Book luxury spa hotels in Panama City

Experience the ultimate relaxation at luxury spa retreats in Panama City

Luxury spa retreats in Panama City provide an extraordinary escape for travelers seeking rejuvenation and tranquility. With a stunning backdrop of vibrant city life and lush nature, these properties offer the perfect blend of relaxation and adventure. Families, couples, and solo travelers can indulge in upscale amenities, including world-class spa services, gourmet dining, and spacious accommodations designed for comfort. Whether you’re unwinding after a day of exploration or simply enjoying quality time with loved ones, Panama City’s luxury spa retreats promise an unforgettable experience filled with pampering and serenity.

Our top choices for a great stay

Hilton Panama

Hilton Panama

5 out of 5
$229 nightly
The price is $252 total per night from Sep 21 to Sep 22
$252 total
Sep 21 - Sep 22
Total with taxes and fees
Stay at this 5-star luxury hotel in Panama City. Enjoy a full-service spa, 4 restaurants, and an attached winery. Our guests praise the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
Hilton Panama
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

4.5 out of 5
$150 nightly
The price is $165 total per night from Sep 3 to Sep 4
$165 total
Sep 3 - Sep 4
Total with taxes and fees
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
$220 nightly
The price is $242 total per night from Sep 20 to Sep 21
$242 total
Sep 20 - Sep 21
Total with taxes and fees
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
Waldorf Astoria Panama
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5 out of 5
$221 nightly
The price is $243 total per night from Sep 20 to Sep 21
$243 total
Sep 20 - Sep 21
Total with taxes and fees
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular attractions Multiplaza Pacific Mall and Avenida Balboa are located nearby.
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
$293 nightly
The price is $322 total per night from Sep 30 to Oct 1
$322 total
Sep 30 - Oct 1
Total with taxes and fees
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
Sofitel Legend Casco Viejo, Panama City
Hotel La Compania, in the Unbound Collection by Hyatt

Hotel La Compania, in the Unbound Collection by Hyatt

4.5 out of 5
$263 nightly
The price is $290 total per night from Sep 5 to Sep 6
$290 total
Sep 5 - Sep 6
Total with taxes and fees
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 5 restaurants. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
Hotel La Compania, in the Unbound Collection by Hyatt
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
$200 nightly
The price is $220 total per night from Oct 3 to Oct 4
$220 total
Oct 3 - Oct 4
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
9.2/10 Wonderful! (981 reviews)
Bristol Panama, a Registry Collection Hotel
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
$113 nightly
The price is $124 total per night from Sep 20 to Sep 21
$124 total
Sep 20 - Sep 21
Total with taxes and fees
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
8.2/10 Very Good! (1,017 reviews)
Megapolis Hotel Panamá
Hyatt Regency Panama City

Hyatt Regency Panama City

4.5 out of 5
$159 nightly
The price is $175 total per night from Sep 12 to Sep 13
$175 total
Sep 12 - Sep 13
Total with taxes and fees
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
Hyatt Regency Panama City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Why choose luxury spa hotels in Panama City for your romantic getaway or retreat?

Opting for luxury spa hotels in Panama City rather than standard hotels can significantly elevate your honeymoon or wellness retreat experience. These wellness-focused accommodations provide a unique atmosphere that fosters relaxation and intimacy, with exclusive spa services designed to pamper you and your partner. Enjoy high-end spa getaways where you can unwind together with couples massages, rejuvenating facials, and tranquil relaxation areas. Unlike traditional hotels, these luxurious retreats often feature serene surroundings, wellness programs, and personalized attention, allowing you to create lasting memories in a peaceful setting. The emphasis on holistic wellness means you can embrace a balanced lifestyle, making it easier to recharge your mind and body. Choosing a luxury spa hotel ensures that your stay is not just about a place to sleep, but a transformative experience dedicated to your well-being and connection.