Santa Isabel Vacations from $208

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Your Santa Isabel Vacation

Our vacation packages to Santa Isabel give you endless opportunities to immerse yourself in new sights, sounds and sensations. And with all the details taken care of, you'll be free to enjoy your city adventure to the fullest. Make your trip to Santa Isabel even more fun and exciting by including some sightseeing. Plaza Comercial La Cachanilla, City Forest and Zoo and Juventud 2000 Sport Center are among the big attractions worth exploring. A few quick clicks is all it takes to put together the perfect Santa Isabel vacation on Expedia.

The Latest Santa Isabel vacation packages

Price found within the past 48 hours. Click for updated prices.
California Comfort and Suites

California Comfort and Suites

3 out of 5
Price was $251, price is now $208 per person
$208
per person
Dec 19 - Dec 24
found 18 hours ago
Roundtrip flight included
Denver (DEN) to Mexicali (MXL)
8.6/10 Excellent! (1,014 reviews)
Clean and efficient

Reviewed on Oct 26, 2025

Hotel Araiza Mexicali

Hotel Araiza Mexicali

4 out of 5
Price was $804, price is now $669 per person
$669
per person
Dec 7 - Dec 14
found 17 hours ago
Roundtrip flight included
Denver (DEN) to Mexicali (MXL)
8.6/10 Excellent! (1,626 reviews)
The hot tub needed a temperature improvement, not hot enough. Staff were very attentive and professional and cordial. Breakfast buffet is impressive and delicious.

Reviewed on Oct 26, 2025

Hotel Lucerna Mexicali

Hotel Lucerna Mexicali

4 out of 5
Price was $835, price is now $713 per person
$713
per person
Dec 7 - Dec 14
found 17 hours ago
Roundtrip flight included
Denver (DEN) to Mexicali (MXL)
9.2/10 Wonderful! (1,392 reviews)
Out of running water !! For hours .drove 12 hours out of state for an event ( only purpose of the room was to have available space for a shower and bathroom.No communication no credit no reimbursement . I have been here plenty of times with an amazing service. This time I was the exception.

Reviewed on Oct 27, 2025

Courtyard by Marriott Mexicali

Courtyard by Marriott Mexicali

3 out of 5
Price was $889, price is now $880 per person
$880
per person
Dec 1 - Dec 5
found 15 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Mexicali (MXL)
9.4/10 Exceptional! (763 reviews)
Room was clean. Friendly staff. Several nearby restaurants

Reviewed on Oct 23, 2025

Fairfield Inn & Suites by Marriott Mexicali

Fairfield Inn & Suites by Marriott Mexicali

2.5 out of 5
Price was $917, price is now $910 per person
$910
per person
Dec 1 - Dec 5
found 15 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Mexicali (MXL)
9.4/10 Exceptional! (1,005 reviews)
Fresh and tasty breakfast, nice beds

Reviewed on Oct 23, 2025

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Discover the most popular places to visit in Santa Isabel

Mexicali Border Port I

After visiting Mexicali Border Port I, make a plan to see the other sights and activities in Mexicali. While in this family-friendly area, you can savor the top-notch restaurants.

Mexicali Border Port I

Eagles Nest Stadium

4.5/5(9 reviews)

Catch an event at Eagles Nest Stadium during your trip to Mexicali. While you're here, you can savor the top-notch restaurants.

Eagles Nest Stadium

Plaza La Gran Via

4.5/5(14 reviews)

You can enjoy retail therapy at Plaza La Gran Via during your trip to Mexicali. While in this family-friendly area, you can savor the top-notch restaurants.

Plaza La Gran Via

Santa Isabel Hotel Deals

Hotel Araiza Mexicali

Hotel Araiza Mexicali

4 out of 5
Blvd. Benito Juarez 2220, Fracc Jardines Del Valle, Mexicali, BC
Fully refundable
$106 nightly
The price is $119 total per night from Nov 12 to Nov 13
$119 total
Nov 12 - Nov 13
Total with taxes and fees
8.6/10 Excellent! (1,640 reviews)
The hot tub needed a temperature improvement, not hot enough. Staff were very attentive and professional and cordial. Breakfast buffet is impressive and delicious.

