Title: Sikeston Vacation Rentals from $108: Search Short-Term Rentals | Expedia.com

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![Good Day Sunshine Early Morning Sunshine passes through the fog and scatters through the leaves of a tree in Scott County Missouri ](https://images.trvl-media.com/place/6058766/3f78823b-e4e9-4186-9eb4-70d81c753510.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6058766/3f78823b-e4e9-4186-9eb4-70d81c753510.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Apr 24 - Apr 26](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-04-24&endDate=2026-04-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[Jun 5 - Jun 7](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-06-05&endDate=2026-06-07&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[Jul 3 - Jul 5](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-07-03&endDate=2026-07-05&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jul 31 - Aug 2](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-07-31&endDate=2026-08-02&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Sikeston vacation rentals

![Living area](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/143b0eab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/3867ac72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/927199d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/9ff1a808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Little Blue Cottage on Spanish

[](https://www.expedia.com/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information)

Cape Girardeau

8.2/10

Very Good

(54 reviews)

"Cozy and perfect for a couple. Great communication with the host"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Beth G.

$101 nightly

$108 total

Apr 9 - Apr 10

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/64000000/63170000/63162900/63162828/e8e18ca6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/64000000/63170000/63162900/63162828/de8fdc64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/64000000/63170000/63162900/63162828/4b9b083c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, stereo](https://images.trvl-media.com/lodging/64000000/63170000/63162900/63162828/73866b5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Dexter Homestead. Very Cozy & NEW Remodel !

[](https://www.expedia.com/Dexter-Hotels-Dexter-Homestead-Very-Cozy-NEW-Remodel.h63162828.Hotel-Information)

Dexter

7.8/10

Good

(31 reviews)

"Stayed many times. Nice and comfortable "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Susan R.

$189 nightly

$203 total

Apr 7 - Apr 8

Total with taxes and fees

[](https://www.expedia.com/Dexter-Hotels-Dexter-Homestead-Very-Cozy-NEW-Remodel.h63162828.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/469a5901.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/a97a55c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/211494f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/d33a9d5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

[](https://www.expedia.com/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information)

Cape Girardeau

8.8/10

Excellent

(39 reviews)

"Will definitely book again! Great location, comfortable stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Pynktoria !.

$210 nightly

$221 total

Apr 7 - Apr 8

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/1c1368ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/f4fbd89f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor spa tub](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/b8327ae6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/0b3aaea0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Twisted Sassafras Treehouse 

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information)

Cape Girardeau

10/10

Exceptional

(33 reviews)

"Amazing stay, loved the bed and hot tub. Close to town but also away. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Maria B.

$293 nightly

$308 total

Apr 7 - Apr 8

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/0c802aa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/60c56f2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/5f66921b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/860b4de6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming Secluded Getaway Cabin within minutes of amenities 

[](https://www.expedia.com/Cape-Girardeau-Hotels-Charming-Getaway-Cabin.h75891457.Hotel-Information)

Cape girardeau

10/10

Exceptional

(18 reviews)

"We had a great time at Blair and her family's property. The cabin was very comfortable and as advertised. I would be happy to recommend it to others "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tammy M.

$292 nightly

$307 total

Apr 7 - Apr 8

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Charming-Getaway-Cabin.h75891457.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557550/68e05443.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557550/b4eaf9f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557550/a4370343.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557550/b03fe6cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Modern 2BR Apt w Electric Fireplace By KeenStays

[](https://www.expedia.com/Cape-Girardeau-Hotels-Modern-2BR-Apt-W-Electric-Fireplace-By-KeenStays.h127557550.Hotel-Information)

Cape Girardeau

$200 nightly

$209 total

Apr 7 - Apr 8

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Modern-2BR-Apt-W-Electric-Fireplace-By-KeenStays.h127557550.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/f432dafb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/564d6e43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/a340bc3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace, DVD player, books](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/6d0c8b74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Serenity South -- Gardens, River-Views, and Refreshing Space

[](https://www.expedia.com/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information)

Cape Girardeau

10/10

Exceptional

(152 reviews)

"Wonderful location! WonderfulStay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Alison C.

