$331 Cheap Flights from Knoxville (TYS) to Santa Rosa (STS)

View $331 flight on Sat, Sep 6, 2025Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to Santa Rosa, CA (STS-Sonoma County)

Cheap Flights from Knoxville to Santa Rosa (TYS-STS)

Prices were available within the past 7 days and start at $331 for one-way flights and $701 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Oct 24 - Wed, Oct 29
TYS
Knoxville
STS
Santa Rosa
$701 Roundtrip, found 3 days ago
$701
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Oct 24 from Knoxville to Santa Rosa, returning Wed, Oct 29, priced at $701 found 3 days ago
American Airlines
Tue, Jan 27 - Sat, Jan 31
TYS
Knoxville
STS
Santa Rosa
$716 Roundtrip, found 20 hours ago
$716
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Tue, Jan 27 from Knoxville to Santa Rosa, returning Sat, Jan 31, priced at $716 found 20 hours ago
American Airlines
Thu, Oct 2 - Mon, Oct 6
TYS
Knoxville
STS
Santa Rosa
$716 Roundtrip, found 20 hours ago
$716
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Thu, Oct 2 from Knoxville to Santa Rosa, returning Mon, Oct 6, priced at $716 found 20 hours ago
American Airlines
Thu, Jan 29 - Sun, Feb 1
TYS
Knoxville
STS
Santa Rosa
$721 Roundtrip, found 20 hours ago
$721
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Thu, Jan 29 from Knoxville to Santa Rosa, returning Sun, Feb 1, priced at $721 found 20 hours ago
American Airlines
Tue, Jan 27 - Wed, Feb 4
TYS
Knoxville
STS
Santa Rosa
$735 Roundtrip, found 20 hours ago
$735
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Tue, Jan 27 from Knoxville to Santa Rosa, returning Wed, Feb 4, priced at $735 found 20 hours ago
American Airlines
Mon, Oct 20 - Tue, Oct 21
TYS
Knoxville
STS
Santa Rosa
$756 Roundtrip, found 19 hours ago
$756
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Mon, Oct 20 from Knoxville to Santa Rosa, returning Tue, Oct 21, priced at $756 found 19 hours ago
American Airlines
Tue, Jan 27 - Mon, Feb 2
TYS
Knoxville
STS
Santa Rosa
$761 Roundtrip, found 20 hours ago
$761
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Tue, Jan 27 from Knoxville to Santa Rosa, returning Mon, Feb 2, priced at $761 found 20 hours ago
American Airlines
Tue, Jan 27 - Sun, Feb 1
TYS
Knoxville
STS
Santa Rosa
$780 Roundtrip, found 20 hours ago
$780
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Tue, Jan 27 from Knoxville to Santa Rosa, returning Sun, Feb 1, priced at $780 found 20 hours ago
American Airlines
Tue, Sep 30 - Sat, Oct 4
TYS
Knoxville
STS
Santa Rosa
$781 Roundtrip, found 13 hours ago
$781
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Tue, Sep 30 from Knoxville to Santa Rosa, returning Sat, Oct 4, priced at $781 found 13 hours ago
Alaska Airlines
Sat, Nov 1 - Sat, Nov 8
TYS
Knoxville
STS
Santa Rosa
$801 Roundtrip, found 11 hours ago
$801
Roundtrip
found 11 hours ago
Select Alaska Airlines flight, departing Sat, Nov 1 from Knoxville to Santa Rosa, returning Sat, Nov 8, priced at $801 found 11 hours ago
Flights from Knoxville (TYS) to Santa Rosa (STS)
Origin airport
McGhee Tyson
Destination airport
Sonoma County
Airlines serving
Alaska Airlines, American Airlines
Roundtrip price
$701
Distance
2129 mi

Knoxville to Santa Rosa Flights

The cheapest times to fly from Knoxville to Santa Rosa

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Santa Rosa are during the month of October. You can find some of the cheapest flights from Knoxville to Santa Rosa with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Knoxville to Santa Rosa

Sunday is one of the best days to book for cheap flights from Knoxville to Santa Rosa: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Knoxville to Santa Rosa

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Santa Rosa in 2025. You can also book with separate airlines for your outbound and return journeys, from $331 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Santa Rosa flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Santa Rosa airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to Sonoma County Airport (STS) cost?
Secure a cheap one-way flight from $331 or cheap return flight from $701 from McGhee Tyson Airport (TYS) to Sonoma County Airport (STS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from McGhee Tyson Airport (TYS) to Sonoma County Airport (STS)?
October is the most affordable month to fly from TYS to STS. Traveling during quieter months is often the key to landing a great deal.
What is the cheapest airline that flies from McGhee Tyson Airport (TYS) to Sonoma County Airport (STS)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest TYS to STS flight.
How many flights per day from McGhee Tyson Airport (TYS) to Sonoma County Airport (STS)?
Direct flights from McGhee Tyson Airport (TYS) to Sonoma County Airport (STS) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filters. Enter your travel dates and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from TYS to STS?
You'll typically find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from McGhee Tyson Airport (TYS) to Sonoma County Airport (STS)?
To touch down at Sonoma County Airport (STS) on schedule, choose a flight that leaves from McGhee Tyson Airport (TYS) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to Sonoma County Airport (STS) last-minute?
Booking your plane ticket from TYS to STS right before your trip is usually more expensive. But if there's some wiggle room with your travel times and dates, you could grab a cheap last-minute fare.
Is it cheaper to book a TYS to STS flight and hotel package?
Booking a TYS to STS flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Choose from our impressive range of hotels and then add activities, car rentals and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to Sonoma County Airport (STS)?
In most cases, you're able to cancel or reschedule your TYS to STS flight. However, additional charges may apply, especially if your booking was made over 24 hours ago. Double-check your itinerary for the airline's fees and guidelines on flight changes, or if you want further details, head to our Customer Service portal.

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*Available to One Key members.