San Antonio Vacations from $853

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Your San Antonio Vacation

From its rich history to its cultural experiences and beyond, there's a whole lot to love about San Antonio. Discover the wonders of this exciting city with a San Antonio vacation package that's tailor-made for you. Metromall Panama is just one of the must-see attractions to add to your sightseeing agenda during a trip to San Antonio. A few clicks is all it takes to craft the ideal San Antonio vacation on Expedia.

The Latest San Antonio Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was $1,238, price is now $853 per person
$853
per person
Feb 15 - Feb 21
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (4,515 reviews)
The aesthetics! Very nice looking Hotel!

Reviewed on Dec 10, 2025

Villa Marina Lodge & Condos

Villa Marina Lodge & Condos

3.5 out of 5
Save 100% on your flight
Price was $2,056, price is now $1,372 per person
$1,372
per person
Feb 12 - Feb 17
found 1 day ago
Roundtrip flight included
New York (NYC) to Panama City (PTY)
9/10 Wonderful! (133 reviews)
Love that this property is at the other end of the beach from the late night partying. Walkable beach. Great restaurants nearby. The property was adding coffee makers and mini fridges the day we were leaving. Great staff, restaurant and drinks. We’ve been twice with our pooches. Will be back

Reviewed on Jul 14, 2025

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was $1,997, price is now $1,363 per person
$1,363
per person
Jan 29 - Feb 3
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Panama City (PTY)
9/10 Wonderful! (1,002 reviews)
Breakfast was simple but tasty. Staff service was excellent. The room was clean and well maintained and the AC worked perfectly.

Reviewed on Dec 10, 2025

MARINN PLACE Financial District

MARINN PLACE Financial District

3.5 out of 5
Bella Vista
Price was $1,702, price is now $1,164 per person
$1,164
per person
Feb 15 - Feb 21
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.2/10 Wonderful! (298 reviews)
Second stay, very nice

Reviewed on Nov 7, 2025

Casa Mallet by Wynwood House

Casa Mallet by Wynwood House

4 out of 5
Casco Viejo
Save 100% on your flight
Price was $2,267, price is now $1,572 per person
$1,572
per person
Feb 10 - Feb 16
found 1 day ago
Roundtrip flight included
New York (NYC) to Panama City (PTY)
9.8/10 Exceptional! (24 reviews)
Beautiful apartment definitely recommend staying here if you are coming to Panama

Reviewed on Nov 29, 2025

Where to stay in San Antonio

Find the best San Antonio areas and neighborhoods for the activities you enjoy most. Learn more about San Antonio
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Cerro Viento

1 out of top 10 points of interest in this area

Shopping and restaurants are notable features of Cerro Viento. You might consider a stop by Metromall Panama while you're exploring the neighborhood.

Find hotels in Cerro Viento

San Antonio Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$128 nightly
The price is $141 total per night from Dec 15 to Dec 16
$141 total
Dec 15 - Dec 16
Total with taxes and fees
9/10 Wonderful! (4,620 reviews)
Very good breakfast and very nice hotel and close to lots of restaurants

Reviewed on Dec 6, 2025

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$110 nightly
The price is $121 total per night from Dec 23 to Dec 24
$121 total
Dec 23 - Dec 24
Total with taxes and fees
8.4/10 Very Good! (2,315 reviews)
Everything good

Reviewed on Dec 9, 2025

Crowne Plaza Panama Airport by IHG
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $177 total per night from Jan 9 to Jan 10
$177 total
Jan 9 - Jan 10, 2026
Total with taxes and fees
8.8/10 Excellent! (1,000 reviews)
$304 for 3 nights I was nervous. But it surprised me. It was a very clean, convenient and way more than I expected. I would definitely return.

Reviewed on Dec 2, 2025

Las Americas Golden Tower Panama
See all 1,676 properties in San Antonio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in San Antonio

Metromall Panama

4.5/5(168 reviews)

During your trip to San Miguelito, you can search for that perfect souvenir at Metromall Panama. Make time to visit the area's casinos, or simply enjoy its lively bars.

Metromall Panama

Templo Bahá'í

3.5/5(5 reviews)

You can find out about the history of San Miguelito with a visit to Templo Bahá'í. Stroll along the seaside or visit the shops in this vibrant area.

Templo Bahá'í

Things to do

Boat tour in the Panama Canal to Monkeys and sloths islands

Boat tour in the Panama Canal to Monkeys and sloths islands

$74
per adult
92% of travellers recommend
Boat tour in the Panama Canal to Monkeys and sloths islands
Panama City: Poin Full Package Experience

Panama City: Poin Full Package Experience

$155
per adult
90% of travellers recommend
Panama City: Poin Full Package Experience
Panama City: Poin Glass Observation Deck Ticket with VR Tour

Panama City: Poin Glass Observation Deck Ticket with VR Tour

$32
per adult
100% of travellers recommend
Panama City: Poin Glass Observation Deck Ticket with VR Tour
See all activities in San Miguelito
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.