Butler County Vacations & Trips from $616

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Your Butler County Vacation

Answer the call of adventure with a customized vacation package to Butler County. Wherever it is you're headed and whatever you have planned, get ready to immerse yourself in a destination that'll make you truly feel alive. A trip to Butler County offers lots of things to see and do. Not sure where to begin? Poplar Bluff is one of the most popular cities to stay here. From the instant you book your Butler County vacation to when you get back home, Expedia has you covered every step of the way.

Top destinations in Butler County

A sunset over a calm lake with red autumn leaves on the right.

Poplar Bluff

Poplar Bluff

The Latest Butler County Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

$616
per person
Dec 26 - Dec 30
found 12 hours ago
Roundtrip flight included
Baltimore (BWI) to Cape Girardeau (CGI)
9.2/10 Wonderful! (630 reviews)
Very nice facility, great staff, overall wonderful experience

Reviewed on Oct 14, 2026

Find the Best Butler County Vacation Packages

Butler County Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)

Butler County Hotel Deals

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$91 nightly
$102 total
Nov 1 - Nov 2
Total with taxes and fees
9.4/10 Exceptional! (992 reviews)
"Hampton Inn has been our go to when we are on the road for many years. The only thing I could suggest is to make the free breakfast a little bit better. The eggs always seem to be runny no matter which Hampton and we stay in and it would be nice to have a few more options."

Reviewed on Oct 19, 2026

Hampton Inn Poplar Bluff
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$79 nightly
$83 total
Oct 22 - Oct 23
Total with taxes and fees
8/10 Very Good! (1,000 reviews)
"Super clean and helpful friendly staff. Rooms are a bit small but still nice and modern. Only downside was no breakfast."

Reviewed on Oct 21, 2026

Motel 6 Poplar Bluff, MO
Lake Wappapello

Lake Wappapello

8005 Missouri 172 Williamsville MO
Fully refundableReserve now, pay when you stay
$100 nightly
$105 total
Oct 22 - Oct 23
Total with taxes and fees
9.4/10 Exceptional! (6 reviews)
"This a cabin in a state park. It was very clean and had newer upgrades. Bring the food you need because it's fairly distance from a grocery. We came later in the day because we needed one night and this was a great price and not a chain hotel which we like. There is a little store not too far from ..."

Reviewed on Sep 9, 2026

Lake Wappapello
See all 109 properties in Butler County
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Butler County attractions

Black River Coliseum

8.2/10 (30 reviews)
Catch an event at Black River Coliseum during your trip to Poplar Bluff. While in this family-friendly area, you can enjoy the restaurants.
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Rockwood Point Recreation Area

Explore the great outdoors at Rockwood Point Recreation Area, a lovely green space in Wappapello.
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Mo-Ark Regional Railroad Museum

6.8/10 (13 reviews)
You can study the exhibits at Mo-Ark Regional Railroad Museum, a museum with a storied past, during your travels to Poplar Bluff. While in this family-friendly area, you can enjoy the restaurants.
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Margaret Harwell Art Museum

5.8/10 (8 reviews)
You can study the exhibits at Margaret Harwell Art Museum, a museum with a storied past, during your travels to Poplar Bluff. Stroll along the riverfront or experience the entertainment venues in this family-friendly area.
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North Main Street Historic District

You can find out about the history of Poplar Bluff with a trip to North Main Street Historic District. While in this family-friendly area, you can enjoy the restaurants.
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Ozark Ridge Golf Course

7.4/10 (3 reviews)
Enjoy a round of golf in Poplar Bluff at Ozark Ridge Golf Course. Take in the entertainment venues and waterfalls in the area.
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Redman Creek Recreation Area

Explore the great outdoors at Redman Creek Recreation Area, a lovely green space in Wappapello.
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Poplar Bluff History Museum

You can spend time browsing the exhibits at Poplar Bluff History Museum in Poplar Bluff. While in this family-friendly area, you can enjoy the restaurants.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.