Title: Santa Cruz Vacation Rentals from $71: Search Short-Term Rentals | Expedia.com [Hotels in Santa Cruz](https://expedia.com/Santa-Cruz-Hotels.d6047957.Travel-Guide-Hotels)[Flights to Santa Cruz](https://expedia.com/Cheap-Flights-To-Santa-Cruz.d6047957.Travel-Guide-Flights)[Things to do in Santa Cruz](https://expedia.com/Things-To-Do-In-Santa-Cruz.d6047957.Travel-Guide-Activities)[Car Rentals in Santa Cruz](https://expedia.com/Car-Rentals-In-Santa-Cruz.d6047957.Car-Rental-Guide)[Santa Cruz Vacation Packages](https://expedia.com/Santa-Cruz.d6047957.Destination-Travel-Guides) ![Rows of vineyards, Santa Cruz, Chile](https://images.trvl-media.com/place/6047957/e58d3014-ef10-4c60-9e03-08890e2f5494.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6047957/e58d3014-ef10-4c60-9e03-08890e2f5494.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ## Check prices for these dates In two weeks [Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=6047957&startDate=2026-04-17&endDate=2026-04-19&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [May 29 - May 31](https://www.expedia.com/Hotel-Search?regionId=6047957&startDate=2026-05-29&endDate=2026-05-31&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [Jun 26 - Jun 28](https://www.expedia.com/Hotel-Search?regionId=6047957&startDate=2026-06-26&endDate=2026-06-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [Jul 24 - Jul 26](https://www.expedia.com/Hotel-Search?regionId=6047957&startDate=2026-07-24&endDate=2026-07-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santa Cruz vacation rentals ![1 bedroom, laptop workspace, soundproofing, free WiFi](https://images.trvl-media.com/lodging/113000000/112020000/112019700/112019659/a6261078.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/113000000/112020000/112019700/112019659/cc686363.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/113000000/112020000/112019700/112019659/0501d5fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/113000000/112020000/112019700/112019659/2934ee8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Colchagua Tiny Lodge [](https://www.expedia.com/Santa-Cruz-Hotels-Colchagua-Tiny-Lodge.h112019659.Hotel-Information) Santa Cruz 9.8/10 Exceptional (8 reviews) "Cute lodge with friendly staff that helps you to your cozy room- sets up your hot tub and brings an amazing basket for breakfast! Can’t wait to go back " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jonathan $200 nightly $200 total Apr 23 - Apr 24 [](https://www.expedia.com/Santa-Cruz-Hotels-Colchagua-Tiny-Lodge.h112019659.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/39000000/38120000/38118300/38118253/48553e33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/39000000/38120000/38118300/38118253/b9cfe331.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/39000000/38120000/38118300/38118253/da1d039e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, WiFi](https://images.trvl-media.com/lodging/39000000/38120000/38118300/38118253/4fb40573.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The ambush. Field and comfort [](https://www.expedia.com/Santa-Cruz-Hotels-The-Ambush-Field-And-Comfort.h38118253.Hotel-Information) Santa Cruz $165 nightly $193 total Apr 3 - Apr 4 [](https://www.expedia.com/Santa-Cruz-Hotels-The-Ambush-Field-And-Comfort.h38118253.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/94000000/93190000/93188700/93188687/db0556a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, soap, shampoo](https://images.trvl-media.com/lodging/94000000/93190000/93188700/93188687/b6b66859.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/94000000/93190000/93188700/93188687/3f23d36b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cookware/dishes/utensils](https://images.trvl-media.com/lodging/94000000/93190000/93188700/93188687/33c91c4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hostel Turismo San Vicente Tagua Tagua [](https://www.expedia.com/San-Vicente-Hotels-Hostel-Turismo-San-Vicente-Tagua-Tagua.h93188687.Hotel-Information) San Vicente de Taguatagua $79 nightly $79 total Apr 3 - Apr 4 [](https://www.expedia.com/San-Vicente-Hotels-Hostel-Turismo-San-Vicente-Tagua-Tagua.h93188687.Hotel-Information) ![Room](https://images.trvl-media.com/lodging/107000000/106960000/106959200/106959122/427ba2e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/107000000/106960000/106959200/106959122/4799451f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/107000000/106960000/106959200/106959122/0f55f463.