Photo by Jessica King

Find Hotels in Sikeston, MO from $54

Search over 1 million properties and 550 airlines worldwide.

Members save 10% more on select hotels, cars, activities and vacation rentals. Sign up.

Most hotels are fully refundable. Because flexibility matters.

Filter by

Drury Inn & Suites Cape Girardeau
3 out of 5
3303 Campster Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is $108 per night from Sep 30 to Sep 30
29.29 mi from city center
4.6/5Exceptional! (512 reviews)
"I STAY @ DRURY EVERYTIME I TRAVEL & I HAVE YET TO HAVE A NEGATIVE EXPERIENCE. I LOVE DRURY & THE STAFF ALWAYS GOES ABOVE & BEYOND TO MAKE SURE EVERYTHING IS PERFECT. I WOULD RATE IT 10 STARS IF I COULD ❤️❤️"

Reviewed on Sep 10, 2021

Drury Inn & Suites Cape Girardeau
Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is $117 per night from Oct 3 to Oct 3
29.57 mi from city center
4.8/5Exceptional! (630 reviews)
"Wonderful breakfast!"

Reviewed on Jul 26, 2021

Drury Plaza Hotel Cape Girardeau Conference Center
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 out of 5
3248 William St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is $67 per night from Oct 17 to Oct 17
29.34 mi from city center
4.3/5Excellent! (984 reviews)
"Clean. Great employees Best stay we have had in a long time. Would definitely recommend."

Reviewed on Aug 12, 2021

Pear Tree Inn Cape Girardeau Near the Medical Center
You could be seeing lower prices

You could be seeing lower prices

With member prices, you could save 10% or more right now on thousands of properties.
Pear Tree Inn Cape Girardeau West
2.5 out of 5
103 Cape West Pkwy, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is $72 per night from Oct 20 to Oct 20
29.31 mi from city center
4.3/5Excellent! (850 reviews)
"Rooms were clean and the air conditioning worked amazingly well on such a hot day. We had an emergency and didn’t get back to the room late and the staff answered our phone call at 4 am and graciously gave us a late check out so we could get some rest."

Reviewed on Sep 13, 2021

Pear Tree Inn Cape Girardeau West
Pear Tree Inn Sikeston
2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is $99 per night from Oct 10 to Oct 10
3.06 mi from city center
4.5/5Wonderful! (976 reviews)
"The facility is well kept and the staff is very friendly."

Reviewed on Sep 12, 2021

Pear Tree Inn Sikeston
Drury Inn & Suites Sikeston, MO
3 out of 5
2608 East Malone Ave, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is $117 per night from Oct 3 to Oct 3
3.11 mi from city center
4.6/5Exceptional! (902 reviews)
"This is now my favorite hotel. Like literally I’m looking for Drury Inns when planning any trip. The hotel staff was awesome, pool was real nice, breakfast was terrific, but then the side perks: Free Dinner and alcohol! I mean granted it was chicken nuggets, hot dogs, and the like, but I got kids ..."

Reviewed on Sep 5, 2021

Drury Inn & Suites Sikeston, MO
Hampton Inn Cape Girardeau I 55 East
2.5 out of 5
207 S Mt Auburn Rd, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is $106 per night from Oct 17 to Oct 17
29.13 mi from city center
4.8/5Exceptional! (377 reviews)
"Check inn was quick and easy, front desk staff super friendly. Everything was super clean and the bed was comfortable."

Reviewed on Sep 19, 2021

Hampton Inn Cape Girardeau I 55 East
Drury Inn & Suites Jackson MO
3 out of 5
225 Drury Lane, Jackson, MO
Fully refundableReserve now, pay when you stay
The price is $85 per night from Sep 29 to Sep 29
38.16 mi from city center
4.7/5Exceptional! (655 reviews)
"The staff was superb. The food was delicious. The property was very clean. We sat near the dining area and chatted several hours. They mopped twice during that time."

