Title: Sikeston Vacation Rentals from $108: Search Short-Term Rentals | Expedia.com

[Sikeston Travel Guide](https://expedia.com/Sikeston.dx6058766)[Hotels in Sikeston](https://expedia.com/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)[Flights to Sikeston](https://expedia.com/Cheap-Flights-To-Sikeston.d6058766.Travel-Guide-Flights)[Car Rentals in Sikeston](https://expedia.com/Car-Rentals-In-Sikeston.d6058766.Car-Rental-Guide)[Sikeston Vacation Packages](https://expedia.com/Sikeston.d6058766.Destination-Travel-Guides)

![Pre-teen girl walking through corn maze during fall](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-04-17&endDate=2026-04-19&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[May 29 - May 31](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-05-29&endDate=2026-05-31&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[Jun 26 - Jun 28](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-06-26&endDate=2026-06-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jul 24 - Jul 26](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-07-24&endDate=2026-07-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Sikeston vacation rentals

![Interior](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/804f0425.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/2cb1c224.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Queen Bed with Sofa bed, Pets Allowed | Interior](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/d395df9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/9e44784b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Atrium - A Boutique Hotel

[](https://www.expedia.com/Perryville-Hotels-The-Atrium-A-Boutique-Hotel.h126617355.Hotel-Information)

Perryville

$135 nightly

$155 total

Apr 1 - Apr 2

Total with taxes and fees

[](https://www.expedia.com/Perryville-Hotels-The-Atrium-A-Boutique-Hotel.h126617355.Hotel-Information)

![House (1 Bedroom) | Front of property](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661842/aa6e717a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661842/02464d31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661842/3ac16db9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661842/d5f4e688.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pet Friendly! Countryside Couples Stay in Illinois

[](https://www.expedia.com/Murphysboro-Hotels-Lakefront.h123661842.Hotel-Information)

Murphysboro

$217 nightly

$238 total

Mar 31 - Apr 1

Total with taxes and fees

[](https://www.expedia.com/Murphysboro-Hotels-Lakefront.h123661842.Hotel-Information)

![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/84406cc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![55-inch Smart TV with digital channels, TV, streaming services](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/586044dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Egyptian cotton sheets, premium bedding, down comforters](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/0b4f194a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![55-inch Smart TV with digital channels, TV, streaming services](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/8010cd32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Urban Lofts

[](https://www.expedia.com/Perryville-Hotels-Urban-Lofts.h76388000.Hotel-Information)

Perryville

9.2/10

Wonderful

(17 reviews)

"Great place to stay! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Eric

$256 nightly

$293 total

Apr 5 - Apr 6

Total with taxes and fees

[](https://www.expedia.com/Perryville-Hotels-Urban-Lofts.h76388000.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-13&endDate=2026-04-14&regionId=6058766&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-06-28&d1=2026-06-28&endDate=2026-07-01&d2=2026-07-01&lodging=CABIN)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-06-28&d1=2026-06-28&endDate=2026-07-01&d2=2026-07-01&lodging=VACATION_HOME)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-06-28&d1=2026-06-28&endDate=2026-07-01&d2=2026-07-01&lodging=COTTAGE)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-06-28&d1=2026-06-28&endDate=2026-07-01&d2=2026-07-01&lodging=APARTMENT)

Aparthotels

[](https://www.expedia.com/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-06-28&d1=2026-06-28&endDate=2026-07-01&d2=2026-07-01&lodging=APART_HOTEL)

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## Top Sikeston Hotel Reviews

![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg)

### Drury Inn & Suites Sikeston, MO

10/10 Excellent

"."

[](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg)

### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"Your hotel was a very nice place staff was wonderful !! Very clean !!! Easy parking !! Great room !!! Love it Breakfast was hot and ready to go . At 6 am "

[](https://expedia.com/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

![Drury Inn & Suites Jackson MO](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg)

### Drury Inn & Suites Jackson MO

10/10 Excellent

"Breakfast was fresh a s very tasty. Eggs, sausage, buscuits, gravy, waffles, juice, soda, and coffee. Parking was ample and safe. Pool In room fridge. Everything was clean and fresh smelling. I had a very pleasant stay here and will return again in my future trips here. :)"

[](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg)

### Hampton Inn Sikeston

4/10 Poor

"The property is deceiving, Chicken sausage on the breakfast buffet But worst of all hair in my shower and as I’m checking out to confirm the hair that had been on my baby’s bottle when it had fell on the floor. A guest left with three large cages full of cats. So these room rooms are allowed to have pets of any kind and as many as you want apparently in them."

