Book luxury spa hotels in Panama City

Experience the ultimate relaxation at luxury spa retreats in Panama City

Luxury spa retreats in Panama City provide an extraordinary escape for travelers seeking rejuvenation and tranquility. With a stunning backdrop of vibrant city life and lush nature, these properties offer the perfect blend of relaxation and adventure. Families, couples, and solo travelers can indulge in upscale amenities, including world-class spa services, gourmet dining, and spacious accommodations designed for comfort. Whether you’re unwinding after a day of exploration or simply enjoying quality time with loved ones, Panama City’s luxury spa retreats promise an unforgettable experience filled with pampering and serenity.

Our top choices for a great stay

Hilton Panama

Hilton Panama

5 out of 5
$223 nightly
The price is $245 total per night from Oct 25 to Oct 26
$245 total
Oct 25 - Oct 26
Total with taxes and fees
Stay at this 5-star luxury hotel in Panama City. Enjoy a full-service spa, 4 restaurants, and an attached winery. Our guests praise the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
8.8/10 Excellent! (1,003 reviews)
Opens in a new windowHilton Panama
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

4.5 out of 5
$135 nightly
The price is $149 total per night from Nov 1 to Nov 2
$149 total
Nov 1 - Nov 2
Total with taxes and fees
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
8.6/10 Excellent! (996 reviews)
Opens in a new windowSortis Hotel, Spa & Casino, Autograph Collection by Marriott
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
$188 nightly
The price is $207 total per night from Nov 7 to Nov 8
$207 total
Nov 7 - Nov 8
Total with taxes and fees
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
8.8/10 Excellent! (1,003 reviews)
Opens in a new windowWaldorf Astoria Panama
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5 out of 5
$204 nightly
The price is $225 total per night from Oct 31 to Nov 1
$225 total
Oct 31 - Nov 1
Total with taxes and fees
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular attractions Multiplaza Pacific Mall and Avenida Balboa are located nearby.
9.6/10 Exceptional! (618 reviews)
Opens in a new windowThe Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
$293 nightly
The price is $322 total per night from Nov 2 to Nov 3
$322 total
Nov 2 - Nov 3
Total with taxes and fees
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
9.8/10 Exceptional! (521 reviews)
Opens in a new windowSofitel Legend Casco Viejo, Panama City
Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo

4.5 out of 5
$293 nightly
The price is $323 total per night from Nov 3 to Nov 4
$323 total
Nov 3 - Nov 4
Total with taxes and fees
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 5 restaurants. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
9.6/10 Exceptional! (237 reviews)
Opens in a new windowHotel La Compañía Casco Antiguo
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
$188 nightly
The price is $206 total per night from Nov 22 to Nov 23
$206 total
Nov 22 - Nov 23
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
9.2/10 Wonderful! (1,009 reviews)
Opens in a new windowBristol Panama, a Registry Collection Hotel
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
$101 nightly
The price is $111 total per night from Nov 16 to Nov 17
$111 total
Nov 16 - Nov 17
Total with taxes and fees
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
8.4/10 Very Good! (1,138 reviews)
Opens in a new windowMegapolis Hotel Panamá
Hyatt Regency Panama City

Hyatt Regency Panama City

4.5 out of 5
$149 nightly
The price is $164 total per night from Nov 1 to Nov 2
$164 total
Nov 1 - Nov 2
Total with taxes and fees
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
10/10 Exceptional! (85 reviews)
Opens in a new windowHyatt Regency Panama City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Why choose luxury spa hotels in Panama City for your romantic getaway or retreat?

Opting for luxury spa hotels in Panama City rather than standard hotels can significantly elevate your honeymoon or wellness retreat experience. These wellness-focused accommodations provide a unique atmosphere that fosters relaxation and intimacy, with exclusive spa services designed to pamper you and your partner. Enjoy high-end spa getaways where you can unwind together with couples massages, rejuvenating facials, and tranquil relaxation areas. Unlike traditional hotels, these luxurious retreats often feature serene surroundings, wellness programs, and personalized attention, allowing you to create lasting memories in a peaceful setting. The emphasis on holistic wellness means you can embrace a balanced lifestyle, making it easier to recharge your mind and body. Choosing a luxury spa hotel ensures that your stay is not just about a place to sleep, but a transformative experience dedicated to your well-being and connection.