Title: New Madrid Vacation Rentals from $239: Search Short-Term Rentals | Expedia.com

[New Madrid Travel Guide](https://expedia.com/New-Madrid.dx3000445315)[Hotels in New Madrid](https://expedia.com/New-Madrid-Hotels.d3000445315.Travel-Guide-Hotels)[Flights to New Madrid](https://expedia.com/Cheap-Flights-To-New-Madrid.d3000445315.Travel-Guide-Flights)[Car Rentals in New Madrid](https://expedia.com/Car-Rentals-In-New-Madrid.d3000445315.Car-Rental-Guide)[New Madrid Vacation Packages](https://expedia.com/New-Madrid.d3000445315.Destination-Travel-Guides)

![Mississippi River Walk at New Madrid.  A magnificent view of the Mississippi river from atop of the levee.  A steamboat is docked down river. . ](https://images.trvl-media.com/place/3000445315/970b11d9-266d-426a-9577-5e745e0939b7.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/3000445315/970b11d9-266d-426a-9577-5e745e0939b7.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_bundle_and_save.svg)  
###  
Bundle & Save  
Get more, spend less whenever you see Bundle & Save deals
- ![](https://a.travel-assets.com/travel-assets-manager/pictograms-expedia/light__onekey.svg)  
###  
OneKeyCash  
Earn OneKeyCash on all your eligible bookings
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_ftc.svg)  
###  
Upfront pricing  
We are not like the others - we include taxes and fees

## Check prices for these dates

In two weeks

[Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=3000445315&startDate=2026-03-27&endDate=2026-03-29&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[May 8 - May 10](https://www.expedia.com/Hotel-Search?regionId=3000445315&startDate=2026-05-08&endDate=2026-05-10&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[Jun 5 - Jun 7](https://www.expedia.com/Hotel-Search?regionId=3000445315&startDate=2026-06-05&endDate=2026-06-07&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jul 3 - Jul 5](https://www.expedia.com/Hotel-Search?regionId=3000445315&startDate=2026-07-03&endDate=2026-07-05&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

[Book now](https://expedia.com/deals?rfrr=VR_SPRING_PROMO_3000445315)

## Find vacation rentals that suit your style

Cabins

[](https://www.expedia.com/Hotel-Search?destination=New+Madrid%2C+Missouri%2C+United+States+of+America&regionId=3000445315&latLong=36.586578%2C-89.527046&adults=2&startDate=2026-06-07&d1=2026-06-07&endDate=2026-06-10&d2=2026-06-10&lodging=CABIN)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=New+Madrid%2C+Missouri%2C+United+States+of+America&regionId=3000445315&latLong=36.586578%2C-89.527046&adults=2&startDate=2026-06-07&d1=2026-06-07&endDate=2026-06-10&d2=2026-06-10&lodging=VACATION_HOME)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=New+Madrid%2C+Missouri%2C+United+States+of+America&regionId=3000445315&latLong=36.586578%2C-89.527046&adults=2&startDate=2026-06-07&d1=2026-06-07&endDate=2026-06-10&d2=2026-06-10&lodging=COTTAGE)

Condos

[](https://www.expedia.com/Hotel-Search?destination=New+Madrid%2C+Missouri%2C+United+States+of+America&regionId=3000445315&latLong=36.586578%2C-89.527046&adults=2&startDate=2026-06-07&d1=2026-06-07&endDate=2026-06-10&d2=2026-06-10&lodging=CONDO)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=New+Madrid%2C+Missouri%2C+United+States+of+America&regionId=3000445315&latLong=36.586578%2C-89.527046&adults=2&startDate=2026-06-07&d1=2026-06-07&endDate=2026-06-10&d2=2026-06-10&lodging=APARTMENT)

![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg)

Save an average of 15% on thousands of hotels when you're signed in

[Sign in

](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FNew-Madrid-Vacation-Rentals.d3000445315.Travel-Guide-VacationRentals)[

Sign up, it's free

](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FNew-Madrid-Vacation-Rentals.d3000445315.Travel-Guide-VacationRentals)

## Top New Madrid Hotel Reviews

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg)

