$169 Cheap Delta flights Myrtle Beach (MYR) to Knoxville (TYS)

Grab affordable return Delta Air Lines flights from $234 from MYR to TYS by sorting your results from "Price (lowest to highest)" on Expedia. Or look for bargains from $169 for a one-way journey.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

To find cheap Delta Air Lines fares from Myrtle Beach Intl. Airport (MYR) to McGhee Tyson Airport (TYS), start searching one to three months before your planned departure. Reserving domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also impact the price you pay. Sunday is usually the cheapest, while Monday is often the most expensive for domestic flights. You can save 6% on average by choosing to book on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Filter your results by "Early Morning" and "Morning" to browse the earliest departures from MYR to TYS. Heading off early means you're less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.

Taking off from MYR to TYS with Delta Air Lines means enjoying a host of benefits, including a rewarding loyalty program and an excellent in-flight experience. Plus, when booking through Expedia, One Key™ members can earn OneKeyCash™* to use on select future travel purchases. That's on top of the Delta SkyMiles points you can earn with Delta Air Lines.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.