Title: Visit Santa Cruz: 2026 Travel Guide for Santa Cruz, O'Higgins Region | Expedia.com

[Hotels in Santa Cruz](https://expedia.com/Santa-Cruz-Hotels.d6047957.Travel-Guide-Hotels)[Vacation Rentals in Santa Cruz](https://expedia.com/Santa-Cruz-Vacation-Rentals.d6047957.Travel-Guide-VacationRentals)[Flights to Santa Cruz](https://expedia.com/Cheap-Flights-To-Santa-Cruz.d6047957.Travel-Guide-Flights)[Things to do in Santa Cruz](https://expedia.com/Things-To-Do-In-Santa-Cruz.d6047957.Travel-Guide-Activities)[Car Rentals in Santa Cruz](https://expedia.com/Car-Rentals-In-Santa-Cruz.d6047957.Car-Rental-Guide)[Santa Cruz Vacation Packages](https://expedia.com/Santa-Cruz.d6047957.Destination-Travel-Guides)

# Santa Cruz

## Travel Guide

![Rows of vineyards, Santa Cruz, Chile](https://images.trvl-media.com/place/6047957/e58d3014-ef10-4c60-9e03-08890e2f5494.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh)

![Chilean Wine - Vineyards - Chile](https://images.trvl-media.com/place/6047957/cdb9eb51-9321-43be-93a7-cc61dddb971b.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh)

![Vineyards in the Colchagua Valley - Chile](https://images.trvl-media.com/place/6047957/a319a664-b489-4d8b-88b2-e380b1fe83ec.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh)

![Amazing place to relax and enjoy the view after tasting good wine...](https://images.trvl-media.com/place/6047957/3f6f573a-78af-41a2-967b-d9399720ea19.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh)

![Great winery and very unique 4 room hotel part of Relais & Chateau group. This is the vinoteca or wine cellar lined with Clos Apalta wine with its blue capsule. Really fantastic place to stay and taste the wines. #BVSBlue](https://images.trvl-media.com/place/6047957/f768a89d-e5dc-49f1-898d-c44500189966.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh)

## Visit Santa Cruz

Things to do

- Santa Cruz Hotel Deals
- Vacation Rentals in Santa Cruz

![Santa Cruz Plaza](https://images.trvl-media.com/lodging/2000000/1410000/1406700/1406642/3fe1c8d9_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Santa Cruz Plaza

Plaza De Armas 286 Santa Cruz O'Higgins

$126 nightly

$126 total

Apr 5 - Apr 6

Book a stay at this spa hotel in Santa Cruz. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...

8.8/10 Excellent! (349 reviews)

Me parecio un lindo hotel, el Desayuno es muy completo tipico chileno. Creo que en el chek in deberian informar de las cosas con que cuenta el hotel y paseos, creo que tener que ir a otra oficina es una perdida de recursos. Nos toco una habitacion con tinaja la que disfrutamos es algo muy bueno, ...

Reviewed on Mar 20, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=1406642&PinnedHotelID=1406642&HadPinnedHotel=true&regionId=6047957)

![Hotel Cava Colchagua](https://images.trvl-media.com/lodging/10000000/9430000/9423000/9422950/38e10dec_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hotel Cava Colchagua

Barreales´s Way Santa Cruz O'Higgins

Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and an attached winery. Popular attractions Laura Hartwig Winery and Casino ...

[Get rates](https://expedia.com/Hotel-Search?startDate=4%2F3%2F2026&endDate=4%2F4%2F2026&selected=9422950&PinnedHotelID=9422950&HadPinnedHotel=true&regionId=6047957)

[](https://expedia.com/Hotel-Search?startDate=4%2F3%2F2026&endDate=4%2F4%2F2026&selected=9422950&PinnedHotelID=9422950&HadPinnedHotel=true&regionId=6047957)

![Hotel Vendimia Parador](https://images.trvl-media.com/lodging/23000000/22440000/22438600/22438533/93f91da4_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hotel Vendimia Parador

Camino Los Boldos SN Santa Cruz O'Higgins

$95 nightly

$95 total

Mar 21 - Mar 22

Stay at this hotel in Santa Cruz. Enjoy free WiFi, free parking, and free grocery shopping service. Our guests praise the helpful staff in our reviews. Popular ...

9.6/10 Exceptional! (83 reviews)

This is a lovely family run establishment in a small traditional building, the interior is delightfully decorated with antique curios. The grounds include a nice pool overlooked by a sun deck which affords views of the surrounding countryside. It also has secure parking. Our room was large and tastefully ...

Reviewed on Mar 19, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F21%2F2026&endDate=3%2F22%2F2026&selected=22438533&PinnedHotelID=22438533&HadPinnedHotel=true&regionId=6047957)

[See all 56 properties in Santa Cruz](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=3%2F21%2F2026&endDate=3%2F22%2F2026&regionId=6047957)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

![Colchagua Tiny Lodge](https://images.trvl-media.com/lodging/113000000/112020000/112019700/112019659/a6261078_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Colchagua Tiny Lodge

I-350 kilometro 4,5 Santa Cruz O'Higgins

Stay at this cabin in Santa Cruz. Enjoy free WiFi, free parking, and private hot tubs. Popular attractions Lapostolle Clos Apalta Winery and Bodega Viña Viu ...

