Title: TOP 10 Hotels in Santa Isabel (from $40) - COMPETITIVE PRICES | Expedia.com [Vacation Rentals in Santa Isabel](https://expedia.com/Santa-Isabel-Vacation-Rentals.d553248635975869828.Travel-Guide-VacationRentals)[Car Rentals in Santa Isabel](https://expedia.com/Car-Rentals-In-Santa-Isabel.d553248635975869828.Car-Rental-Guide)[Santa Isabel Vacation Packages](https://expedia.com/Santa-Isabel.d553248635975869828.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Santa Isabel Family friendly [](https://www.expedia.com/Hotel-Search?destination=Santa+Isabel%2C+Mexicali%2C+Baja+California%2C+Mexico®ionId=553248635975869828&latLong=32.632687%2C-115.577461&adults=2&startDate=2026-04-21&d1=2026-04-21&endDate=2026-04-23&d2=2026-04-23&travelerType=family_friendly) Pool [](https://www.expedia.com/Hotel-Search?destination=Santa+Isabel%2C+Mexicali%2C+Baja+California%2C+Mexico®ionId=553248635975869828&latLong=32.632687%2C-115.577461&adults=2&startDate=2026-04-21&d1=2026-04-21&endDate=2026-04-23&d2=2026-04-23&amenities=POOL) Pet friendly [](https://www.expedia.com/Hotel-Search?destination=Santa+Isabel%2C+Mexicali%2C+Baja+California%2C+Mexico®ionId=553248635975869828&latLong=32.632687%2C-115.577461&adults=2&startDate=2026-04-21&d1=2026-04-21&endDate=2026-04-23&d2=2026-04-23&amenities=PETS) Apart­ment [](https://www.expedia.com/Hotel-Search?destination=Santa+Isabel%2C+Mexicali%2C+Baja+California%2C+Mexico®ionId=553248635975869828&latLong=32.632687%2C-115.577461&adults=2&startDate=2026-04-21&d1=2026-04-21&endDate=2026-04-23&d2=2026-04-23&lodging=APARTMENT) ## Check prices for these dates Tonight [Apr 7 - Apr 8](https://www.expedia.com/Hotel-Search?regionId=553248635975869828&startDate=2026-04-07&endDate=2026-04-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Apr 8 - Apr 9](https://www.expedia.com/Hotel-Search?regionId=553248635975869828&startDate=2026-04-08&endDate=2026-04-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=553248635975869828&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=553248635975869828&startDate=2026-04-17&endDate=2026-04-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santa Isabel hotels ![Lounge](https://images.trvl-media.com/lodging/1000000/30000/22600/22592/c02f77f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room | Premium bedding, pillowtop beds, minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/30000/22600/22592/3424fa53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor banquet area](https://images.trvl-media.com/lodging/1000000/30000/22600/22592/63cdf133.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/30000/22600/22592/4380e4be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Araiza Mexicali [](https://www.expedia.com/Mexicali-Hotels-Hotel-Araiza-Mexicali.h22592.Hotel-Information) Mexicali 8.6/10 Excellent (1,816 reviews) "We absolutely loved staying here. The room was beautiful. Will continue to stay here." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Saray Rios 4 days ago $124 nightly $140 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Mexicali-Hotels-Hotel-Araiza-Mexicali.h22592.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/440000/437500/437408/b85b0cb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bungalow, 1 King Bed | Down comforters, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/440000/437500/437408/4fff491a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/1000000/440000/437500/437408/4ee323df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/1000000/440000/437500/437408/5a6c7074.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Lucerna Mexicali [](https://www.expedia.com/Mexicali-Hotels-Hotel-Lucerna-Mexicali.h437408.Hotel-Information) Mexicali 9.2/10 Wonderful (1,561 reviews) "Stay very pleasant. Restaurant on premises was excellent." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jose 5 days ago $110 nightly $125 total May 3 - May 4 Total with taxes and fees [](https://www.expedia.com/Mexicali-Hotels-Hotel-Lucerna-Mexicali.h437408.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/610000/600500/600405/f3959466.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/610000/600500/600405/8e09f6a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite Ejecutiva King | Living area | 32-inch flat-screen TV with satellite channels, TV](https://images.trvl-media.com/lodging/1000000/610000/600500/600405/fa2419f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite Ejecutiva King | Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/610000/600500/600405/4ffb0763.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Real Inn Mexicali [](https://www.expedia.com/Mexicali-Hotels-Real-Inn-Mexicali.h600405.Hotel-Information) Civic Center 8.2/10 Very Good (1,666 reviews) "The room was very clean. The pool was good." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maria 19 days ago $81 nightly $91 total May 3 - May 4 Total with taxes and fees [](https://www.expedia.com/Mexicali-Hotels-Real-Inn-Mexicali.h600405.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/45000000/44950000/44945400/44945342/d08d8cef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/45000000/44950000/44945400/44945342/0cad0e57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/45000000/44950000/44945400/44945342/62099386.