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Top Seneca Resorts & Hotels with Spas

Lakeside Lodge Clemson

2.5 star property
9.0 out of 10, Wonderful, (942)
"Great overall stay."
$112 nightly
The price is $123
Jul 15 - Jul 16
Total includes taxes and fees
Lakeside Lodge Clemson

Tru by Hilton Seneca Clemson

2.5 star property
9.2 out of 10, Wonderful, (735)
"Great overall stay."
$120 nightly
The price is $132
Jul 31 - Aug 1
Total includes taxes and fees
Tru by Hilton Seneca Clemson

Quality Inn Seneca Clemson Area US-123

2.5 star property
8.0 out of 10, Very Good, (609)
"Really good place "
$90 nightly
The price is $98
Jul 21 - Jul 22
Total includes taxes and fees
Quality Inn Seneca Clemson Area US-123

Days Inn by Wyndham Seneca / Clemson Area

2.0 star property
6.8 out of 10, (690)
"The property was near the area that I needed to be in. It has ample shops and restaurants in the area "
$68 nightly
The price is $75
Jul 20 - Jul 21
Total includes taxes and fees
Days Inn by Wyndham Seneca / Clemson Area

Best Western Seneca-Clemson

2.5 star property
8.4 out of 10, Very Good, (594)
"The admission attendant was friendly"
$93 nightly
The price is $102
Jul 21 - Jul 22
Total includes taxes and fees
Best Western Seneca-Clemson

Carolina’s Cottage Cove-Lake Keowee

9.6 out of 10, Exceptional, (19)
"We absolutely LOVED this house and would love to stay again! Next time a little longer! "
Carolina’s Cottage Cove-Lake Keowee

The HART of Tiger Town! Lakefront home less than 4 miles to Clemson University

7.0 out of 10, Good, (2)
"Thank you so much for letting us use your house. One of the guests who has ALS slipped out the shower and broke off the front corner of the lip to the toilet bowl. I have left money in the kitchen drawer to the right of the dishwasher to cover the expense"
The HART of Tiger Town! Lakefront home less than 4 miles to Clemson University

Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub

10.0 out of 10, Exceptional, (144)
"Great set up for family Christmas reunion "
Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub

5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

10.0 out of 10, Exceptional, (84)
"We had a perfect family vacation on the lake. The layout and design of the property is so thoughtful and well done. There was plenty of space for our large group to spread out, play, and relax. The kitchen is well appointed with everything you need entertain. We could not have had a better time. "
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger

9.8 out of 10, Exceptional, (121)
"We were so pleased with this home and our overall stay at this property. The kitchen was very well stocked, it was very spacious, kayaks were such a fun bonus! "
$730 nightly
The price is $803
Jul 17 - Jul 18
Total includes taxes and fees
Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Seneca

Find out more about Seneca

Top Seneca attractions for a relaxing vacation

Seneca, South Carolina, offers an enticing blend of natural beauty and relaxation, making it a perfect spot for travelers seeking hotels with spas. Explore the stunning Lake Hartwell, where you can indulge in a leisurely afternoon of fishing or boating, followed by a soothing massage at a nearby spa. The picturesque Oconee State Park provides hiking trails that lead you through lush forests and serene waterfalls, ideal for a refreshing retreat after a day of wellness. For a unique experience, visit the South Carolina Botanical Garden, where you can stroll through beautifully curated landscapes and enjoy the tranquility of nature, setting the perfect mood for a day of pampering. Don’t miss out on the charming downtown area, filled with local boutiques and cafes that invite you to unwind. Consider staying in a hotel near the lakefront where you can enjoy stunning sunset views while planning your next spa treatment, ensuring a restful and rejuvenating getaway.

Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the lakeside setting in Seneca - worth a picture or two! Be sure to enjoy the coffeehouses during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Seneca?
Hampton Inn & Suites Seneca-Clemson Area, SC is a top spa hotel featuring a pool and a 24-hour fitness center.
How many spa hotels will I find in Seneca?
Among Expedia's 147 accommodation options in Seneca, there is 1 spa hotel.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Lake Keowee, Keowee Key Golf Course, and Lake Hartwell. If you have extra time while you're in the area, you might want to see Oconee County Library Seneca Branch and Keowee Reservoir.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services including couples massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.