Title: O Brien, FL Condos for Rent | Expedia.com [O Brien Travel Guide](https://expedia.com/O-Brien.dx3000431472)[Hotels in O Brien](https://expedia.com/O-Brien-Hotels.d3000431472.Travel-Guide-Hotels)[Vacation Rentals in O Brien](https://expedia.com/O-Brien-Vacation-Rentals.d3000431472.Travel-Guide-VacationRentals)[Flights to O Brien](https://expedia.com/Cheap-Flights-To-O-Brien.d3000431472.Travel-Guide-Flights)[Car Rentals in O Brien](https://expedia.com/Car-Rentals-In-O-Brien.d3000431472.Car-Rental-Guide)[O Brien Vacation Packages](https://expedia.com/O-Brien.d3000431472.Destination-Travel-Guides) ![kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida](https://images.trvl-media.com/place/553248635976197691/42181e6d-fd52-4c3e-bdcb-128d4daebc91.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248635976197691/42181e6d-fd52-4c3e-bdcb-128d4daebc91.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_bundle_and_save.svg) ### Bundle & Save Get more, spend less whenever you see Bundle & Save deals - ![](https://a.travel-assets.com/travel-assets-manager/pictograms-expedia/light__onekey.svg) ### OneKeyCash Earn OneKeyCash on all your eligible bookings - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_ftc.svg) ### Upfront pricing We are not like the others - we include taxes and fees ## Check prices for these dates In two weeks [Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-04-10&endDate=2026-04-12&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [May 22 - May 24](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-05-22&endDate=2026-05-24&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [Jun 19 - Jun 21](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-06-19&endDate=2026-06-21&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [Jul 17 - Jul 19](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-07-17&endDate=2026-07-19&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) No exact matches found, but these alternatives could be just right ## Recommended hotels in O Brien ![Terrace/patio](https://images.trvl-media.com/lodging/120000000/119060000/119059200/119059176/df5d6f6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/120000000/119060000/119059200/119059176/d058bd1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/120000000/119060000/119059200/119059176/07a1c031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/120000000/119060000/119059200/119059176/a22dd354.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Our Spring Getaway Is Across The Street From Royal Springs [](https://www.expedia.com/O-Brien-Hotels-Our-Spring-Getaway-Across-Street-From-Royal-Springs.h119059176.Hotel-Information) O'Brien 8.8/10 Excellent (3 reviews) "Place is as described. Nice and clean. Large property plenty of room for parking." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) J S. $172 nightly $187 total Mar 31 - Apr 1 Total with taxes and fees [](https://www.expedia.com/O-Brien-Hotels-Our-Spring-Getaway-Across-Street-From-Royal-Springs.h119059176.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/36000000/35540000/35530500/35530445/40faca7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/36000000/35540000/35530500/35530445/f5ddf271.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/36000000/35540000/35530500/35530445/1007f0bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/36000000/35540000/35530500/35530445/1deb5c26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY [](https://www.expedia.com/O-Brien-Hotels-Margaritaville-BY-THE-Suwannee-River-Royal-Springs-PET-Friendly.h35530445.Hotel-Information) O'Brien 9.4/10 Exceptional (59 reviews) "A great get away for Labor Day weekend to do a little jet skiing with friends on the river and visiting all the local springs!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Heather H. $362 nightly $394 total Mar 25 - Mar 26 Total with taxes and fees [](https://www.expedia.com/O-Brien-Hotels-Margaritaville-BY-THE-Suwannee-River-Royal-Springs-PET-Friendly.h35530445.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/0ead3b62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/82bfa53d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/f498da18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/2cdf35a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn White Springs Suwanee [](https://www.expedia.com/Lake-City-Hotels-Quality-Inn.h1378708.Hotel-Information) Live Oak 7.2/10 Good (650 reviews) "Great breakfast! The best staff you can get at a hotel!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) vicki $68 nightly $75 total Apr 7 - Apr 8 Total with taxes and fees [](https://www.expedia.com/Lake-City-Hotels-Quality-Inn.h1378708.Hotel-Information) ![3 outdoor pools, open 10:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/112000000/111770000/111760600/111760596/994169e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Classic Cabin, Resort View | In-room dining](https://images.trvl-media.com/lodging/112000000/111770000/111760600/111760596/c163ad60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Classic Cabin, Resort View | Terrace/patio](https://images.trvl-media.com/lodging/112000000/111770000/111760600/111760596/d134c1d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Tent | Individually decorated, individually furnished, free WiFi, bed sheets](https://images.trvl-media.com/lodging/112000000/111770000/111760600/111760596/ab1e5af8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Suwannee River Rendezvous [](https://www.expedia.com/Mayo-Hotels-Suwannee-River-Rendezvous.h111760596.Hotel-Information) Mayo 8.8/10 Excellent (25 reviews) "Awesome place to stay, beautiful location and great accommodations. Friendly staff and lots to do!