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/45000000/44950000/44945400/44945342/w3995h2667x0y0-4074ca3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### City Express Plus by Marriott Mexicali [](https://www.expedia.com/Mexicali-Hotels-City-Express-Plus-Mexicali.h44945342.Hotel-Information) Mexicali 8.6/10 Excellent (1,003 reviews) "Clean , safe and good was delicious." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Claudia 11 hours ago $88 nightly $99 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Mexicali-Hotels-City-Express-Plus-Mexicali.h44945342.Hotel-Information) ![Interior detail](https://images.trvl-media.com/lodging/18000000/17970000/17969200/17969178/8413905f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/18000000/17970000/17969200/17969178/5a8679ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds | Desk, blackout drapes, bed sheets](https://images.trvl-media.com/lodging/18000000/17970000/17969200/17969178/656b3a54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 8:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/18000000/17970000/17969200/17969178/4c46b9cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Extended Suites Mexicali Cataviña [](https://www.expedia.com/Mexicali-Hotels-Extended-Suites-Mexicali-Catavina.h17969178.Hotel-Information) Mexicali 8.0/10 Very Good (2,333 reviews) "Room are always very clean My husband. My self always stay here." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alma 14 days ago $50 nightly $60 total Apr 19 - Apr 20 Total with taxes and fees [](https://www.expedia.com/Mexicali-Hotels-Extended-Suites-Mexicali-Catavina.h17969178.Hotel-Information) ![Daily buffet breakfast for a fee](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152269/48bb48a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152269/14bd10ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152269/3134e983.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business center](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152269/0b1abeec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fiesta Inn Mexicali [](https://www.expedia.com/Mexicali-Hotels-Fiesta-Inn-Mexicali.h1152269.Hotel-Information) Civic Center 8.4/10 Very Good (1,009 reviews) "The new bar remodel works great!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Luis 1 day ago $90 nightly $102 total Apr 25 - Apr 26 Total with taxes and fees [](https://www.expedia.com/Mexicali-Hotels-Fiesta-Inn-Mexicali.h1152269.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/34000000/33640000/33638200/33638137/a02730fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/34000000/33640000/33638200/33638137/586cc6c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 7:00 AM to 10:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/34000000/33640000/33638200/33638137/28a69af3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/34000000/33640000/33638200/33638137/880c2ba5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Mexicali [](https://www.expedia.com/Mexicali-Hotels-Fairfield-Inn-Suites-By-Marriott-Mexicali.h33638137.Hotel-Information) Mexicali 9.6/10 Exceptional (1,009 reviews) "The receptionist have always been kind enough to assist me or offer other options." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ivan 4 days ago $110 nightly $124 total May 1 - May 2 Total with taxes and fees [](https://www.expedia.com/Mexicali-Hotels-Fairfield-Inn-Suites-By-Marriott-Mexicali.h33638137.Hotel-Information) ![TV](https://images.trvl-media.com/lodging/1000000/920000/916300/916204/33d78c31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/920000/916300/916204/df5fc8d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/920000/916300/916204/d898e4f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/920000/916300/916204/f2c1f75c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Colonial Mexicali [](https://www.expedia.com/Mexicali-Hotels-Hotel-Colonial-Mexicali.h916204.Hotel-Information) Civic Center 7.8/10 Good (1,006 reviews) "Is was good the hotel." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael James October 27th, 2025 $80 nightly $90 total Apr 19 - Apr 20 Total with taxes and fees [](https://www.expedia.com/Mexicali-Hotels-Hotel-Colonial-Mexicali.h916204.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/9000000/8750000/8747200/8747120/744c9a61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch and dinner served, Mexican cuisine](https://images.trvl-media.com/lodging/9000000/8750000/8747200/8747120/065d731c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/9000000/8750000/8747200/8747120/95c01e21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Room, Non Smoking, City View | Desk, laptop workspace, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/9000000/8750000/8747200/8747120/ad6c2bfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel del Norte [](https://www.expedia.com/Mexicali-Hotels-Hotel-Del-Norte.h8747120.Hotel-Information) Mexicali Historic Center 8.2/10 Very Good (1,002 reviews) "The AC was worked great." