Matlacha Isles Vacations from $486
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Your Matlacha Isles Vacation
Make planning your travels simple by locking in a vacation package to Matlacha Isles. We'll look after the details, so you can focus on soaking up everything this neighborhood has to offer. If you'd love to sightsee during your trip to Matlacha Isles, don't miss nearby attractions such as Royal Tee Golf Club. Don't just wish for it — make it a reality! Lock in your perfect Matlacha Isles vacation with Expedia and get to where you're going your way.
The Latest Matlacha Isles Vacation Packages
Hilton Garden Inn Ft Myers
Reviewed on Dec 9, 2025
The Perry Hotel Naples
Reviewed on Dec 9, 2025
Innovation Hotel
Reviewed on Dec 4, 2025
Matanzas Inn Bayside Resort and Marina
Reviewed on Dec 10, 2025
Hyatt Vacation Club at Coconut Cove, Bonita Springs
Reviewed on Dec 10, 2025
Where to stay in Matlacha Isles
Pelican
If you're spending some time in Pelican, Tarpon Point and Harbour View Gallery are top sights worth seeing.
Matlacha Isles Hotel Deals
Margaritaville Beach Resort Fort Myers
This hotel had spectacular sunsets from your hotel room! We were able to look at the waves in am and at night- so calming and peaceful. Room had a lot of space. Bathrooms were big and great showers. Staff were very professional and pleasant, and went above and beyond
Reviewed on Dec 7, 2025
Lani Kai Beachfront Resort
First time at Lani Kai, room was clean and nice, great view off the balcony. Staff was very good. If the beach bars stayed open later on the weekends that would be a plus. Drink prices seemed inflated. Would def stay again.
Reviewed on Dec 9, 2025
Holiday Inn Express Cape Coral-Fort Myers Area by IHG
Friendly and accommodating staff, great breakfast selection, nicely-maintained pool, located across the street from many good local restaurants.
Reviewed on Dec 11, 2025
Discover the most popular places to visit in Matlacha Isles
Four Mile Cove Ecological Preserve
Enjoy the beautiful sunsets and explore Four Mile Cove Ecological Preserve, a lovely green space in Cape Coral. Amble around this family-friendly area's beautiful beaches or attend a baseball game.
Cape Coral Yacht Club Beach
Why not spend a lazy afternoon at Cape Coral Yacht Club Beach during your trip to Cape Coral?
Sun Splash Water Park
Enjoy the thrill rides with your kiddos at Sun Splash Water Park during your trip to Cape Coral. Stroll along the marina or discover the beautiful sunsets in this family-friendly area.
Things to do
