/lodging/91000000/90830000/90821500/90821467/fa4ef12a_y.jpg) ### Country Yard Inn and Suite 4/10 Poor "Yes, parking seemed just like a regular parkikg area. Well lit i believe. The room was able to be kept sufficiently cool. " [](https://expedia.com/Sikeston-Hotels-Country-Yard-Inn-And-Suite.h90821467.Hotel-Information) ## More cheap stays in East Prairie ![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 100 Matthews Lane Sikeston MO $65 nightly $75 total Mar 30 - Mar 31 Total with taxes and fees 8.4/10 Very Good! (755 reviews) [](https://expedia.com/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) ![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/be0d2e33_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Days Inn and Suites by Wyndham Sikeston 220 S Interstate Dr Sikeston MO $68 nightly $78 total Mar 31 - Apr 1 Total with taxes and fees 7.2/10 Good! (1,000 reviews) [](https://expedia.com/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ![Sleep Inn at Discovery Park of America](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/2a51d3d0_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Sleep Inn at Discovery Park of America 1111 BLue Heron Lane Union City TN $76 nightly $90 total Apr 5 - Apr 6 Total with taxes and fees 9.2/10 Wonderful! (369 reviews) [](https://expedia.com/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information) ![Holiday Inn Express & Suites Sikeston Southwest by IHG](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express & Suites Sikeston Southwest by IHG 115 Hospitality Dr Sikeston MO $93 nightly $105 total Apr 12 - Apr 13 Total with taxes and fees 8.6/10 Excellent! (451 reviews) [](https://expedia.com/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information) ![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Best Western Plus Sikeston I-55 120 S Interstate Drive Sikeston MO $93 nightly $106 total Apr 2 - Apr 3 Total with taxes and fees 8.4/10 Very Good! (1,000 reviews) [](https://expedia.com/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn Sikeston 1240 Commerce Drive Sikeston MO $98 nightly $111 total Apr 12 - Apr 13 Total with taxes and fees 9/10 Wonderful! (517 reviews) [](https://expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ## Hotels in East Prairie with star-rating ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 5 properties [](https://expedia.com/3Star-East-Prairie-Hotels.s30-0-d3000349349.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 28 properties [](https://expedia.com/2Star-East-Prairie-Hotels.s20-0-d3000349349.Travel-Guide-Filter-Hotels) ## Find out more about East Prairie ### Top reasons to visit East Prairie - **Outdoor Adventures:** East Prairie is perfect for hiking, camping, and exploring scenic recreational areas, making it an ideal destination for nature lovers. - **Dog Park Fun:** Enjoy quality time with your furry friends at local dog parks, providing a great space for pets and their owners to relax and socialize. - **Cultural Experiences:** Delve into local history through museums and art galleries, offering a glimpse into the region's rich heritage. - **Family-Friendly Activities:** Enjoy a welcoming atmosphere with various excursions suitable for all ages, ensuring fun for the whole family. - **Comfortable Accommodations:** Choose from a range of pet-friendly hotels and motels that cater to both business and leisure travelers. ### Find great hotels near East Prairie Discover a range of comfortable accommodations in East Prairie, Missouri, perfect for every type of traveler. From pet-friendly hotels to welcoming motels, you'll find options that cater to business travelers and those seeking an inclusive experience. Whether you're looking for hotels near East Prairie or the best motels in the area, you can enjoy a relaxing stay surrounded by Southern hospitality. - **[Days Inn and Suites by Wyndham Sikeston: ](https://www.expedia.com/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)** Located 11 miles from East Prairie, Days Inn and Suites by Wyndham Sikeston is the perfect budget-friendly option for travelers seeking a comfortable stay without breaking the bank. This hotel caters to both business and leisure guests, allowing pets on-site, making it an excellent choice for pet owners. With amenities such as free Wi-Fi, complimentary breakfast, and a pool, guests can enjoy a pleasant stay. The hotel’s pet policy includes specific