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christy 24 days ago $53 nightly $65 total Apr 9 - Apr 10 Total with taxes and fees [](https://www.expedia.com/Mexicali-Hotels-Hotel-Del-Norte.h8747120.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/2000000/1670000/1661300/1661225/a79edbbe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/2000000/1670000/1661300/1661225/d67d6079.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 Queen Bed | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1670000/1661300/1661225/009d8f30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1670000/1661300/1661225/1b3d0904.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### City Express by Marriott Mexicali [](https://www.expedia.com/Mexicali-Hotels-City-Express-Mexicali.h1661225.Hotel-Information) Mexicali 8.4/10 Very Good (1,002 reviews) "Very friendly, clean and food was good and convenient." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Patty 4 days ago $85 nightly $97 total May 8 - May 9 Total with taxes and fees [](https://www.expedia.com/Mexicali-Hotels-City-Express-Mexicali.h1661225.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/22600/22599/2e8db822.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food and drink](https://images.trvl-media.com/lodging/1000000/30000/22600/22599/da930419.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gym](https://images.trvl-media.com/lodging/1000000/30000/22600/22599/w2994h1998x6y0-159f4237.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Double Room | In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/30000/22600/22599/ecfa586d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Calafia Hotel [](https://www.expedia.com/Mexicali-Hotels-Calafia-Hotel.h22599.Hotel-Information) Mexicali 8.4/10 Very Good (1,006 reviews) "Positive pet friendly, easy check in and out." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christian 1 day ago $83 nightly $94 total May 4 - May 5 Total with taxes and fees [](https://www.expedia.com/Mexicali-Hotels-Calafia-Hotel.h22599.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/71000000/70920000/70919700/70919640/35c16f11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/71000000/70920000/70919700/70919640/e9d53767.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, Multiple Beds | In-room safe, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/71000000/70920000/70919700/70919640/e49e64aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/71000000/70920000/70919700/70919640/1f83fcf4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Mexicali [](https://www.expedia.com/Mexicali-Hotels-Courtyard-By-Marriott-Mexicali.h70919640.Hotel-Information) Mexicali 9.4/10 Exceptional (923 reviews) "The hotel was clean. Shower were comfortable." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dustin 22 days ago $122 nightly $138 total May 8 - May 9 Total with taxes and fees [](https://www.expedia.com/Mexicali-Hotels-Courtyard-By-Marriott-Mexicali.h70919640.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/13000000/12510000/12506500/12506422/107aba98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/13000000/12510000/12506500/12506422/d5c9e706.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/13000000/12510000/12506500/12506422/b6aa67b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/13000000/12510000/12506500/12506422/7f649732.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Mexicali by IHG [](https://www.expedia.com/Mexicali-Hotels-Holiday-Inn-Express-Suites-Mexicali.h12506422.Hotel-Information) Mexicali 9.4/10 Exceptional (1,005 reviews) "Very clean room. Continental breakfast was excellent. We stay here often." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) AURELIA 17 hours ago $133 nightly $150 total Apr 10 - Apr 11 Total with taxes and fees [](https://www.expedia.com/Mexicali-Hotels-Holiday-Inn-Express-Suites-Mexicali.h12506422.Hotel-Information) ![Interior entrance](https://images.trvl-media.com/lodging/25000000/24090000/24081400/24081334/9bc6d08f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/25000000/24090000/24081400/24081334/90810982.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/25000000/24090000/24081400/24081334/7c858064.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Double Beds, Non Smoking | Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/25000000/24090000/24081400/24081334/e0f97674.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn Mexicali [](https://www.expedia.com/Mexicali-Hotels-Sleep-Inn-Mexicali.h24081334.Hotel-Information) Mexicali 8.2/10 Very Good (1,000 reviews) "Cool rooms , good staff, good breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alfonso 7 days ago [](https://www.expedia.com/Mexicali-Hotels-Sleep-Inn-Mexicali.h24081334.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/19000000/18310000/18301100/18301092/e443b787.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/19000000/18310000/18301100/18301092/51dae268.