Mississippi River Walk at New Madrid. A magnificent view of the Mississippi river from atop of the levee. A steamboat is docked down river. .

New Madrid Vacation Rentals

  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals

  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings

  • Upfront pricing

    We are not like the others - we include taxes and fees

Check prices for these dates

In two weeks
Jul 10 - Jul 12
In two months
Aug 21 - Aug 23
In three months
Sep 18 - Sep 20
In four months
Oct 16 - Oct 18
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top New Madrid Hotel Reviews

Hampton Inn Sikeston

Hampton Inn Sikeston

10/10 Excellent
"Hampton are always comfortable…you know what to expect…friendly, clean and well maintained"
Raymond 1-night trip
Posted 9 hours ago
Hampton Inn Sikeston

Find out more about New Madrid

Everything you need to know about New Madrid vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the New Madrid vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect New Madrid vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

New Madrid vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in New Madrid. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit New Madrid in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $228 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on New Madrid rentals

At Expedia, we put the best New Madrid vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top New Madrid rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream New Madrid vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around New Madrid. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find vacation rentals in New Madrid?

Yes, we offer vacation rentals near well known points of interest in New Madrid, or you can choose a more remote option if you'd like a relaxing place to stay. New Madrid is known for its parks and museums.

What's the top vacation rental in New Madrid?

Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!: Visitors give good reviews to this New Madrid vacation home rental, which offers a garden, a selection of games, and air-conditioning to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop.

What’s there to see and do in New Madrid?

Cultural attractions include New Madrid Historical Museum and Hunter-Dawson State Historic Site, whereas Mississippi River is one spot to enjoy nature. River Ridge Winery and Marston Community Center are a couple of places you'll find in the larger area.

What’s a vacation rental in New Madrid like?

Vacation rentals are privately owned properties you can book for a couple of days or more in New Madrid. Vacation rentals provide amenities like laundry facilities and kitchens so you'll have all the comforts of home. If you're concerned about a clean environment, a vacation rental can provide a sense of privacy away from shared hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also find more space in a vacation rental than in a traditional hotel, which makes a vacation rental an attractive option for a small group gathering.