Santa Clara Vacations from $1,032

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Your Santa Clara Vacation

Lock in a Santa Clara vacation package that has everything you need without any unnecessary extras. Great for distilleries and craft breweries, bars and pubs and cafes, think about staying in the neighborhood of El Cangrejo. A trip to Santa Clara is an excellent opportunity to take in the sights. Make sure you visit big-name attractions such as Multiplaza Pacific Mall, Avenida Balboa and Via Espana. A few clicks is all it takes to create a customized Santa Clara vacation on Expedia.

The Latest Santa Clara Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
San Francisco
Price was $1,457, price is now $1,032 per person
$1,032
per person
May 30 - Jun 6
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (1,004 reviews)
Breakfast was incredible and the staff was so kind and helpful!

Reviewed on Apr 11, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was $2,334, price is now $1,412 per person
$1,412
per person
May 30 - Jun 6
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (1,000 reviews)
Excellent staff. Super friendly. And everyone recognized us in the hotel, including the fabulous manager. The food was top notch drinks were outstanding. We were there during the four days of Easter celebration. What a unique experience of the culture.

Reviewed on Apr 9, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was $1,843, price is now $1,241 per person
$1,241
per person
May 30 - Jun 6
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,482 reviews)
The breakfast was very good, better than expected. Spa was relaxing but the sauna should have been included. The lights in the bathroom should be brighter.

Reviewed on Apr 11, 2026

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was $1,472, price is now $1,036 per person
$1,036
per person
May 30 - Jun 6
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (5,182 reviews)
The breakfast was amazing !

Reviewed on Apr 11, 2026

Casa Mallet by Wynwood House

Casa Mallet by Wynwood House

4 out of 5
Casco Viejo
Price was $1,706, price is now $1,277 per person
$1,277
per person
Jun 16 - Jun 23
found 1 day ago
Roundtrip flight included
Georgetown (GEO) to Panama City (PTY)
9.8/10 Exceptional! (27 reviews)
In the middle of the old town, lovely rooftop. Beautiful apartment. Easy check in. WhatsApp line is available if anything was needed or if we had questions.

Reviewed on Mar 12, 2026

Where to stay in Santa Clara

Find the best Santa Clara areas and neighborhoods for the activities you enjoy most. Learn more about Santa Clara
View of the Panama City Old Town

Casco Viejo

4.5/5(179 area reviews)

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Santa Clara Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$138 nightly
The price is $151 total per night from May 5 to May 6
$151 total
May 5 - May 6
Total with taxes and fees
9/10 Wonderful! (5,281 reviews)
The breakfast was amazing !

Reviewed on Apr 11, 2026

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$133 nightly
The price is $146 total per night from May 5 to May 6
$146 total
May 5 - May 6
Total with taxes and fees
8.6/10 Excellent! (2,508 reviews)
Only there for one night but had everything we needed.

Reviewed on Apr 10, 2026

Crowne Plaza Panama Airport by IHG
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $139 total per night from May 1 to May 2
$139 total
May 1 - May 2
Total with taxes and fees
8.6/10 Excellent! (1,004 reviews)
The staff greeted us with a warm smile every day. The breakfast was delicious. We would definitely stay here again.

Reviewed on Apr 10, 2026

Sheraton Grand Panama
See all 1,411 properties in Santa Clara
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Santa Clara

Multiplaza Pacific Mall

Multiplaza Pacific Mall

4.5/5(643 reviews)

During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall
Causeway, Amador, Panama

Amador Causeway

4.5/5(766 reviews)

You can learn about the history of Ancon with a stop at Amador Causeway. Stroll along the seaside or visit the shops in this vibrant area.

Amador Causeway
Panama City night skyline

Avenida Balboa

4/5(562 reviews)

You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.

Avenida Balboa

Things to do

Panama City: POIN Swing Experience

Panama City: POIN Swing Experience

$32
per adult
100% of travellers recommend
Panama City: POIN Swing Experience
Tour to a waterfall and Embera village with lunch included

Tour to a waterfall and Embera village with lunch included

$50
per adult
94% of travellers recommend
Tour to a waterfall and Embera village with lunch included
From Panama City: San Blas Island Hopping Day Tour

From Panama City: San Blas Island Hopping Day Tour

$145
per adult
98% of travellers recommend
From Panama City: San Blas Island Hopping Day Tour
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.