Top 10 Hotels in Matthews, MO (from $54) 2026 - Competitive Prices

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Our top choices for Matthews hotels

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

1. Hampton Inn Sikeston

Sikeston

Carolyn

$105 nightly

$120 total

Oct 18 - Oct 19

Total with taxes and fees

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A kitchenette with a coffee machine, a kettle, and storage shelves.

A buffet with various food items, including omelets and baked goods, served in metal containers.

A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.

2. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Melissa

$91 nightly

$103 total

Nov 8 - Nov 9

Total with taxes and fees

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

3. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

$101 nightly

$115 total

Oct 15 - Oct 16

Total with taxes and fees

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

4. TownePlace Suites by Marriott Sikeston

Sikeston

Stacy

$101 nightly

$115 total

Oct 18 - Oct 19

Total with taxes and fees

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

5. Drury Inn & Suites Sikeston, MO

Sikeston

Scott

$94 nightly

$108 total

Oct 18 - Oct 19

Total with taxes and fees

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.

A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

6. Best Western Plus Sikeston I-55

Sikeston

Shelley

$84 nightly

$96 total

Oct 11 - Oct 12

Total with taxes and fees

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.

A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.

A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

7. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

William

$57 nightly

$65 total

Oct 15 - Oct 16

Total with taxes and fees

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

8. Days Inn and Suites by Wyndham Sikeston

Sikeston

David

$66 nightly

$76 total

Nov 1 - Nov 2

Total with taxes and fees

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.

A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.

A Travel Inn and Suites with a brick facade, a flat roof, and a welcoming entrance.

9. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Craig

$58 nightly

$66 total

Oct 14 - Oct 15

Total with taxes and fees

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.

A bathroom with a bathtub, toilet, and shower curtain.

A reception area with a counter, a coffee machine, and seating.

10. Country Yard Inn and Suite

Sikeston

William

$53 nightly

$60 total

Oct 11 - Oct 12

Total with taxes and fees

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A living room with two sofas, a coffee table, a TV, and a cabinet.

A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

11. Comfort Inn & Suites Sikeston I-55

Sikeston

Kathryn

$83 nightly

$95 total

Nov 1 - Nov 2

Total with taxes and fees

A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

A modern kitchen with a built-in microwave, a black refrigerator, and a wooden countertop.

A hotel with a central entrance, multiple parking spaces, and a well-lit facade.

A modern kitchen with a stone backsplash, a dining area with red chairs, and a red accent wall with a framed picture.

12. Super 8 By Wyndham Marston

Marston

Brenda

$56 nightly

$64 total

Oct 21 - Oct 22

Total with taxes and fees

A building with a fountain and flower beds in front.

A reception area with a stone wall, wooden cabinets, and a sign for The Riverstone Hotel.

A hotel room with a beige sofa, two patterned armchairs, a ceiling fan, a flat-screen TV, and a window with curtains.

A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

13. The Riverstone Hotel Charleston-Sikeston

Charleston

Kathleen

$66 nightly

$74 total

Oct 11 - Oct 12

Total with taxes and fees

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

A kitchen with wooden cabinets, a granite countertop, a built-in microwave, and a window with a view.

A motel with a sign reading "Eagle Inn" and a parking lot with several cars.

A hotel room with two beds, a nightstand, a lamp, and a window with curtains.

14. Eagle Inn Charleston

Charleston

Jackson

$66 nightly

$74 total

Oct 9 - Oct 10

Total with taxes and fees

A hotel room with two beds, a television, a desk, and a mirror.

A motel with a covered outdoor seating area and a parking lot.

A bathroom with a sink, mirror, and chair.

A covered pavilion with a roof, wooden railing, and a barbecue grill.

15. Travel Inn Marston I-55 by Hotel O

Marston

Frank

$47 nightly

$54 total

Oct 26 - Oct 27

Total with taxes and fees

A modern hotel lobby with a bar area, seating, and artwork on the walls.

A modern kitchen with a large island, bar stools, wine bottles, and a built-in TV.

A modern hotel with a prominent sign, a covered entrance, and a well-lit exterior.

A swimming pool with clear blue water, surrounded by sun loungers and a lifeguard stand.

16. Hampton Inn By Hilton Dexter

Dexter

Kendall

$98 nightly

$111 total

Oct 18 - Oct 19

Total with taxes and fees

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.

A reception area with a counter, a flat-screen TV, and a window with blinds.

17. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

William

$60 nightly

$67 total

Oct 11 - Oct 12

Total with taxes and fees

A hotel room with a bed, a desk, a chair, a bathroom with a bathtub, and a patterned floor.

A hotel reception area with a reception desk, framed certificates, and a painting on the wall.

A kitchen with wooden cabinets, a stainless steel sink, a microwave, and a dishwasher.

A hotel with a brick facade, multiple windows, and a covered entrance area.

18. Econo Lodge Dexter

Dexter

Herman

$51 nightly

$58 total

Nov 7 - Nov 8

Total with taxes and fees

A coffee shop with a coffee machine, espresso cups, a sink, and a trash bin.

A hotel hallway with patterned carpet, light green walls, and a ceiling with recessed lighting.

A kitchen with a white microwave, a fruit basket, a coffee maker, and a storage container.

A hotel lobby with a reception desk, a waiting area with a sofa and armchairs, and a patterned carpet.

19. Dexter Inn

Dexter

Edward

$69 nightly

$78 total

Oct 10 - Oct 11

Total with taxes and fees

A diner with booth seating, a checkered floor, and a counter with a cash register.

A gym with multiple exercise machines, a clock on the wall, and a window with blinds.

A reception area with a marble counter, potted plants, a clock, and a TV on the wall.

A lobby with a round rug, two potted plants, three framed artworks, and two black leather chairs.

20. Travelodge by Wyndham Dexter

Dexter

Steven

$86 nightly

$98 total

Oct 25 - Oct 26

Total with taxes and fees

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Where to stay near Matthews

Matthews, Missouri offers a charming escape for outdoor enthusiasts and romantics alike. Enjoy the breathtaking scenery on a leisurely hike or indulge in family-friendly adventures nearby. With its welcoming atmosphere, Matthews promises a relaxing getaway filled with memorable excursions and friendly faces.

A tree with sunlight filtering through its leaves, creating a warm glow.

A building with three tall chimneys, surrounded by blooming trees with pink and white flowers.

A sign for Lambert's, a place of worship.

Sikeston

Discover Sikeston, a welcoming destination perfectly suited for travelers looking for a blend of business, family fun, and outdoor adventures. With highlights like the Sikeston Depot Museum and the Central Park, visitors can enjoy cultural experiences and relaxing green spaces. The nearby lake and national state park offer breathtaking nature escapes. Located about 9 miles by car from Matthews, Sikeston is a smart choice for a hotel stay, providing easy access to both adventure and leisure.

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Canalou

Experience the charm of Canalou, a great hub for family-oriented travelers looking to connect with nature and enjoy budget-friendly adventures. This inviting city is just 6 miles from Matthews, offering easy access to delightful attractions like the Sikeston Depot Museum, Central Park, and the City of Miner Convention Center. With a welcoming atmosphere year-round, Canalou makes an excellent choice for those eager to explore scenic landscapes and outdoor activities. Choose Canalou for your stay and discover a relaxing getaway that feels like home.

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Morehouse

Family travelers will love Morehouse, known for its welcoming atmosphere and access to delightful attractions. Explore the Sikeston Depot Museum for a taste of local history, enjoy the lush surroundings of Central Park, or host events at the City of Miner Convention Center. With visitor numbers peaking in the summer months, Morehouse offers a vibrant experience year-round. Located about 8 miles from Matthews, it’s an ideal spot for budget-friendly accommodations that ensure a memorable stay.

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A rural road curving through a field of yellow crops, with a forested hill on the right and a cloudy sky above.

A tree-lined street with autumn leaves, a sidewalk, and a house.

Miner

Ideally situated for families and nature lovers, Miner offers a delightful escape near Matthews, Missouri. Visitors can explore the City of Miner Convention Center for events, immerse themselves in the rich history at the Sikeston Depot Museum, or unwind at Central Park’s scenic beauty. With only about a 10-mile drive from Matthews, getting to Miner is easy and hassle-free. Choosing Miner for your stay ensures a memorable blend of culture, outdoor experiences, and budget-friendly options.

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Baker

Travelers visiting the area often choose Baker, particularly families and nature enthusiasts seeking a vibrant experience. This charming city offers a delightful blend of attractions, including the Sikeston Depot Museum, the Dexter Welcome Center Depot and Museum, and The Heritage House, perfect for discovering art, history, and local heritage. With a steady flow of visitors year-round, Baker is conveniently located about 10 miles from Matthews, making it an excellent choice for your next vacation stay.

