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Find Resorts & Hotels with Spas in Seneca, SC

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Pick from 67 Seneca Resorts & Hotels with Spas and compare room rates, reviews, and availability. Most hotels are fully refundable.

Beach nearby, sun loungers, beach towels
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
10.0 out of 10, Exceptional, (65)
"This was my 2nd time using the property for my company ELT (Executive Leadership Team) offsite. My team enjoyed the house and amenities. Most of our meetings were held in the screened in porch. Having the calming water views was a huge bonus. Several team members have requested we return for our July or October ELT."
The price is $795
$1,613 total
includes taxes & fees
May 23 - May 24
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
Property grounds
Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub
10.0 out of 10, Exceptional, (26)
"The house was beautiful and accommodating for our family. Was a little disappointed in the cleanliness of the house and the driveway was difficult. Enjoyed our stay!!"
Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub
Exterior
Lake Keowee/Clemson Vacation Home for Family, Friends & Football WINTER DEALS!
10.0 out of 10, Exceptional, (93)
"We thoroughly enjoyed this home. Everything we could have needed was provided."
Lake Keowee/Clemson Vacation Home for Family, Friends & Football WINTER DEALS!
Terrace/patio
Tru by Hilton Seneca Clemson
2.5 star property
9.2 out of 10, Wonderful, (568)
"Clean and comfortable. Seems newer than some of the other Clemson area properties. Good water pressure and updated bathroom. Allows dogs and seems walkable to Death Valley. Across the street from Clemsons rec area by the lake. "
The price is $116
$128 total
includes taxes & fees
May 28 - May 29
Tru by Hilton Seneca Clemson
Property grounds
What a family lake house should be! Natural Beauty w/ space for each to enjoy!!!
9.2 out of 10, Wonderful, (22)
"House was wonderful and just as described. Mary Kate went above and beyond to answer any questions and quickly resolve any issues we had. The layout of the house and all furnishings (including beds) were perfect! Loved having the dock for our boat rental."
What a family lake house should be! Natural Beauty w/ space for each to enjoy!!!
Aerial view
Lakeside Lodge Clemson
2.5 star property
9.0 out of 10, Wonderful, (605)
"Great two night stay. The bartenders were awesome!! Amazing tequila and Manhattan! The room (1 BR with kitchen) was clean and comfortable. I am staying at LL again this upcoming week... Looking very forward to another good trip."
The price is $109
$133 total
includes taxes & fees
May 22 - May 23
Lakeside Lodge Clemson
Lobby
Best Western Seneca-Clemson
2.5 star property
8.4 out of 10, Very Good, (519)
"Very nice and convenient location to the university. "
The price is $99
$108 total
includes taxes & fees
Jun 11 - Jun 12
Best Western Seneca-Clemson
Property grounds
Incredible 10 BR home with pool and hot tub
Incredible 10 BR home with pool and hot tub
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See all available properties in Seneca
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Seneca Resorts & Hotels with Spas information

 

Resorts & Hotels with Spas in Seneca

67

Highest price
$795
Cheapest price
$99
Number of guest reviews
1,874
Total number of hotels in Seneca
1,485

 

Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the lakeside setting in Seneca - worth a picture or two! Be sure to enjoy the coffeehouses during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Seneca?
Hampton Inn & Suites Seneca-Clemson Area, SC is a top spa hotel featuring a pool and a 24-hour fitness center.
How many spa hotels will I find in Seneca?
Among Expedia’s 147 accommodation options in Seneca, there is 1 spa hotel.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Lake Keowee, Keowee Key Golf Course, and Lake Hartwell. If you have some spare time during your trip, you might want to check out Keowee Reservoir and Littlejohn Coliseum.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services including couples massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.

Recent reviews of Seneca hotels
Expedia verified reviews

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

5/5 Excellent
"As expected "
A verified traveler stayed at Hampton Inn & Suites Seneca-Clemson Area
Posted 6 days ago
Hampton Inn & Suites Seneca-Clemson Area