[](https://expedia.com/Santa-Cruz-Hotels-Colchagua-Tiny-Lodge.h112019659.Hotel-Information)

![The ambush. Field and comfort](https://images.trvl-media.com/lodging/39000000/38120000/38118300/38118253/48553e33_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

The ambush. Field and comfort

 Santa Cruz Región del Libertador Gral. Bernardo O’Higgins

Stay at this vacation home in Santa Cruz. Enjoy free breakfast, a garden, and patios. Popular attractions Laura Hartwig Winery and Plaza de Armas are located ...

[](https://expedia.com/Santa-Cruz-Hotels-The-Ambush-Field-And-Comfort.h38118253.Hotel-Information)

![Intown Apart Santa Cruz](https://images.trvl-media.com/lodging/19000000/18690000/18680300/18680229/317611de_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Intown Apart Santa Cruz

Claudio Cancino 92 Santa Cruz O'Higgins

Book a stay at this business-friendly apartment in Santa Cruz. Enjoy free WiFi, parking (surcharge), and an airport shuttle (surcharge). Popular attractions ...

10/10 Exceptional! (1 review)

Boa experiência

A experiência no Check In foi muito boa. Mário, quem nos atendeu, foi muito cordial e como estavamos chegando de Pucon (12h de viagem) cheguei às 9h da manhã. Assim mesmo, ele nos proporcionou a antecipação do apartamento para descansarmos. O prédio é novo e o quarto estava em excelentes condições: ...

Reviewed on Sep 26, 2017

[](https://expedia.com/San-Fernando-Hotels-Intown-Apart-Santa-Cruz.h18680229.Hotel-Information)

[See all properties in Santa Cruz](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&regionId=6047957&sort=VACATION_RENTAL)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Check Santa Cruz hotel availability

[Tonight

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6047957&startDate=2026-03-20&endDate=2026-03-21)[Mar 20 - Mar 21](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6047957&startDate=2026-03-20&endDate=2026-03-21)

[Tomorrow night

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6047957&startDate=2026-03-21&endDate=2026-03-22)[Mar 21 - Mar 22](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6047957&startDate=2026-03-21&endDate=2026-03-22)

[This weekend

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6047957&startDate=3%2F20%2F2026&endDate=3%2F22%2F2026)[Mar 20 - Mar 22](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6047957&startDate=3%2F20%2F2026&endDate=3%2F22%2F2026)

### Popular places to visit

#### Lapostolle Clos Apalta Winery

You can enjoy a tasting or tour at Lapostolle Clos Apalta Winery during your travels to Santa Cruz. While in this relaxing area, you can savor the wineries and restaurants. 

[](https://expedia.com/Lapostolle-Clos-Apalta-Winery-Santa-Cruz.d553248621532463283.Vacation-Attraction)

#### Casino Colchagua

Why not roll the dice with a visit to Casino Colchagua during your visit to Santa Cruz? While in this relaxing area, you can savor the wineries and restaurants. 

[](https://expedia.com/Casino-Colchagua-Santa-Cruz.d553248621532463282.Vacation-Attraction)

#### Colchagua Campo y Vino

Enjoy an outing to Colchagua Campo y Vino during your stay in Santa Cruz. While in this relaxing area, you can savor the wineries and restaurants. 

[](https://expedia.com/Colchagua-Campo-Y-Vino-Santa-Cruz.d553248621532463281.Vacation-Attraction)

#### Laura Hartwig Winery

You can enjoy a tasting or tour at Laura Hartwig Winery during your travels to Santa Cruz. While in this relaxing area, you can savor the wineries and restaurants. 

[](https://expedia.com/Laura-Hartwig-Winery-Santa-Cruz.d553248621532463280.Vacation-Attraction)

#### Bodega Viña Viu Manent

You can enjoy a tasting or tour at Bodega Viña Viu Manent during your travels to Santa Cruz. While in this relaxing area, you can savor the wineries and restaurants. 

[](https://expedia.com/Bodega-Vina-Viu-Manent-Santa-Cruz.d873855731647115264.Vacation-Attraction)

#### Museo de Colchagua

You can spend time exploring the galleries in Museo de Colchagua during your trip to Santa Cruz. While in this relaxing area, you can savor the wineries and restaurants. 

