Photo by Ryan Coleman

Sikeston Vacation Rentals

Start date: Check-in selected.
To Date
End date: Check-out

Check prices for these dates

Tonight
Oct 17 - Oct 18
Tomorrow
Oct 18 - Oct 19
This weekend
Oct 17 - Oct 19
Next weekend
Oct 24 - Oct 26

Vacation Rentals in Sikeston

Outdoor spa tub
New cabin in the woods with private hot tub
New cabin in the woods with private hot tub
10.0 out of 10, Exceptional, (128)
"Very nice cabin. "
Anonymous traveler
New cabin in the woods with private hot tub
Exterior
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
10.0 out of 10, Exceptional, (398)
"Serene, well appointed cabin, front porch rocker back deck"
Christine
$187 nightly
The price is $198
Oct 20 - Oct 21
Total with taxes and fees
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Exterior
Notting Hill Cottage
Notting Hill Cottage
9.6 out of 10, Exceptional, (325)
"It was the perfect stay. Great location right by the wine trail. It was secluded and the hot Tub was heavenly. Would recommend to anyone that needs a getaway. "
Autumn B.
Notting Hill Cottage
Exterior
Peaceful secluded cabin located near Horseshoe Lake
Peaceful secluded cabin located near Horseshoe Lake
9.8 out of 10, Exceptional, (19)
"Wasent long enough!"
Rhonda R.
$180 nightly
The price is $191
Oct 19 - Oct 20
Total with taxes and fees
Peaceful secluded cabin located near Horseshoe Lake
Outdoor spa tub
Hot Tub - Minutes from Winetrail, SIU, Giant City, Cedar Lake, Shawnee Forest!
Hot Tub - Minutes from Winetrail, SIU, Giant City, Cedar Lake, Shawnee Forest!
10.0 out of 10, Exceptional, (56)
"Had a great stay"
Angela W.
Hot Tub - Minutes from Winetrail, SIU, Giant City, Cedar Lake, Shawnee Forest!
Exterior
Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery
Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery
10.0 out of 10, Exceptional, (145)
"The cabin was perfect for our weekend getaway to celebrate my fiancés birthday. "
Lisa B.
Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery
Outdoor dining
Beautiful location in the secluded woods
Beautiful location in the secluded woods
10.0 out of 10, Exceptional, (52)
"The house was lovely, the location beautiful and quiet. The host was very attentive and made sure our stay was perfect "
Dianna S.
$169 nightly
The price is $179
Oct 20 - Oct 21
Total with taxes and fees
Beautiful location in the secluded woods
Fridge, microwave, oven, stovetop
Serenity South -- Gardens, River-Views, and Refreshing Space
Serenity South -- Gardens, River-Views, and Refreshing Space
10.0 out of 10, Exceptional, (144)
"Beautiful house. Great stay. Would definitely stay again!"
Vicki R.
$229 nightly
The price is $245
Oct 19 - Oct 20
Total with taxes and fees
Serenity South -- Gardens, River-Views, and Refreshing Space
Exterior
Winetrail Cabin - Giant City SP, SIU, Cedar Lake, & Shawnee Forest minutes away!
Winetrail Cabin - Giant City SP, SIU, Cedar Lake, & Shawnee Forest minutes away!
9.8 out of 10, Exceptional, (40)
"Great location off of route 51 that gets you to all the fun on the wine trail and allows you get to a bunch of different stuff to do outdoor. Enjoyed our stay 4th of July Weekend 2025!"
Hayden R.
Winetrail Cabin - Giant City SP, SIU, Cedar Lake, & Shawnee Forest minutes away!
Exterior
Minutes to Giant City - SIU - Shawnee Winetrail - Shawnee Forest - Wi-Fi
Minutes to Giant City - SIU - Shawnee Winetrail - Shawnee Forest - Wi-Fi
9.4 out of 10, Exceptional, (40)
"The place was great for our needs and as advertised. Very near to beautiful hiking and some nice wineries.The bed was not very comfortable, but everything was great. "
Jim C.
Minutes to Giant City - SIU - Shawnee Winetrail - Shawnee Forest - Wi-Fi
Fridge, microwave, oven, stovetop
On the Wine Trail - Minutes to Giant City, Shawnee Forest, SIU - Amazing Shower
On the Wine Trail - Minutes to Giant City, Shawnee Forest, SIU - Amazing Shower
9.8 out of 10, Exceptional, (174)
"We wanted a good central location for our time in wine country. This place was perfect…and we were able to check out several Wineries during our stay. "
Dan D.
On the Wine Trail - Minutes to Giant City, Shawnee Forest, SIU - Amazing Shower
Interior
On the Shawnee Wine Trail
On the Shawnee Wine Trail
10.0 out of 10, Exceptional, (223)
"Beautiful property!!! "
Kathleen H.
On the Shawnee Wine Trail
Exterior
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
9.8 out of 10, Exceptional, (57)
"Great value and plenty of room, with a nice deck and BBQ. Cabin 2 had separate rooms and a very spacious living room. I would stay there again and it is my favorite for the region."
Joseph
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Outdoor spa tub
Cabin in Southern Illinois - Hot Tub - Romantic Getaway -Shawnee National Forest
Cabin in Southern Illinois - Hot Tub - Romantic Getaway -Shawnee National Forest
10.0 out of 10, Exceptional, (260)
"Had an amazing stay!"
Shauna W.
Cabin in Southern Illinois - Hot Tub - Romantic Getaway -Shawnee National Forest
Interior
The Rested Duck Mallard Room
The Rested Duck Mallard Room
9.2 out of 10, Wonderful, (24)
"It was nice and quiet. Had a relaxing stay. Very clean."
Nick M.
$124 nightly
The price is $131
Oct 19 - Oct 20
Total with taxes and fees
The Rested Duck Mallard Room
Dining
Cozy cabins on beautiful Horseshoe Lake
Cozy cabins on beautiful Horseshoe Lake
9.8 out of 10, Exceptional, (34)
"Lovely and homely little get away spot"
Bryce M.
$124 nightly
The price is $131
Oct 19 - Oct 20
Total with taxes and fees
Cozy cabins on beautiful Horseshoe Lake
2 bedrooms
The Lab! Come stay in our brand new space.
The Lab! Come stay in our brand new space.
9.4 out of 10, Exceptional, (15)
"Great apartment! Modern, clean, roomy, and cold A/C! Would definitely stay again!"
Rachel
$192 nightly
The price is $203
Oct 19 - Oct 20
Total with taxes and fees
The Lab! Come stay in our brand new space.
Outdoor spa tub
Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen
Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen
9.8 out of 10, Exceptional, (162)
"The place was lovely , it was a nice little private getaway "
Amanda M.
Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen
Interior
Little Blue Cottage on Spanish
Little Blue Cottage on Spanish
8.6 out of 10, Excellent, (45)
"We enjoy every time we stay here . We have stayed her many times. There is some repairs that need to be done . Also I think there needs to be a better way to cook besides a microwave. "
Mandi Dickson H.
$101 nightly
The price is $101
Oct 20 - Oct 21
Total with taxes and fees
Little Blue Cottage on Spanish
Exterior
Stones Throw from Giant City Park, Wineries, Hiking, Biking, Hunting and more.
Stones Throw from Giant City Park, Wineries, Hiking, Biking, Hunting and more.
9.8 out of 10, Exceptional, (62)
"Nice place!"
Laura
Stones Throw from Giant City Park, Wineries, Hiking, Biking, Hunting and more.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Sikeston Hotel Reviews