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Stay near popular attractions around Matthews

Matthews offers a charming blend of outdoor beauty and cultural experiences, perfect for romantic getaways or family adventures. Explore scenic landscapes, vibrant arts centers, and engaging museums that will enrich your stay and create lasting memories. Enjoy the allure of this delightful destination!

Sikeston Depot Museum

7.6/10 (57 reviews)

Experience the best of culture at the Sikeston Depot Museum, perfect for art lovers and history buffs. This vibrant museum showcases local heritage and artistic expression, offering a unique glimpse into the region's past. It's about a 9-mile drive from Matthews, making it an easy stop during your visit.

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Central Park

7.2/10 (56 reviews)

Often cited as a favorite for families, Central Park in Sikeston offers a delightful blend of outdoor activities and city vibes. Located about 8 miles by car from Matthews, it’s an ideal spot for a quick visit, making it easy to enjoy a memorable day out in nature.

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New Madrid Historical Museum

8.2/10 (36 reviews)

Ideal for travelers interested in history, the New Madrid Historical Museum offers a fascinating glimpse into the area's rich cultural heritage. Located about 12 miles from Matthews, this museum showcases the history and significance of New Madrid, making it a convenient stop for those exploring the region.

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Hunter-Dawson State Historic Site

7.6/10 (13 reviews)

The perfect starting point for history buffs, Hunter-Dawson State Historic Site offers a glimpse into Missouri's rich cultural heritage. Located about 12 miles from Matthews, this historic house showcases beautifully preserved architecture and unique stories. Staying nearby allows easy access to this fascinating landmark.

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Marston Community Center

Discover the appeal of the Marston Community Center, a vibrant arts hub ideal for culture seekers visiting Matthews, Missouri. Located about 17 miles by car from Matthews, this center offers an engaging atmosphere where you can immerse yourself in local art and community events, making it a convenient stop during your stay.

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Big Oak Tree State Park

8.0/10 (20 reviews)

Enjoy the simplicity of Big Oak Tree State Park, a haven for outdoor lovers seeking adventure and stunning scenery. Located about 18 miles from Matthews, this park offers lush landscapes and unique natural features, making it an ideal spot for a relaxing getaway. Staying nearby allows easy access to its natural beauty.

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Front Street Studio & Art Gallery

8.6/10 (15 reviews)

Perfectly suited for art lovers, Front Street Studio & Art Gallery in Blodgett, Missouri, offers a vibrant cultural experience with unique artworks that reflect local talent. Located about 17 miles from Matthews, it's an inviting destination for those looking to immerse themselves in the region's artistic scene, making it a convenient stop on your travels.

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City of Miner Convention Center

A stellar choice for business travelers, the City of Miner Convention Center offers a professional atmosphere for conferences and events. Located about 10 miles by car from Matthews, it provides easy access for attendees. Staying nearby ensures you’re close to a hub of business activity.

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Top Matthews Hotel Reviews

Hampton Inn Sikeston

10/10 Excellent

"Loved the modern, CLEAN, room and staff was extremely friendly and helpful. We were greeted and served by "Brittany" at check-in who was so nice and friendly and even gave us dinner suggestions. We would definitely stay here again!"

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Everything was up to par, good was excellent."

Comfort Inn & Suites Sikeston I-55

8/10 Good

"Our room was very clean and comfy. The bathroom was clean but could use an update. The bathroom tissue and face tissues are on the thin side. Breafast bar was excellent. The staff was very nice and helpful."

Hampton Inn By Hilton Dexter

10/10 Excellent

"Really nice place to look brand new that was good. TVs were updated. I enjoyed it. Thank you for having me."

Days Inn and Suites by Wyndham Sikeston

8/10 Good

"Everything was good about the room except the bathroom. The stopper on the sink did not work and there was a dent in the wall. The face/wash towels need to be changed out. They are no longer white. They are dull in color. The couch needs to be cleaned and freshen. The staff was excellent and everything else is good. I just wish that breakfast offered hot eggs and meat vs. only waffles. Otherwise the room was good."

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent

"Great place"

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good

"NA NA NA NA NA NA NA NA NA NA NA NA NA"

Super 8 By Wyndham Marston

8/10 Good

"Very clean and a very friendly staff! Air conditioner in room wasn’t working perfectly so it felt very humid but overall was not bad. I would stay here again!"