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lauren $43 nightly $46 total Mar 25 - Mar 26 Total with taxes and fees [](https://www.expedia.com/Mayo-Hotels-Suwannee-River-Rendezvous.h111760596.Hotel-Information) ![Down comforters, pillowtop beds, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/1000000/910000/909400/909334/d338fe80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily cooked-to-order breakfast](https://images.trvl-media.com/lodging/1000000/910000/909400/909334/9866ab41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/910000/909400/909334/826eec73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/910000/909400/909334/3d79d85e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Lake City [](https://www.expedia.com/Lake-City-Hotels-Super-8-By-Wyndham-Lake-City.h909334.Hotel-Information) Lake City 7.2/10 Good (701 reviews) "Daniele at the front was amazing . Loved her , she made sure our stay was perfect ! Breakfast was yummy too!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Megan $65 nightly $74 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Lake-City-Hotels-Super-8-By-Wyndham-Lake-City.h909334.Hotel-Information) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/127000000/126530000/126526500/126526410/3c8063dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/127000000/126530000/126526500/126526410/6eb28891.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/127000000/126530000/126526500/126526410/2edbe2ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Front of property](https://images.trvl-media.com/lodging/127000000/126530000/126526500/126526410/581d600c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### < 1 Mi From Suwannee River, Hideaway w/ Lanai [](https://www.expedia.com/Old-Town-Hotels-1-Mi-From-Suwannee-River.h126526410.Hotel-Information) Old Town 10/10 Exceptional (1 review) "The Air B & B was amazing. The property and the A B & B was awesone, Clean, Quiet and very comfortable. Although some nights got a bit chilly and this property only had AC no heat. We managed just fine. We left it in perfect conditions according to the directions they wanted it left in. Thank you so much and we will be renting again. We also would recommend this to others. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen $357 nightly $390 total Mar 27 - Mar 28 Total with taxes and fees [](https://www.expedia.com/Old-Town-Hotels-1-Mi-From-Suwannee-River.h126526410.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/5b1d647e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/300e501a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin, 1 Queen Bed (View) | Private kitchen | Mini-fridge, stovetop, cookware/dishes/utensils, paper towels](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/76a693e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin, 1 Queen Bed | Private kitchen | Mini-fridge, stovetop, cookware/dishes/utensils, paper towels](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/00bfc462.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy [](https://www.expedia.com/Postcard-Cabins-Gilchrist-Springs.h110494372.Hotel-Information) High Springs 10/10 Exceptional (190 reviews) "Room was spotless, property was nicely groomed, snacks, coffee and water was provided overall great trip." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ashley $209 nightly $230 total Mar 31 - Apr 1 Total with taxes and fees [](https://www.expedia.com/Postcard-Cabins-Gilchrist-Springs.h110494372.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/116000000/115960000/115956900/115956827/a05c6668.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/116000000/115960000/115956900/115956827/79ac086d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/116000000/115960000/115956900/115956827/c9e7e3c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/116000000/115960000/115956900/115956827/e14b74c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Friendlys River Retreat private Rustic Camping Cabin sleeps 4+with tent camping [](https://www.expedia.com/Mayo-Hotels-Friendlys-River-Retreat-Private-Rustic-Camping-Cabin-Sleeps-4with-Tent-Camping.h115956827.Hotel-Information) Mayo 9.8/10 Exceptional (9 reviews) "Had a great weekend away- it was just what me and my girlfriend needed." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mike S. $82 nightly $86 total Mar 25 - Mar 26 Total with taxes and fees [](https://www.expedia.com/Mayo-Hotels-Friendlys-River-Retreat-Private-Rustic-Camping-Cabin-Sleeps-4with-Tent-Camping.h115956827.Hotel-Information) ![Individually decorated, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/90000/85000/84936/9948e87a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/90000/85000/84936/0d07dab7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/90000/85000/84936/24283982.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/90000/85000/84936/d4297742.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Lake City I-10 [](https://www.expedia.com/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-10.h84936.Hotel-Information) Lake City 7.0/10 Good (1,002 reviews) "Not a place we would stay again. Bed comfortable. Room clean. Not much for Breakfast. Area didn’t really feel safe. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Donna Marie $58 nightly $66 total Mar 25 - Mar 26 Total with taxes and fees [](https://www.expedia.com/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-10.h84936.Hotel-Information) ![Studio, 1 King Bed | Premium bedding, desk, blackout drapes, soundproofing](https://images.trvl-media.com/lodging/1000000/50000/40800/40753/51a782f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/50000/40800/40753/62d30ebc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking | Living room | Flat-screen TV](https://images.trvl-media.com/lodging/1000000/50000/40800/40753/d6f46a2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/1000000/50000/40800/40753/b1f4498a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Palms Garden Inn [](https://www.expedia.com/Lake-City-Hotels-Palms-Garden-Inn.h40753.Hotel-Information) Lake City 7.4/10 Good (600 reviews) "room was clean and the air conditioning worked great would recommend" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) david $65 nightly $73 total Mar 25 - Mar 26 Total with taxes and fees [](https://www.expedia.com/Lake-City-Hotels-Palms-Garden-Inn.h40753.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/d6ac3255.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/caeee0a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/0aaf26be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/46f5353a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 – Lake City, Fl – Medical Center [](https://www.expedia.com/Lake-City-Hotels-Motel-6-Lake-City.h119606176.Hotel-Information) Lake City 8.0/10 Very Good (124 reviews) "Dog friendly and price." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John $67 nightly $75 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Lake-City-Hotels-Motel-6-Lake-City.h119606176.Hotel-Information) ![TV, offices](https://images.trvl-media.com/lodging/114000000/113920000/113916600/113916502/521b315f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/114000000/113920000/113916600/113916502/72793d9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/114000000/113920000/113916600/113916502/550c6fda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/114000000/113920000/113916600/113916502/baddf697.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Nook at the Springs | Tiny Home • Full Kitchen [](https://www.expedia.com/Fort-White-Hotels-Ganesh-Tiny-Home-At-Ichetucknee-Springs.h113916502.Hotel-Information) Fort White 9.8/10 Exceptional (6 reviews) "Excellent place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linay $150 nightly $161 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Fort-White-Hotels-Ganesh-Tiny-Home-At-Ichetucknee-Springs.h113916502.Hotel-Information) ![1 bedroom, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112650000/112641200/112641197/a3ee2a3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![40-inch Smart TV with digital channels, Netflix, streaming services](https://images.trvl-media.com/lodging/113000000/112650000/112641200/112641197/86100bd9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![40-inch Smart TV with digital channels, Netflix, streaming services](https://images.trvl-media.com/lodging/113000000/112650000/112641200/112641197/42e07503.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112650000/112641200/112641197/b5e4476a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vista Verde Farm Retreat [](https://www.expedia.com/Lake-City-Hotels-Vista-Verde-Farm-Retreat.h112641197.Hotel-Information) Lake City 9.8/10 Exceptional (17 reviews) "The property is great and I had a fabulous 3 night stay. Ana was fantastic and gave great suggestions for things to do in the area. Loved the location, pet friendly and beautiful. Would came back again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennie $167 nightly $188 total Apr 1 - Apr 2 Total with taxes and fees [](https://www.expedia.com/Lake-City-Hotels-Vista-Verde-Farm-Retreat.h112641197.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/92000000/91100000/91092100/91092031/f86787e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/92000000/91100000/91092100/91092031/0820ad86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/92000000/91100000/91092100/91092031/w1024h1408x0y128-1c37bc4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/92000000/91100000/91092100/91092031/8b97268c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Blanche [](https://www.expedia.com/Lake-City-Hotels-The-Blanche.h91092031.Hotel-Information) Lake City 9.2/10 Wonderful (177 reviews) "Loved the hotel and the location! The bed was very very soft and the microfiber sheets were thin and hot!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kim $145 nightly $164 total Mar 26 - Mar 27 Total with taxes and fees [](https://www.expedia.com/Lake-City-Hotels-The-Blanche.h91092031.Hotel-Information) ![1 bedroom, free WiFi, bed sheets](https://images.trvl-media.com/lodging/118000000/117030000/117028300/117028207/b939a190.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/118000000/117030000/117028300/117028207/2cb8b175.