Butler County Vacations & Trips from $642

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Your Butler County Vacation

Answer the call of adventure with a customized vacation package to Butler County. Wherever it is you're headed and whatever you have planned, get ready to immerse yourself in a destination that'll make you truly feel alive. A trip to Butler County offers lots of things to see and do. Not sure where to begin? Poplar Bluff is one of the most popular cities to stay here. From the instant you book your Butler County vacation to when you get back home, Expedia has you covered every step of the way.

Top destinations in Butler County

A sunset over a calm lake with red autumn leaves on the right.

Poplar Bluff

Poplar Bluff

The Latest Butler County Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Perryville RV Resort

Perryville RV Resort

$642
per person
Nov 11 - Nov 14
found 9 hours ago
Roundtrip non-stop flight included
Grand Rapids (GRR) to Cape Girardeau (CGI)
9.6/10 Exceptional! (4 reviews)
Great time

Reviewed on Aug 11, 2026

Urban Lofts

Urban Lofts

$881
per person
Nov 11 - Nov 14
found 9 hours ago
Roundtrip non-stop flight included
Grand Rapids (GRR) to Cape Girardeau (CGI)
9.4/10 Exceptional! (22 reviews)
Beautiful, clean property in the heart of city center. Many options for food and shopping within short walking distance.

Reviewed on Jun 11, 2026

The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel

$706
per person
Nov 11 - Nov 14
found 9 hours ago
Roundtrip non-stop flight included
Grand Rapids (GRR) to Cape Girardeau (CGI)
9.6/10 Exceptional! (4 reviews)
Makanda Inn

Makanda Inn

$851
per person
Nov 11 - Nov 14
found 9 hours ago
Roundtrip non-stop flight included
Grand Rapids (GRR) to Cape Girardeau (CGI)
10/10 Exceptional! (39 reviews)
I travel to So. Illinois annually to visit but this is my first stay at the Makanda Inn. It will not be my last. I had a very peaceful stay- after long days of family visit and running around with the grands, it was so nice to stay here where it was quiet and relaxing. Breakfast every morning was top notch and just the right portions.

Reviewed on Jul 22, 2026

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

$721
per person
Nov 11 - Nov 14
found 9 hours ago
Roundtrip non-stop flight included
Grand Rapids (GRR) to Cape Girardeau (CGI)
8/10 Very Good! (995 reviews)
Wonderful stay. Clean, quiet, friendly staff. Will choose Candlewood again.

Reviewed on Aug 27, 2026

Find the Best Butler County Vacation Packages

Butler County Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)

Butler County Hotel Deals

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

2781 N Westwood Blvd Poplar Bluff MO
Fully refundable
$88 nightly
$99 total
Sep 13 - Sep 14
Total with taxes and fees
Holiday Inn Poplar Bluff by IHG
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

2220 N Westwood Blvd Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$102 nightly
$115 total
Sep 6 - Sep 7
Total with taxes and fees
9.4/10 Exceptional! (1,004 reviews)
"A very friendly staff"

Reviewed on Aug 29, 2026

Drury Inn & Suites Poplar Bluff
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$78 nightly
$87 total
Sep 7 - Sep 8
Total with taxes and fees
8/10 Very Good! (1,000 reviews)
"The floors were sticky. I couldn't walk on them in my bare feet. I did but then had to wash them."

Reviewed on Aug 25, 2026

Motel 6 Poplar Bluff, MO
See all 109 properties in Butler County
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Butler County attractions

Black River Coliseum

8.2/10 (30 reviews)
Catch an event at Black River Coliseum during your trip to Poplar Bluff. While in this family-friendly area, you can enjoy the restaurants.
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Mo-Ark Regional Railroad Museum

6.8/10 (13 reviews)
You can study the exhibits at Mo-Ark Regional Railroad Museum, a museum with a storied past, during your travels to Poplar Bluff. While in this family-friendly area, you can enjoy the restaurants.
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North Main Street Historic District

You can find out about the history of Poplar Bluff with a trip to North Main Street Historic District. While in this family-friendly area, you can enjoy the restaurants.
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Redman Creek Recreation Area

Explore the great outdoors at Redman Creek Recreation Area, a lovely green space in Wappapello.
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Margaret Harwell Art Museum

5.8/10 (8 reviews)
You can study the exhibits at Margaret Harwell Art Museum, a museum with a storied past, during your travels to Poplar Bluff. Stroll along the riverfront or experience the entertainment venues in this family-friendly area.
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Ozark Ridge Golf Course

7.4/10 (3 reviews)
Enjoy a round of golf in Poplar Bluff at Ozark Ridge Golf Course. Take in the entertainment venues and waterfalls in the area.
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Rockwood Point Recreation Area

Explore the great outdoors at Rockwood Point Recreation Area, a lovely green space in Wappapello.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.