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/19000000/18310000/18301100/18301092/ee9d5f67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Habitacion ejecutiva, dos camas | Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/19000000/18310000/18301100/18301092/179fc335.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Siesta Real [](https://www.expedia.com/Mexicali-Hotels-Hotel-Siesta-Real.h18301092.Hotel-Information) Mexicali 8.2/10 Very Good (978 reviews) "Parking was close to the room great when you have kids." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) ARACELI 9 days ago $60 nightly $68 total Apr 8 - Apr 9 Total with taxes and fees [](https://www.expedia.com/Mexicali-Hotels-Hotel-Siesta-Real.h18301092.Hotel-Information) ![Business center](https://images.trvl-media.com/lodging/18000000/17580000/17577200/17577142/92dcdd98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17580000/17577200/17577142/e8a107f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room, 2 Twin Beds | Premium bedding, in-room safe, desk, free WiFi](https://images.trvl-media.com/lodging/18000000/17580000/17577200/17577142/3e808561.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17580000/17577200/17577142/4a767773.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### One Mexicali [](https://www.expedia.com/Mexicali-Hotels-One-Mexicali.h17577142.Hotel-Information) Mexicali 7.8/10 Good (1,005 reviews) "Breakfast was delicious and it had several choices to pick." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Abraham October 23rd, 2025 $66 nightly $75 total Apr 25 - Apr 26 Total with taxes and fees [](https://www.expedia.com/Mexicali-Hotels-One-Mexicali.h17577142.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/11000000/10080000/10071600/10071570/a231704b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room | Iron/ironing board, free WiFi, wheelchair access](https://images.trvl-media.com/lodging/11000000/10080000/10071600/10071570/f5fe57d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room | Iron/ironing board, free WiFi, wheelchair access](https://images.trvl-media.com/lodging/11000000/10080000/10071600/10071570/49970db3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and lunch served, Mexican cuisine](https://images.trvl-media.com/lodging/11000000/10080000/10071600/10071570/a296e352.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Azteca de Oro Mexicali [](https://www.expedia.com/Mexicali-Hotels-Azteca-De-Oro-Mexicali.h10071570.Hotel-Information) Mexicali 7.8/10 Good (481 reviews) "Convenient good restaurant on site." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) gilbert November 13th, 2025 $48 nightly $54 total Apr 13 - Apr 14 Total with taxes and fees [](https://www.expedia.com/Mexicali-Hotels-Azteca-De-Oro-Mexicali.h10071570.Hotel-Information) ![Deluxe Suite, Jetted Tub | Laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/103000000/102640000/102634000/102634000/6cf93e89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, Jetted Tub | Laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/103000000/102640000/102634000/102634000/0d0da065.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/103000000/102640000/102634000/102634000/6dadaf5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, Jetted Tub | Laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/103000000/102640000/102634000/102634000/f7d40172.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel Cies [](https://www.expedia.com/Mexicali-Hotels-Motel-Cies.h102634000.Hotel-Information) Mexicali 9.2/10 Wonderful (63 reviews) "Great place to stay awesome service." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Arturo $63 nightly $74 total Apr 13 - Apr 14 Total with taxes and fees [](https://www.expedia.com/Mexicali-Hotels-Motel-Cies.h102634000.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/19000000/18310000/18300200/18300174/19520a8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/19000000/18310000/18300200/18300174/88f0140c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/19000000/18310000/18300200/18300174/83c60fc8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18310000/18300200/18300174/94f4887b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Cosmos Don Carlos [](https://www.expedia.com/Mexicali-Hotels-Hotel-Cosmos-Don-Carlos.h18300174.Hotel-Information) Mexicali 8.0/10 Very Good (519 reviews) "Room was very clean no complaints at all. Good place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) gerardo 16 days ago $38 nightly $43 total Apr 11 - Apr 12 Total with taxes and fees [](https://www.expedia.com/Mexicali-Hotels-Hotel-Cosmos-Don-Carlos.h18300174.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/5000000/4620000/4610900/4610858/fbfdde79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/5000000/4620000/4610900/4610858/3b84677b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/5000000/4620000/4610900/4610858/9d3ebf35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/5000000/4620000/4610900/4610858/df417812.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### City Express Junior by Marriott Mexicali [](https://www.expedia.com/Mexicali-Hotels-City-Express-Junior-Mexicali.h4610858.Hotel-Information) Mexicali 8.0/10 Very Good (1,001 reviews) "Clean, fresh breakfast, everything was good." