Title: Sikeston Vacation Rentals from $108: Search Short-Term Rentals | Expedia.com

[Sikeston Travel Guide](https://expedia.com/Sikeston.dx6058766)[Hotels in Sikeston](https://expedia.com/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)[Flights to Sikeston](https://expedia.com/Cheap-Flights-To-Sikeston.d6058766.Travel-Guide-Flights)[Car Rentals in Sikeston](https://expedia.com/Car-Rentals-In-Sikeston.d6058766.Car-Rental-Guide)[Sikeston Vacation Packages](https://expedia.com/Sikeston.d6058766.Destination-Travel-Guides)

![Pre-teen girl walking through corn maze during fall](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-03-27&endDate=2026-03-29&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[May 8 - May 10](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-05-08&endDate=2026-05-10&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[Jun 5 - Jun 7](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-06-05&endDate=2026-06-07&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jul 3 - Jul 5](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-07-03&endDate=2026-07-05&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Sikeston vacation rentals

![Living area](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/143b0eab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/3867ac72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/9ff1a808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/927199d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Little Blue Cottage on Spanish

[](https://www.expedia.com/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information)

Cape Girardeau

8.2/10

Very Good

(53 reviews)

"Cozy and perfect for a couple. Great communication with the host"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Beth G.

$101 nightly

$108 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/0c802aa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/860b4de6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/60c56f2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/5f66921b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming Secluded Getaway Cabin within minutes of amenities 

[](https://www.expedia.com/Cape-Girardeau-Hotels-Charming-Getaway-Cabin.h75891457.Hotel-Information)

Cape girardeau

10/10

Exceptional

(18 reviews)

"We had a great time at Blair and her family's property. The cabin was very comfortable and as advertised. I would be happy to recommend it to others "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tammy M.

$292 nightly

$307 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Charming-Getaway-Cabin.h75891457.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/469a5901.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/a97a55c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/d33a9d5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/6a739ba8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

[](https://www.expedia.com/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information)

Cape Girardeau

8.8/10

Excellent

(39 reviews)

"Will definitely book again! Great location, comfortable stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Pynktoria !.

$208 nightly

$219 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/1c1368ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/c5155680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor spa tub](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/b8327ae6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/0b3aaea0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Twisted Sassafras Treehouse 

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information)

Cape Girardeau

10/10

Exceptional

(31 reviews)

"This is the perfect private romantic getaway! We had such a blast here. Definitely recommend!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Eric S.

$299 nightly

$314 total

Mar 16 - Mar 17

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/81000000/80800000/80794200/80794106/w691h683x160y0-35462827.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/81000000/80800000/80794200/80794106/w693h683x174y0-32d2f409.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/81000000/80800000/80794200/80794106/w675h683x175y0-e472cb80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/81000000/80800000/80794200/80794106/w675h683x175y0-bccaa29a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Relax in the country at Countryside Villas! - Villa A

[](https://www.expedia.com/Jackson-Hotels-Relax-In-The-Country-At-Countryside-Villas.h80794106.Hotel-Information)

Jackson

10/10

Exceptional

(33 reviews)

"Great place to stay, felt like home away from home. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Brittany

$171 nightly

$180 total

Mar 14 - Mar 15

Total with taxes and fees

[](https://www.expedia.com/Jackson-Hotels-Relax-In-The-Country-At-Countryside-Villas.h80794106.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/f432dafb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/0e13dd89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace, DVD player, books](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/6d0c8b74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/a340bc3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Serenity South -- Gardens, River-Views, and Refreshing Space

[](https://www.expedia.com/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information)

Cape Girardeau

10/10

Exceptional

(151 reviews)

"Such a great place and location"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tracy H.

$229 nightly

$248 total

Mar 14 - Mar 15

Total with taxes and fees

[](https://www.expedia.com/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information)

![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/2c8cc497.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/673b3050.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/bb974ed1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/8932b23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Gorgeous 1856 Log Cabin, Completely Renovated

[](https://www.expedia.com/Cape-Girardeau-Hotels-Gorgeous-1856-Log-Cabin.h112868642.Hotel-Information)

Jackson

10/10

Exceptional

(3 reviews)

"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Chandler G.