Reviewed on Aug 2, 2021

Drury Inn & Suites Jackson MO
Best Western Plus Sikeston
2.5 out of 5
120 S Interstate Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is $85 per night from Oct 22 to Oct 22
3.35 mi from city center
4.2/5Excellent! (731 reviews)
"Customer service"

Reviewed on Aug 17, 2021

Best Western Plus Sikeston
Country Yard Inn and Suite
2 out of 5
110 S Interstate Dr, Sikeston, MO
3.44 mi from city center
3.1/5 (191 reviews)
"Stay there was ok. They need some upkeep on the building itself. All door handles loose and bathroom floor was dirty. New plumbing needed."

Reviewed on Jan 17, 2021

Get rates
Country Yard Inn and Suite
Best Western Plus Jackson/Cape Girardeau
2.5 out of 5
3003 SOUTH OLD ORCHARD ROAD, Jackson, MO
Fully refundableReserve now, pay when you stay
The price is $86 per night from Oct 3 to Oct 3
32.93 mi from city center
4.3/5Excellent! (92 reviews)
"This hotel is brand new and beautiful! The only complaint is that for such a beautiful and large hotel the continental breakfast was horrible. The options were very limited with hardly any hot options. Overall though the hotel was very nice but they would benefit from improving their breakfast."

Reviewed on Sep 10, 2021

Best Western Plus Jackson/Cape Girardeau
Super 8 by Wyndham Sikeston/Miner Area
2 out of 5
2609 E Malone Ave, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is $54 per night from Oct 17 to Oct 17
2.87 mi from city center
3.1/5 (413 reviews)
"Great staff, clean room and facility"

Reviewed on Sep 1, 2021

Super 8 by Wyndham Sikeston/Miner Area
Travelodge by Wyndham Dexter
2 out of 5
1608 W Business US Highway 60, Dexter, MO
Fully refundableReserve now, pay when you stay
The price is $84 per night from Oct 2 to Oct 2
22.39 mi from city center
3.7/5Good! (254 reviews)
"I liked the gazebo to sit in for smoke area. Everyone was friendly and accommodating."

Reviewed on Sep 5, 2021

Travelodge by Wyndham Dexter
Super 8 by Wyndham Perryville
2 out of 5
1119 Vincent Dr, Perryville, MO
Fully refundableReserve now, pay when you stay
The price is $76 per night from Sep 26 to Sep 26
59.66 mi from city center
4.2/5Excellent! (452 reviews)
"All great.. Can't be beat for the price. Everyone very friendly and helpful."

Reviewed on Aug 19, 2021

Super 8 by Wyndham Perryville
Lambert’s Homestead. Very Cozy & Clean 5 bed home.
The price is $99 per night from Oct 3 to Oct 3
2.14 mi from city center
5/5Exceptional! (6 reviews)
Great Place to Stay
"The beds were VERY comfortable!! The kitchen was great! My only suggestion is more comfortable living room furniture. Thanks"

Reviewed on Sep 17, 2021

Lambert’s Homestead. Very Cozy & Clean 5 bed home.
Holiday Inn Express & Suites Murphysboro - Carbondale, an IHG Hotel
2.5 out of 5
120 MUDDY MONSTER ROAD, Murphysboro, IL
Fully refundable
The price is $113 per night from Oct 3 to Oct 3
63.12 mi from city center
4.2/5Very Good! (21 reviews)
"Staff were very nice"

Reviewed on Sep 7, 2021

Holiday Inn Express & Suites Murphysboro - Carbondale, an IHG Hotel
Candlewood Suites Cape Girardeau, an IHG Hotel
2.5 out of 5
485 S Mount Auburn Rd, Cape Girardeau, MO
Fully refundable
The price is $91 per night from Oct 9 to Oct 9
28.45 mi from city center
4.1/5Very Good! (376 reviews)
"Friendly, efficient staff. If anything was needed they were quick to respond. Will definitely stay here again."