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) SANTIAGO 7 days ago $75 nightly $85 total Apr 8 - Apr 9 Total with taxes and fees [](https://www.expedia.com/Mexicali-Hotels-City-Express-Junior-Mexicali.h4610858.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-21&endDate=2026-04-22®ionId=553248635975869828&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Isabel-Hotels.d553248635975869828.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Isabel-Hotels.d553248635975869828.Travel-Guide-Hotels) ## Top Santa Isabel Hotel Reviews ![Extended Suites Mexicali Cataviña](https://images.trvl-media.com/lodging/18000000/17970000/17969200/17969178/8413905f_y.jpg) ### Extended Suites Mexicali Cataviña 10/10 Excellent "Room was cleaned AC was fresh " [](https://expedia.com/Mexicali-Hotels-Extended-Suites-Mexicali-Catavina.h17969178.Hotel-Information) ![City Express Plus by Marriott Mexicali](https://images.trvl-media.com/lodging/45000000/44950000/44945400/44945342/d08d8cef_y.jpg) ### City Express Plus by Marriott Mexicali 10/10 Excellent "Clean , safe and good was delicious" [](https://expedia.com/Mexicali-Hotels-City-Express-Plus-Mexicali.h44945342.Hotel-Information) ![Hotel Colonial Mexicali](https://images.trvl-media.com/lodging/1000000/920000/916300/916204/33d78c31_y.jpg) ### Hotel Colonial Mexicali 8/10 Good "Clean but very very very old towels" [](https://expedia.com/Mexicali-Hotels-Hotel-Colonial-Mexicali.h916204.Hotel-Information) ![Courtyard by Marriott Mexicali](https://images.trvl-media.com/lodging/71000000/70920000/70919700/70919640/35c16f11_y.jpg) ### Courtyard by Marriott Mexicali 10/10 Excellent "Clean room" [](https://expedia.com/Mexicali-Hotels-Courtyard-By-Marriott-Mexicali.h70919640.Hotel-Information) ![Hotel Lucerna Mexicali](https://images.trvl-media.com/lodging/1000000/440000/437500/437408/b85b0cb3_y.jpg) ### Hotel Lucerna Mexicali 10/10 Excellent "Buena eatamcia" [](https://expedia.com/Mexicali-Hotels-Hotel-Lucerna-Mexicali.h437408.Hotel-Information) ![Holiday Inn Express & Suites Mexicali by IHG](https://images.trvl-media.com/lodging/13000000/12510000/12506500/12506422/107aba98_y.jpg) ### Holiday Inn Express & Suites Mexicali by IHG 10/10 Excellent "Very clean room. Continental breakfast was excellent. We stay here often. " [](https://expedia.com/Mexicali-Hotels-Holiday-Inn-Express-Suites-Mexicali.h12506422.Hotel-Information) ![Fiesta Inn Mexicali](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152269/48bb48a1_y.jpg) ### Fiesta Inn Mexicali 10/10 Excellent "The new bar remodel works great!! Congratulations " [](https://expedia.com/Mexicali-Hotels-Fiesta-Inn-Mexicali.h1152269.Hotel-Information) ![Hotel Araiza Mexicali](https://images.trvl-media.com/lodging/1000000/30000/22600/22592/c02f77f8_y.jpg) ### Hotel Araiza Mexicali 10/10 Excellent "Wonderful staff, comfortable rooms. The finest lodging in Mexicali " [](https://expedia.com/Mexicali-Hotels-Hotel-Araiza-Mexicali.h22592.Hotel-Information) ![Hotel Siesta Real](https://images.trvl-media.com/lodging/19000000/18310000/18301100/18301092/e443b787_y.jpg) ### Hotel Siesta Real 10/10 Excellent "Great location and clean rooms" [](https://expedia.com/Mexicali-Hotels-Hotel-Siesta-Real.h18301092.Hotel-Information) ## More cheap stays in Santa Isabel ![Motel Las Fuentes](https://images.trvl-media.com/lodging/19000000/18760000/18760000/18759923/2c4a970b_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Motel Las Fuentes Blvd Lopez Mateos 1655 Mexicali BC $33 nightly $40 total Apr 10 - Apr 11 Total with taxes and fees 8/10 Very Good! (159 reviews) [](https://expedia.com/Mexicali-Hotels-Motel-Las-Fuentes.h18759923.Hotel-Information) ![Hotel Misión Plaza Mexicali](https://images.trvl-media.com/lodging/102000000/101490000/101486400/101486351/5a73a5c7_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Misión Plaza Mexicali 366 Av. Francisco I. Madero Mexicali BC [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F21%2F2026&endDate=4%2F22%2F2026&selected=101486351&PinnedHotelID=101486351&HadPinnedHotel=true®ionId=553248635975869828) 7.2/10 Good! (54 reviews) [](https://expedia.com/Tijuana-Hotels-Hotel-Mision-Plaza-Mexicali.h101486351.Hotel-Information) ![Motel Kiss](https://images.trvl-media.com/lodging/17000000/16500000/16490500/16490424/5c14c763_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Motel Kiss Carretera a Aeropuerto 4300 Mexicali BC [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F21%2F2026&endDate=4%2F22%2F2026&selected=16490424&PinnedHotelID=16490424&HadPinnedHotel=true®ionId=553248635975869828) 7.8/10 Good! (179 reviews) [](https://expedia.com/Mexicali-Hotels-Motel-Fronorte-Adults-Only.h16490424.Hotel-Information) ![HOTEL DON QUIJOTE](https://images.trvl-media.com/lodging/112000000/111350000/111343500/111343437/6318d665_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### HOTEL DON QUIJOTE Calz Independencia Independencia Mexicali BC [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F21%2F2026&endDate=4%2F22%2F2026&selected=111343437&PinnedHotelID=111343437&HadPinnedHotel=true®ionId=553248635975869828) [](https://expedia.com/Mexicali-Hotels-HOTEL-DON-QUIJOTE.h111343437.Hotel-Information) ![Motel