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Miscellaneous](https://images.trvl-media.com/lodging/118000000/117030000/117028300/117028207/5509f81c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Miscellaneous](https://images.trvl-media.com/lodging/118000000/117030000/117028300/117028207/e4cf1fa4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi, [](https://www.expedia.com/Mayo-Hotels-Friendlys-River-Retreat-1-Cozy-Couples-Cabin-In-Awesome-Mayo-With-WiFi.h117028207.Hotel-Information) Mayo 9.8/10 Exceptional (6 reviews) "Stacey is always very welcoming & I had everything I needed. It is very calm, serene and relaxing place." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cathryn H. $64 nightly $67 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Mayo-Hotels-Friendlys-River-Retreat-1-Cozy-Couples-Cabin-In-Awesome-Mayo-With-WiFi.h117028207.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/fddc9a15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/ad8fe69d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/abb205a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/016b48da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Americas Best Value Inn Lake City [](https://www.expedia.com/Lake-City-Hotels-Americas-Best-Value-Inn-Lake-City.h1039754.Hotel-Information) Lake City 8.6/10 Excellent (1,003 reviews) "Clean place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle $67 nightly $76 total Mar 25 - Mar 26 Total with taxes and fees [](https://www.expedia.com/Lake-City-Hotels-Americas-Best-Value-Inn-Lake-City.h1039754.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/4156d709.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/737c0544.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed | Premium bedding, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/39f90afc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/ec822d01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard By Marriott Lake City [](https://www.expedia.com/Lake-City-Hotels-Courtyard-By-Marriott-Lake-City.h99922616.Hotel-Information) Lake City 9.6/10 Exceptional (227 reviews) "The rooms were spotless and the staff very nice and kind!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Deborah $112 nightly $126 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Lake-City-Hotels-Courtyard-By-Marriott-Lake-City.h99922616.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/6400/6383/c32c2e15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/6400/6383/7972b5b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Accessible, Non Smoking | Free WiFi, bed sheets, wheelchair access](https://images.trvl-media.com/lodging/1000000/10000/6400/6383/54cfccbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Accessible, Smoking | Free WiFi, bed sheets, wheelchair access](https://images.trvl-media.com/lodging/1000000/10000/6400/6383/a3f5a08d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge Live Oak [](https://www.expedia.com/Lake-City-Hotels-Econo-Lodge-Live-Oak.h6383.Hotel-Information) Live Oak 7.0/10 Good (287 reviews) "Everiting are good" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jean-louis $65 nightly $72 total Apr 23 - Apr 24 Total with taxes and fees [](https://www.expedia.com/Lake-City-Hotels-Econo-Lodge-Live-Oak.h6383.Hotel-Information) ![Pillowtop beds, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/eb9ba6b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/86c94896.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/42c18c29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/90e37569.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Lake City I-75 [](https://www.expedia.com/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-75.h17650.Hotel-Information) Lake City 7.6/10 Good (1,000 reviews) "Was very good as a traveling stop over. Amazing food choices all within walking distance. Close to hiway. Room was more than adequate. I was happy I selected this hotel. It is also priced very well." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brian $63 nightly $71 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-75.h17650.Hotel-Information) ![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/102000000/101880000/101870900/101870897/dbe58aca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, DVD player](https://images.trvl-media.com/lodging/102000000/101880000/101870900/101870897/5073c41c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, DVD player](https://images.trvl-media.com/lodging/102000000/101880000/101870900/101870897/79b7132e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/102000000/101880000/101870900/101870897/ab879f95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quiet Cabin Escape Near Springs in Suwannee [](https://www.expedia.com/Live-Oak-Hotels-The-Loft-In-Live-Oak.h101870897.Hotel-Information) Live Oak 10/10 Exceptional (29 reviews) "Our stay was perfect! This was a sweet and cozy getaway for me and my husband's 24th Anniversary. Very secluded and peaceful! The host Cyndi was very pleasant and responded quickly to any assistance or recommendations we had. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer R. $145 nightly $158 total Mar 30 - Mar 31 Total with taxes and fees [](https://www.expedia.com/Live-Oak-Hotels-The-Loft-In-Live-Oak.h101870897.