$229 nightly

$248 total

Apr 7 - Apr 8

Total with taxes and fees

[](https://www.expedia.com/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information)

![Living area](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557548/e671b9f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557548/ae9b919f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557548/ada31fc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557548/7a844c3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fresh & Cozy Retreat w/ King Bed · By KeenStays

[](https://www.expedia.com/Cape-Girardeau-Hotels-Fresh-Cozy-Retreat-W-King-Bed-By-KeenStays.h127557548.Hotel-Information)

Cape Girardeau

$160 nightly

$167 total

Apr 26 - Apr 27

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Fresh-Cozy-Retreat-W-King-Bed-By-KeenStays.h127557548.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/81000000/80800000/80794200/80794106/w691h683x160y0-35462827.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/81000000/80800000/80794200/80794106/w677h639x174y44-d15b07a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/81000000/80800000/80794200/80794106/w675h683x175y0-e472cb80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/81000000/80800000/80794200/80794106/w675h683x175y0-bccaa29a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Relax in the country at Countryside Villas! - Villa A

[](https://www.expedia.com/Jackson-Hotels-Relax-In-The-Country-At-Countryside-Villas.h80794106.Hotel-Information)

Jackson

10/10

Exceptional

(33 reviews)

"Great place to stay, felt like home away from home. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Brittany

$172 nightly

$181 total

Apr 7 - Apr 8

Total with taxes and fees

[](https://www.expedia.com/Jackson-Hotels-Relax-In-The-Country-At-Countryside-Villas.h80794106.Hotel-Information)

![1 bedroom, desk, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/add99418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/1862bab6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/94d9c4c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/2aecac3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Cottage, Rusted Route Farms

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Cottage.h112868647.Hotel-Information)

Jackson

10/10

Exceptional

(2 reviews)

"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Renee C.

$199 nightly

$199 total

Apr 12 - Apr 13

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Cottage.h112868647.Hotel-Information)

![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/2c8cc497.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/8932b23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/3619a392.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/673b3050.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Gorgeous 1856 Log Cabin, Completely Renovated

[](https://www.expedia.com/Cape-Girardeau-Hotels-Gorgeous-1856-Log-Cabin.h112868642.Hotel-Information)

Jackson

10/10

Exceptional

(3 reviews)

"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Chandler G.

$315 nightly

$315 total

Apr 7 - Apr 8

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Gorgeous-1856-Log-Cabin.h112868642.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/426ccc72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/91a8cbb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/fcf2830c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/04f26ada.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

###  Villa B offers peace and quiet with beautiful views of the countryside.

[](https://www.expedia.com/Jackson-Hotels-Villa-B-Offers-Peace-And-Quiet-With-Beautiful-Views-Of-The-Countryside.h93056190.Hotel-Information)

Jackson

10/10

Exceptional

(11 reviews)

"It was great. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Benjamin Q.

$170 nightly

$179 total

May 1 - May 2

Total with taxes and fees

[](https://www.expedia.com/Jackson-Hotels-Villa-B-Offers-Peace-And-Quiet-With-Beautiful-Views-Of-The-Countryside.h93056190.Hotel-Information)

![Living area](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557541/c4e4597e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557541/470e2ce0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557541/7f0c9c8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557541/a552cbde.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Luxe 2KBR Apt w/ Electric Fireplace · By KeenStays

[](https://www.expedia.com/Cape-Girardeau-Hotels-Luxe-2KBR-Apt-W-Electric-Fireplace-By-KeenStays.h127557541.Hotel-Information)

Cape Girardeau

$200 nightly

$209 total

Apr 12 - Apr 13

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Luxe-2KBR-Apt-W-Electric-Fireplace-By-KeenStays.h127557541.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/w1440h810x0y3-bf19009e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, video games, foosball](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/62582c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, video games, foosball](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/a7fa16a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/d2b33581.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

[](https://www.expedia.com/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(8 reviews)

"Nice place, great times"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jace W.

$422 nightly

$443 total

Apr 7 - Apr 8

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information)

![Meeting facility](https://images.trvl-media.com/lodging/104000000/103900000/103892700/103892640/1c6c31ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/104000000/103900000/103892700/103892640/450d2061.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/104000000/103900000/103892700/103892640/7dffb73b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/104000000/103900000/103892700/103892640/d39634e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Building at Cape Girardeau Regional Airport

[](https://www.expedia.com/Scott-City-Hotels-Building-At-Cape-Girardeau-Regional-Airport.h103892640.Hotel-Information)

Scott City

$571 nightly

$620 total

Apr 8 - Apr 9

Total with taxes and fees

[](https://www.expedia.com/Scott-City-Hotels-Building-At-Cape-Girardeau-Regional-Airport.h103892640.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/804f0425.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/2cb1c224.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/9e44784b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/aa7536c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Atrium - A Boutique Hotel

[](https://www.expedia.com/Perryville-Hotels-The-Atrium-A-Boutique-Hotel.h126617355.Hotel-Information)

Perryville

$137 nightly

$156 total

May 5 - May 6

Total with taxes and fees

[](https://www.expedia.com/Perryville-Hotels-The-Atrium-A-Boutique-Hotel.h126617355.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/d22aee4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/b0f0a7b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, DVD player](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/ded6701c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/12dcf221.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Rest, Relax and Renew. Our log cabin experience awaits your arrival. 