### Hampton Inn Sikeston

10/10 Excellent

"Overall our stay was great with the exception of the room smelling like a dog had been living there. The order was in the carpet and the bed covers. "

[](https://expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Fairfield Inn & Suites by Marriott Sikeston](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54_y.jpg)

### Fairfield Inn & Suites by Marriott Sikeston

10/10 Excellent

"Nice quiet hotel "

[](https://expedia.com/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

![Holiday Inn Express & Suites Sikeston Southwest by IHG](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a_y.jpg)

### Holiday Inn Express & Suites Sikeston Southwest by IHG

10/10 Excellent

"Nice room"

[](https://expedia.com/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information)

![Reelfoot Lake Inn](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/543bd231_y.jpg)

### Reelfoot Lake Inn

10/10 Excellent

"Everything great "

[](https://expedia.com/Union-City-Hotels-Reelfoot-Lake-Inn.h16769945.Hotel-Information)

![Super 8 By Wyndham Marston](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/5b4d84d0_y.jpg)

### Super 8 By Wyndham Marston

10/10 Excellent

"Decent hotel"

[](https://expedia.com/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information)

![New Orleans Inn Portageville ](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936_y.jpg)

### New Orleans Inn Portageville 

10/10 Excellent

"The staff was great very helpful and friendly "

[](https://expedia.com/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information)

![Duck Hunting, Fishing or Relaxing Family Vacation](https://images.trvl-media.com/lodging/37000000/36090000/36089000/36088974/d93cc56b_y.jpg)

### Duck Hunting, Fishing or Relaxing Family Vacation

10/10 Excellent

"The house was clean, had everything we needed and the scenery was incredible. We had one unforeseeable issue with the smoke alarm battery and the host solved the issue within minutes. We could not recommend any higher. We would absolutely stay here again and highly recommend to anyone looking in this area."

[](https://expedia.com/Hornbeak-Hotels-Duck-Hunting.h36088974.Hotel-Information)

![ For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier.](https://images.trvl-media.com/lodging/35000000/34330000/34322400/34322352/13c903a5_y.jpg)

###  For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier.

10/10 Excellent

"Clean and convenient! Great stay, we will be back!"

[](https://expedia.com/Hornbeak-Hotels-For-Larger-Groups-Right-On-Reelfoot-Lake-Private-Dock-And-Pier.h34322352.Hotel-Information)

![Come and relax at the Refuge at beautiful Reelfoot Lake!](https://images.trvl-media.com/lodging/84000000/83580000/83572000/83571978/0a58d14b_y.jpg)

### Come and relax at the Refuge at beautiful Reelfoot Lake!

10/10 Excellent

"Everything was great"

[](https://expedia.com/Hornbeak-Hotels-Enjoy-Beautiful-Sunsets-At-The-HUT-2-At-Beautiful-Reelfoot-Lake.h83571978.Hotel-Information)

## Find out more about New Madrid

**Everything you need to know about New Madrid vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the New Madrid vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect New Madrid vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**New Madrid vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in New Madrid. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit New Madrid in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $239 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on New Madrid rentals**

At Expedia, we put the best New Madrid vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top New Madrid rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream New Madrid vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around New Madrid. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