$310 nightly

$310 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Gorgeous-1856-Log-Cabin.h112868642.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/426ccc72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/c31730ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/fcf2830c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/04f26ada.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

###  Villa B offers peace and quiet with beautiful views of the countryside.

[](https://www.expedia.com/Jackson-Hotels-Villa-B-Offers-Peace-And-Quiet-With-Beautiful-Views-Of-The-Countryside.h93056190.Hotel-Information)

Jackson

10/10

Exceptional

(11 reviews)

"It was great. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Benjamin Q.

$170 nightly

$179 total

Mar 31 - Apr 1

Total with taxes and fees

[](https://www.expedia.com/Jackson-Hotels-Villa-B-Offers-Peace-And-Quiet-With-Beautiful-Views-Of-The-Countryside.h93056190.Hotel-Information)

![1 bedroom, desk, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/add99418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/b0435fb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/2aecac3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/1862bab6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Cottage, Rusted Route Farms

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Cottage.h112868647.Hotel-Information)

Jackson

10/10

Exceptional

(2 reviews)

"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Renee C.

$196 nightly

$196 total

Mar 18 - Mar 19

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Cottage.h112868647.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/w1440h810x0y3-bf19009e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, video games, foosball](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/a7fa16a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Game room](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/f1c736a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, video games, foosball](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/62582c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

[](https://www.expedia.com/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(8 reviews)

"Nice place, great times"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jace W.

$416 nightly

$437 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information)

![Meeting facility](https://images.trvl-media.com/lodging/104000000/103900000/103892700/103892640/1c6c31ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/104000000/103900000/103892700/103892640/824c377e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/104000000/103900000/103892700/103892640/7dffb73b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/104000000/103900000/103892700/103892640/450d2061.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Building at Cape Girardeau Regional Airport

[](https://www.expedia.com/Scott-City-Hotels-Building-At-Cape-Girardeau-Regional-Airport.h103892640.Hotel-Information)

Scott City

$571 nightly

$620 total

Mar 14 - Mar 15

Total with taxes and fees

[](https://www.expedia.com/Scott-City-Hotels-Building-At-Cape-Girardeau-Regional-Airport.h103892640.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/804f0425.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/2cb1c224.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/aa7536c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/9e44784b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Atrium - A Boutique Hotel

[](https://www.expedia.com/Perryville-Hotels-The-Atrium-A-Boutique-Hotel.h126617355.Hotel-Information)

Perryville

$137 nightly

$158 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Perryville-Hotels-The-Atrium-A-Boutique-Hotel.h126617355.Hotel-Information)

![Exterior detail](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/3d5ec048.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/6e1fe8fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/48434221.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/853dbdda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

[](https://www.expedia.com/Makanda-Hotels-3-Minutes-To-Giant-City-6-Minutes-To-SIU-4-Minutes-To-Shawnee-Winetrail.h88869111.Hotel-Information)

Makanda

9.8/10

Exceptional

(62 reviews)

"Stephen very friendly and accomadations excellent!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Walter H.

$164 nightly

$181 total

Mar 16 - Mar 17

Total with taxes and fees

[](https://www.expedia.com/Makanda-Hotels-3-Minutes-To-Giant-City-6-Minutes-To-SIU-4-Minutes-To-Shawnee-Winetrail.h88869111.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/d22aee4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, DVD player](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/ded6701c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/2c1a0ed0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/12dcf221.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Rest, Relax and Renew. Our log cabin experience awaits your arrival. 

[](https://www.expedia.com/Anna-Hotels-Rest.h31189922.Hotel-Information)

Anna

10/10

Exceptional

(407 reviews)

"Great location. Cozy cabin. Would stay there again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

jeffrey s

$190 nightly

$201 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Anna-Hotels-Rest.h31189922.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/f8286145.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/8a8ad86a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/249ed696.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/63184534.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

[](https://www.expedia.com/Makanda-Hotels-Winetrail-Cabin-SIU.h88928399.Hotel-Information)

Makanda

9.6/10

Exceptional

(43 reviews)

"Everything was very nice. We enjoyed our stay! The cabin had everything we needed."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Cheri U.

