Find hotels in East Prairie, MO from $49

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Our top choices for East Prairie hotels

MainStay Suites Union City, TN

MainStay Suites Union City, TN
2.5 star property
Union City
8.6 out of 10, Excellent, (42)
"Perfect, staff was very helpful."
United States
Marcos
$89 nightly
The price is $106
Dec 29 - Dec 30
Total with taxes and fees
MainStay Suites Union City, TN

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (321)
"Wonderful breakfast, awesome room"
United States
Kimberly
$80 nightly
The price is $95
Jan 2 - Jan 3, 2026
Total with taxes and fees
Sleep Inn at Discovery Park of America

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (310)
"Rooms were spotless and comfortable. The bathroom had all the amenities. Great view. Awesome buffet breakfast to wake up to. "
United States
Rickey Smith
$94 nightly
The price is $112
Jan 2 - Jan 3, 2026
Total with taxes and fees
Holiday Inn Express & Suites Union City by IHG

Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, (370)
"Easy to check in.. Clean Room..Lots of food options near by.. "
United States
Pooran
$54 nightly
The price is $65
Jan 25 - Jan 26, 2026
Total with taxes and fees
Hospitality House Union City I 69 / US 51

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (549)
"Clean rooms, helpful and polite staff"
United States
Jennifer
$72 nightly
The price is $85
Dec 29 - Dec 30
Total with taxes and fees
Country Hearth Inn & Suites Union City

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (165)
"Clean room, nice breakfast"
United States
STUART
$103 nightly
The price is $122
Jan 4 - Jan 5, 2026
Total with taxes and fees
Hampton Inn Union City

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very Good, (488)
"The Staff for sure is what keeps me coming back! Plus the rooms are very clean!"
United States
Walter
$67 nightly
The price is $80
Jan 11 - Jan 12, 2026
Total with taxes and fees
Quality Inn Union City US 51

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (274)
"Break fast was excellent "
United States
Uma
$71 nightly
The price is $79
Jan 17 - Jan 18, 2026
Total with taxes and fees
Quality Inn Cairo I-57

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (105)
"Middle of nowhere hotel was ok"
United States
David
$60 nightly
The price is $67
Dec 28 - Dec 29
Total with taxes and fees
Eagle Inn Charleston

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (614)
"Staff was great! Room was nice. "
United States
Lana
$62 nightly
The price is $69
Dec 28 - Dec 29
Total with taxes and fees
Super 8 by Wyndham Charleston/Sikeston East MO

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (461)
"Bed bugs in two separate rooms, wouldn’t refund my room"
United States
Jacquelynn
$68 nightly
The price is $78
Dec 28 - Dec 29
Total with taxes and fees
Reelfoot Lake Inn

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (121)
"Great spot en route home from Mississippi. Staff put me in a room that ended up being in a quiet section of the hotel. Great sleep."
United States
Andrew
$55 nightly
The price is $62
Dec 28 - Dec 29
Total with taxes and fees
Country Yard Inn and Suite

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1003)
"Staff was very nice. Room layout with two separate rooms was appreciated, especially at this price point. Good bed and bedding. Not super high end or careful about the rehab, and the breakfast was a carb fest, but overall we still felt it was a very good value "
United States
Lois
$63 nightly
The price is $72
Dec 29 - Dec 30
Total with taxes and fees
Days Inn and Suites by Wyndham Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1002)
"Great stay, everything was clean and comfortable. "
United States
Charles
$76 nightly
The price is $86
Dec 28 - Dec 29
Total with taxes and fees
Best Western Plus Sikeston

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
"This our favorite place to stop for a good night sleep. "
United States
Eileen
$90 nightly
The price is $103
Dec 31 - Jan 1, 2026
Total with taxes and fees
Drury Inn & Suites Sikeston, MO

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (723)
"Room was good as usual. This is 4th stay over past 5 years. Only issue I had on this stay was the orange juice from breakfast options. "
United States
Todd
$54 nightly
The price is $62
Dec 28 - Dec 29
Total with taxes and fees
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very Good, (282)
"Room was clean, breakfast was very good. "
United States
Connie
$88 nightly
The price is $100
Dec 28 - Dec 29
Total with taxes and fees
Comfort Inn & Suites Sikeston I-55

