$282 Cheap Flights from Key West (EYW) to Santo Domingo (SDQ)

View $282 flight on Mon, Nov 3, 2025Opens in a new window

Popular airlines from Key West Intl. Airport (EYW) to Las Americas Intl. Airport (SDQ)

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Cheap Flights from Key West to Santo Domingo (EYW-SDQ)

Prices were available within the past 7 days and start at $282 for one-way flights and $528 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sun, Mar 8 - Thu, Mar 12
EYW
Key West
SDQ
Santo Domingo
$528 Roundtrip, found 1 day ago
$528
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sun, Mar 8 from Key West to Santo Domingo, returning Thu, Mar 12, priced at $528 found 1 day ago
American Airlines
Sun, Mar 8 - Thu, Mar 12
EYW
Key West
SDQ
Santo Domingo
$535 Roundtrip, found 1 day ago
$535
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sun, Mar 8 from Key West to Santo Domingo, returning Thu, Mar 12, priced at $535 found 1 day ago
American Airlines
Sun, Mar 8 - Thu, Mar 12
EYW
Key West
SDQ
Santo Domingo
$538 Roundtrip, found 1 day ago
$538
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sun, Mar 8 from Key West to Santo Domingo, returning Thu, Mar 12, priced at $538 found 1 day ago
American Airlines
Sun, Mar 8 - Thu, Mar 12
EYW
Key West
SDQ
Santo Domingo
$541 Roundtrip, found 1 day ago
$541
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sun, Mar 8 from Key West to Santo Domingo, returning Thu, Mar 12, priced at $541 found 1 day ago
American Airlines
Sun, Mar 8 - Thu, Mar 12
EYW
Key West
SDQ
Santo Domingo
$545 Roundtrip, found 1 day ago
$545
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sun, Mar 8 from Key West to Santo Domingo, returning Thu, Mar 12, priced at $545 found 1 day ago
American Airlines
Sun, Mar 8 - Thu, Mar 12
EYW
Key West
SDQ
Santo Domingo
$551 Roundtrip, found 1 day ago
$551
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sun, Mar 8 from Key West to Santo Domingo, returning Thu, Mar 12, priced at $551 found 1 day ago
American Airlines
Sat, Mar 7 - Tue, Mar 10
EYW
Key West
SDQ
Santo Domingo
$573 Roundtrip, found 1 day ago
$573
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Mar 7 from Key West to Santo Domingo, returning Tue, Mar 10, priced at $573 found 1 day ago
American Airlines
Thu, Mar 5 - Tue, Mar 10
EYW
Key West
SDQ
Santo Domingo
$584 Roundtrip, found 1 day ago
$584
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Mar 5 from Key West to Santo Domingo, returning Tue, Mar 10, priced at $584 found 1 day ago
American Airlines
Sat, Mar 7 - Sat, Mar 14
EYW
Key West
SDQ
Santo Domingo
$588 Roundtrip, found 1 day ago
$588
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Mar 7 from Key West to Santo Domingo, returning Sat, Mar 14, priced at $588 found 1 day ago
American Airlines
Sat, Mar 7 - Sun, Mar 15
EYW
Key West
SDQ
Santo Domingo
$593 Roundtrip, found 1 day ago
$593
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Mar 7 from Key West to Santo Domingo, returning Sun, Mar 15, priced at $593 found 1 day ago
Flights from Key West (EYW) to Santo Domingo (SDQ)
Origin airport
Key West Intl.
Destination airport
Las Americas Intl.
Airlines serving
American Airlines
Roundtrip price
$527
Distance
883 mi

Key West to Santo Domingo Flights

The cheapest times to fly from Key West to Santo Domingo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Key West to Santo Domingo are during the month of March. You can find some of the cheapest flights from Key West to Santo Domingo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Key West to Santo Domingo

Sunday is one of the best days to book for cheap flights from Key West to Santo Domingo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Key West to Santo Domingo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Key West to Santo Domingo in 2025. You can also book with separate airlines for your outbound and return journeys, from $282 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Key West to Santo Domingo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Key West to Santo Domingo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Key West Intl. Airport (EYW) to Las Americas Intl. Airport (SDQ) cost?
Grab a cheap one-way flight from $282 or cheap return flight from $528 from Key West Intl. Airport (EYW) to Las Americas Intl. Airport (SDQ) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Key West Intl. Airport (EYW) to Las Americas Intl. Airport (SDQ)?
Planning your trip for March is a good way to save, as it's the cheapest month for flights between EYW and SDQ. You'll usually find the lowest prices during off-peak months.
What is the cheapest airline that flies from Key West Intl. Airport (EYW) to Las Americas Intl. Airport (SDQ)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest EYW to SDQ flight.
How many flights per day from Key West Intl. Airport (EYW) to Las Americas Intl. Airport (SDQ)?
You'll have to hop on a flight with a layover when traveling from Key West Intl. Airport (EYW) to Las Americas Intl. Airport (SDQ). Direct flights don't operate daily on this route. However, just filter your search to include one or two stops to discover an option that works for you.
What day of the week has the most flights from EYW to SDQ?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can vary based on a number of factors, such as the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Key West Intl. Airport (EYW) to Las Americas Intl. Airport (SDQ)?
Book a flight from Key West Intl. Airport (EYW) to Las Americas Intl. Airport (SDQ) that leaves before 3 PM to reduce the likelihood of delays and cancellations. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Key West Intl. Airport (EYW) to Las Americas Intl. Airport (SDQ) last-minute?
Booking your plane ticket from EYW to SDQ shortly before your journey is typically more expensive. However, if you're flexible with your itinerary, you could score a cheap last-minute fare.
Is it cheaper to book an EYW to SDQ flight and hotel package?
Opting for an EYW to SDQ flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our wide range of accommodations and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Key West Intl. Airport (EYW) to Las Americas Intl. Airport (SDQ)?
Typically, you're able to reschedule or cancel your EYW to SDQ flight. However, additional charges may apply, especially if you made your booking over 24 hours ago. Check your itinerary for the airline's guidelines and fees on flight changes, or if you need further information, head to our Customer Service portal.

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*Available to One Key members.