$191 nightly

$211 total

Mar 16 - Mar 17

Total with taxes and fees

[](https://www.expedia.com/Makanda-Hotels-Winetrail-Cabin-SIU.h88928399.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/09707f79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, DVD player](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/3f7db1ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/30627e31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, DVD player](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/c221a56c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming cottage overlooking Lake Acre

[](https://www.expedia.com/Charming-Cabin-Overlooking-5-Acre-Lake.h39671140.Hotel-Information)

Dongola

10/10

Exceptional

(102 reviews)

"Enjoyed our stay great hospitality, everything we needed was addressed. We would highly recommend staying there. Great location "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

carlton h.

$265 nightly

$281 total

Mar 16 - Mar 17

Total with taxes and fees

[](https://www.expedia.com/Charming-Cabin-Overlooking-5-Acre-Lake.h39671140.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/d70c82b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/1959f5ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/29d5afe7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/73a1d2fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Rested Duck Mallard Room

[](https://www.expedia.com/The-Rested-Duck-Mallard-Room.h90331048.Hotel-Information)

Olive Branch

9.4/10

Exceptional

(28 reviews)

"This is an excellent place to stay. With a nice lake right across the street. If i. In the are i will stay again for sure"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

mike b.

$133 nightly

$140 total

Mar 14 - Mar 15

Total with taxes and fees

[](https://www.expedia.com/The-Rested-Duck-Mallard-Room.h90331048.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/124000000/123380000/123379000/123378902/9d870958.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/124000000/123380000/123379000/123378902/277407ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/124000000/123380000/123379000/123378902/a79b8818.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, internet, bed sheets](https://images.trvl-media.com/lodging/124000000/123380000/123379000/123378902/078ea3f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pet-Friendly Lakeside Gem 4 Mi to Dtwn Murphysboro

[](https://www.expedia.com/Murphysboro-Hotels-Lakefront.h123378902.Hotel-Information)

Murphysboro

8.0/10

Very Good

(3 reviews)

"Perfect but beware if you are a sensitive sleeper as the mattress on the queen bed is saggy and in need of replacing. Probably fine for 1 person but 2 people easily roll into the middle making for a not-so-good night's sleep."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Pamela S.

$218 nightly

$237 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Murphysboro-Hotels-Lakefront.h123378902.Hotel-Information)

![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/84406cc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![55-inch Smart TV with digital channels, TV, streaming services](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/586044dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Egyptian cotton sheets, premium bedding, down comforters](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/0b4f194a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![55-inch Smart TV with digital channels, TV, streaming services](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/8010cd32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Urban Lofts

[](https://www.expedia.com/Perryville-Hotels-Urban-Lofts.h76388000.Hotel-Information)

Perryville

9.2/10

Wonderful

(17 reviews)

"Great place to stay! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Eric

$223 nightly

$255 total

Mar 19 - Mar 20

Total with taxes and fees

[](https://www.expedia.com/Perryville-Hotels-Urban-Lofts.h76388000.Hotel-Information)

![House (1 Bedroom) | Front of property](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661842/aa6e717a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661842/02464d31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661842/3ac16db9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661842/3ed90f05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pet Friendly! Countryside Couples Stay in Illinois

[](https://www.expedia.com/Murphysboro-Hotels-Lakefront.h123661842.Hotel-Information)

Murphysboro

$217 nightly

$238 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Murphysboro-Hotels-Lakefront.h123661842.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-27&endDate=2026-03-28&regionId=6058766&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

[Book now](https://expedia.com/deals?rfrr=VR_SPRING_PROMO_6058766)

## Find vacation rentals that suit your style

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-06-11&d1=2026-06-11&endDate=2026-06-14&d2=2026-06-14&lodging=CABIN)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-06-11&d1=2026-06-11&endDate=2026-06-14&d2=2026-06-14&lodging=VACATION_HOME)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-06-11&d1=2026-06-11&endDate=2026-06-14&d2=2026-06-14&lodging=COTTAGE)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-06-11&d1=2026-06-11&endDate=2026-06-14&d2=2026-06-14&lodging=APARTMENT)

Aparthotels

[](https://www.expedia.com/Hotel-Search?destination=Sikeston%2C+Missouri%2C+United+States+of+America&regionId=6058766&latLong=36.877819%2C-89.589561&adults=2&startDate=2026-06-11&d1=2026-06-11&endDate=2026-06-14&d2=2026-06-14&lodging=APART_HOTEL)

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## Top Sikeston Hotel Reviews

![Country Yard Inn and Suite](https://images.trvl-media.com/lodging/91000000/90830000/90821500/90821467/fa4ef12a_y.jpg)

