Title: Visit Santa Ana: 2026 Travel Guide for Santa Ana, Misiones Province | Expedia.com [Hotels in Santa Ana](https://expedia.com/Santa-Ana-Hotels.d6201393.Travel-Guide-Hotels)[Vacation Rentals in Santa Ana](https://expedia.com/Santa-Ana-Vacation-Rentals.d6201393.Travel-Guide-VacationRentals)[Flights to Santa Ana](https://expedia.com/Cheap-Flights-To-Santa-Ana.d6201393.Travel-Guide-Flights)[Car Rentals in Santa Ana](https://expedia.com/Car-Rentals-In-Santa-Ana.d6201393.Car-Rental-Guide)[Santa Ana Vacation Packages](https://expedia.com/Santa-Ana.d6201393.Destination-Travel-Guides) # Santa Ana ## Travel Guide ## Visit Santa Ana Things to do ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=DX_SPRING_PROMO_6201393) - Santa Ana Hotel Deals - Vacation Rentals in Santa Ana ![MOMORA DISTRITO SELVA](https://images.trvl-media.com/lodging/115000000/114370000/114368800/114368788/bf20b32a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### MOMORA DISTRITO SELVA LOTE AGRICOLA Santa Ana Misiones $293 nightly $297 total Feb 18 - Feb 19 Stay at this lodge in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Nuestra Senora de Santa Ana is located nearby. [](https://expedia.com/Hotel-Search?startDate=2%2F18%2F2026&endDate=2%2F19%2F2026&selected=114368788&PinnedHotelID=114368788&HadPinnedHotel=true®ionId=6201393) ![Al Kamar Lodge Spa](https://images.trvl-media.com/lodging/35000000/34770000/34768600/34768559/d7e72b5a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Al Kamar Lodge Spa Lote 26 Fracción C Santa Ana Misiones Book a stay at this spa lodge in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Nuestra Senora de Santa Ana is located ... [Get rates](https://expedia.com/Hotel-Search?startDate=3%2F3%2F2026&endDate=3%2F4%2F2026&selected=34768559&PinnedHotelID=34768559&HadPinnedHotel=true®ionId=6201393) [](https://expedia.com/Hotel-Search?startDate=3%2F3%2F2026&endDate=3%2F4%2F2026&selected=34768559&PinnedHotelID=34768559&HadPinnedHotel=true®ionId=6201393) ![On the Jesuit road, rest in this cozy little house.](https://images.trvl-media.com/lodging/123000000/122690000/122686500/122686454/w2400h1080x4y0-cc697588_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### On the Jesuit road, rest in this cozy little house. Santa Ana Misiones Stay at this cabin in Santa Ana. Enjoy free WiFi, breakfast (surcharge), and a garden. Popular attraction Nuestra Senora de Santa Ana is located nearby. [Get rates](https://expedia.com/Hotel-Search?startDate=3%2F3%2F2026&endDate=3%2F4%2F2026&selected=122686454&PinnedHotelID=122686454&HadPinnedHotel=true®ionId=6201393) [](https://expedia.com/Hotel-Search?startDate=3%2F3%2F2026&endDate=3%2F4%2F2026&selected=122686454&PinnedHotelID=122686454&HadPinnedHotel=true®ionId=6201393) [See all 53 properties in Santa Ana](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=2%2F18%2F2026&endDate=2%2F19%2F2026®ionId=6201393) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![On the Jesuit road, rest in this cozy little house.](https://images.trvl-media.com/lodging/123000000/122690000/122686500/122686454/w2400h1080x4y0-cc697588_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### On the Jesuit road, rest in this cozy little house. Santa Ana Misiones Stay at this cabin in Santa Ana. Enjoy free WiFi, breakfast (surcharge), and a garden. Popular attraction Nuestra Senora de Santa Ana is located nearby. [](https://expedia.com/Santa-Ana-Hotels-Vrbo-Property.h122686454.Hotel-Information) ![Irová Apart Hotel](https://images.trvl-media.com/lodging/37000000/36850000/36846700/36846641/941a766e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Irová Apart Hotel 6605 Av. Quaranta Posadas Misiónes Stay at this aparthotel in Posadas. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Aloe-Spa Salute per Aloe - Posadas and Museo de Ciencias ... [](https://expedia.com/Posadas-Hotels-Irova-Apart-Hotel.h36846641.Hotel-Information) ![Apart Hotel Las Violetas](https://images.trvl-media.com/lodging/92000000/91280000/91272000/91271956/0b3e9773_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Apart Hotel Las Violetas Barrio del Lago Candelaria Misiones Stay at this aparthotel in Candelaria. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Sanctuary of the Virgin of Itacua is located ... [](https://expedia.com/Candelaria-Hotels-Apart-Hotel-Las-Violetas.h91271956.Hotel-Information) [See all properties in Santa Ana](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=6201393&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Santa Ana hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6201393&startDate=2026-02-17&endDate=2026-02-18)[Feb 17 - Feb 18](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6201393&startDate=2026-02-17&endDate=2026-02-18) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6201393&startDate=2026-02-18&endDate=2026-02-19)[Feb 18 - Feb 19](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6201393&startDate=2026-02-18&endDate=2026-02-19) [This weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6201393&startDate=2%2F20%2F2026&endDate=2%2F22%2F2026)[Feb 20 - Feb 22](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6201393&startDate=2%2F20%2F2026&endDate=2%2F22%2F2026) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6201393&startDate=2%2F27%2F2026&endDate=3%2F1%2F2026)[Feb 27 - Mar 1](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6201393&startDate=2%2F27%2F2026&endDate=3%2F1%2F2026) ### Popular places to visit #### Nuestra Senora de Santa Ana You can find out about the history of Santa Ana when you stop by Nuestra Senora de Santa Ana. Amble around the area's gardens or visit its monuments. [](https://expedia.com/Nuestra-Senora-De-Santa-Ana-Santa-Ana.d6096808.Vacation-Attraction) ## Cities near Santa Ana ![The impressive gateway of the church stands as testament to the power the Jesuit missions held over the local populations. This red sandstone gateway once stood 30ft tall (10m) as it welcomed the native Christian population into it's cavernous interior. San Ignacio Mini was a Jesuit mission established in 1610 with the aim of converting the local Guaraní natives. The mission moved to this location in 1666 and a large complex was erected to house and protect up to 4000 converts. The complex was built in Spanish baroque style around a central courtyard and included a large church, school, hospital, cemetery, dormitories and workshops. The mission was largely abandoned when the Jesuits were expelled by Spanish decree in 1767, and was then destroyed by Paraguayan decree some 50 years later. The remains of the mission were rediscovered in 1897 and are now listed as a UNESCO World Heritage Site.](https://images.trvl-media.com/place/6096806/28597e60-87ca-49e8-bf0c-db607cfd2360.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### San Ignacio ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Hotels near Nuestra Senora de Santa Ana ](https://www.expedia.com/Nuestra-Senora-De-Santa-Ana-Hotels.0-l6096808-0.Travel-Guide-Filter-Hotels) - [Hotels near Casa de Horacio Quiroga ](https://www.expedia.com/Casa-De-Horacio-Quiroga-Hotels.0-l553248621532374358-0.Travel-Guide-Filter-Hotels) - [Hotels near San Ignacio Miní ](https://www.expedia.com/San-Ignacio-Mini-Hotels.0-l6096806-0.Travel-Guide-Filter-Hotels) - [San Ignacio Hotels ](https://www.expedia.com/San-Ignacio-Hotels.d6201391.Travel-Guide-Hotels) - [Cabin Rentals in San Ignacio ](https://www.expedia.com/San-Ignacio-Cabins.d6201391-aaCabins.Travel-Guide-Accommodation) - [Hotels with Free Breakfast in San Ignacio ](https://www.expedia.com/San-Ignacio-Hotels-Hotels-With-Complimentary-Breakfast.0-0-d6201391-tHotelswithComplimentaryBreakfast.Travel-Guide-Filter-Hotels) - 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[Flights from Toronto (YYZ) to Posadas (PSS) ](https://www.expedia.com/lp/flights/yyz/pss/toronto-to-posadas) - [Flights from Salta (SLA) to Posadas (PSS) ](https://www.expedia.com/lp/flights/sla/pss/salta-to-posadas) - [Flights from Boston (BOS) to Posadas (PSS) ](https://www.expedia.com/lp/flights/bos/pss/boston-to-posadas) - [Casa de Horacio Quiroga ](https://www.expedia.com/Casa-De-Horacio-Quiroga-San-Ignacio.d553248621532374358.Vacation-Attraction) - [San Ignacio Miní ](https://www.expedia.com/San-Ignacio-Mini-San-Ignacio.d6096806.Vacation-Attraction) - [Visit San Ignacio ](https://www.expedia.com/San-Ignacio.dx6201391) - [Horacio Quiroga Home ](https://www.expedia.com/Horacio-Quiroga-Home-San-Ignacio.d553248621532464072.Vacation-Attraction) - [Visit Colonia Finlandesa ](https://www.expedia.com/Colonia-Finlandesa.dx3000007373) - [Argentina-Paraguay Bridge ](https://www.expedia.com/Argentina-Paraguay-Bridge-Posadas.d6279454.Vacation-Attraction) - [Visit Misiones Province ](https://www.expedia.com/Misiones-Province.dx6232393) - [Fundación Artesanías Misioneras ](https://www.expedia.com/Fundacion-Artesanias-Misioneras-Posadas.d553248621532374353.Vacation-Attraction) - [Parque Republica del Paraguay ](https://www.expedia.com/Parque-Republica-Del-Paraguay-Posadas.d6279450.Vacation-Attraction) - [Misiones Province Vacations ](https://www.expedia.com/Misiones-Province.d6232393.Destination-Travel-Guides) - [Visit Posadas ](https://www.expedia.com/Posadas.dx2887) - [Posadas Vacations ](https://www.expedia.com/Posadas.d2887.Destination-Travel-Guides) - [Aloe-Spa Salute per Aloe - Posadas ](https://www.expedia.com/Aloe-Spa-Salute-Per-Aloe-Posadas-Posadas.d553248621532464064.Vacation-Attraction) - [Visit Santo Pipó ](https://www.expedia.com/Santo-Pipo.dx3000007164) - [Car rentals near San Ignacio Miní ](https://www.expedia.com/Car-Rentals-In-San-Ignacio-Mini.d6096806.Car-Rental-Guide) - [Car rentals near San Ignacio ](https://www.expedia.com/Car-Rentals-In-San-Ignacio.d6201391.Car-Rental-Guide) - [Car rentals near Candelaria ](https://www.expedia.com/Car-Rentals-In-Candelaria.d553248635924011300.Car-Rental-Guide) - [Car rentals near Olegario Víctor Andrade ](https://www.expedia.com/Car-Rentals-In-Olegario-Victor-Andrade.d553248635924012090.Car-Rental-Guide) - [Car rentals near Corpus Christi ](https://www.expedia.com/Car-Rentals-In-Corpus-Christi.d553248635924011723.Car-Rental-Guide) - [Car rentals near Parque Republica del Paraguay ](https://www.expedia.com/Car-Rentals-In-Parque-Republica-Del-Paraguay.d6279450.Car-Rental-Guide) - [Car rentals near Misiones Province ](https://www.expedia.com/Destinations-In-Misiones-Province.d6232393.Car-Rental-Destinations) - [Localiza Argentina Rental Cars in Posadas ](https://www.expedia.com/Localiza-Argentina-Car-Rentals-In-Posadas.d2887-c1097.Car-Rental-Guide-Suppliers) - [Car rentals near Posadas ](https://www.expedia.com/Car-Rentals-In-Posadas.d2887.Car-Rental-Guide) - [Hertz Rental Cars in Posadas ](https://www.expedia.com/Hertz-Car-Rentals-In-Posadas.d2887-c40.Car-Rental-Guide-Suppliers) - [Budget Rental Cars in Posadas ](https://www.expedia.com/Budget-Car-Rentals-In-Posadas.d2887-c39.Car-Rental-Guide-Suppliers) - [Van Car Rentals in Posadas ](https://www.expedia.com/Van-Car-Rentals-In-Posadas.d2887-tVan.Car-Rental-Guide-Class) - [Suv Car Rentals in Posadas ](https://www.expedia.com/SUV-Car-Rentals-In-Posadas.d2887-tSUV.Car-Rental-Guide-Class) - [San Ignacio Vacation Rentals ](https://www.expedia.com/San-Ignacio-Vacation-Rentals.d6201391.Travel-Guide-VacationRentals) - [Posadas Vacation Rentals ](https://www.expedia.com/Posadas-Vacation-Rentals.d2887.Travel-Guide-VacationRentals) - [Things to do in San Ignacio ](https://www.expedia.com/Things-To-Do-In-San-Ignacio.d6201391.Travel-Guide-Activities) - [Things to do in Misiones Province ](https://www.expedia.com/Things-To-Do-In-Misiones-Province.d6232393.Travel-Guide-Activities) - Cities near Santa Ana - Places of interest [San Ignacio](https://expedia.com/San-Ignacio.dx6201391) - [San Ignacio Miní ](https://expedia.com/San-Ignacio-Mini-San-Ignacio.d6096806.Vacation-Attraction) - [Argentina-Paraguay Bridge ](https://expedia.com/Argentina-Paraguay-Bridge-Posadas.d6279454.Vacation-Attraction) - [Parque Republica del Paraguay ](https://expedia.com/Parque-Republica-Del-Paraguay-Posadas.d6279450.Vacation-Attraction) - [Museo Municipal De Bellas Artes Lucas Braulio Areco ](https://expedia.com/Museo-Municipal-De-Bellas-Artes-Lucas-Braulio-Areco-Posadas.d553248621532374352.Vacation-Attraction) - [San Ignacio Mini - Jesuit Missions of the Guaranis ](https://expedia.com/San-Ignacio-Mini-Jesuit-Missions-Of-The-Guaranis-Gobernador-Roca.d553248621532464073.Vacation-Attraction) - [Casa de Horacio Quiroga ](https://expedia.com/Casa-De-Horacio-Quiroga-San-Ignacio.d553248621532374358.Vacation-Attraction) - [9 de Julio Plaza ](https://expedia.com/9-De-Julio-Plaza-Posadas.d6279448.Vacation-Attraction) - [Parque de las Fiestas ](https://expedia.com/Parque-De-Las-Fiestas-Posadas.d895040051505872896.Vacation-Attraction) - [Fundación Artesanías Misioneras ](https://expedia.com/Fundacion-Artesanias-Misioneras-Posadas.d553248621532374353.Vacation-Attraction) - [Aloe-Spa Salute per Aloe - Posadas ](https://expedia.com/Aloe-Spa-Salute-Per-Aloe-Posadas-Posadas.d553248621532464064.Vacation-Attraction) - [Horacio Quiroga Home ](https://expedia.com/Horacio-Quiroga-Home-San-Ignacio.d553248621532464072.Vacation-Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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