restrictions, ensuring a welcoming environment for all furry companions. - **[Drury Inn & Suites Sikeston, MO: ](https://www.expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)** With a stellar guest rating of 9.4 out of 10, Drury Inn & Suites Sikeston, MO is a 3-star hotel that stands out for families and business travelers alike. Situated 11 miles from East Prairie, this hotel offers a range of child-friendly amenities, including free cribs. Its pet-friendly policy allows for furry family members to join the fun, with certain restrictions in place. Guests can indulge in complimentary breakfast, evening snacks, and a welcoming atmosphere that makes every stay memorable. - **[Best Western Plus Sikeston I-55: ](https://www.expedia.com/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)** Rated 8.4 out of 10, Best Western Plus Sikeston I-55 is another excellent budget-friendly choice located 11 miles from East Prairie. This hotel ensures a cozy stay for pet owners, with specific pet policies that allow pets on the property. Guests can enjoy amenities like free Wi-Fi, hot breakfast, and a fitness center. Ideal for travelers looking for convenience and comfort, this hotel combines quality service with excellent facilities, ensuring a pleasant experience for all who stay. ### Where to stay near East Prairie East Prairie, Missouri, is a hidden gem for outdoor enthusiasts and adventure seekers alike. Nestled in a serene landscape, this charming city offers family-friendly excursions and a welcoming atmosphere. Explore the beautiful prairies and enjoy the friendly local culture. Nearby destinations provide additional opportunities for relaxation and exploration, making East Prairie an ideal base for discovering the scenic wonders of the region. Get ready for an unforgettable vacation experience. - **[Sikeston: ](https://www.expedia.com/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)** Located 13 miles from East Prairie, Sikeston is a vibrant city that offers a mix of outdoor and family-friendly activities. Visitors often flock here for its recreational areas and arena entertainment facilities. The city’s appeal peaks during the summer months, making it a great spot for those looking to enjoy warm-weather adventures. Sikeston is also home to a shopping center that caters to various tastes. Nature enthusiasts will appreciate the nearby lake and national state park, providing ample opportunities for hiking, fishing, and relaxation in picturesque surroundings. - **[Anniston: ](https://www.expedia.com/Anniston-Hotels.d553248634983588922.Travel-Guide-Hotels)** Just 5 miles from East Prairie, Anniston is a charming city that invites families and outdoor lovers alike. While its visitor numbers remain steady year-round, the summer months see the most activity. Here, you can explore educational venues, enjoy shopping at local centers, and take advantage of the city's urban parks. Anniston's attractions also include a museum that showcases the area’s rich history, making it an excellent destination for those interested in culture and exploration. Its welcoming atmosphere and convenient amenities ensure a pleasant travel experience. - **[Charleston: ](https://www.expedia.com/Charleston-Hotels.d7182.Travel-Guide-Hotels)** Situated 10 miles away from East Prairie, Charleston is an adventurous city that captivates visitors with its stunning scenery. Popular for outdoor enthusiasts, the city offers a variety of recreational areas and a lively shopping center. Travelers are drawn to Charleston for its outdoor adventures, particularly in the spring and summer months. The nearby national state park and lake provide a beautiful backdrop for hiking and water activities, while historic sites highlight the region's past. Whether you're seeking adventure or relaxation, Charleston has something for everyone. ### Things to do in East Prairie East Prairie, Missouri, is perfect for an outdoor adventure getaway, offering a range of activities such as exploring scenic recreational areas, enjoying time at a dog park, or hitting the links at a local golf course. Whether you're looking for weekend camping options or simply a relaxing trip, East Prairie provides the ideal backdrop for memorable outdoor experiences and fun weekend trips. **Shopping** In East Prairie, visit local shops for unique gifts and souvenirs. If you're up for a drive, check out the Sikeston Factory Outlet