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/107000000/106960000/106959200/106959122/1420bffd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tiny Corazon de Colchagua Cabin [](https://www.expedia.com/Bouvet-Island-Hotels-Cozy-And-Comfortable-Tiny-Cottage.h106959122.Hotel-Information) Nancagua $75 nightly $75 total Apr 3 - Apr 4 [](https://www.expedia.com/Bouvet-Island-Hotels-Cozy-And-Comfortable-Tiny-Cottage.h106959122.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/120000000/119240000/119237300/119237202/b1e5a2d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/120000000/119240000/119237300/119237202/b0a32316.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/120000000/119240000/119237300/119237202/ef1b9b5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119240000/119237300/119237202/28ad04b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### House in a natural setting [](https://www.expedia.com/Teno-Hotels-House-In-A-Natural-Setting.h119237202.Hotel-Information) Curico $92 nightly $106 total Apr 10 - Apr 11 [](https://www.expedia.com/Teno-Hotels-House-In-A-Natural-Setting.h119237202.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/121000000/120830000/120821100/120821060/64aa2b27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, free WiFi, bed sheets](https://images.trvl-media.com/lodging/121000000/120830000/120821100/120821060/96634182.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/121000000/120830000/120821100/120821060/e5b1788f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/121000000/120830000/120821100/120821060/1965fb23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Refugio Campestre, Cabaña con Tinaja (Cabin with Tinaja) [](https://www.expedia.com/Chimbarongo-Hotels-Vrbo-Property.h120821060.Hotel-Information) Chimbarongo $71 nightly $71 total Apr 7 - Apr 8 [](https://www.expedia.com/Chimbarongo-Hotels-Vrbo-Property.h120821060.Hotel-Information) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/117000000/116740000/116738800/116738795/bd08745e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/117000000/116740000/116738800/116738795/a9e9f4ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/117000000/116740000/116738800/116738795/d58c976f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/117000000/116740000/116738800/116738795/cb86fe34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The most comfortable apartment in San Fernando [](https://www.expedia.com/San-Fernando-Hotels-Vrbo-Property.h116738795.Hotel-Information) San Fernando $137 nightly $137 total Apr 7 - Apr 8 [](https://www.expedia.com/San-Fernando-Hotels-Vrbo-Property.h116738795.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/124000000/123780000/123777400/123777358/58ef3ff1_edited_6d5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/124000000/123780000/123777400/123777358/0303abd5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/124000000/123780000/123777400/123777358/ddfe58f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/124000000/123780000/123777400/123777358/9abb34f0_edited_f464.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful 5-bedroom home near Santa Cruz perfect for your getaway [](https://www.expedia.com/Peralillo-Hotels-Beautiful-5-Bedroom-Home-Near-Santa-Cruz-Perfect-For-Your-Getaway.h123777358.Hotel-Information) Santa Cruz $568 nightly $568 total Apr 7 - Apr 8 [](https://www.expedia.com/Peralillo-Hotels-Beautiful-5-Bedroom-Home-Near-Santa-Cruz-Perfect-For-Your-Getaway.h123777358.Hotel-Information) ![Room](https://images.trvl-media.com/lodging/128000000/127210000/127208800/127208783/2ec1b104.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/128000000/127210000/127208800/127208783/a587f9e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/128000000/127210000/127208800/127208783/6b875935.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/128000000/127210000/127208800/127208783/2f94ea5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Curico FULL furnished house, central location, roofed parking lot [](https://www.expedia.com/Curico-Hotels-Vrbo-Property.h127208783.Hotel-Information) Curicó $92 nightly $106 total Apr 3 - Apr 4 [](https://www.expedia.com/Curico-Hotels-Vrbo-Property.h127208783.