Title: $241 Cheap flights from Florence to Melbourne (FLO to MLB) - Expedia.com ![Botanical Gardens which includes a park](https://images.trvl-media.com/place/553248621532653201/24f8a575-4e74-42d8-8522-e2c401023b46.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248621532653201/24f8a575-4e74-42d8-8522-e2c401023b46.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # $241 Cheap Flights from Florence (FLO) to Melbourne (MLB) [View $241 flight on Sat, May 2, 2026](https://expedia.com/Flights-Search?trip=oneway&leg1=from:FLO,to:MLB,departure:5/2/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:240.20&airProductToken=AQpmCjEIwYIBEgQ1OTExGOVyIOKaASi08osDMPbyiwM4T0AAWAFqBE1BSU5yCE9XQVhaTk4xCjEIwYIBEgQ1MzM5GOKaASDsCiil9IsDMJv1iwM4T0ABWAFqBE1BSU5yCE9XQVhaTk4xEgwIARABGAEqAkFBMgAYASIECAEQASgCKAMoBDAL) - [Roundtrip](?flightType=roundtrip) - [One-way](?flightType=oneway) - [Multi-city](?flightType=multicity) ### Travelers Adults ChildrenAges 2 to 17 InfantsYounger than 2 EconomyPremium economyBusiness classFirst class Leaving from Going to Departing Returning Add a place to stay Add a car Direct flights only ## Popular airlines from Florence, SC (FLO-Florence Regional) to Melbourne Orlando Intl. Airport (MLB) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AA.svg) American Airlines [](https://www.expedia.com/Flights-Search?leg1=from:FLO,to:MLB,departure:2/25/2026TANYT&leg2=from:MLB,to:FLO,departure:3/4/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AA"}}]) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 30% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our OneKeyCash [Learn about One Key](https://www.expedia.com/welcome-one-key) ## Cheap Flights from Florence to Melbourne (FLO-MLB) Prices were available within the past 7 days and start at $241 for one-way flights and $407 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Sat, May 2 - Sat, May 9 FLO Florence MLB Melbourne $407 Roundtrip found 3 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:FLO,to:MLB,departure:5/2/2026TANYT&leg2=from:MLB,to:FLO,departure:5/9/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:406.40&airProductToken=AQpoCjIIwYIBEgQ1OTExGOVyIOKaASi08osDMPbyiwM4QkAAWAFqBUJBU0lDcghPV0ZXVU5CWgoyCMGCARIENTMzORjimgEg7AoopfSLAzCb9YsDOEJAAVgBagVCQVNJQ3IIT1dGV1VOQloKaAoyCMGCARIENTM0MRjsCiDimgEo78aMAzDmx4wDOEJAAFgBagVCQVNJQ3IIT1dGV1VOQloKMgjBggESBDU4OTMY4poBIOVyKKXJjAMw6cmMAzhCQAFYAWoFQkFTSUNyCE9XRldVTkJaEgwIARABGAEqAkFBMgAYASIECAEQASgCKAMoBDAL) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Sat, May 2 - Sat, May 9 FLO Florence MLB Melbourne $437 Roundtrip found 3 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:FLO,to:MLB,departure:5/2/2026TANYT&leg2=from:MLB,to:FLO,departure:5/9/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:436.40&airProductToken=AQpoCjIIwYIBEgQ1OTExGOVyIOKaASi08osDMPbyiwM4QkAAWAFqBUJBU0lDcghPV0ZXVU5CWgoyCMGCARIENTMzORjimgEg7AoopfSLAzCb9YsDOEJAAVgBagVCQVNJQ3IIT1dGV1VOQloKaAoyCMGCARIENTMzORjsCiDimgEomsSMAzCPxYwDOEJAAFgBagVCQVNJQ3IIUTBGV1VOQloKMgjBggESBDYwMDMY4poBIOVyKMPFjAMwhsaMAzhCQAFYAWoFQkFTSUNyCFEwRldVTkJaEgwIARABGAEqAkFBMgAYASIECAEQASgCKAMoBDAL) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Sat, May 2 - Sat, May 9 FLO Florence MLB Melbourne $467 Roundtrip found 3 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:FLO,to:MLB,departure:5/2/2026TANYT&leg2=from:MLB,to:FLO,departure:5/9/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:466.40&airProductToken=AQpmCjEIwYIBEgQ1OTExGOVyIOKaASi08osDMPbyiwM4T0AAWAFqBE1BSU5yCE9XRldVTk0xCjEIwYIBEgQ1MzM5GOKaASDsCiil9IsDMJv1iwM4T0ABWAFqBE1BSU5yCE9XRldVTk0xCmYKMQjBggESBDUzNDEY7Aog4poBKO_GjAMw5seMAzhPQABYAWoETUFJTnIIT1dGV1VOTTEKMQjBggESBDU4OTMY4poBIOVyKKXJjAMw6cmMAzhPQAFYAWoETUFJTnIIT1dGV1VOTTESDAgBEAEYASoCQUEyABgBIgQIARABKAIoAygEMAs) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Wed, Apr 