### Country Yard Inn and Suite

6/10 Okay

"Parking was convenient, ac and hear worked perfect... shower was nice and warm.. "

[](https://expedia.com/Sikeston-Hotels-Country-Yard-Inn-And-Suite.h90821467.Hotel-Information)

![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg)

### Drury Inn & Suites Sikeston, MO

10/10 Excellent

"We didn’t use the pool but the happy hour/ buffet was delicious! Breakfast was very nice!! Room was very clean and staff friendly and helpful "

[](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Super 8 by Wyndham Sikeston/Miner Area](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/d9ee28fe_y.jpg)

### Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent

"The AC and heat were great. So was staff. The amenities were minimal as reflected in the affordable price. The breakfast was also not significant, but you do have a McDonalds 50 feet away!"

[](https://expedia.com/Sikeston-Hotels-Super-8-By-Wyndham-SikestonMiner-Area.h855478.Hotel-Information)

![Candlewood Suites Cape Girardeau by IHG](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85_y.jpg)

### Candlewood Suites Cape Girardeau by IHG

10/10 Excellent

"Good stay,quiet. We mainly slept, took shower and gone most of the day ."

[](https://expedia.com/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information)

![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/be0d2e33_y.jpg)

### Days Inn and Suites by Wyndham Sikeston

6/10 Okay

"Close access to I-55."

[](https://expedia.com/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf_y.jpg)

### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

6/10 Okay

"There was no hot water, and nothing offered because of the inconvenience. "

[](https://expedia.com/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information)

![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c_y.jpg)

### Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"Everything was great with this hotel!"

[](https://expedia.com/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/6966efed_y.jpg)

### Drury Inn & Suites Cape Girardeau

10/10 Excellent

"Easy parking. Very clean room. Accommodating. Nice and helpful staff. "

[](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information)

![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg)

### Best Western Plus Sikeston I-55

6/10 Okay

"nice and covenant have stay here a few times, staff always has a smile. "

[](https://expedia.com/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

## Find out more about Sikeston

**Everything you need to know about Sikeston vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Sikeston vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Sikeston vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Sikeston vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Sikeston. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Sikeston in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $108 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Sikeston rentals**

At Expedia, we put the best Sikeston vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Sikeston rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Sikeston vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Sikeston. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

## Explore a world of travel with Expedia

- Trending destinations on Expedia.com
- All accommodation types in Sikeston

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- [Lake of the Ozarks Vacation Rentals ](https://www.expedia.com/Lake-Ozark-Vacation-Rentals.d177772.Travel-Guide-VacationRentals)
- [Florida Vacation Rentals ](https://www.expedia.com/Destinations-In-Florida.d211.Vacation-Rental-Destinations)
- [Hawaii Vacation Rentals ](https://www.expedia.com/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations)
- [Michigan Vacation Rentals ](https://www.expedia.com/Destinations-In-Michigan.d224.Vacation-Rental-Destinations)

- [Vacation Homes in Sikeston ](https://expedia.com/Sikeston-Private-Vacation-Homes.d6058766-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Cabin Rentals in Sikeston ](https://expedia.com/Sikeston-Cabins.d6058766-aaCabins.Travel-Guide-Accommodation)
- [Apartments in Sikeston ](https://expedia.com/Sikeston-Apartments.d6058766-aaApartments.Travel-Guide-Accommodation)
- [Motels in Sikeston ](https://expedia.com/Sikeston-Motels.d6058766-aaMotels.Travel-Guide-Accommodation)
- [Lodges in Sikeston ](https://expedia.com/Sikeston-Lodges.d6058766-aaLodges.Travel-Guide-Accommodation)
- [Cottages in Sikeston ](https://expedia.com/Sikeston-Cottages.d6058766-aaCottages.Travel-Guide-Accommodation)
- [RV Parks in Sikeston ](https://expedia.com/Sikeston-RV-Parks.d6058766-aaRVParks.Travel-Guide-Accommodation)
- [Farmstay in Sikeston ](https://expedia.com/Sikeston-Agritourism.d6058766-aaAgritourism.Travel-Guide-Accommodation)
- [B&B in Sikeston ](https://expedia.com/Sikeston-Bed-And-Breakfast.d6058766-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Aparthotels in Sikeston ](https://expedia.com/Sikeston-Apart-Hotels.d6058766-aaApartHotels.Travel-Guide-Accommodation)