Las Dunas](https://images.trvl-media.com/lodging/25000000/24320000/24316400/24316345/24aa1208_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Motel Las Dunas Calle Rio Culiacan s/n, Compuertas Mexicali BC [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F21%2F2026&endDate=4%2F22%2F2026&selected=24316345&PinnedHotelID=24316345&HadPinnedHotel=true®ionId=553248635975869828) 7.6/10 Good! (38 reviews) [](https://expedia.com/Mexicali-Hotels-Motel-Las-Dunas.h24316345.Hotel-Information) ![Casa Movil tipo estudio](https://images.trvl-media.com/lodging/116000000/115010000/115009100/115009033/c481d718_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Casa Movil tipo estudio Sierra Sta Clara Sur Lomas de Abasolo Mexicali BC [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F21%2F2026&endDate=4%2F22%2F2026&selected=115009033&PinnedHotelID=115009033&HadPinnedHotel=true®ionId=553248635975869828) [](https://expedia.com/Mexicali-Hotels-Casa-Movil-Tipo-Estudio.h115009033.Hotel-Information) ## Find out more about Santa Isabel ### Top reasons to visit Santa Isabel - **Outdoor Adventures:** Enjoy nature walks and hiking in the picturesque landscapes surrounding Santa Isabel. - **Family-Friendly Activities:** The recreational area and recreation center offer fun for visitors of all ages. - **Rich Cultural Experience:** Explore local museums and historic buildings that highlight the region's vibrant culture. - **Charming Neighborhoods:** Experience the warmth and friendliness of local culture in vibrant neighborhoods. - **Relaxing Beaches:** Unwind on beautiful beaches, soaking up the sun and enjoying the serene atmosphere. ### Find great hotels near Santa Isabel Experience the charm of Santa Isabel in Mexicali, Baja California, with a variety of hotel accommodations designed for every traveler. From eco-certified resorts to business-friendly hotels, you’ll find options that cater to your needs. Whether you're looking for the best hotels like Hotel Santa Isabel, Hotel Las Vegas, or Habaguanex, you’re sure to enjoy a warm, welcoming atmosphere, including LGBTQIA-friendly options for a memorable stay. - **[Real Inn Mexicali: ](https://www.expedia.com/Mexicali-Hotels-Real-Inn-Mexicali.h600405.Hotel-Information)** Real Inn Mexicali is a 3.5-star hotel, boasting a solid guest rating of 8.2, making it an excellent choice for eco-conscious travelers. Located 6 miles from Santa Isabel, this property is eco-certified, ensuring that your stay is not only comfortable but also environmentally friendly. The hotel features well-appointed rooms suited for business travelers, complete with modern amenities, a business center, and meeting facilities. Guests appreciate the focus on sustainability, along with friendly service and a relaxing atmosphere, perfect for unwinding after a busy day. - **[Fiesta Inn Mexicali: ](https://www.expedia.com/Mexicali-Hotels-Fiesta-Inn-Mexicali.h1152269.Hotel-Information)** With a guest rating of 8.4, Fiesta Inn Mexicali is a 3.5-star hotel that caters primarily to business travelers, located 6 miles from Santa Isabel. This hotel offers a sleek, modern design paired with essential amenities such as high-speed internet, a business center, and comfortable meeting spaces. Guests enjoy the on-site restaurant that serves a variety of delicious meals, along with a fitness center for those looking to maintain their workout routine. The welcoming atmosphere and attentive staff make it an ideal base for both work and leisure. - **[Hotel del Norte: ](https://www.expedia.com/Mexicali-Hotels-Hotel-Del-Norte.h8747120.Hotel-Information)** Hotel del Norte is a 3-star hotel with a guest rating of 8.2, situated 5 miles from Santa Isabel in the heart of the city. This property features a vibrant city theme, making it perfect for travelers eager to explore the urban landscape. With its convenient location, guests have easy access to local attractions, dining, and shopping. The hotel offers comfortable accommodations alongside essential amenities that cater to business travelers, including Wi-Fi and meeting facilities. Its friendly environment and city-centric vibe make it a great choice for both work and play. ### Where to stay in Santa Isabel Santa Isabel offers a charming blend of family-friendly activities and outdoor adventures. Explore the picturesque landscapes surrounding the village, perfect for hiking and enjoying nature. Nearby, discover vibrant neighborhoods that showcase the warmth of local culture and friendly people. Don't miss the chance to relax on the beautiful beaches of the region, where you can soak up the sun and unwind. Whether you're seeking recreation or a taste of local life, Santa Isabel has something for everyone. - **[Mexicali: ](https://www.expedia.com/Mexicali-Hotels.d2478.Travel-Guide-Hotels)** As the capital city of Baja California, Mexicali offers a vibrant atmosphere that beautifully blends urban life with cultural experiences. Located in the heart of the region, Santa Isabel is nestled within this bustling city. Visitors flock to Mexicali for family-friendly activities, business