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-07&endDate=2026-04-08®ionId=3000431472&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ## Find vacation rentals that suit your style Cabins [](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America®ionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-06-22&d1=2026-06-22&endDate=2026-06-25&d2=2026-06-25&lodging=CABIN) Private vacation homes [](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America®ionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-06-22&d1=2026-06-22&endDate=2026-06-25&d2=2026-06-25&lodging=VACATION_HOME) Cottages [](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America®ionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-06-22&d1=2026-06-22&endDate=2026-06-25&d2=2026-06-25&lodging=COTTAGE) Aparthotels [](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America®ionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-06-22&d1=2026-06-22&endDate=2026-06-25&d2=2026-06-25&lodging=APART_HOTEL) Apartments [](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America®ionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-06-22&d1=2026-06-22&endDate=2026-06-25&d2=2026-06-25&lodging=APARTMENT) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FO-Brien-Condos.d3000431472-aaCondos.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FO-Brien-Condos.d3000431472-aaCondos.Travel-Guide-Accommodation) ## Top O Brien Hotel Reviews ![Americas Best Value Inn Lake City](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/fddc9a15_y.jpg) ### Americas Best Value Inn Lake City 8/10 Good "Clean Room" [](https://expedia.com/Lake-City-Hotels-Americas-Best-Value-Inn-Lake-City.h1039754.Hotel-Information) ![Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/5b1d647e_y.jpg) ### Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy 10/10 Excellent "Perfect getaway for us with our dogs. It was peaceful and relaxing." [](https://expedia.com/Postcard-Cabins-Gilchrist-Springs.h110494372.Hotel-Information) ![Holiday Inn Express & Suites Live Oak by IHG](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/ddd17ce3_y.jpg) ### Holiday Inn Express & Suites Live Oak by IHG 10/10 Excellent "Good clean place " [](https://expedia.com/Lake-City-Hotels-Holiday-Inn-Express-Hotel-Suites-LIVE-OAK.h798756.Hotel-Information) ![Best Western Plus Lake City](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca_y.jpg) ### Best Western Plus Lake City 10/10 Excellent "Room was clean and well kept. The bed was very comfortable" [](https://expedia.com/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information) ![Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!](https://images.trvl-media.com/lodging/92000000/91440000/91435900/91435872/c7d330d9_y.jpg) ### Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! 10/10 Excellent "We really enjoyed our stay. The host ( Christine) greeted us upon arrival and was eager to share recommendations for things to do in the area. The house was clean, comfortable, and well maintained. The whole family had a blast!" [](https://expedia.com/O-Brien-Hotels-Royal-Springs-Riverfront-Retreat.h91435872.Hotel-Information) ![Days Inn by Wyndham Lake City I-75](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/eb9ba6b8_y.jpg) ### Days Inn by Wyndham Lake City I-75 10/10 Excellent "Accessable really was accessible " [](https://expedia.com/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-75.h17650.Hotel-Information) ![Tru by Hilton Lake City](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/539e711a_y.jpg) ### Tru by Hilton Lake City 10/10 Excellent "Great experience all the amenities needed" [](https://expedia.com/Lake-City-Hotels-Tru-By-Hilton-Lake-City.h34865542.Hotel-Information) ![Baymont by Wyndham Lake City I-75](https://images.trvl-media.com/lodging/1000000/20000/15800/15747/84b0e094_y.jpg) ### Baymont by Wyndham Lake City I-75 2/10 Terrible "Horrible property. Room was not as nice as the pictures on hotels Com website. Bathroom was nasty. Door looked like it had been kicked in a few times. We didn't even stay we ended up at La Quinta hotel down the street." [](https://expedia.com/Lake-City-Hotels-Baymont-By-Wyndham-Lake-City.h15747.Hotel-Information) ![Holiday Inn Express & Suites Alachua - Gainesville Area by IHG](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/e851cfaf_y.jpg) ### Holiday Inn Express & Suites Alachua - Gainesville Area by IHG 10/10 Excellent "The hotels common areas were super clean. We did have an issue with the cleanliness of my room upon check in but the front desk staff was very efficient in handling the matter. Breakfast was decent. Overall good experience! Staff was super friendly!" [](https://expedia.com/Gainesville-Hotels-Holiday-Inn-Express-Suites-Alachua-Gainesville-Area.h22858269.Hotel-Information) ## Find out more about O Brien ## O Brien Condo Rentals information | Number of reviews | 5,516 | | ----------------- | --------------- | | Accommodation | 0 Condo Rentals | | Lowest Price | $46 | | Highest Price | $394 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Hotels near Troy Spring State Park ](https://www.expedia.com/Troy-Spring-State-Park-Hotels.0-l6285999-0.Travel-Guide-Filter-Hotels) - [Motels in Branford ](https://www.expedia.com/Branford-Motels.d6188028-aaMotels.Travel-Guide-Accommodation) - [Cabin Rentals in Branford ](https://www.expedia.com/Branford-Cabins.d6188028-aaCabins.Travel-Guide-Accommodation) - [Rv Parks in Branford ](https://www.expedia.com/Branford-RV-Parks.d6188028-aaRVParks.Travel-Guide-Accommodation) - [Apartments in Branford ](https://www.expedia.com/Branford-Apartments.d6188028-aaApartments.Travel-Guide-Accommodation) - 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