Stores, about 12 miles away, offering a variety of brand-name merchandise at discounted prices, perfect for finding that special item. **Recreation** In East Prairie, rejuvenate at the Healing Touch Wellness Center, where you can indulge in holistic therapies and massage treatments tailored to your needs. For outdoor fun, explore local parks for hiking and fishing, embracing nature's tranquility while enjoying the area's serene landscapes. **Adventure** East Prairie offers thrilling outdoor activities, including fishing at Lake Coutra, where you can reel in bass and catfish. Explore the nearby Mississippi River for kayaking adventures, or take a scenic hike in the surrounding woodlands, perfect for spotting local wildlife and enjoying the natural beauty. **Nightlife** In East Prairie, you can enjoy a laid-back nightlife atmosphere with local bars and eateries offering live music and friendly vibes. The Prairie Dog Saloon is popular for its casual setting and drinks, while nearby events often showcase regional talent, creating a charming community feel. \*Distances are measured in a straight line; actual driving distances may vary depending on the route. ### Booking tips and Expedia advantages for East Prairie - **The most and least expensive months on average to stay in a hotel:** The cheapest months to stay in East Prairie are December to February, where the prices are slightly lower. This is in comparison to April, June and August, where prices are slightly higher. - **The most and least expensive days on average to stay in a hotel:** The least expensive day to stay in East Prairie is Sunday. The most expensive day to stay in East Prairie is Saturday. - **Find cheap hotels on Expedia:** Certainly. Here's a paraphrased version of the text in a trusted and attentive tone:Expedia's user-friendly search tool enables you to set your budget, choose your desired location, and much more. You can easily arrange your results to display hotels from the most affordable to the higher-priced options, ensuring you find the best deals first. Additionally, you have the option to refine your search by hotel type. For instance, by selecting the Eco-certified filter, you'll be shown a selection of sustainable and environmentally-friendly hotels that are available for booking. - **Consider bundling your trip:** You can save money by combining your hotel stay in East Prairie with your flights and activities through an Expedia package deal. ### Find the best attractions near East Prairie East Prairie, Missouri, offers an exciting blend of outdoor adventures and cultural experiences for tourists. Visitors can explore nearby national and state parks, delve into local history at museums, and appreciate art at nearby galleries. Whether you're seeking scenic landscapes or rich cultural insights, East Prairie provides a variety of attractions that cater to every traveler's interests, ensuring a memorable vacation. - **[Columbus-Belmont State Park: ](https://www.expedia.com/Columbus-Belmont-State-Park-Hotels.0-l6091579-0.Travel-Guide-Filter-Hotels)** Discover stunning landscapes and outdoor adventures at this beautiful state park, located 15 miles from East Prairie. Enjoy hiking, picnicking, and exploring the rich history of the area, including its Civil War significance. - **[Central Park: ](https://www.expedia.com/Central-Park-Hotels.0-l6305608-0.Travel-Guide-Filter-Hotels)** This urban gem, situated 13 miles away, is perfect for families looking to relax and enjoy the outdoors. Stroll through lush green spaces, partake in recreational activities, and soak in the vibrant city atmosphere. - **[Sikeston Depot Museum: ](https://www.expedia.com/Sikeston-Depot-Museum-Hotels.0-l6305602-0.Travel-Guide-Filter-Hotels)** Located 13 miles from East Prairie, this art museum offers a glimpse into local culture and history. Explore fascinating exhibits that showcase the region's heritage and artistic talent. ### Best time to go to East Prairie The best time to visit East Prairie is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are moderately high and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are moderately high and weather is mostly sunny with light rain. | **![calendar](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/calendar.png)Calendar