## Explore a world of travel with Expedia

- Trending destinations on Expedia.com
- All accommodation types in New Madrid

### Trending destinations on Expedia.com

- [Destin Vacation Rentals ](https://www.expedia.com/Destin-Vacation-Rentals.d6906.Travel-Guide-VacationRentals)
- [Panama City Vacation Rentals ](https://www.expedia.com/Panama-City-Beach-Vacation-Rentals.d8021.Travel-Guide-VacationRentals)
- [Hilton Head Vacation Rentals ](https://www.expedia.com/Hilton-Head-Island-Vacation-Rentals.d601684.Travel-Guide-VacationRentals)
- [Gulf Shores Vacation Rentals ](https://www.expedia.com/Gulf-Shores-Vacation-Rentals.d603078.Travel-Guide-VacationRentals)
- [Key West Vacation Rentals ](https://www.expedia.com/Key-West-Vacation-Rentals.d1187.Travel-Guide-VacationRentals)
- [Gatlinburg Vacation Rentals ](https://www.expedia.com/Gatlinburg-Vacation-Rentals.d7474.Travel-Guide-VacationRentals)
- [Maui Vacation Rentals ](https://www.expedia.com/Maui-Vacation-Rentals.d180073.Travel-Guide-VacationRentals)
- [Orlando Vacation Rentals ](https://www.expedia.com/Orlando-Vacation-Rentals.d178294.Travel-Guide-VacationRentals)
- [Myrtle Beach Vacation Rentals ](https://www.expedia.com/Myrtle-Beach-Vacation-Rentals.d601685.Travel-Guide-VacationRentals)
- [Orange Beach Vacation Rentals ](https://www.expedia.com/Orange-Beach-Vacation-Rentals.d9136.Travel-Guide-VacationRentals)
- [Pigeon Forge Vacation Rentals ](https://www.expedia.com/Pigeon-Forge-Vacation-Rentals.d8264.Travel-Guide-VacationRentals)
- [Ocean City Vacation Rentals ](https://www.expedia.com/Ocean-City-Vacation-Rentals.d9151.Travel-Guide-VacationRentals)
- [Outer Banks Vacation Rentals ](https://www.expedia.com/Outer-Banks-Vacation-Rentals.d602135.Travel-Guide-VacationRentals)
- [San Diego Vacation Rentals ](https://www.expedia.com/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)
- [Siesta Key Vacation Rentals ](https://www.expedia.com/Siesta-Key-Vacation-Rentals.d6881.Travel-Guide-VacationRentals)
- [Galveston Vacation Rentals ](https://www.expedia.com/Galveston-Vacation-Rentals.d1341.Travel-Guide-VacationRentals)
- [Clearwater Beach Vacation Rentals ](https://www.expedia.com/Clearwater-Beach-Vacation-Rentals.d10759.Travel-Guide-VacationRentals)
- [Palm Springs Vacation Rentals ](https://www.expedia.com/Palm-Springs-Vacation-Rentals.d180676.Travel-Guide-VacationRentals)
- [Florida Keys Vacation Rentals ](https://www.expedia.com/Florida-Keys-Vacation-Rentals.d6023765.Travel-Guide-VacationRentals)
- [Lake Tahoe Vacation Rentals ](https://www.expedia.com/South-Lake-Tahoe-Vacation-Rentals.d10150.Travel-Guide-VacationRentals)
- [Lake of the Ozarks Vacation Rentals ](https://www.expedia.com/Lake-Ozark-Vacation-Rentals.d177772.Travel-Guide-VacationRentals)
- [Florida Vacation Rentals ](https://www.expedia.com/Destinations-In-Florida.d211.Vacation-Rental-Destinations)
- [Hawaii Vacation Rentals ](https://www.expedia.com/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations)
- [Michigan Vacation Rentals ](https://www.expedia.com/Destinations-In-Michigan.d224.Vacation-Rental-Destinations)

- [Vacation Homes in New Madrid ](https://expedia.com/New-Madrid-Private-Vacation-Homes.d3000445315-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Lodges in New Madrid ](https://expedia.com/New-Madrid-Lodges.d3000445315-aaLodges.Travel-Guide-Accommodation)
- [Cottages in New Madrid ](https://expedia.com/New-Madrid-Cottages.d3000445315-aaCottages.Travel-Guide-Accommodation)
- [Apartments in New Madrid ](https://expedia.com/New-Madrid-Apartments.d3000445315-aaApartments.Travel-Guide-Accommodation)
- [Motels in New Madrid ](https://expedia.com/New-Madrid-Motels.d3000445315-aaMotels.Travel-Guide-Accommodation)
- [Condo Rentals in New Madrid ](https://expedia.com/New-Madrid-Condos.d3000445315-aaCondos.Travel-Guide-Accommodation)
- [Cabin Rentals in New Madrid ](https://expedia.com/New-Madrid-Cabins.d3000445315-aaCabins.Travel-Guide-Accommodation)