29 - Wed, May 6 FLO Florence MLB Melbourne $502 Roundtrip found 3 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:FLO,to:MLB,departure:4/29/2026TANYT&leg2=from:MLB,to:FLO,departure:5/6/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:501.39&airProductToken=AQpGCiEIwYIBEgQ1OTExGOVyIOKaASjU0IsDMJbRiwM4T0AAWAEKIQjBggESBDUzMzkY4poBIOwKKMXSiwMwu9OLAzhPQAFYAQpGCiEIwYIBEgQ1MzQxGOwKIOKaASiPpYwDMIamjAM4UUAAWAEKIQjBggESBDU4OTMY4poBIOVyKMWnjAMwiaiMAzhRQAFYARIKCAEQARgBKgJBQRgBIgQIARABKAQwAQ) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Sat, May 2 - Sat, May 9 FLO Florence MLB Melbourne $531 Roundtrip found 3 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:FLO,to:MLB,departure:5/2/2026TANYT&leg2=from:MLB,to:FLO,departure:5/9/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:530.40&airProductToken=AQpmCjEIwYIBEgQ1OTExGOVyIOKaASi08osDMPbyiwM4T0AAWAFqBE1BSU5yCE9XQVhaTk4xCjEIwYIBEgQ1MzM5GOKaASDsCiil9IsDMJv1iwM4T0ABWAFqBE1BSU5yCE9XQVhaTk4xEgwIARABGAEqAkFBMgAYASIECAEQASgCKAMoBDAL) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Tue, May 5 - Sat, May 9 FLO Florence MLB Melbourne $537 Roundtrip found 3 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:FLO,to:MLB,departure:5/5/2026TANYT&leg2=from:MLB,to:FLO,departure:5/9/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:536.40&airProductToken=AQpGCiEIwYIBEgQ1OTExGOVyIOKaASjHlIwDMIqVjAM4UUAAWAEKIQjBggESBDUzMzkY4poBIOwKKPGVjAMw55aMAzhRQAFYAQpGCiEIwYIBEgQ1MzQxGOwKIOKaASjvxowDMObHjAM4UUAAWAEKIQjBggESBDU4OTMY4poBIOVyKKXJjAMw6cmMAzhRQAFYARIKCAEQARgBKgJBQRgBIgQIARABKAQwAQ) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Sat, May 2 - Sat, May 9 FLO Florence MLB Melbourne $542 Roundtrip found 3 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:FLO,to:MLB,departure:5/2/2026TANYT&leg2=from:MLB,to:FLO,departure:5/9/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:541.40&airProductToken=AQpqCjMIwYIBEgQ1OTExGOVyIOKaASi08osDMPbyiwM4T0AAWAFqBk1BSU5QTHIIT1dBWFpOVDEKMwjBggESBDUzMzkY4poBIOwKKKX0iwMwm_WLAzhPQAFYAWoGTUFJTlBMcghPV0FYWk5UMRIMCAIQARgCKgJBQTIAGAEiBAgBEAEoAigDKAQwCw) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Wed, Apr 29 - Thu, May 7 FLO Florence MLB Melbourne $547 Roundtrip found 3 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:FLO,to:MLB,departure:4/29/2026TANYT&leg2=from:MLB,to:FLO,departure:5/7/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:546.39&airProductToken=AQpGCiEIwYIBEgQ1OTExGOVyIOKaASjU0IsDMJbRiwM4T0AAWAEKIQjBggESBDUzMzkY4poBIOwKKMXSiwMwu9OLAzhPQAFYAQpGCiEIwYIBEgQ1MzQxGOwKIOKaASivsIwDMKaxjAM4TkAAWAEKIQjBggESBDU4OTMY4poBIOVyKOWyjAMwqbOMAzhOQAFYARIKCAEQARgBKgJBQRgBIgQIARABKAQwAQ) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Sat, May 2 - Sat, May 9 FLO Florence MLB Melbourne $553 Roundtrip found 3 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:FLO,to:MLB,departure:5/2/2026TANYT&leg2=from:MLB,to:FLO,departure:5/9/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:552.40&airProductToken=AQpoCjIIwYIBEgQ2MDAzGOVyIOKaASjA94sDMIX4iwM4QkAAWAFqBUJBU0lDcghRV0FYWk5CWgoyCMGCARIENTM2NBjimgEg7AootvqLAzCe-4sDOEJAAVgBagVCQVNJQ3IIUVdGV1VOQlgKaAoyCMGCARIENTM0MRjsCiDimgEo78aMAzDmx4wDOEJAAFgBagVCQVNJQ3IIT1dGV1VOQloKMgjBggESBDU4OTMY4poBIOVyKKXJjAMw6cmMAzhCQAFYAWoFQkFTSUNyCE9XRldVTkJaEgwIARABGAEqAkFBMgAYASIECAEQASgCKAMoBDAL) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Sat, May 2 - Sat, May 9 FLO Florence MLB Melbourne $567 Roundtrip found 3 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:FLO,to:MLB,departure:5/2/2026TANYT&leg2=from:MLB,to:FLO,departure:5/9/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:566.40&airProductToken=AQpqCjMIwYIBEgQ1OTExGOVyIOKaASi08osDMPbyiwM4T0AAWAFqBk1BSU5GTHIIT1dGV1VSVTEKMwjBggESBDUzMzkY4poBIOwKKKX0iwMwm_WLAzhPQAFYAWoGTUFJTkZMcghPV0ZXVVJVMQpqCjMIwYIBEgQ1MzQxGOwKIOKaASjvxowDMObHjAM4T0AAWAFqBk1BSU5GTHIIT1dGV1VSVTEKMwjBggESBDU4OTMY4poBIOVyKKXJjAMw6cmMAzhPQAFYAWoGTUFJTkZMcghPV0ZXVVJVMRIMCAEQARgBKgJBQTIAGAEiBAgBEAEoAigDKAQwCw) __Flights