ventures, and city-themed exploration. Key highlights include expansive shopping malls and lively entertainment arenas, perfect for an afternoon of fun. Sports enthusiasts will appreciate the local stadiums and convention centers, which host a variety of events throughout the year. With a peak in visitor numbers from March to July, Mexicali is an inviting destination year-round. - **[Mexicali Historic Center: ](https://www.expedia.com/Mexicali-Historic-Center-Mexicali-Hotels.0-n901234610068078592-0.Travel-Guide-Filter-Hotels)** Just 5 miles from Santa Isabel, the Mexicali Historic Center offers a glimpse into the city's rich cultural past. This neighborhood is a treasure trove of museums and symbolic landmarks that reflect the heritage of the region. While visitor numbers are highest from October to December, the Historic Center remains an engaging destination at any time of the year. Travelers seeking a deep dive into local culture will find this area irresistible, as it combines historical charm with modern conveniences. - **[Civic Center: ](https://www.expedia.com/Civic-Center-Mexicali-Hotels.0-n6336107-0.Travel-Guide-Filter-Hotels)** Located 6 miles from Santa Isabel, the Civic Center is a bustling neighborhood that caters to families, business travelers, and city explorers alike. The area is known for its shopping centers and entertainment venues, making it an ideal spot for a day out. Visitors can enjoy the local stadium and convention center, as well as historic buildings that add character to the landscape. With peak tourist activity from October to December, the Civic Center offers a lively atmosphere filled with opportunities for enjoyment and discovery. ### Things to do in Santa Isabel Santa Isabel offers a delightful mix of family-friendly activities and outdoor adventures, making it an ideal vacation spot. Visitors can enjoy the recreational area and recreation center, perfect for leisure and fun. Nature walks provide a chance to explore the beautiful surroundings, while the former mansion adds a touch of history to your visit. Experience the charm and local culture as you explore this vibrant community in Mexicali, Baja California. **Shopping** In Santa Isabel, enjoy local shops and markets for unique souvenirs and gifts. If you're up for a drive, visit Plaza Cachanilla, located 10 miles away, featuring a mix of retail stores, dining options, and entertainment. It's a great spot for shopping and experiencing local culture. **Recreation** In Santa Isabel, indulge in rejuvenating therapies at local wellness retreats, where holistic treatments blend with serene desert landscapes. Enjoy yoga sessions and guided meditations that connect you with nature, while nearby hiking trails offer invigorating outdoor activities for a refreshing escape from daily routines. **Adventure** Explore the stunning landscapes of Sierra de los Cucapah, perfect for hiking and mountain biking. Experience thrilling off-road adventures in the surrounding desert, or try your hand at rock climbing for a breathtaking view of the area. Don't miss the rich local culture and delicious cuisine. **Nightlife** In Santa Isabel, the vibrant nightlife offers lively bars and local music venues, perfect for soaking up the atmosphere. Grab a drink at a local cantina, enjoy live mariachi performances, or dance the night away at a nearby club, immersing yourself in the unique culture of Mexicali. \*Distances are measured in a straight line; actual driving distances may vary depending on the route. ### Booking tips and Expedia advantages for Santa Isabel - **The most and least expensive months on average to stay in a hotel:** The cheapest months to stay in Santa Isabel are July to September, where the prices are slightly lower. This is in comparison to February to March and May, where prices are slightly higher. - **The most and least expensive days on average to stay in a hotel:** The least expensive day to stay in Santa Isabel is Sunday. The most expensive day to stay in Santa Isabel is Saturday. - **Find cheap hotels on Expedia:** Utilize Expedia’s search tool to narrow down your options based on your budget, preferred location, and desired hotel type. To find the best prices and deals, simply arrange the price filter from lowest to highest. - **Consider bundling your trip:** You can save money by combining your Santa Isabel hotel reservation with your flights and activities when you book an Expedia package. ### Find the best attractions near Santa Isabel Santa Isabel offers a delightful blend of family-friendly activities and outdoor adventures, making it perfect for a memorable vacation. Visitors can explore a variety of civic and historic buildings, as well as local museums that showcase the region's rich culture and history. Whether you're seeking a cultural experience or outdoor fun, Santa Isabel has something for everyone to enjoy. - **[Mexicali Border Port I: ](https://www.expedia.com/Mexicali-Border-Port-I-Hotels.0-l553248635998150182-0.Travel-Guide-Filter-Hotels)** Experience the bustling atmosphere of Mexicali Border Port I, located a mere 5 miles from Santa Isabel. This civic site serves