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Find Resorts & Hotels with Spas in Seneca, SC

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Top Seneca Resorts & Hotels with Spas

Our top choices for Seneca hotels with a spa

Lakeside Lodge Clemson

2.5 star property
9.0 out of 10, Wonderful, (1001)
"Great place!"
$124 nightly
The price is $137
Aug 31 - Sep 1
Total with taxes and fees
Lakeside Lodge Clemson

Tru by Hilton Seneca Clemson

2.5 star property
9.2 out of 10, Wonderful, (763)
"Staff and property were top-notch! "
$115 nightly
The price is $127
Sep 14 - Sep 15
Total with taxes and fees
Tru by Hilton Seneca Clemson

Quality Inn Seneca Clemson Area US-123

2.5 star property
8.0 out of 10, Very Good, (633)
"Ok hotel for a quick stay "
$90 nightly
The price is $98
Sep 7 - Sep 8
Total with taxes and fees
Quality Inn Seneca Clemson Area US-123

Days Inn by Wyndham Seneca / Clemson Area

2.0 star property
6.8 out of 10, (693)
"The property was near the area that I needed to be in. It has ample shops and restaurants in the area "
$71 nightly
The price is $79
Sep 8 - Sep 9
Total with taxes and fees
Days Inn by Wyndham Seneca / Clemson Area

Best Western Seneca-Clemson

2.5 star property
8.4 out of 10, Very Good, (602)
"We ABSOLUTELY loved our stay!! Our room was clean!!! The staff was very nice!! Will definitely stay again!!!"
$101 nightly
The price is $111
Sep 7 - Sep 8
Total with taxes and fees
Best Western Seneca-Clemson

Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock

10.0 out of 10, Exceptional, (5)
Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock

5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

10.0 out of 10, Exceptional, (86)
"We had a perfect family vacation on the lake. The layout and design of the property is so thoughtful and well done. There was plenty of space for our large group to spread out, play, and relax. The kitchen is well appointed with everything you need entertain. We could not have had a better time. "
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

Carolina’s Cottage Cove-Lake Keowee

9.6 out of 10, Exceptional, (20)
"We absolutely LOVED this house and would love to stay again! Next time a little longer! "
Carolina’s Cottage Cove-Lake Keowee

Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub

10.0 out of 10, Exceptional, (147)
"Great set up for family Christmas reunion "
Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub

New to VRBO! Big water views, private dock, pool table, 15 min Clemson!

10.0 out of 10, Exceptional, (43)
"Went for Easter holiday with family. Perfect location - nice and quiet. Family all had a good visit. "
New to VRBO! Big water views, private dock, pool table, 15 min Clemson!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Seneca Hotel Reviews

Find out more about Seneca

Find out more about Seneca

Top Seneca attractions for a relaxing vacation

Seneca, South Carolina, offers an enticing blend of natural beauty and relaxation, making it a perfect spot for travelers seeking hotels with spas. Explore the stunning Lake Hartwell, where you can indulge in a leisurely afternoon of fishing or boating, followed by a soothing massage at a nearby spa. The picturesque Oconee State Park provides hiking trails that lead you through lush forests and serene waterfalls, ideal for a refreshing retreat after a day of wellness. For a unique experience, visit the South Carolina Botanical Garden, where you can stroll through beautifully curated landscapes and enjoy the tranquility of nature, setting the perfect mood for a day of pampering. Don’t miss out on the charming downtown area, filled with local boutiques and cafes that invite you to unwind. Consider staying in a hotel near the lakefront where you can enjoy stunning sunset views while planning your next spa treatment, ensuring a restful and rejuvenating getaway.

Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the lakeside setting in Seneca - worth a picture or two! Be sure to enjoy the coffeehouses during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Keowee Reservoir, Lake Keowee, and Keowee Key Golf Course. If you have extra time while you're in the area, you might want to see Lake Hartwell and Oconee County Library Seneca Branch.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services including couples massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.

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