Month** | **![temperature](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__hot.png)Temperature** | **![rain](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__rain.png)Precipitation** | **![mostly](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/weather__day_mostly_cloudy.png)Cloudiness** | **![occupation](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/peoplebex.png)Occupancy** | **![price](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/currency_dollar.png)Pricing** | | ---------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------- | | January | 36.3°F (2.4°C) | Light Rain | Mostly Sunny | Moderately High | Slightly Low | | February | 39.4°F (4.1°C) | Light Rain | Mostly Sunny | Average | Slightly Low | | March | 49.5°F (9.7°C) | Light Rain | Mostly Sunny | Average | Average | | April | 58.5°F (14.7°C) | Light Rain | Mostly Sunny | Average | Slightly High | | May | 68.2°F (20.1°C) | Light Rain | Mostly Sunny | Average | Average | | June | 77.0°F (25.0°C) | Light Rain | Mostly Sunny | Moderately High | Slightly High | | July | 79.5°F (26.4°C) | Light Rain | Mostly Sunny | Moderately High | Average | | August | 77.5°F (25.3°C) | Light Rain | Mostly Sunny | Average | Slightly High | | September | 72.1°F (22.3°C) | Light Rain | Mostly Sunny | Average | Average | | October | 60.8°F (16.0°C) | Light Rain | Mostly Sunny | Moderately Low | Average | | November | 48.6°F (9.2°C) | Light Rain | Mostly Sunny | Moderately Low | Average | | December | 41.2°F (5.1°C) | Light Rain | Mostly Sunny | Moderately Low | Slightly Low | ### The nearest major airports for your trip to East Prairie Traveling to East Prairie, Missouri, can be conveniently done via several nearby airports. Jackson, TN ([MKL](https://www.expedia.com/McKellar-Sipes-Regional-Airport-Hotels.0-aMKL-0.Travel-Guide-Filter-Hotels)\-McKellar-Sipes Regional) is 85 miles away, with excellent hotel options such as the 4-star [DoubleTree by Hilton Hotel Jackson](https://www.expedia.com/Jackson-Hotels-DoubleTree-By-Hilton-Hotel-Jackson.h40716.Hotel-Information) and the 3-star Hilton Garden Inn, both 5 miles from the airport. The Cape Girardeau, MO ([CGI](https://www.expedia.com/Cape-Girardeau-Municipal-Airport-Hotels.0-aCGI-0.Travel-Guide-Filter-Hotels)\-Cape Girardeau Municipal) airport is a closer option at 32 miles, featuring hotels like the Drury Plaza Hotel and Drury Inn & Suites, both within 6 miles. Additionally, Marion, IL ([MWA](https://www.expedia.com/Veterans-Airport-Of-Southern-Illinois-Airport-Hotels.0-aMWA-0.Travel-Guide-Filter-Hotels)\-Williamson County Regional) is 70 miles away, offering the [Drury Inn & Suites Marion](https://www.expedia.com/Carbondale-Hotels-Drury-Inn-Marion.h42025.Hotel-Information) just 2 miles from the airport for easy access. ## Frequently asked questions ### When is the best time to go to East Prairie? > Spring brings mild temperatures and blooming flora, making it ideal for outdoor activities like exploring the nearby floodplains or attending local community events. The average high temperatures range from the low 60s to mid-70s Fahrenheit, providing comfortable conditions for sightseeing. > > > Fall offers cooler, crisp air and often clear skies, great for enjoying the changing leaves in the surrounding rural landscapes. Temperatures typically range from the mid-70s in September to the mid-50s in October, making it comfortable for strolls or day trips. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a East Prairie hotel booking with Expedia? > \*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo. ### How much is the nightly rate at a East Prairie hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Bertrand Hotels ](https://www.expedia.com/Bertrand-Hotels.d3000349285.Travel-Guide-Hotels) - [Charleston Hotels ](https://www.expedia.com/Charleston-Hotels.d7182.Travel-Guide-Hotels) - [Motels in Bertrand ](https://www.expedia.com/Bertrand-Motels.d3000349285-aaMotels.Travel-Guide-Accommodation) - [4 Star Hotels in Bertrand ](https://www.expedia.com/4Star-Bertrand-Hotels.s40-0-d3000349285.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Bertrand ](https://www.expedia.com/3Star-Bertrand-Hotels.s30-0-d3000349285.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Bertrand ](https://www.expedia.com/5Star-Bertrand-Hotels.s50-0-d3000349285.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Charleston ](https://www.expedia.com/Charleston-Hotels-Pet-Friendly-Hotel.0-0-d7182-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - 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