Santa Cruz Vacation Rentals

Check prices for these dates

In two weeks
Apr 24 - Apr 26
In two months
Jun 5 - Jun 7
In three months
Jul 3 - Jul 5
In four months
Jul 31 - Aug 2

Our top choices for Santa Cruz vacation rentals

1 bedroom, laptop workspace, soundproofing, free WiFi

Colchagua Tiny Lodge

Colchagua Tiny Lodge
3.5 star property
Santa Cruz
9.8 out of 10, Exceptional, (8 reviews)
"Cute lodge with friendly staff that helps you to your cozy room- sets up your hot tub and brings an amazing basket for breakfast! Can’t wait to go back "
United States
Jonathan
$206 nightly
The price is $206
Apr 13 - Apr 14
Colchagua Tiny Lodge
Exterior

The ambush. Field and comfort

The ambush. Field and comfort
Santa Cruz
$168 nightly
The price is $195
Apr 13 - Apr 14
The ambush. Field and comfort
Property grounds

Hostel Turismo San Vicente Tagua Tagua

Hostel Turismo San Vicente Tagua Tagua
San Vicente de Taguatagua
$80 nightly
The price is $80
Apr 13 - Apr 14
Hostel Turismo San Vicente Tagua Tagua
Room

Tiny Corazon de Colchagua Cabin

Tiny Corazon de Colchagua Cabin
Nancagua
$75 nightly
The price is $75
Apr 13 - Apr 14
Tiny Corazon de Colchagua Cabin
Dining

House in a natural setting

House in a natural setting
Curico
$94 nightly
The price is $108
Apr 18 - Apr 19
House in a natural setting
Interior

Refugio Campestre, Cabaña con Tinaja (Cabin with Tinaja)

Refugio Campestre, Cabaña con Tinaja (Cabin with Tinaja)
Chimbarongo
$72 nightly
The price is $72
Apr 14 - Apr 15
Refugio Campestre, Cabaña con Tinaja (Cabin with Tinaja)
Room

Curico FULL furnished house, central location, roofed parking lot

Curico FULL furnished house, central location, roofed parking lot
Curicó
$106 nightly
The price is $122
Apr 13 - Apr 14
Curico FULL furnished house, central location, roofed parking lot
Outdoor pool

Beautiful 5-bedroom home near Santa Cruz perfect for your getaway

Beautiful 5-bedroom home near Santa Cruz perfect for your getaway
Santa Cruz
$576 nightly
The price is $576
Apr 13 - Apr 14
Beautiful 5-bedroom home near Santa Cruz perfect for your getaway
3 bedrooms, iron/ironing board, WiFi, bed sheets

The most comfortable apartment in San Fernando

The most comfortable apartment in San Fernando
San Fernando
$139 nightly
The price is $139
Apr 13 - Apr 14
The most comfortable apartment in San Fernando
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Hotel Vendimia Parador

Hotel Vendimia Parador

10/10 Excellent
" "I had a wonderful experience at this hotel. The location is fantastic—central and convenient to everything I wanted to see. The room was spotless and well-maintained, which I really appreciated. But what truly sets this place apart is the staff. From the front desk to the housekeeping team, everyone was genuinely warm, helpful, and went out of their way to be friendly. It made all the difference. I would absolutely stay here again." "
Yorba 1-night trip
Posted 11 days ago
Hotel Vendimia Parador

Find out more about Santa Cruz

Everything you need to know about Santa Cruz vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Cruz vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Cruz vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Santa Cruz vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santa Cruz. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santa Cruz in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $72 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Santa Cruz rentals

At Expedia, we put the best Santa Cruz vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santa Cruz rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Cruz vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Cruz. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, there are vacation rentals in Santa Cruz close to Colchagua Campo y Vino, or you can choose a more secluded option if you want a relaxing stay. Our travelers say Santa Cruz has a good selection of wineries and the restaurants. Make sure you have time to check out the local tours and casinos during your trip.

What's the top vacation rental that Santa Cruz has to offer?

The ambush. Field and comfort: This highly rated vacation home rental in Santa Cruz is located in a rural location and has a patio, a garden, and cable TV to put you at ease in your new surroundings.

What can I see and do in Santa Cruz?

Cultural attractions include Museo de Colchagua, whereas Millahue Valley is a spot to enjoy nature. Colchagua Campo y Vino and Casino Colchagua are other places to visit while you're in town.

What are vacation rentals like in Santa Cruz?

Vacation rentals are private properties you can stay in for several days or longer in Santa Cruz. Vacation rentals feature amenities such as patios, hot tubs, and fire pits so you'll feel just like you're staying in your own home. If you're concerned about a clean environment, a vacation rental can offer a sense of safety away from shared hotel elevators and busy lobbies while still allowing you the experience of travel. You'll also find more space in a vacation rental than in a hotel, which makes a vacation rental a popular option for a family getaway.