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-16&endDate=2026-04-17®ionId=6047957&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ## Find vacation rentals that suit your style Cabins [](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+O%27Higgins+Region%2C+Chile®ionId=6047957&latLong=-34.640343%2C-71.365997&adults=2&startDate=2026-07-01&d1=2026-07-01&endDate=2026-07-04&d2=2026-07-04&lodging=CABIN) Private vacation homes [](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+O%27Higgins+Region%2C+Chile®ionId=6047957&latLong=-34.640343%2C-71.365997&adults=2&startDate=2026-07-01&d1=2026-07-01&endDate=2026-07-04&d2=2026-07-04&lodging=VACATION_HOME) Apartments [](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+O%27Higgins+Region%2C+Chile®ionId=6047957&latLong=-34.640343%2C-71.365997&adults=2&startDate=2026-07-01&d1=2026-07-01&endDate=2026-07-04&d2=2026-07-04&lodging=APARTMENT) Cottages [](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+O%27Higgins+Region%2C+Chile®ionId=6047957&latLong=-34.640343%2C-71.365997&adults=2&startDate=2026-07-01&d1=2026-07-01&endDate=2026-07-04&d2=2026-07-04&lodging=COTTAGE) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Cruz-Vacation-Rentals.d6047957.Travel-Guide-VacationRentals)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Cruz-Vacation-Rentals.d6047957.Travel-Guide-VacationRentals) ## Top Santa Cruz Hotel Reviews ![Hotel Vendimia Parador](https://images.trvl-media.com/lodging/23000000/22440000/22438600/22438533/93f91da4_y.jpg) ### Hotel Vendimia Parador 10/10 Excellent " "I had a wonderful experience at this hotel. The location is fantastic—central and convenient to everything I wanted to see. The room was spotless and well-maintained, which I really appreciated. But what truly sets this place apart is the staff. From the front desk to the housekeeping team, everyone was genuinely warm, helpful, and went out of their way to be friendly. It made all the difference. I would absolutely stay here again." " [](https://expedia.com/San-Fernando-Hotels-Hotel-Vendimia-Parador.h22438533.Hotel-Information) ![Hotel Boutique Grand Cru](https://images.trvl-media.com/lodging/112000000/111720000/111717800/111717705/60f6a89d_y.jpg) ### Hotel Boutique Grand Cru 10/10 Excellent "Great breakfast. Super host Juan Luis. Great location. Comfy bed. Spacious loft style rooms " [](https://expedia.com/Santa-Cruz-Hotels-Hotel-Boutique-Grand-Cru.h111717705.Hotel-Information) ![Casa Calfu](https://images.trvl-media.com/lodging/20000000/19900000/19897100/19897092/6f9059fe_y.jpg) ### Casa Calfu 10/10 Excellent "Excellent " [](https://expedia.com/San-Fernando-Hotels-Casa-Calfu-Hostal-Bed-And-Breakfast.h19897092.Hotel-Information) ![Santa Cruz Plaza](https://images.trvl-media.com/lodging/2000000/1410000/1406700/1406642/3fe1c8d9_y.jpg) ### Santa Cruz Plaza 8/10 Good "Me parecio un lindo hotel, el Desayuno es muy completo tipico chileno. Creo que en el chek in deberian informar de las cosas con que cuenta el hotel y paseos, creo que tener que ir a otra oficina es una perdida de recursos. Nos toco una habitacion con tinaja la que disfrutamos es algo muy bueno, pero me hubiera encantado alguin que te explique todo lo qie puedes hacer en el hotel y alrededores de una forma mas practica." [](https://expedia.com/San-Fernando-Hotels-Santa-Cruz-Plaza.h1406642.Hotel-Information) ![Hotel Boutique Vendimia Premium](https://images.trvl-media.com/lodging/3000000/2960000/2959500/2959484/e7728f8a_y.jpg) ### Hotel Boutique Vendimia Premium 10/10 Excellent "Lovely!!" [](https://expedia.com/San-Fernando-Hotels-Hotel-Boutique-Vendimia-Premium.h2959484.Hotel-Information) ![TerraViña](https://images.trvl-media.com/lodging/4000000/3780000/3775300/3775207/5e3744e0_y.jpg) ### TerraViña 10/10 Excellent "The hotel had a great buffet breakfast which was included with your stay. The staff were helpful and friendly would offer to book restaurant reservations. The only complaint was we found the air conditioner fan to loud." [](https://expedia.com/San-Fernando-Hotels-TerraVina.h3775207.Hotel-Information) ![La