$228 Cheap Copa flights San Francisco (SFO) to Medellín (MDE)

You can find cheap return Copa Airlines flights from $425 from SFO to MDE by filtering your results from "Price (lowest to highest)" on Expedia. Or search for deals from $228 for a one-way trip.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Check for Copa Airlines flights from SFO to MDE about one month before you want to go. The most affordable time to reserve an international flight is generally 18 to 29 days ahead of your travel date when you can save 17% versus booking four to five months in advance. Regardless of itinerary and fare class, the best day to book international airfare is usually Sunday. Friday can be the most expensive. Travelers who book on a Sunday can save 17% on average compared to those who book on a Friday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Sort your results by "Morning" and "Early Morning" to browse the earliest departures from SFO to MDE. Leaving early means you're 20% less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.