More cheap stays in Matthews

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO

$57 nightly

$65 total

Oct 15 - Oct 16

Total with taxes and fees

7/10 Good! (683 reviews)

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO

$60 nightly

$67 total

Oct 11 - Oct 12

Total with taxes and fees

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

$66 nightly

$76 total

Nov 1 - Nov 2

Total with taxes and fees

7.2/10 Good! (1,000 reviews)

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

$84 nightly

$96 total

Oct 11 - Oct 12

Total with taxes and fees

8.4/10 Very Good! (1,001 reviews)

Holiday Inn Express & Suites Sikeston Southwest by IHG

115 Hospitality Dr Sikeston MO

$91 nightly

$103 total

Nov 8 - Nov 9

Total with taxes and fees

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

$105 nightly

$120 total

Oct 18 - Oct 19

Total with taxes and fees

9/10 Wonderful! (632 reviews)

Hotels in Matthews with star-rating

Frequently asked questions

What is the best area to stay in Matthews?

The best area to stay in Matthews is the town center, particularly along Main Street, as it offers the most convenient access to local amenities and attractions.This area serves as the heart of Matthews, featuring a concentration of local businesses, dining options, and community spaces. You'll find the town hall, the public library, and several small shops within easy walking distance. It's also where many local events and markets take place.For couples seeking a relaxed and convenient base, staying in the town center is ideal. You can easily walk to local eateries for dinner, enjoy a stroll through the town's small park, or explore the unique boutiques without needing to drive. It provides a pleasant and centralized experience.Travelers looking for a peaceful stay will also appreciate the town center. While it's the most active part of Matthews, it maintains a quiet, small-town ambiance, especially in the evenings.

When is the best time to go to Matthews?

The best time to go to Matthews is during the spring (late April to early June) and fall (September to October) when the weather is most pleasant for outdoor activities.Spring offers mild temperatures, typically ranging from the 60s to high 70s Fahrenheit, with blooming wildflowers and lush greenery. This season is ideal for couples who enjoy exploring the area's natural beauty, perhaps with a scenic drive or a leisurely picnic in one of the local parks. The comfortable weather makes it great for enjoying the outdoors without the intense heat of summer.Fall brings comfortable temperatures, often in the 60s and low 70s, and beautiful autumn foliage as the leaves change color. This period is great for travelers who appreciate picturesque landscapes and outdoor pursuits like hiking or visiting local farms.

Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Matthews.

How much is the nightly rate at a Matthews hotel?

Prices for hotels in Matthews often vary, but you can find a great deal from $54 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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Sikeston Vacation Rentals

Find hotels in Matthews, MO from $54

Upfront pricing

Treat yourself

Be picky

Go beyond your typical stay in Matthews

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Matthews hotels

1. Hampton Inn Sikeston

2. Holiday Inn Express & Suites Sikeston Southwest by IHG

3. Fairfield Inn & Suites by Marriott Sikeston

4. TownePlace Suites by Marriott Sikeston

5. Drury Inn & Suites Sikeston, MO

6. Best Western Plus Sikeston I-55

7. Super 8 by Wyndham Sikeston/Miner Area

8. Days Inn and Suites by Wyndham Sikeston

9. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10. Country Yard Inn and Suite

11. Comfort Inn & Suites Sikeston I-55

12. Super 8 By Wyndham Marston

13. The Riverstone Hotel Charleston-Sikeston

14. Eagle Inn Charleston

15. Travel Inn Marston I-55 by Hotel O

16. Hampton Inn By Hilton Dexter

17. Super 8 by Wyndham Charleston/Sikeston East MO

18. Econo Lodge Dexter

19. Dexter Inn

20. Travelodge by Wyndham Dexter

Where to stay near Matthews

Sikeston

Canalou

Morehouse

Miner

Baker

Stay near popular attractions around Matthews

Sikeston Depot Museum

Central Park

New Madrid Historical Museum

Hunter-Dawson State Historic Site

Marston Community Center

Big Oak Tree State Park

Front Street Studio & Art Gallery

City of Miner Convention Center

Top Matthews Hotel Reviews

Hampton Inn Sikeston

Drury Inn & Suites Sikeston, MO

Comfort Inn & Suites Sikeston I-55

Hampton Inn By Hilton Dexter

Days Inn and Suites by Wyndham Sikeston

Super 8 by Wyndham Sikeston/Miner Area

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Super 8 By Wyndham Marston

More cheap stays in Matthews

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Charleston/Sikeston East MO

Days Inn and Suites by Wyndham Sikeston

Best Western Plus Sikeston I-55

Holiday Inn Express & Suites Sikeston Southwest by IHG

Hampton Inn Sikeston

Hotels in Matthews with star-rating

Frequently asked questions

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