[](https://expedia.com/Museo-De-Colchagua-Santa-Cruz.d6099456.Vacation-Attraction)

### Things to do

![Make Your Own Wine & Guided Vineyard Tour ](https://mediaim.expedia.com/localexpert/46200977/2edfdc20-7979-4beb-b97e-2ba00246939c.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Make Your Own Wine & Guided Vineyard Tour

$46

per adult

[](https://expedia.com/things-to-do/make-your-own-wine-guided-vineyard-tour.a46200977.activity-details)

![Viu Manent tour](https://mediaim.expedia.com/localexpert/46790586/8281bde6-a8fc-407d-ba24-3d5b37d230c6.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Viu Manent and Montes Winery, Colchagua Valley from semi-private

$280

per adult

[](https://expedia.com/things-to-do/viu-manent-and-montes-winery.a46790586.activity-details)

![Santiago Full day tour to Colchahua Valley, include entraces](https://mediaim.expedia.com/localexpert/851768/6ac7ea3d-43c1-45ac-91f7-7a704615f25e.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Santiago Full day tour to Colchahua Valley, include entraces

$390

per adult

[](https://expedia.com/things-to-do/santiago-full-day-tour-to-colchahua-valley.a851768.activity-details)

[See all activities in Santa Cruz](https://expedia.com/Things-To-Do-In-Santa-Cruz.d6047957.Travel-Guide-Activities)

## Cities near Santa Cruz

![Chilean Wine - Vineyards - Chile](https://images.trvl-media.com/place/3000006320/4658bcc8-5c8b-43b8-8012-60ae7119b00e.jpg?impolicy=fcrop&w=512&h=288&q=medium)

### Peralillo

![Discovered my favorite grape in the vineyards of Chile. What grape is it? Carménère
#Culture](https://images.trvl-media.com/place/3000006362/d1f31aae-7d9f-4840-923c-a5919fefcb2b.jpg?impolicy=fcrop&w=512&h=288&q=medium)

### Lolol

- Cities near Santa Cruz
- Places of interest

[Palmilla](https://expedia.com/Palmilla.dx6285090)[Peralillo](https://expedia.com/Peralillo.dx3000006320)[Nancagua](https://expedia.com/Nancagua.dx3000006338)[Lolol](https://expedia.com/Lolol.dx3000006362)[Cunaco](https://expedia.com/Cunaco.dx3000006419)

- [Lapostolle Clos Apalta Winery ](https://expedia.com/Lapostolle-Clos-Apalta-Winery-Santa-Cruz.d553248621532463283.Vacation-Attraction)
- [Colchagua Campo y Vino ](https://expedia.com/Colchagua-Campo-Y-Vino-Santa-Cruz.d553248621532463281.Vacation-Attraction)
- [Casino Colchagua ](https://expedia.com/Casino-Colchagua-Santa-Cruz.d553248621532463282.Vacation-Attraction)
- [Museo de Colchagua ](https://expedia.com/Museo-De-Colchagua-Santa-Cruz.d6099456.Vacation-Attraction)
- [Colchagua Valley Wine Route ](https://expedia.com/Colchagua-Valley-Wine-Route-Lolol.d553248621532463279.Vacation-Attraction)
- [Hacienda El Huique ](https://expedia.com/Hacienda-El-Huique-Palmilla.d6099458.Vacation-Attraction)
- [Plaza de Curico ](https://expedia.com/Plaza-De-Curico-Curico.d6099462.Vacation-Attraction)
- [MontGras Winery ](https://expedia.com/MontGras-Winery-Palmilla.d6283554.Vacation-Attraction)
- [Millahue Valley ](https://expedia.com/Millahue-Valley-San-Vicente.d553248635976913024.Vacation-Attraction)
- [Chimbarongo Plaza De Armas ](https://expedia.com/Chimbarongo-Plaza-De-Armas-Chimbarongo.d553248621594280468.Vacation-Attraction)
- [Curico Valley Wine Route ](https://expedia.com/Curico-Valley-Wine-Route-Curico.d553248621532463278.Vacation-Attraction)
- [Plaza de San Fernando ](https://expedia.com/Plaza-De-San-Fernando-San-Fernando.d6099450.Vacation-Attraction)
- [TreMonte Winery / Vina TreMonte ](https://expedia.com/TreMonte-Winery-Vina-TreMonte-San-Vicente.d553248621532463284.Vacation-Attraction)
- [Plaza de Armas ](https://expedia.com/Plaza-De-Armas-Curico.d792675003125030912.Vacation-Attraction)
- [Colchagua Automobile Museum ](https://expedia.com/Colchagua-Automobile-Museum-Lolol.d553248635997986367.Vacation-Attraction)
- [Viña Maquis ](https://expedia.com/Vina-Maquis-Palmilla.d790718034965401600.Vacation-Attraction)
- [Viña Escondida ](https://expedia.com/Vina-Escondida-Placilla.d553248635975257805.Vacation-Attraction)
- [Iglesia de San Francisco ](https://expedia.com/Iglesia-De-San-Francisco-San-Fernando.d6099452.Vacation-Attraction)
- [San Vicente Square ](https://expedia.com/San-Vicente-Square-San-Vicente.d553248621558085385.Vacation-Attraction)

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