Photo by Cindy Keese

Find Resorts & Hotels with Spas in Seneca, SC

Start date: Check-in selected.
To Date
End date: Check-out

Check availability on Seneca Resorts & Hotels with Spas

Top Seneca Resorts & Hotels with Spas

We don't have any properties that match your exact search
See all properties in Seneca

Recommended hotels in Seneca

Lakeside Lodge Clemson
2.5 star property
9.0 out of 10, Wonderful, (1022)
"Very beautiful place to stay"
United States
Steven
$123 nightly
The price is $135
Oct 19 - Oct 20
Total with taxes and fees
Lakeside Lodge Clemson
Quality Inn Seneca Clemson Area US-123
2.5 star property
8.0 out of 10, Very Good, (648)
"Staff was friendly very clean "
United States
Mary
$86 nightly
The price is $94
Oct 26 - Oct 27
Total with taxes and fees
Quality Inn Seneca Clemson Area US-123
Best Western Seneca-Clemson
2.5 star property
8.4 out of 10, Very Good, (622)
"Convenient for Clemson visits."
United States
Kathleen
$85 nightly
The price is $94
Oct 27 - Oct 28
Total with taxes and fees
Best Western Seneca-Clemson
Fairfield Inn & Suites Seneca Clemson Univ Area
2.5 star property
9.4 out of 10, Exceptional, (199)
"Nice hotel by the lake"
United States
Mike
$129 nightly
The price is $142
Oct 27 - Oct 28
Total with taxes and fees
Fairfield Inn & Suites Seneca Clemson Univ Area
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
9.8 out of 10, Exceptional, (42)
"The place was absolutely magnificent."
United States
David
$169 nightly
The price is $186
Oct 20 - Oct 21
Total with taxes and fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Hampton Inn & Suites Seneca-Clemson Area
2.5 star property
9.4 out of 10, Exceptional, (647)
"Great place to stay"
United States
Jose
$134 nightly
The price is $147
Oct 19 - Oct 20
Total with taxes and fees
Hampton Inn & Suites Seneca-Clemson Area
Tru by Hilton Seneca Clemson
2.5 star property
9.2 out of 10, Wonderful, (776)
"Clean room, staff was great, will always stay at this hotel in Clemson. Best place to stay!"
United States
Gretchen
$106 nightly
The price is $116
Oct 29 - Oct 30
Total with taxes and fees
Tru by Hilton Seneca Clemson
Charming 1-bedroom farmhouse in marvelous Seneca with WiFi, AC
10.0 out of 10, Exceptional, (8)
"The location was perfect for what we needed last minute. Our hosts and hosts family were so friendly and welcoming. We absolutely adored the homestead and market that was set up and our son loved having all the animals around. Waking up to the chickens and the sunrise was the perfect start to each day!"
United States
Emily E.
$188 nightly
The price is $207
Oct 19 - Oct 20
Total with taxes and fees
Charming 1-bedroom farmhouse in marvelous Seneca with WiFi, AC
Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
10.0 out of 10, Exceptional, (12)
"Very nice, great surroundings. Everyone was nice and pleasant to meet while there. Great place to stay for Clemson games!!! "
United States
Glenda
$182 nightly
The price is $200
Oct 20 - Oct 21
Total with taxes and fees
Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
Boutique hotel in historic downtown Seneca. Room #4, King bed.
9.4 out of 10, Exceptional, (13)
"Great location, updated, well decorated, and very comfy. Great communication with property manager. "
United States
Ali R.
$194 nightly
The price is $210
Oct 20 - Oct 21
Total with taxes and fees
Boutique hotel in historic downtown Seneca. Room #4, King bed.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Seneca

Top Seneca attractions for a relaxing vacation

Seneca, South Carolina, offers an enticing blend of natural beauty and relaxation, making it a perfect spot for travelers seeking hotels with spas. Explore the stunning Lake Hartwell, where you can indulge in a leisurely afternoon of fishing or boating, followed by a soothing massage at a nearby spa. The picturesque Oconee State Park provides hiking trails that lead you through lush forests and serene waterfalls, ideal for a refreshing retreat after a day of wellness. For a unique experience, visit the South Carolina Botanical Garden, where you can stroll through beautifully curated landscapes and enjoy the tranquility of nature, setting the perfect mood for a day of pampering. Don’t miss out on the charming downtown area, filled with local boutiques and cafes that invite you to unwind. Consider staying in a hotel near the lakefront where you can enjoy stunning sunset views while planning your next spa treatment, ensuring a restful and rejuvenating getaway.

Top Seneca Hotel Reviews

Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the lakeside setting in Seneca - worth a picture or two! Be sure to enjoy the coffeehouses during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Keowee Reservoir, Lake Keowee, and Keowee Key Golf Course. If you have extra time while you're in the area, you might want to see Lake Hartwell and Oconee County Library Seneca Branch.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services including couples massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.

Explore a world of travel with Expedia