as a significant gateway between the U.S. and Mexico, showcasing the vibrant exchange of cultures and commerce. - **[Vicente Guerrero Park: ](https://www.expedia.com/Vicente-Guerrero-Park-Hotels.0-l553248621551385135-0.Travel-Guide-Filter-Hotels)** Enjoy a family-friendly atmosphere at Vicente Guerrero Park, 6 miles away from Santa Isabel. This urban park is perfect for outdoor activities, offering lush landscapes and recreational facilities that invite relaxation and fun for all ages. - **[State Center for the Arts (CEART): ](https://www.expedia.com/State-Center-For-The-Arts-Hotels.0-l553248621551385137-0.Travel-Guide-Filter-Hotels)** Immerse yourself in the rich culture at the State Center for the Arts (CEART), located 5 miles from Santa Isabel. This arts center hosts various exhibitions and performances, celebrating local and international artistry in a stunning architectural setting. ### The nearest major airports for your trip to Santa Isabel Traveling to Santa Isabel, Mexicali, Baja California, offers mult[IPL](https://www.expedia.com/Imperial-County-Airport-Hotels.0-aIPL-0.Travel-Guide-Filter-Hotels)e airport options. [TIJ](https://www.expedia.com/General-Abelardo-L-Rodriguez-Intl-Airport-Hotels.0-aTIJ-0.Travel-Guide-Filter-Hotels)uana International Airport (TIJ) is 82 miles away, with hotels like Real Inn Tijuana and [Quartz Hotel & SPA](https://www.expedia.com/Tijuana-Hotels-Quartz-Hotel-SPA.h36996325.Hotel-Information), both just 3 miles from the airport. Mexicali International Airport ([MXL](https://www.expedia.com/General-Rodolfo-Sanchez-Taboada-Intl-Airport-Hotels.0-aMXL-0.Travel-Guide-Filter-Hotels)) is much closer, located 19 miles from Santa Isabel, with nearby accommodations such as Courtyard by Marriott and Holiday Inn Express & Suites, approximately 9 to 10 miles away. Additionally, [YUM](https://www.expedia.com/Yuma-Intl-Airport-Hotels.0-aYUM-0.Travel-Guide-Filter-Hotels)a International Airport (YUM) is 57 miles away, featuring hotels like [Radisson Hotel Yuma](https://www.expedia.com/Yuma-Hotels-Radisson-Hotel-Yuma.h2409993.Hotel-Information), located 3 miles from the airport. Each hotel provides various transportation services to facilitate your travel to these airports. ## Frequently asked questions ### What is the best area to stay in Santa Isabel? > This area is the commercial and administrative heart of Santa Isabel, offering a concentrated selection of hotels, restaurants, and shops. It's well-connected and provides easy access to the city's main public buildings and services. While not a tourist destination in itself, it's a practical base for travelers passing through or conducting business. > > > For solo travelers, staying in the city center provides convenience for dining and accessing transportation. You'll find a variety of local eateries and coffee shops within walking distance, making it easy to grab a meal or a quick coffee before heading out. > > > Business travelers will find the city center particularly suitable due to its proximity to government offices and corporate spaces. ### When is the best time to go to Santa Isabel? > These seasons offer pleasant weather with comfortable temperatures and less humidity, making it ideal for exploring the area's natural beauty and enjoying outdoor activities. You'll find the climate just right for relaxing on the beaches or engaging in water sports without the intense heat of summer or the cooler temperatures of winter. > > > For couples looking for a tranquil getaway, these shoulder seasons provide a more relaxed experience with fewer crowds. You can enjoy quiet walks along the coastline, explore local eateries, and take in the scenic views without feeling rushed. It's an excellent time for those who appreciate a calm and unhurried vacation pace. > > > Travelers interested in outdoor adventures will also find these times perfect. The conditions are favorable for activities like fishing, kayaking, or simply enjoying the ocean breeze. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Santa Isabel hotel booking with Expedia? > \*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo. ### How much is the nightly rate at a Santa Isabel hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - More ways to book - [Hotels near Lucerna ](https://www.expedia.com/Lucerna-Mexicali-Hotels.0-n553248635976008646-0.Travel-Guide-Filter-Hotels) - [Hotels near Mexicali Border Port I ](https://www.expedia.com/Mexicali-Border-Port-I-Hotels.0-l553248635998150182-0.Travel-Guide-Filter-Hotels) - [Hotels near Hospital de las Californias ](https://www.expedia.com/Hospital-De-Las-Californias-Hotels.0-l553248635998002053-0.Travel-Guide-Filter-Hotels) - [Hotels near City Forest and Zoo ](https://www.expedia.com/City-Forest-And-Zoo-Hotels.0-l6224745-0.Travel-Guide-Filter-Hotels) - [Hotels near House of Culture ](https://www.expedia.com/House-Of-Culture-Hotels.0-l553248621551385141-0.Travel-Guide-Filter-Hotels) - [Hotels near Secretary of Foreign Relations ](https://www.expedia.com/Secretary-Of-Foreign-Relations-Hotels.0-l690860151814795264-0.Travel-Guide-Filter-Hotels) - 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