Reviewed on Oct 26, 2025

Hotel Araiza Mexicali
Hotel Lucerna Mexicali

Hotel Lucerna Mexicali

4 out of 5
Boulevard Benito Juarez 2151, Mexicali, BC
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $115 total per night from Nov 16 to Nov 17
$115 total
Nov 16 - Nov 17
Total with taxes and fees
9.2/10 Wonderful! (1,395 reviews)
Disappointed
I did not have breakfast there so i could not rate it. I had no complaints about my stay besides the amount of people visiting location to take pictures. I guess many people book photo sessions at this location for its vibrant trees and water features. The pool was not private for guests so we didn't ...

Reviewed on Oct 27, 2025

Hotel Lucerna Mexicali
Real Inn Mexicali

Real Inn Mexicali

4 out of 5
Avenida de Los Heroes 201, Centro Civico, Mexicali, BC
Fully refundableReserve now, pay when you stay
$78 nightly
The price is $88 total per night from Nov 9 to Nov 10
$88 total
Nov 9 - Nov 10
Total with taxes and fees
8.2/10 Very Good! (1,494 reviews)
Safe

Reviewed on Oct 22, 2025

Real Inn Mexicali
See all 71 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Isabel Vacation Packages

Santa Isabel Essential Information

Language
Spanish
Currency
Mexican pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
General Rodolfo Sanchez Taboada Intl. Airport (MXL)
Population
29,300
Top Sights
City Forest and Zoo, Sol Childrens Museum and Aguilas de Mexicali Stadium

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Frequently asked questions

How much does a Santa Isabel vacation package cost?
You'll find cheap prices from $208 on Expedia for your Santa Isabel getaway. However, factors like the season, length of stay and your choice of hotel will influence how much your vacation to Santa Isabel costs.
What are the cheapest months to go to Santa Isabel?
If you're hoping to snag a cheap Santa Isabel vacation package, consider visiting in January, June and December. You'll usually find lower rates on accommodations and flights during these quieter months — perfect for a budget-friendly break.
How many days is enough for Santa Isabel?
Generally, a handful of days is enough to see the main sights during your Santa Isabel vacation. However, if you prefer to have some time to relax or go on day trips, think about extending your itinerary.
How to find the best Santa Isabel package deals?
Start your search for a Santa Isabel package deal by entering your preferred travel dates and destination under our "Packages" tab. Then apply a few filters, like "Guest rating" and "Property type," to tailor the results to your exact needs. You can also sort by "Package discount" and discover offers that come with irresistible savings. If you don't find the perfect Santa Isabel package deal straight away, simply tweak your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Santa Isabel escape underway.
Is it cheaper to book a Santa Isabel vacation as a package?
Expedia vacation packages are designed to make your money go further. Bundle your flight, car rental and hotel into one great-value price and you could save hundreds of dollars. You'll generally land a better deal than booking each component individually. And you'll still have the flexibility to create a personalized Santa Isabel vacation by choosing your favorite accommodation type, airline and car class.
When to book a vacation package to Santa Isabel?
If you have your Santa Isabel vacation dates confirmed, book as soon as you can to grab some incredible deals. With Expedia, you can generally reserve some flights up to a year in advance. Prefer spontaneous adventures? Our last-minute deals are perfect for traveling on a whim.
Does Expedia offer Book Now, Pay Later Santa Isabel vacation packages?
Your Santa Isabel trip is meant to be a relaxing escape from your busy life, not a source of money worries. So to allow you extra flexibility, we've joined up with online lender Affirm to bring you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and split up the total cost over 3, 6 or 12 months. Plus, there aren't any late payment fees or hidden costs to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.