## Frequently asked questions

### Can I find vacation rentals in New Madrid?

### What's the top vacation rental in New Madrid?

### What’s there to see and do in New Madrid?

### What’s a vacation rental in New Madrid like?

### Expedia's Latest Trends

Hotels

- [Hotels in Columbia](https://expedia.com/Columbia-Hotels.d901.Travel-Guide-Hotels)
- [Hotels in St. Joseph](https://expedia.com/St-Joseph-Hotels.d9934.Travel-Guide-Hotels)
- [Hotels in Hermann](https://expedia.com/Hermann-Hotels.d183475.Travel-Guide-Hotels)
- [Hotels in Branson](https://expedia.com/Branson-Hotels.d6058734.Travel-Guide-Hotels)
- [Cheap Hotels in Branson](https://expedia.com/Branson-Hotels-Cheap-Hotels.0-0-d6058734-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Hotels in Poplar Bluff](https://expedia.com/Poplar-Bluff-Hotels.d9449.Travel-Guide-Hotels)
- [Hotels in Cape Girardeau](https://expedia.com/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels)
- [Hotels with an Indoor Pool in Branson](https://expedia.com/Branson-Hotels-Hotels-With-Indoor-Pool.0-0-d6058734-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels)
- [Hotels in Sikeston](https://expedia.com/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)
- [Hotels in Ridgedale](https://expedia.com/Ridgedale-Hotels.d183490.Travel-Guide-Hotels)
- [Hotels in Springfield](https://expedia.com/Springfield-Hotels.d602962.Travel-Guide-Hotels)
- [Hotels in Lake Ozark](https://expedia.com/Lake-Ozark-Hotels.d177772.Travel-Guide-Hotels)
- [Family Hotels in Branson](https://expedia.com/Branson-Hotels-Family-Hotel.0-0-d6058734-tFamilyHotel.Travel-Guide-Filter-Hotels)
- [Hotels in Joplin](https://expedia.com/Joplin-Hotels.d1705.Travel-Guide-Hotels)
- [Hotels in Sedalia](https://expedia.com/Sedalia-Hotels.d6880.Travel-Guide-Hotels)
- [Hotels in Rolla](https://expedia.com/Rolla-Hotels.d6058783.Travel-Guide-Hotels)
- [Cheap Hotels in Springfield](https://expedia.com/Springfield-Hotels-Cheap-Hotels.0-0-d602962-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Hotels in Hannibal](https://expedia.com/Hannibal-Hotels.d6068.Travel-Guide-Hotels)
- [Hotels in Jefferson City](https://expedia.com/Jefferson-City-Hotels.d8072.Travel-Guide-Hotels)
- [Hotels in Camdenton](https://expedia.com/Camdenton-Hotels.d6048169.Travel-Guide-Hotels)

Flights

- [Cheap Flights to Fort Leonard Wood](https://expedia.com/Cheap-Flights-To-Fort-Leonard-Wood.d3378.Travel-Guide-Flights)
- [Cheap Flights to Branson](https://expedia.com/Cheap-Flights-To-Branson.d6058734.Travel-Guide-Flights)
- [Cheap Flights to Columbia](https://expedia.com/Cheap-Flights-To-Columbia.d901.Travel-Guide-Flights)
- [Cheap Flights to Springfield](https://expedia.com/Cheap-Flights-To-Springfield.d602962.Travel-Guide-Flights)

Cars

- [Car rentals in Columbia](https://expedia.com/Car-Rentals-In-Columbia.d901.Car-Rental-Guide)
- [Car rentals in Springfield](https://expedia.com/Car-Rentals-In-Springfield.d602962.Car-Rental-Guide)

Activities

- [Things to do in Branson](https://expedia.com/Things-To-Do-In-Branson.d6058734.Travel-Guide-Activities)

Packages

- [Branson Vacation](https://expedia.com/Branson.d6058734.Destination-Travel-Guides)

Vacation Rentals

- [Branson Vacation Rentals](https://expedia.com/Branson-Vacation-Rentals.d6058734.Travel-Guide-VacationRentals)

General

- [Visit Osage Beach](https://expedia.com/Osage-Beach.dx6058781)

![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg)

## Go further with the Expedia app

Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go.

Scan the QR code with your device camera and download our app