[](https://expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Fairfield Inn & Suites by Marriott Sikeston](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54_y.jpg)

### Fairfield Inn & Suites by Marriott Sikeston

8/10 Good

"The hotel is beautiful and absolutely gorgeous!! Brand new. Very clean and the staff were all very friendly and welcoming and I mean All of the staff down to housekeeping. I would have given 5 stars but the pool heater wasn’t working and it was a bit too cold to swim so that was a little disappointing. Id definitely return again 😊"

[](https://expedia.com/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/71011e95_y.jpg)

### Pear Tree Inn Cape Girardeau West

8/10 Good

"Very decent hotel, Affordable, free pop corn abd soda, nice touch, good breakfast."

[](https://expedia.com/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg)

### The Riverview

10/10 Excellent

"The room was good. The bed was comfy."

[](https://expedia.com/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7_y.jpg)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good

"Stayed here as we were just passing through the area. Room was clean. Pillows were not very soft. Breakfast was very limited. Was as expected for the price."

[](https://expedia.com/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/6966efed_y.jpg)

### Drury Inn & Suites Cape Girardeau

10/10 Excellent

"Clean room, friendly staff, great breakfast. "

[](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information)

## Find out more about Sikeston

**Everything you need to know about Sikeston vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Sikeston vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Sikeston vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Sikeston vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Sikeston. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Sikeston in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $108 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Sikeston rentals**

At Expedia, we put the best Sikeston vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Sikeston rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Sikeston vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Sikeston. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

## Explore a world of travel with Expedia

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- [Vacation Homes in Sikeston ](https://expedia.com/Sikeston-Private-Vacation-Homes.d6058766-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Cabin Rentals in Sikeston ](https://expedia.com/Sikeston-Cabins.d6058766-aaCabins.Travel-Guide-Accommodation)
- [Apartments in Sikeston ](https://expedia.com/Sikeston-Apartments.d6058766-aaApartments.Travel-Guide-Accommodation)
- [Cottages in Sikeston ](https://expedia.com/Sikeston-Cottages.d6058766-aaCottages.Travel-Guide-Accommodation)
- [Motels in Sikeston ](https://expedia.com/Sikeston-Motels.d6058766-aaMotels.Travel-Guide-Accommodation)
- [Lodges in Sikeston ](https://expedia.com/Sikeston-Lodges.d6058766-aaLodges.Travel-Guide-Accommodation)
- [Farmstay in Sikeston ](https://expedia.com/Sikeston-Agritourism.d6058766-aaAgritourism.Travel-Guide-Accommodation)
- [RV Parks in Sikeston ](https://expedia.com/Sikeston-RV-Parks.d6058766-aaRVParks.Travel-Guide-Accommodation)
- [B&B in Sikeston ](https://expedia.com/Sikeston-Bed-And-Breakfast.d6058766-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Aparthotels in Sikeston ](https://expedia.com/Sikeston-Apart-Hotels.d6058766-aaApartHotels.Travel-Guide-Accommodation)
- [Guest Houses in Sikeston ](https://expedia.com/Sikeston-Guest-Houses.d6058766-aaGuestHouses.Travel-Guide-Accommodation)

## Frequently asked questions

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Hotels

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Flights

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Cars

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Activities

- [Things to do in Branson](https://expedia.com/Things-To-Do-In-Branson.d6058734.Travel-Guide-Activities)

Packages

- [Branson Vacation](https://expedia.com/Branson.d6058734.Destination-Travel-Guides)

Vacation Rentals

- [Branson Vacation Rentals](https://expedia.com/Branson-Vacation-Rentals.d6058734.Travel-Guide-VacationRentals)

General

- [Visit Osage Beach](https://expedia.com/Osage-Beach.dx6058781)

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