Reviewed on Sep 6, 2021

Candlewood Suites Cape Girardeau, an IHG Hotel
Days Inn and Suites by Wyndham Sikeston
2 out of 5
220 S Interstate Dr, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is $73 per night from Sep 26 to Sep 26
3.34 mi from city center
3.5/5Good! (670 reviews)
"The staff were friendly and helpful. The room was clean but devoid of any extras. There were few towels, cups, no extra blanket, no TV guide or literature on the area, activities, etc. There was not a coffee pot in the room. They advertise free breakfast but did not have it. It was okay for one night ..."

Reviewed on Sep 17, 2021

Days Inn and Suites by Wyndham Sikeston
Town House Inn
2.5 out of 5
517 E Jackson Blvd, Jackson, MO
The price is $60 per night from Oct 17 to Oct 17
34.61 mi from city center
4/5Very Good! (163 reviews)
"Everything was wonderful"

Reviewed on Sep 13, 2021

Town House Inn
Courtyard by Marriott Cape Girardeau Downtown
3 out of 5
400 Broadway St., Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is $125 per night from Oct 17 to Oct 17
29.83 mi from city center
4.8/5Exceptional! (190 reviews)
"Awesome hotel downtown and close to everything"

Reviewed on Aug 26, 2021

Courtyard by Marriott Cape Girardeau Downtown
Don't see what you're looking for?
See all available properties in Sikeston
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Visiting Sikeston

Families will find kid-friendly activities in Sikeston, and visitors give high marks for the top-notch restaurants and shopping. This welcoming city also attracts tourists with its riverfront and university setting. Top sights in the city include Isle Casino Cape Girardeau and Shawnee National Forest.

  • There are 39 hotels and other accommodations in Sikeston
  • The closest major airport is in Cairo, IL (CIR-Cairo Regional), 23.8 mi (38.3 km) from the city center
  • The next closest is in Cape Girardeau, MO (CGI-Cape Girardeau Municipal), 24.2 mi (38.9 km) away

Sightseeing and Staying in Sikeston

The city's cultural venues include Sikeston Depot Museum and Dexter Welcome Center Depot and Museum. Families come for attractions such as Cape Splash Family Aquatic Center, Cape Girardeau Conservation Nature Center, and Lazy L Safari Park. Notable city landmarks like The Heritage House and Keller Veteran Memorial might be worth a visit.

As you plan your holiday getaway, you'll find 39 hotels and other lodging options to choose from in Sikeston. Below are top ranked ones based on Expedia user reviews:

  • Hampton Inn Cape Girardeau I 55 East - This 2.5-star hotel features free breakfast, an indoor pool, and free WiFi. It's a favorite with Expedia travelers for its clean, comfortable rooms and room size.
  • Holiday Inn Express Hotel & Suites Cape Girardeau I-55 - Our customers like the overall value and clean, comfortable rooms at this hotel. With a stay at this 2.5-star hotel, guests can enjoy access to an indoor pool and free parking, along with free WiFi.
  • Drury Inn & Suites Cape Girardeau - This 3-star hotel features free breakfast, an indoor pool, and free WiFi. Expedia customers like its helpful staff and comfortable rooms.

Other top sights in Sikeston include Isle Casino Cape Girardeau and Shawnee National Forest.

Dressing for Sikeston

  • Between January and March, you can expect average temperatures of 65°F during the day and 27°F at night
  • From April to June, the average during the day is 91°F, while the average at night is 44°F
  • July through September has daytime averages of 92°F with nighttime averages of 54°F
  • In October-December, you can expect daytime averages of 78°F and nighttime averages of 28°F
  • Sikeston gets about 49.33 inches of rain per year
  • Usually July and August are the hottest months with an average of 91°F, whereas January and December are often coldest, averaging 30°F

Frequently asked questions

Recent reviews of Sikeston hotels

More trip options