Title: The Best 4 Star Hotels in Sikeston, MO from $109 | Expedia.com

[Sikeston Travel Guide](https://expedia.com/Sikeston.dx6058766)[Hotels in Sikeston](https://expedia.com/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)[Vacation Rentals in Sikeston](https://expedia.com/Sikeston-Vacation-Rentals.d6058766.Travel-Guide-VacationRentals)[Flights to Sikeston](https://expedia.com/Cheap-Flights-To-Sikeston.d6058766.Travel-Guide-Flights)[Car Rentals in Sikeston](https://expedia.com/Car-Rentals-In-Sikeston.d6058766.Car-Rental-Guide)[Sikeston Vacation Packages](https://expedia.com/Sikeston.d6058766.Destination-Travel-Guides)

![Pre-teen girl walking through corn maze during fall](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check availability on Sikeston 4 Star Hotels

Tonight

[Feb 22 - Feb 23](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-02-22&endDate=2026-02-23&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 23 - Feb 24](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-02-23&endDate=2026-02-24&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-02-27&endDate=2026-03-01&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-03-06&endDate=2026-03-08&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Sikeston 4-star hotels

![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Grand Riverview Two Queen Room | Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/8ba17328.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/53cb7546.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Jackpot Suite | Living area | LED TV, Netflix, Hulu, first-run movies](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/e87009c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Riverview

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

Cape Girardeau

9.4/10

Exceptional

(510 reviews)

"The room was clean and I was able to check in a bit early."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Sara

$96 nightly

$109 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

![Street view](https://images.trvl-media.com/lodging/40000000/39930000/39926100/39926011/1b66adae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Urban Loft #2 | Private kitchen | Oven, stovetop, dishwasher, coffee/tea maker](https://images.trvl-media.com/lodging/40000000/39930000/39926100/39926011/ab222ad3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![City view from property](https://images.trvl-media.com/lodging/40000000/39930000/39926100/39926011/4840d660.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, streaming services](https://images.trvl-media.com/lodging/40000000/39930000/39926100/39926011/eeb333c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Urban Lofts

[](https://www.expedia.com/Perryville-Hotels-Urban-Lofts.h39926011.Hotel-Information)

Perryville

[](https://www.expedia.com/Perryville-Hotels-Urban-Lofts.h39926011.Hotel-Information)

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## Sikeston and related destinations

- Sikeston
- Florence
- Los Banos
- Lima

Home to Lambert's Café, the 'Home of Throwed Rolls,' where servers toss fresh bread across the room to hungry diners. Visit the historic Sikeston Depot or catch the annual rodeo where professional cowboys compete in thrilling events each August.

[See all hotels in Sikeston](https://www.expedia.com/Hotel-Search?startDate=2026-03-08&endDate=2026-03-09&adults=2&regionId=6058766)

![Pre-teen girl walking through corn maze during fall](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=900&h=599&p=1&q=high)

## Top Sikeston Hotel Reviews

![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg)

### The Riverview

10/10 Excellent

"Wonderful stay at hotel and casino! The band, Next of Kin, was fantastic on Valentine’s Day night. Food was excellent too! Highly recommend!!! "

[](https://expedia.com/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

## Find out more about Sikeston

## Sikeston Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Sikeston, Missouri are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Sikeston 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Sikeston. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Sikeston, Missouri, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Sikeston hotels offer everything your heart desires.

## Frequently asked questions

### How much does it cost to stay in a 4-star hotel in Sikeston?

> - Search for the lowest price from $109

### What's the difference between 5-star and 4-star hotels in Sikeston?

### Does Sikeston have any 4-star all-inclusive resorts?

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