Sikeston, MO

Travel Guide

A tree with sunlight filtering through its leaves, creating a warm glow.
A person walking through a cornfield.
A building with three tall chimneys, surrounded by blooming trees with pink and white flowers.
A sign for Lambert's, a place of worship.
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
$94 nightly
The price is $108 total per night from Sep 27 to Sep 28
$108 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,001 reviews)
"Our stay was comfortable and the room was nice. The staff was very kind and helpful. Complimentary dinner was a great surprise and very tasty. I've never stayed at a Drury Inn before and am very satisfied. I will look for availability from now on when we travel."

Reviewed on Sep 17, 2026

Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
$66 nightly
The price is $76 total per night from Sep 21 to Sep 22
$76 total
Sep 21 - Sep 22
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,003 reviews)
"Staff was prompt and helpful in getting us set up in a new room. Only because the outlet for the blowdryer wasn't working. The facilities were kinda updated. There could have been additional attention paid to light switch covers being VERY outdated and furniture being worn and tattered."

Reviewed on Sep 17, 2026

Days Inn and Suites by Wyndham Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
$87 nightly
The price is $99 total per night from Sep 27 to Sep 28
$99 total
Sep 27 - Sep 28
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,001 reviews)
"Clean rooms, great parking, very nice staff"

Reviewed on Sep 18, 2026

Best Western Plus Sikeston I-55
See all 316 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Anna IL
Stay at this cabin in Anna. Enjoy a garden, patios, and cable/satellite TV service. Our guests praise the helpful staff and the property condition in our reviews. ...
10/10 Exceptional! (426 reviews)
"Beautiful little cabin in a peaceful spot"

Reviewed on Sep 11, 2026

Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery

Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery

Cobden IL
Stay at this cabin in Anna. Enjoy patios, an in-room coffeemaker, and in-room fireplaces. Popular attractions StarView Vineyards and King Neptune Memorial are ...
10/10 Exceptional! (178 reviews)
"This is an isolated cabin that is well maintained and fairly new. nice hot tub. One draw back is that there is no internet and the smart tv is not so smart. Other than that, this is well placed next to hiking and wineries and great for a couple to get away."

Reviewed on Aug 22, 2026

Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery
New cabin in the woods with private hot tub

New cabin in the woods with private hot tub

Cobden IL
Stay at this cabin in Anna. Enjoy patios, an in-room coffeemaker, and air conditioning. Popular attractions StarView Vineyards and King Neptune Memorial are ...
9.8/10 Exceptional! (165 reviews)
"Was very nice for our first trip"

Reviewed on Aug 30, 2026

New cabin in the woods with private hot tub
See all properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Sikeston attractions

Central Park

7.2/10 (56 reviews)
Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants.
See properties

Cities near Sikeston

A sunset over a calm lake with tall trees reflected in the water.

Charleston

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East Prairie

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