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1004)
"Everything was clean, staff was friendly "
United States
Matthew
$75 nightly
The price is $86
Dec 30 - Dec 31
Total with taxes and fees
Pear Tree Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (452)
"clean room, comfy bedding, nice staff, convenient location "
United States
Alexa
$98 nightly
The price is $110
Jan 4 - Jan 5, 2026
Total with taxes and fees
Hampton Inn Sikeston

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.8 out of 10, (568)
"Awesomeness "
United States
Rick
$59 nightly
The price is $68
Dec 28 - Dec 29
Total with taxes and fees
Super 8 by Wyndham Sikeston/Miner Area
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Stay near popular East Prairie attractions

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

More cheap stays in East Prairie

Hotels in East Prairie with star-rating

Find out more about East Prairie

Top reasons to visit East Prairie

  • Outdoor Adventures: East Prairie offers stunning recreational areas ideal for hiking, picnicking, and enjoying nature.
  • Cultural Experiences: Visitors can explore local museums and immerse themselves in the vibrant culture of the area.
  • Scenic Parks: Just a short drive away, enjoy beautiful parks perfect for relaxation and family-friendly activities.
  • Charming Local Shops: Discover unique local shops that enhance the welcoming atmosphere of this small town.
  • Diverse Accommodations: East Prairie provides a range of lodging options, from cozy motels to pet-friendly stays.

Find great hotels near East Prairie

Discover a variety of hotel accommodations in East Prairie, Missouri, designed to meet your travel needs. Whether you're seeking a cozy motel, a pet-friendly option, or a family-friendly stay, East Prairie has something for everyone. Enjoy convenient amenities and services tailored for business travelers or those on vacation. With numerous hotel reviews available, finding the best hotels in East Prairie is just a click away.

  • Days Inn and Suites by Wyndham Sikeston: Experience comfort and convenience at Days Inn and Suites by Wyndham Sikeston, ideally situated 11 miles from East Prairie. This hotel is perfect for business travelers seeking a pet-friendly environment. The property features dedicated business amenities, including multiple meeting rooms, ensuring a productive stay. Guests appreciate the welcoming atmosphere for pets, with specific policies that allow dogs and cats, making it easy to travel with your furry companions. Enjoy a hassle-free vacation while enjoying the thoughtful services tailored for your needs.
  • Best Western Plus Sikeston: Best Western Plus Sikeston offers a warm and inviting stay just 11 miles from East Prairie. This hotel is an excellent choice for those traveling with pets, providing a friendly environment that welcomes your four-legged friends. With clear pet policies in place, including restrictions and service animal accommodations, guests can relax knowing their pets are well taken care of. Enjoy comfortable rooms and convenient amenities that ensure a pleasant and enjoyable experience during your stay.
  • Drury Inn & Suites Sikeston, MO: Discover a welcoming atmosphere at Drury Inn & Suites Sikeston, MO, a 3-star hotel located 11 miles from East Prairie. This property is ideal for both business and LGBTQIA travelers, offering a supportive and inclusive environment. With multiple meeting rooms and a fully equipped business center, it caters to professionals seeking productivity during their stay. Guests rave about the hotel's commitment to comfort and service, making it a popular choice for those looking for a memorable and enjoyable experience in Sikeston.

Where to stay near East Prairie

For an unforgettable vacation, East Prairie, Missouri, offers a delightful blend of outdoor adventures and family-friendly experiences. Just a short drive from downtown Sikeston, visitors can enjoy scenic parks, charming local shops, and a welcoming atmosphere. Explore the expansive open spaces perfect for relaxation and excursions, or connect with friendly locals who enhance the vibrant community spirit. Whether you're seeking adventure or a peaceful retreat, East Prairie is an ideal destination for all travelers.

