Cheap American Airlines flights Amsterdam (AMS) to Kirksville (IRK)

Scoring cheap one-way American Airlines flights from AMS to IRK on Expedia couldn't be simpler — just filter by "Price (lowest to highest)." Alternatively, check out our affordable round-trip fares for your next break.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Getting the best American Airlines deals from AMS to IRK is typically all about timing. You can save 17% on international flights when you book 18 to 29 days before takeoff instead of four to five months ahead. What's more, you can pocket 17% on average by buying your fare on a Sunday compared to a Friday, which is usually the most expensive day to book.* It's smart to kick off your flight search about one month before you plan to travel.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Browse American Airlines's earliest flights from AMS to IRK by checking the "Early Morning" and "Morning" filters. Not only will you get to your destination sooner, early departures also have a 20% less chance of being canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.