Upstate South Carolina Vacations from $567
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Your Upstate South Carolina Vacation
When adventure calls, answer it with a tailor-made vacation package to Upstate South Carolina. Wherever it is you're going and whatever your plans are, prepare to experience a destination with plenty to offer. Start your trip to Upstate South Carolina with a few nights in Greenville visiting popular sights like Falls Park on the Reedy and Bon Secours Wellness Arena. Spartanburg is another city that draws crowds from far and wide. WestGate Mall and Tyger River Park are two of the top places to see in this destination. Find some travel buddies and start packing, because your Upstate South Carolina vacation is just a few clicks away with Expedia.
The Latest Upstate South Carolina vacation packages
Price found within the past 48 hours. Click for updated prices.
Liberty Hall Bed and Breakfast
per person
Sep 5 - Sep 7
found 1 day ago
Roundtrip non-stop flight included
Philadelphia (PHL) to Greenville (GSP)
10/10 Exceptional! (65 reviews)
In town for a recent college visit. Great location in a stunning historic BNB. Breakfast was wonderful and customer service was exceptional. Would absolutely recommend staying here and plan to stay again.
Reviewed on Jun 13, 2025
The Restoration Asheville
Downtown Asheville
Save 100% on your flight
per person
Oct 3 - Oct 5
found 1 day ago
Roundtrip non-stop flight included
Fort Lauderdale (FLL) to Asheville (AVL)
9.8/10 Exceptional! (839 reviews)
Wonderful hotel in downtown Asheville. Staff was attentive, decir was impecable. Great experience!!
Reviewed on Aug 1, 2025
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View all tripsWhere to stay in Upstate South Carolina
Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville Downtown
3 out of top 10 points of interest in this area
5/5(654 area reviews)
The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.
Discover the most popular places to visit in Upstate South Carolina
Clemson University
Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.
Lake Keowee
Commune with nature and explore the great outdoors at Lake Keowee during your travels in Salem. While you're in the area, wander around the college campus.
Falls Park on the Reedy
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.
What to do in Upstate South Carolina
Greenville on the Go A 1 Hour Rydable Adventure
$59
per adult
Upstate South Carolina Hotel Deals
Hyatt Regency Greenville
220 N Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $153 total per night from Aug 17 to Aug 18
$153 total
Aug 17 - Aug 18
Total includes taxes and fees
8.6/10 Excellent! (1,005 reviews)
"Everything about our stay was fantastic. The only small challenge is that the room air conditioning would not go below 71°."
Reviewed on Jul 31, 2025
Hilton Greenville
45 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $117 total per night from Aug 10 to Aug 11
$117 total
Aug 10 - Aug 11
Total includes taxes and fees
8/10 Very Good! (1,003 reviews)
"One night stay passing through. Good price and location."
Reviewed on Jul 26, 2025
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd, Greenville, SC
Fully refundable
$99 nightly
The price is $109 total per night from Aug 17 to Aug 18
$109 total
Aug 17 - Aug 18
Total includes taxes and fees
8.4/10 Very Good! (1,004 reviews)
"The Crowne Plaza is a very clean and quiet hotel. The staff were all very friendly, breakfast had a good variety and was yummy and there was always parking available near the entrance. Check in and check out were both a very smooth process. Room was equipped with the essentials needed (shampoo, conditioner, ..."
Reviewed on Aug 1, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.