Roxana Vacation Rentals

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Our top choices for Roxana vacation rentals

Apartment in Grand Center

White House at Grand Central
4.0 star property
8.6 out of 10, Excellent, (124)
"Very clean and very friendly people "
United States
Mary
$117 nightly
The price is $137
Jan 11 - Jan 12, 2026
Total with taxes and fees
White House at Grand Central
10.0 out of 10, Exceptional, (14)
"Very comfortable, cozy, and quaint decor. Lovely gardens. Made to feel welcome by host."
United States
Rayma P.
$117 nightly
The price is $124
Dec 27 - Dec 28
Total with taxes and fees
Cozy studio located in small town America, Bunker Hill, IL.

Apartment in Soulard

Top of Geyer apartment
9.8 out of 10, Exceptional, (43)
"Convenient location "
United States
julie s.
$189 nightly
The price is $189
Dec 29 - Dec 30
Total with taxes and fees
Top of Geyer apartment
9.8 out of 10, Exceptional, (160)
"Very clean, check in was easy, great neighborhood with lots of food close. "
United States
Laura H.
$141 nightly
The price is $143
Jan 4 - Jan 5, 2026
Total with taxes and fees
Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!

Apartment in Marine Villa

Stylish South City King 1BR Apt
2.0 star property
10.0 out of 10, Exceptional, (9)
"Great location, great accommodations, great host."
United States
Scott W.
$165 nightly
The price is $179
Dec 28 - Dec 29
Total with taxes and fees
Stylish South City King 1BR Apt
9.6 out of 10, Exceptional, (59)
"Enjoyed the vibe of the neighborhood "
United States
Brett
$178 nightly
The price is $192
Jan 13 - Jan 14, 2026
Total with taxes and fees
Cozy Soulard 2BR w/ Free Parking
10.0 out of 10, Exceptional, (2)
"We had an excellent stay and would 100% recommend this place. The restroom and kitchen was very cleanand the beds were very comfortable to sleep on after a long day of venturing out in the city. "
United States
Ernest P.
Cozy & Modern 2BR Apartment in the Heart of St. Louis

Apartment in The Gate

Classy Midtown 3BR, King Master
10.0 out of 10, Exceptional, (61)
"Very charming and comfortable accommodations in a safe and beautiful part of town, convenient to many attractions."
United States
Robin L.
$193 nightly
The price is $207
Jan 13 - Jan 14, 2026
Total with taxes and fees
Classy Midtown 3BR, King Master
9.6 out of 10, Exceptional, (7)
"Property met all our needs and management a was prompt and friendly responding to any questions. "
United States
Kevin
$315 nightly
The price is $318
Dec 28 - Dec 29
Total with taxes and fees
This apartment is a 2 bedroom(s), 1 bathrooms, located in St. Louis, MO.
3.0 star property
$425 nightly
The price is $469
Dec 25 - Dec 26
Total with taxes and fees
Lakefront Family Home 13 Mi From Gateway Arch!
2.0 star property
10.0 out of 10, Exceptional, (2)
"Great place to stay "
United States
Karl W.
$423 nightly
The price is $448
Dec 30 - Dec 31
Total with taxes and fees
Spacious 5-bedroom house in gorgeous Glen Carbon with AC

Apartment in Grand Center

Sleek & Central Studio by SLU
10.0 out of 10, Exceptional, (1)
"The apartment was very nice. I loved it. It was my favorite place that I’ve stayed in St. Louis so far. Clean, small, easy to manage. Heather was so great and responsive. My only suggestion would be to make really clear how many steps there are. Haha. "
United States
Kelly S.
$146 nightly
The price is $158
Dec 28 - Dec 29
Total with taxes and fees
Sleek & Central Studio by SLU
9.8 out of 10, Exceptional, (53)
"Easy check-in, great communication with owner, nice area that is close to restaurants, bars, very clean."
United States
Vickie L.
$189 nightly
The price is $203
Jan 13 - Jan 14, 2026
Total with taxes and fees
Classic Soulard 2BD King Master & Private Deck
10.0 out of 10, Exceptional, (1)
"We really enjoyed our time in the Grove. This renovated property was clean and comfortable and the host was very happy to answer any questions. Highly recommend!"
United States
Suzanne L.
$201 nightly
The price is $217
Jan 20 - Jan 21, 2026
Total with taxes and fees
Stylish 2BR/2BA House in The Grove w/ Free Parking

Apartment in The Grove

Classy 3BR King Apt in The Grove
9.6 out of 10, Exceptional, (15)
"Lots of cute restaurants and bars within walking distance. The apartment was clean and neat. The kitchen was well stocked and we really enjoyed our stay! "
United States
Amelia D.
$195 nightly
The price is $210
Jan 13 - Jan 14, 2026
Total with taxes and fees
Classy 3BR King Apt in The Grove
9.8 out of 10, Exceptional, (18)
"It was a great place to stay for the night. Comfortable and close to the stadium. "
United States
Bryan D.
$189 nightly
The price is $203
Jan 13 - Jan 14, 2026
Total with taxes and fees
Spacious & Centrally Located Apt (Sleeps 8)
7.0 out of 10, Good, (4)
"Amazing property and access was easy. Would highly recommend."
United States
Armhad
$142 nightly
The price is $153
Jan 4 - Jan 5, 2026
Total with taxes and fees
1BR Apartment – Washer/Dryer, Fenced Backyard, Free Parking, Near Arch
9.8 out of 10, Exceptional, (139)
"Great little place and location was close to our event."
United States
RL T.
$136 nightly
The price is $159
Dec 28 - Dec 29
Total with taxes and fees
Centrally located in the Tower Grove East neighborhood!
10.0 out of 10, Exceptional, (8)
"Property is as described and worked well for our family. "
United States
Laura J.
$320 nightly
The price is $329
Jan 4 - Jan 5, 2026
Total with taxes and fees
TOP RATED! FANTASTIC LOCATION! 3 bedroom near WASHU, LOOP, Pageant, Forest Park
3.0 star property
$193 nightly
The price is $211
Dec 27 - Dec 28
Total with taxes and fees
12 Mi to St Louis: Pet-friendly Metro East Home
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Roxana Hotel Reviews

Find out more about Roxana

Everything you need to know about Roxana vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Roxana vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Roxana vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Roxana vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Roxana. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Roxana in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $100 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Roxana rentals

At Expedia, we put the best Roxana vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Roxana rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Roxana vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Roxana. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Are there vacation rentals in Roxana?

Yes, we give you a choice of vacation rentals near popular sights in Roxana, or you can go with a secluded option if you'd like a relaxing place to stay.

What are some of the best vacation home rentals that Roxana has to offer?

Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!: Visitors like this Roxana vacation home rental. It is located in the city center and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. You and your friends and family can relax into your vacation with amenities like a selection of games.

What’s there to see and do in Roxana?

While exploring the area, visit family-friendly sights like Cardinals Hall of Fame and Museum, or get outside and enjoy nature at The Gardens at SIUE. While in the area, you can also visit popular places like St. Louis Union Station and Busch Stadium.

What’s a vacation rental in Roxana like?

Vacation rentals are privately owned properties you can stay in for a few weeks or just a few days in Roxana. Vacation rentals offer amenities like kitchens and laundry facilities so you'll feel just like you're at home. If you're concerned about a sanitized environment, vacation rentals can offer a sense of security away from public hotel elevators and busy concierge desks while still allowing you the experience of travel. You'll also find more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is a popular option for a family trip or a small group gathering.