[](https://www.expedia.com/Anna-Hotels-Rest.h31189922.Hotel-Information)

Anna

10/10

Exceptional

(407 reviews)

"Great location. Cozy cabin. Would stay there again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

jeffrey s

$189 nightly

$200 total

Apr 8 - Apr 9

Total with taxes and fees

[](https://www.expedia.com/Anna-Hotels-Rest.h31189922.Hotel-Information)

![Smart TV](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/1be40475.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/d47379a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/13ed0134.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, bed sheets](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/d4f180ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Peaceful secluded cabin located near Horseshoe Lake 

[](https://www.expedia.com/Peaceful-Secluded-Cabin-Located-Near-Horseshoe-Lake.h109730068.Hotel-Information)

Miller City

9.8/10

Exceptional

(24 reviews)

"The cabin is perfect for a quiet getaway. Location is great close to Dollar General, gas station and restaurants"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Marsha G.

$175 nightly

$185 total

Apr 7 - Apr 8

Total with taxes and fees

[](https://www.expedia.com/Peaceful-Secluded-Cabin-Located-Near-Horseshoe-Lake.h109730068.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/09707f79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/7bfe8087.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, DVD player](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/3f7db1ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, DVD player](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/c221a56c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming cottage overlooking Lake Acre

[](https://www.expedia.com/Charming-Cabin-Overlooking-5-Acre-Lake.h39671140.Hotel-Information)

Dongola

10/10

Exceptional

(102 reviews)

"Enjoyed our stay great hospitality, everything we needed was addressed. We would highly recommend staying there. Great location "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

carlton h.

$268 nightly

$284 total

Apr 11 - Apr 12

Total with taxes and fees

[](https://www.expedia.com/Charming-Cabin-Overlooking-5-Acre-Lake.h39671140.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/124000000/123380000/123379000/123378902/9d870958.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/124000000/123380000/123379000/123378902/a79b8818.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/124000000/123380000/123379000/123378902/8d6feb60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/124000000/123380000/123379000/123378902/277407ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pet-Friendly Lakeside Gem 4 Mi to Dtwn Murphysboro

[](https://www.expedia.com/Murphysboro-Hotels-Lakefront.h123378902.Hotel-Information)

Murphysboro

8.0/10

Very Good

(3 reviews)

"Perfect but beware if you are a sensitive sleeper as the mattress on the queen bed is saggy and in need of replacing. Probably fine for 1 person but 2 people easily roll into the middle making for a not-so-good night's sleep."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Pamela S.

$214 nightly

$233 total

Apr 7 - Apr 8

Total with taxes and fees

[](https://www.expedia.com/Murphysboro-Hotels-Lakefront.h123378902.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-20&endDate=2026-04-21&regionId=6058766&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-07-05&d1=2026-07-05&endDate=2026-07-08&d2=2026-07-08&lodging=CABIN)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-07-05&d1=2026-07-05&endDate=2026-07-08&d2=2026-07-08&lodging=VACATION_HOME)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-07-05&d1=2026-07-05&endDate=2026-07-08&d2=2026-07-08&lodging=COTTAGE)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-07-05&d1=2026-07-05&endDate=2026-07-08&d2=2026-07-08&lodging=APARTMENT)

Aparthotels

[](https://www.expedia.com/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-07-05&d1=2026-07-05&endDate=2026-07-08&d2=2026-07-08&lodging=APART_HOTEL)

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## Top Sikeston Hotel Reviews

![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf_y.jpg)

### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent

"Yes the Church of Jesus Christ is just up the road about 3 miles 😊"

[](https://expedia.com/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information)

![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg)

### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"Clean room. "

[](https://expedia.com/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg)

### Drury Inn & Suites Sikeston, MO

8/10 Good

"It would be nice to have bacon sometime."

[](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/71011e95_y.jpg)

### Pear Tree Inn Cape Girardeau West

8/10 Good

"Everything was as expected. "

[](https://expedia.com/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c_y.jpg)

### Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"Rooms are very nice and clean, the staff was very friendly, many choices at breakfast, and parking is nice wherever your room is located. This is our go to hotel when we travel to Cape Girardeau. "

[](https://expedia.com/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg)

### Hampton Inn Sikeston

10/10 Excellent

"Was very clean & pet-friendly. Great place to stop on toad"

[](https://expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Drury Inn & Suites Jackson MO](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg)

### Drury Inn & Suites Jackson MO

4/10 Poor

"I’ve stayed at this hotel twice now while visiting family in the area. The property itself is very nice—clean, well‑maintained, and in a great location right off the interstate. The staff has also been friendly during both of my stays. However, both times my mom and I were placed in the exact same room directly above the atrium, and that unfortunately made the stay much less restful. The noise from the lobby carries straight up into the room. Late at night you can clearly hear people talking and laughing in the dining area, chairs scraping across the floor, and every sound seems amplified. Then very early in the morning, you’re woken up again by staff setting up breakfast and guests eating downstairs. I’m honestly frustrated with myself for not thinking to request a room away from the lobby this time, because I didn’t expect to be put in the same noisy room again. The hotel is great in many ways, but I would strongly recommend requesting a room far from the atrium if you’re a light sleeper or want a quiet stay."