  • Sikeston: Located 13 miles from East Prairie, Sikeston offers a delightful mix of outdoor activities and scenic beauty. Known for its vibrant atmosphere, visitors flock here for romantic getaways and recreational adventures. From its stunning lakes and national parks to the engaging arena entertainment facilities, there's something for everyone. Whether you're exploring the local landscapes or enjoying a fun day at the recreational area, Sikeston promises an enriching travel experience.
  • Charleston: Just 10 miles away from East Prairie, Charleston is a hidden gem that invites travelers to embrace the great outdoors. With a focus on adventure and scenic exploration, this city is perfect for those who love camping and hiking amidst nature. The proximity to national parks and lakes, along with its welcoming recreational areas, makes Charleston a fantastic spot for a day trip. The peak travel season in April and summer months adds to the vibrant energy of this charming city.
  • Bertrand: Also located 10 miles from East Prairie, Bertrand is an ideal destination for families and outdoor enthusiasts alike. With its beautiful nature reserve and inviting visitor center, you can indulge in various outdoor activities that cater to all ages. Visitors can enjoy the tranquil lakes and nature trails while soaking in the serene environment. The best times to visit are in April, August, and during the holiday season, ensuring your trip is filled with memorable experiences surrounded by nature.

Things to do near East Prairie

East Prairie, Missouri, offers a delightful blend of outdoor adventures and scenic beauty for tourists. Visitors can explore the recreational areas, perfect for various activities like hiking and picnicking. The charm of prairie tourism is highlighted by its major attractions that allow for a relaxing escape into nature. Whether you seek adventure or tranquility, East Prairie promises an enjoyable experience for all who visit.

Shopping

In East Prairie, you can visit local shops for unique gifts and souvenirs. If you're up for a drive, County Market Place, located 31 miles away, offers a variety of businesses with a friendly, family-oriented atmosphere perfect for shopping.

Recreation

Experience tranquility at the East Prairie Wellness Center, where you can indulge in rejuvenating massage therapies and yoga classes. For outdoor recreation, explore the nearby Mississippi River for fishing, hiking, and birdwatching, immersing yourself in nature’s beauty and serenity.

Adventure

In East Prairie, explore the scenic trails of the nearby Mingo National Wildlife Refuge, perfect for hiking and wildlife watching. Enjoy thrilling water activities at the nearby Mississippi River, where you can kayak or fish in a serene environment surrounded by nature.

Nightlife

The nightlife in East Prairie offers a charming experience, with the Union City Masquerade Theatre just 31 miles away. Enjoy captivating performances in a venue that blends culture and romance, perfect for family outings or a romantic evening out.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for East Prairie

To save money on your trip to East Prairie, consider visiting between December and February when prices are lower. Sundays are the cheapest days to stay, while Saturdays tend to be the most expensive. Use Expedia to compare hotel rates and filter for budget-friendly options, including eco-certified hotels. Consider bundling your hotel, flights, and activities for additional savings, and join Expedia's One Key membership for exclusive discounts and future cash rewards. Look out for deals on hotel amenities to maximize your stay while keeping costs down.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in East Prairie are December to February, where the prices are slightly lower. This is in comparison to April, June and August, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in East Prairie is Sunday. The most expensive day to stay in East Prairie is Saturday.
  • Find cheap hotels on Expedia: Expedia's search feature lets you specify your budget, ideal location, and additional preferences. You can easily sort the results to display hotels from the lowest price to the highest, ensuring you find the most affordable options first. Additionally, you can refine your choices by hotel type; for instance, selecting the Eco-certified filter will showcase sustainable and environmentally friendly hotels that you can book.
  • Consider bundling your trip: You can save money by combining your East Prairie hotel reservation with your flights and activities through an Expedia package.
  • Become a One Key member: Join Expedia's One Key membership program for exclusive discounts and deals on hotel bookings. You can also earn OneKeyCash to use on future selected hotels.

Find the best attractions in and around East Prairie

East Prairie, Missouri, offers a delightful blend of outdoor adventures and cultural experiences. Nature enthusiasts can explore the nearby national and state parks, while art lovers can visit local museums. This charming town is perfect for those seeking adventure and scenic beauty, with various attractions that cater to diverse interests. Don't miss the opportunity to immerse yourself in the area's vibrant culture and breathtaking landscapes during your visit.