from Florence (FLO) to Melbourne (MLB)__ | Origin airport | Florence Regional | | ------------------- | ----------------------- | | Destination airport | Orlando Melbourne Intl. | | Airlines serving | American Airlines | | Roundtrip price | $406 | | Distance | 424 mi | ## Florence to Melbourne Flights The cheapest times to fly from Florence to Melbourne On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Florence to Melbourne are during the month of May. You can find some of the cheapest flights from Florence to Melbourne with Expedia's search tool and vast selection of airlines. The best time to book a flight from Florence to Melbourne Sunday is one of the best days to book for cheap flights from Florence to Melbourne: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance. How to find cheap round-trip tickets from Florence to Melbourne Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Florence to Melbourne in 2026\. You can also book with separate airlines for your outbound and return journeys, from $241 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference\*. This is available for a small fee, and is free to One Key Gold and Platinum tier members. Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Florence to Melbourne flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps. You could also save big by booking one of Expedia's [vacation packages](https://www.expedia.com/package-deals). Bundling together your Florence to Melbourne airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures. \*Terms apply. Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023\. The percentages you see are averages. ## Frequently asked questions ### How much does a flight from Florence Regional Airport (FLO) to Orlando Melbourne Intl. Airport (MLB) cost? ### What is the cheapest month to fly from Florence Regional Airport (FLO) to Orlando Melbourne Intl. Airport (MLB)? ### What is the cheapest airline that flies from Florence Regional Airport (FLO) to Orlando Melbourne Intl. Airport (MLB)? ### How many flights per day from Florence Regional Airport (FLO) to Orlando Melbourne Intl. Airport (MLB)? ### What day of the week has the most flights from FLO to MLB? ### What is the best time to fly from Florence Regional Airport (FLO) to Orlando Melbourne Intl. Airport (MLB)? ### Is it cheaper to buy a plane ticket from Florence Regional Airport (FLO) to Orlando Melbourne Intl. Airport (MLB) last-minute? ### Is it cheaper to book a FLO to MLB flight and hotel package? ### Can I cancel or change the date of my flight from Florence Regional Airport (FLO) to Orlando Melbourne Intl. Airport (MLB)? \*Flight schedules are subject to change. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - [Melbourne Hotels ](https://www.expedia.com/Melbourne-Hotels.d2342.Travel-Guide-Hotels) - [Hotels near Holmes Regional Medical Center ](https://www.expedia.com/Holmes-Regional-Medical-Center-Hotels.0-l553248635975883219-0.Travel-Guide-Filter-Hotels) - [Flights to Orlando ](https://www.expedia.com/Cheap-Flights-To-Orlando.d178294.Travel-Guide-Flights) - [Flights to Melbourne ](https://www.expedia.com/Cheap-Flights-To-Melbourne.d2342.Travel-Guide-Flights) - [Flights from Melbourne ](https://www.expedia.com/lp/flights/2342/flights-from-melbourne) - [Flights from Fort Pierce to Melbourne ](https://www.expedia.com/lp/flights/7301/2342/fort-pierce-to-melbourne) - [Flights from Destin to Melbourne ](https://www.expedia.com/lp/flights/6906/2342/destin-to-melbourne) - [Flights from Naples to Melbourne ](https://www.expedia.com/lp/flights/602724/2342/naples-to-melbourne) - 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