[](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/6966efed_y.jpg)

### Drury Inn & Suites Cape Girardeau

10/10 Excellent

"Wonderful. I will definitely stay here again. "

[](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information)

![Fairfield Inn & Suites by Marriott Sikeston](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54_y.jpg)

### Fairfield Inn & Suites by Marriott Sikeston

10/10 Excellent

"Quick and friendly check where they offered us bottles of water. They added a lounge/bar that is very convenient. The outside lounge are is very nice as well. Room is clean with a comfortable bed and 2 different styles of pillows. Which is nice considering most hotels give you one kind of pillow and it is not great. "

[](https://expedia.com/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

## Find out more about Sikeston

**Everything you need to know about Sikeston vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Sikeston vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Sikeston vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Sikeston vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Sikeston. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Sikeston in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $108 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Sikeston rentals**

At Expedia, we put the best Sikeston vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Sikeston rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Sikeston vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Sikeston. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

## Explore a world of travel with Expedia

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- [Florida Vacation Rentals ](https://www.expedia.com/Destinations-In-Florida.d211.Vacation-Rental-Destinations)
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- [Michigan Vacation Rentals ](https://www.expedia.com/Destinations-In-Michigan.d224.Vacation-Rental-Destinations)

- [Vacation Homes in Sikeston ](https://expedia.com/Sikeston-Private-Vacation-Homes.d6058766-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Cabin Rentals in Sikeston ](https://expedia.com/Sikeston-Cabins.d6058766-aaCabins.Travel-Guide-Accommodation)
- [Apartments in Sikeston ](https://expedia.com/Sikeston-Apartments.d6058766-aaApartments.Travel-Guide-Accommodation)
- [Cottages in Sikeston ](https://expedia.com/Sikeston-Cottages.d6058766-aaCottages.Travel-Guide-Accommodation)
- [Motels in Sikeston ](https://expedia.com/Sikeston-Motels.d6058766-aaMotels.Travel-Guide-Accommodation)
- [Lodges in Sikeston ](https://expedia.com/Sikeston-Lodges.d6058766-aaLodges.Travel-Guide-Accommodation)
- [Farmstay in Sikeston ](https://expedia.com/Sikeston-Agritourism.d6058766-aaAgritourism.Travel-Guide-Accommodation)
- [RV Parks in Sikeston ](https://expedia.com/Sikeston-RV-Parks.d6058766-aaRVParks.Travel-Guide-Accommodation)
- [B&B in Sikeston ](https://expedia.com/Sikeston-Bed-And-Breakfast.d6058766-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Aparthotels in Sikeston ](https://expedia.com/Sikeston-Apart-Hotels.d6058766-aaApartHotels.Travel-Guide-Accommodation)
- [Guest Houses in Sikeston ](https://expedia.com/Sikeston-Guest-Houses.d6058766-aaGuestHouses.Travel-Guide-Accommodation)

## Frequently asked questions

### Can I find a vacation rental in Sikeston?

### What's the top vacation rental in Sikeston?

### What’s there to see and do in Sikeston?

### What’s a vacation rental in Sikeston like?

### Expedia's Latest Trends

Hotels

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Flights

- [Cheap Flights to Branson](https://expedia.com/Cheap-Flights-To-Branson.d6058734.Travel-Guide-Flights)
- [Cheap Flights to Columbia](https://expedia.com/Cheap-Flights-To-Columbia.d901.Travel-Guide-Flights)
- [Cheap Flights to Springfield](https://expedia.com/Cheap-Flights-To-Springfield.d602962.Travel-Guide-Flights)

Cars

- [Car rentals in Columbia](https://expedia.com/Car-Rentals-In-Columbia.d901.Car-Rental-Guide)
- [Car rentals in Springfield](https://expedia.com/Car-Rentals-In-Springfield.d602962.Car-Rental-Guide)

Activities

- [Things to do in Branson](https://expedia.com/Things-To-Do-In-Branson.d6058734.Travel-Guide-Activities)

Packages

- [Branson Vacation](https://expedia.com/Branson.d6058734.Destination-Travel-Guides)

Vacation Rentals

- [Branson Vacation Rentals](https://expedia.com/Branson-Vacation-Rentals.d6058734.Travel-Guide-VacationRentals)

General

- [Visit Osage Beach](https://expedia.com/Osage-Beach.dx6058781)

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