"We chose Hotel Rene as it looked more our style, a bit more relaxed and a homely feel. Our instinct was right. What a wonderful hotel, small, charming, good amenities and wonderful owners and staff. They could not do more to help if they tried. Exactly what we wanted and needed.
We really enjoyed sitting on our balcony taking in the excellent view, chilling by the nicely sized pool (reasonsbly rare in Skiathos town). It is a short walk to the beach (5-10mins), and also very quick to town (10-15mins depending where you want to go). The bus stop is just at the bottom of the road to explore the island (very convenient), and right next to that is the Super Market for anything you might need. That being said the Hotel also has a reasonably priced store for any food, water or other drinks you might need.
I would definitely look at staying here again when visiting Skiathos. You may have noticed others saying the hotel is situated on top of a hill, the upside of this - great views and a very easy walk to town or the beach! The downside is of course coming back. I must say if you are of low-moderate fitness (like me) this should be manageable for most people. It is 2-3 minutes of a steep up hill then you're done. If you have mobility issues it may not be advisable, but taxis will take you from the town for 10€.
Please don't let this put you off, but you should be aware of it. It didn't worry us, and we did not regret it our choice!"