New Madrid, MO

Travel Guide

Mississippi River Walk at New Madrid.  A magnificent view of the Mississippi river from atop of the levee.  A steamboat is docked down river. .
0_16158
The Mississippi River near Hannibal, Missouri, USA
Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

New Madrid MO
$343 nightly
The price is $369 total per night from Jun 22 to Jun 23
$369 total
Jun 22 - Jun 23
Total with taxes and fees
Stay at this vacation home in New Madrid. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions New Madrid Historical Museum and River Ridge ...
10/10 Exceptional! (1 review)
"The host was very quick to respond and so great to work with for on our stay."

Reviewed on Nov 11, 2025

Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
$104 nightly
The price is $117 total per night from Jul 19 to Jul 20
$117 total
Jul 19 - Jul 20
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (578 reviews)
"."

Reviewed on Jun 15, 2026

Hampton Inn Sikeston
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $125 total per night from Jun 28 to Jun 29
$125 total
Jun 28 - Jun 29
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.4/10 Exceptional! (93 reviews)
"Everything was good. Rooms were cleaned, breakfast was good and fresh, and staff was helpful and nice.."

Reviewed on Jun 16, 2026

Fairfield Inn & Suites by Marriott Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

New Madrid MO
Stay at this vacation home in New Madrid. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions New Madrid Historical Museum and River Ridge ...
10/10 Exceptional! (1 review)
"The host was very quick to respond and so great to work with for on our stay."

Reviewed on Nov 11, 2025

Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!
The Tackle Box at Reelfoot

The Tackle Box at Reelfoot

Hornbeak TN
Stay at this vacation home in Hornbeak. Enjoy an in-room coffeemaker and air conditioning. Popular attractions Willow Towhead and Rat Island are located ...
10/10 Exceptional! (39 reviews)
"Clean and was just what I needed"

Reviewed on May 23, 2026

The Tackle Box at Reelfoot
Duck Hunting, Fishing or Relaxing Family Vacation

Duck Hunting, Fishing or Relaxing Family Vacation

Hornbeak TN
Stay at this vacation home in Hornbeak. Enjoy a garden, laundry facilities, and patios. Popular attractions Willow Towhead and Rat Island are located ...
10/10 Exceptional! (232 reviews)
"Beautiful property"

Reviewed on Jun 14, 2026

Duck Hunting, Fishing or Relaxing Family Vacation
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Cities near New Madrid

Explore a world of travel with Expedia