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55

10/10 Excellent
"The Jacuzzi was the Best!!! 👏"
Shonta' 6-night trip
Posted 3 days ago
Comfort Inn & Suites Sikeston I-55

Find out more about Sikeston

Everything you need to know about Sikeston vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Sikeston vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Sikeston vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Sikeston vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Sikeston. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Sikeston in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $101 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Sikeston rentals

At Expedia, we put the best Sikeston vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Sikeston rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Sikeston vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Sikeston. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find a vacation rental in Sikeston?

Yes, there are vacation rentals close to the most popular local attractions in Sikeston, or you can choose a more remote option if you're looking for relaxation. Tourists like the array of shops and top-notch restaurants in Sikeston. Make sure you allow time to enjoy the riverfront during your vacation.

What's the top vacation rental in Sikeston?

Notting Hill Cottage: Visitors like this Sikeston vacation home rental. It offers a patio, a private yard, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. You and your friends and family can relax into your vacation with amenities like a hot tub.

What’s there to see and do in Sikeston?

Cultural attractions include Sikeston Depot Museum, whereas Central Park is a spot to enjoy nature. In the larger area, you’ll find Front Street Studio & Art Gallery and Stoddard County Civil War Memorial Cemetery.

What’s a vacation rental in Sikeston like?

A vacation rental is a private property you can book for a couple of days or more in Sikeston. Vacation rentals feature extras such as kitchens and laundry facilities so you'll feel right at home. If you're concerned about a clean environment, a vacation rental can offer a sense of security away from public hotel elevators and busy reception areas while still allowing you to travel. You'll also get more space in a vacation rental than in a hotel, which is another reason why a vacation rental is a popular option for a small group gathering.