  • Big Oak Tree State Park: Immerse yourself in nature at this beautiful national park located in East Prairie. Known for its breathtaking scenery and towering trees, it's the perfect spot for outdoor adventures, hiking, and enjoying the peaceful surroundings.
  • Sikeston Depot Museum: Located 13 miles away, this art museum offers a glimpse into local culture and history. Explore fascinating exhibits that highlight the heritage of the area and appreciate the artistic contributions that define Sikeston.
  • Central Park: Just 13 miles from East Prairie, Central Park is a vibrant urban park ideal for families. Enjoy outdoor activities, playgrounds, and beautiful walking paths in a lively city atmosphere, perfect for relaxation and recreation.

Best time to go to East Prairie

The best time to visit East Prairie can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in East Prairie falls in July, when visitor numbers are moderately high and weather is mostly sunny with light rain. The coolest average temperature in East Prairie falls in January, visitor numbers are moderately high and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January36.3°F (2.4°C)Light RainMostly SunnyModerately HighSlightly Low
February39.4°F (4.1°C)Light RainMostly SunnyAverageSlightly Low
March49.5°F (9.7°C)Light RainMostly SunnyAverageAverage
April58.5°F (14.7°C)Light RainMostly SunnyAverageSlightly High
May68.2°F (20.1°C)Light RainMostly SunnyAverageAverage
June77.0°F (25.0°C)Light RainMostly SunnyModerately HighSlightly High
July79.5°F (26.4°C)Light RainMostly SunnyModerately HighAverage
August77.5°F (25.3°C)Light RainMostly SunnyAverageSlightly High
September72.1°F (22.3°C)Light RainMostly SunnyAverageAverage
October60.8°F (16.0°C)Light RainMostly SunnyModerately LowAverage
November48.6°F (9.2°C)Light RainMostly SunnyModerately LowAverage
December41.2°F (5.1°C)Light RainMostly SunnyModerately LowSlightly Low

The nearest major airports for your trip to East Prairie

When planning your trip to East Prairie, Missouri, you have several airport options. Paducah, KY (PAH-Barkley Regional) is 39 miles away, with nearby hotels like The Respite Bed and Breakfast, located 9 miles from the airport, and Harrah's Metropolis Hotel & Casino, 6 miles away. Cape Girardeau, MO (CGI-Cape Girardeau Municipal) is 32 miles from East Prairie, offering accommodations such as Drury Plaza Hotel, 6 miles away, and Drury Inn & Suites, 5 miles away. Cairo, IL (CIR-Cairo Regional) is the closest at 21 miles, with options like Quality Inn Cairo I-57, just 2 miles away, providing convenient access for travelers.

Frequently asked questions

When is the best time to go to East Prairie?
The most popular time to visit East Prairie is June, when the area comes alive with vibrant festivities and outdoor activities. With temperatures typically ranging from the mid-70s to low 80s Fahrenheit, this month offers a comfortable climate that's superb for exploring the natural beauty and local attractions.

During the peak season from June to August, East Prairie sees an uptick in visitors eager to enjoy its scenic landscapes and engage with the community during various events. This bustling atmosphere not only enhances the experience but also provides ample opportunities for adventure, whether you're hiking scenic trails, fishing in nearby lakes, or savoring local cuisine at outdoor festivals.

For travelers who appreciate attentive service and quality experiences, June is particularly appealing. The warm weather allows for leisurely strolls through parks and gardens, making it an ideal time to connect with nature and immerse yourself in the local culture. Additionally, with longer daylight hours, you'll have plenty of time to explore without feeling rushed.

If you're looking for a more budget-friendly option, consider visiting in November. While this month is less crowded, it offers a chance to enjoy a quieter experience while still soaking up the charm of East Prairie.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in East Prairie.
How can I save on a East Prairie hotel booking with Expedia?
One Key™ - Expedia's free travel rewards program - gives you instant access to perks and Member Prices on East Prairie hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings.

*OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a East Prairie hotel?
Prices for hotels in East Prairie often vary, but you can find a great deal from $49 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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