Perla Hotel](https://images.trvl-media.com/lodging/19000000/18060000/18057500/18057456/afe65d1c_y.jpg) ### La Perla Hotel 10/10 Excellent "Excellent Staff, excellent facilities, and an excellent sleep in a very quiet location." [](https://expedia.com/San-Fernando-Hotels-La-Perla-Hotel.h18057456.Hotel-Information) ![Hotel Boutique Solaz Bella Vista de Colchagua](https://images.trvl-media.com/lodging/5000000/4250000/4248400/4248321/d436566a_y.jpg) ### Hotel Boutique Solaz Bella Vista de Colchagua 10/10 Excellent "The hotel was in a great location and the garden and pool made it a very relaxing place to stay. All the staff were so friendly and helpful - they had given great advice before we arrived and booked wine tours for us which made our stay all the more enjoyable! Breakfast was also really good. We would certainly stay here again. " [](https://expedia.com/San-Fernando-Hotels-Hotel-Boutique-Solaz-Bella-Vista-De-Colchagua.h4248321.Hotel-Information) ## Find out more about Santa Cruz **Everything you need to know about Santa Cruz vacation rentals** Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Cruz vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on. There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Cruz vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. **Santa Cruz vacation rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in Santa Cruz. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santa Cruz in high season. Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $71 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals! **How to find incredible deals on Santa Cruz rentals** At Expedia, we put the best Santa Cruz vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. To find some top Santa Cruz rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Cruz vacation. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Cruz. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. ## Explore a world of travel with Expedia - Trending destinations on Expedia.com - All accommodation types in Santa Cruz ### Trending destinations on Expedia.com - [Destin Vacation Rentals ](https://www.expedia.com/Destin-Vacation-Rentals.d6906.Travel-Guide-VacationRentals) - [Panama City Vacation Rentals ](https://www.expedia.com/Panama-City-Beach-Vacation-Rentals.d8021.Travel-Guide-VacationRentals) - [Hilton Head Vacation Rentals ](https://www.expedia.com/Hilton-Head-Island-Vacation-Rentals.d601684.Travel-Guide-VacationRentals) - [Gulf Shores Vacation Rentals ](https://www.expedia.com/Gulf-Shores-Vacation-Rentals.d603078.Travel-Guide-VacationRentals) - [Key West Vacation Rentals ](https://www.expedia.com/Key-West-Vacation-Rentals.d1187.Travel-Guide-VacationRentals) - [Gatlinburg Vacation Rentals ](https://www.expedia.com/Gatlinburg-Vacation-Rentals.d7474.Travel-Guide-VacationRentals) - [Maui Vacation Rentals ](https://www.expedia.com/Maui-Vacation-Rentals.d180073.Travel-Guide-VacationRentals) - [Orlando Vacation Rentals ](https://www.expedia.com/Orlando-Vacation-Rentals.d178294.Travel-Guide-VacationRentals) - [Myrtle Beach Vacation Rentals ](https://www.expedia.com/Myrtle-Beach-Vacation-Rentals.d601685.Travel-Guide-VacationRentals) - [Orange Beach Vacation Rentals ](https://www.expedia.com/Orange-Beach-Vacation-Rentals.d9136.Travel-Guide-VacationRentals) - [Pigeon Forge Vacation Rentals ](https://www.expedia.com/Pigeon-Forge-Vacation-Rentals.d8264.Travel-Guide-VacationRentals) - [Ocean City Vacation Rentals ](https://www.expedia.com/Ocean-City-Vacation-Rentals.d9151.Travel-Guide-VacationRentals) - [Outer Banks Vacation Rentals ](https://www.expedia.com/Outer-Banks-Vacation-Rentals.d602135.Travel-Guide-VacationRentals) - [San Diego Vacation Rentals ](https://www.expedia.com/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals) - [Siesta Key Vacation Rentals ](https://www.expedia.com/Siesta-Key-Vacation-Rentals.d6881.Travel-Guide-VacationRentals) - [Galveston Vacation Rentals ](https://www.expedia.com/Galveston-Vacation-Rentals.d1341.Travel-Guide-VacationRentals) - [Clearwater Beach Vacation Rentals ](https://www.expedia.com/Clearwater-Beach-Vacation-Rentals.d10759.Travel-Guide-VacationRentals) - [Palm Springs Vacation Rentals ](https://www.expedia.com/Palm-Springs-Vacation-Rentals.d180676.Travel-Guide-VacationRentals) - [Florida Keys Vacation Rentals ](https://www.expedia.com/Florida-Keys-Vacation-Rentals.d6023765.Travel-Guide-VacationRentals) - [Lake Tahoe Vacation Rentals ](https://www.expedia.com/South-Lake-Tahoe-Vacation-Rentals.d10150.Travel-Guide-VacationRentals) - [Lake of the Ozarks Vacation Rentals ](https://www.expedia.com/Lake-Ozark-Vacation-Rentals.d177772.Travel-Guide-VacationRentals) - [Florida Vacation Rentals ](https://www.expedia.com/Destinations-In-Florida.d211.Vacation-Rental-Destinations) - [Hawaii Vacation Rentals ](https://www.expedia.com/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations) - [Michigan Vacation Rentals ](https://www.expedia.com/Destinations-In-Michigan.d224.Vacation-Rental-Destinations) - [B&B in Santa Cruz ](https://expedia.com/Santa-Cruz-Bed-And-Breakfast.d6047957-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Vacation Homes in Santa Cruz ](https://expedia.com/Santa-Cruz-Private-Vacation-Homes.d6047957-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Lodges in Santa Cruz ](https://expedia.com/Santa-Cruz-Lodges.d6047957-aaLodges.Travel-Guide-Accommodation) - [Hostels in Santa Cruz ](https://expedia.com/Santa-Cruz-Hostels.d6047957-aaHostels.Travel-Guide-Accommodation) ## Frequently asked questions ### Can I find a vacation rental in Santa Cruz? ### What's the top vacation rental that Santa Cruz has to offer? ### What can I see and do in Santa Cruz? ### What are vacation rentals like in Santa Cruz? ### Expedia's Latest Trends Hotels - [Best Hotels in San Pedro de Atacama](https://expedia.com/San-Pedro-De-Atacama-Hotels.d500224.Travel-Guide-Hotels) - [Rancagua Resorts & Hotels with Spas](https://expedia.com/Rancagua-Hotels-Spa-Hotel.0-0-d6085078-tSpaHotel.Travel-Guide-Filter-Hotels) - [Pichilemu Pet-friendly Hotels](https://expedia.com/Pichilemu-Hotels-Pet-Friendly-Hotel.0-0-d6130903-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Best Hotels in San Fernando](https://expedia.com/San-Fernando-Hotels.d6053655.Travel-Guide-Hotels) - [Best Hotels in Coltauco](https://expedia.com/Coltauco-Hotels.d3000477949.Travel-Guide-Hotels) - [Best Hotels in Vina del Mar](https://expedia.com/Vina-Del-Mar-Hotels.d6053651.Travel-Guide-Hotels) - [San Vicente Resorts & Hotels with Spas](https://expedia.com/San-Vicente-Hotels-Spa-Hotel.0-0-d6338195-tSpaHotel.Travel-Guide-Filter-Hotels) Flights - [Flights to PUQ](https://expedia.com/Cheap-Flights-To-Punta-Arenas.d2904.Travel-Guide-Flights) - [Flights to Lolol](https://expedia.com/Cheap-Flights-To-Lolol.d3000006362.Travel-Guide-Flights) Cars - [Car rentals in Los Angeles](https://expedia.com/Car-Rentals-In-Los-Angeles.d500226.Car-Rental-Guide) - [Car rentals in Punta Arenas](https://expedia.com/Car-Rentals-In-Punta-Arenas.d2904.Car-Rental-Guide) - [Car rentals in Pichilemu](https://expedia.com/Car-Rentals-In-Pichilemu.d6130903.Car-Rental-Guide) Activities - [Things to do in San Antonio](https://expedia.com/Things-To-Do-In-San-Antonio.d6336623.Travel-Guide-Activities) - [Things to do in Rancagua](https://expedia.com/Things-To-Do-In-Rancagua.d6085078.Travel-Guide-Activities) - [Things to do in Iquique](https://expedia.com/Things-To-Do-In-Iquique.d1623.Travel-Guide-Activities) - [Things to do in Mostazal](https://expedia.com/Things-To-Do-In-Mostazal.d6340588.Travel-Guide-Activities) Packages - [Museo de Colchagua](https://expedia.com/Museo-De-Colchagua-Santa-Cruz.d6099456.Vacation-Attraction) - [Navidad Vacation Packages](https://expedia.com/Navidad.d3000458771.Destination-Travel-Guides) - [Pichilemu Vacation Packages](https://expedia.com/Pichilemu.d6130903.Destination-Travel-Guides) General - [Visit Chimbarongo](https://expedia.com/Chimbarongo.dx6354855) - [Visit Marchihue](https://expedia.com/Marchihue.dx6176398) - [Visit Pichilemu](https://expedia.com/Pichilemu.dx6130903) - [Visit Concepción](https://expedia.com/Concepcion.dx790) - [Visit Graneros](https://expedia.com/Graneros.dx3000445547) - [Visit Mostazal](https://expedia.com/Mostazal.dx6340588) - [Visit Vina del Mar](https://expedia.com/Vina-Del-Mar.dx6053651) - [Visit Lolol](https://expedia.com/Lolol.dx3000006362) - [Visit Los Andes](https://expedia.com/Los-Andes.dx6272982) - [Visit Hanga Roa](https://expedia.com/Hanga-Roa.dx6053647)