## Frequently asked questions

### Can I find a vacation rental in Sikeston?

### What's the top vacation rental in Sikeston?

### What’s there to see and do in Sikeston?

### What’s a vacation rental in Sikeston like?

### Expedia's Latest Trends

Hotels

- [Hotels in Columbia](https://expedia.com/Columbia-Hotels.d901.Travel-Guide-Hotels)
- [Hotels in St. Joseph](https://expedia.com/St-Joseph-Hotels.d9934.Travel-Guide-Hotels)
- [Hotels in Hermann](https://expedia.com/Hermann-Hotels.d183475.Travel-Guide-Hotels)
- [Hotels in Branson](https://expedia.com/Branson-Hotels.d6058734.Travel-Guide-Hotels)
- [Cheap Hotels in Branson](https://expedia.com/Branson-Hotels-Cheap-Hotels.0-0-d6058734-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Hotels in Poplar Bluff](https://expedia.com/Poplar-Bluff-Hotels.d9449.Travel-Guide-Hotels)
- [Waterpark Hotels in Branson](https://expedia.com/Branson-Hotels-Waterpark-Hotels.0-0-d6058734-tWaterparkHotels.Travel-Guide-Filter-Hotels)
- [Hotels in Cape Girardeau](https://expedia.com/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels)
- [Hotels with an Indoor Pool in Branson](https://expedia.com/Branson-Hotels-Hotels-With-Indoor-Pool.0-0-d6058734-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels)
- [Hotels in Ridgedale](https://expedia.com/Ridgedale-Hotels.d183490.Travel-Guide-Hotels)
- [Hotels in Springfield](https://expedia.com/Springfield-Hotels.d602962.Travel-Guide-Hotels)
- [Hotels in Lake Ozark](https://expedia.com/Lake-Ozark-Hotels.d177772.Travel-Guide-Hotels)
- [Family Hotels in Branson](https://expedia.com/Branson-Hotels-Family-Hotel.0-0-d6058734-tFamilyHotel.Travel-Guide-Filter-Hotels)
- [Hotels in Joplin](https://expedia.com/Joplin-Hotels.d1705.Travel-Guide-Hotels)
- [Hotels in Sedalia](https://expedia.com/Sedalia-Hotels.d6880.Travel-Guide-Hotels)
- [Hotels in Rolla](https://expedia.com/Rolla-Hotels.d6058783.Travel-Guide-Hotels)
- [Cheap Hotels in Springfield](https://expedia.com/Springfield-Hotels-Cheap-Hotels.0-0-d602962-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Hotels in Hannibal](https://expedia.com/Hannibal-Hotels.d6068.Travel-Guide-Hotels)
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- [Hotels in Camdenton](https://expedia.com/Camdenton-Hotels.d6048169.Travel-Guide-Hotels)
- [Pet-friendly Hotels in Branson](https://expedia.com/Branson-Hotels-Pet-Friendly-Hotel.0-0-d6058734-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)

Flights

- [Cheap Flights to Branson](https://expedia.com/Cheap-Flights-To-Branson.d6058734.Travel-Guide-Flights)
- [Cheap Flights to Columbia](https://expedia.com/Cheap-Flights-To-Columbia.d901.Travel-Guide-Flights)
- [Cheap Flights to Springfield](https://expedia.com/Cheap-Flights-To-Springfield.d602962.Travel-Guide-Flights)

Cars

- [Car rentals in Columbia](https://expedia.com/Car-Rentals-In-Columbia.d901.Car-Rental-Guide)
- [Car rentals in Springfield](https://expedia.com/Car-Rentals-In-Springfield.d602962.Car-Rental-Guide)

Activities

- [Things to do in Branson](https://expedia.com/Things-To-Do-In-Branson.d6058734.Travel-Guide-Activities)

Packages

- [Branson Vacation](https://expedia.com/Branson.d6058734.Destination-Travel-Guides)

Vacation Rentals

- [Branson Vacation Rentals](https://expedia.com/Branson-Vacation-Rentals.d6058734.Travel-Guide-VacationRentals)

General

- [Visit Osage Beach](https://expedia.com/Osage-Beach.dx6058781)

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