Hotels in Sikeston that Travelers Love

Top 10 Hotels in Sikeston

See all 34 Hotels in Sikeston
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Sikeston 63801

3.0 out of 5.0

Located in the heart of Sikeston, this hotel is 0.2 mi (0.3 km) from The Book Bug and within 6 mi (10 km) of Sikeston Depot …

$105
per night
Best Western Plus Sikeston
Best Western Plus Sikeston

120 S Interstate Drive, Sikeston 63801

2.5 out of 5.0

Situated in Sikeston, this hotel is 0.8 mi (1.2 km) from The Book Bug and within 6 mi (10 km) of Sikeston Depot Museum and …

$79
per night
Pear Tree Inn - Sikeston
Pear Tree Inn - Sikeston

2602 E Malone Avenue, Sikeston 63801

2.5 out of 5.0

Located in the heart of Sikeston, this hotel is 0.2 mi (0.3 km) from The Book Bug and 3.1 mi (5 km) from Sikeston Depot Museu …

$80
per night
Comfort Inn And Suites
Comfort Inn And Suites

109 Matthews Ln, Sikeston 63801

2.5 out of 5.0

Located in the heart of Sikeston, this hotel is 0.6 mi (0.9 km) from The Book Bug and within 6 mi (10 km) of Sikeston Depot …

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Americas Best Value Inn & Suites Sikeston
Americas Best Value Inn & Suites Sikeston

220 S Interstate Dr, Sikeston 63801

2.0 out of 5.0

This family-friendly Sikeston hotel is located in a rural location, 1 mi (1.6 km) from The Book Bug, and within 6 mi (10 km …

$63
per night
Motel 6 Sikeston MO
Motel 6 Sikeston MO

110 S Interstate Dr, Sikeston 63801

2.0 out of 5.0

Situated in Sikeston, this motel is 0.6 mi (1 km) from The Book Bug and within 6 mi (10 km) of Sikeston Depot Museum and Boot …

$55
per night
Super 8 - Sikeston/Miner Area
Super 8 - Sikeston/Miner Area

2609 E Malone Ave, Sikeston 63801

2.0 out of 5.0

Situated in Sikeston, this hotel is 0.2 mi (0.4 km) from The Book Bug and within 3 mi (5 km) of Sikeston Depot Museum and Boo …

$47
per night
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy, Cape Girardeau 63701

2.5 out of 5.0

Located in the heart of Cape Girardeau, this hotel is 2.8 mi (4.4 km) from Cape Splash Family Aquatic Center and within 6 mi …

$75
per night
Holiday Inn Express & Suites Sikeston Southwest
Holiday Inn Express & Suites Sikeston Southwest

115 Hospitality Dr, Sikeston 63801

2.5 out of 5.0

Situated in a rural location, this hotel is 1 mi (1.7 km) from Central Park and 1.4 mi (2.3 km) from Sikeston Depot Museum. …

$93
per night
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St, Cape Girardeau 63701

2.0 out of 5.0

Located in the heart of Cape Girardeau, this hotel is 2.2 mi (3.6 km) from Cape Splash Family Aquatic Center and 2.9 mi (4. …

$85
per night

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Where to stay in Sikeston

Sikeston Hotel Guide

Are you traveling through Southeast Missouri and are looking to choose a room in or around Sikeston? You'll find 9 Expedia-listed hotels and apartments within 6 miles of the downtown area.

You'll find Days Inn Sikeston and Holiday Inn Express & Suites Sikeston Southwest within 2 miles of Sikeston's city center.

Places to stay in Dexter which is 20 miles away include Hickory House Inn and Dexter Inn. Cape Girardeau, roughly 30 miles from downtown Sikeston is home to Pear Tree Inn Cape Girardeau West and Holiday Inn Express Hotel & Suites Cape Girardeau I-55.

Families, students and those watching their budget can choose from great Sikeston lodging options that won't break the bank. 20 miles away from Sikeston's downtown is where you'll find the Oak Tree Inn Dexter. The Americas Best Value Inn & Suites Sikeston is only 3 miles away. Different lower-cost room options are the Super 8 - Sikeston/Miner Area and the Super 8 Cape Girardeau.

3 miles away from downtown Sikeston, is the Comfort Inn And Suites. Alternatively, the Quality Inn Charleston is situated 13 miles away. The Super 8 Charleston MO and also the Pear Tree Inn - Sikeston are other alternative accommodation options in Sikeston.

45 miles to the south of Sikeston you will find Hayti, where you can enjoy Hayti Pentecostal Holiness Church and Hayti Park. If you'd like to spend a few nights in Hayti, check Expedia's booking pages for the latest deals at the Comfort Inn Hayti and Drury Inn & Suites Hayti Caruthersville. 60 miles to the north of Sikeston, you can also stay at Perryville, which is home to the Super 8 Perryville and Days Inn Perryville. While in Perryville, don't miss the National Shrine of Our Lady of the Miraculous Medal and Perryville Country Club.

Why not spend a few hours rubbing shoulders and cheering along with Southeast Missouri sports fans at a local game. You'll find Players Bluegrass Downs 55 miles to the east of Sikeston. Book accommodation close to the action at the Holiday Inn Express Hotel & Suites Paducah West or the Residence Inn by Marriott Paducah.

Now that you have checked out hotels and apartments options in Sikeston, be sure to check out Expedia's Sikeston travel guide for the inside scoop on things to do and see here.