$1,024 Cheap Flights from Orange County (SNA) to São Tomé Island (TMS)

View $1,024 flight on Wed, Nov 5, 2025Opens in a new window

Popular airlines from John Wayne Airport (SNA) to São Tomé Island (TMS-São Tomé Intl.)

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Cheap Flights from Orange County to São Tomé Island (SNA-TMS)

Prices were available within the past 7 days and start at $1,024 for one-way flights and $1,862 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Wed, Nov 5 - Wed, Nov 19
SNA
Orange County
TMS
São Tomé Island
$1,862 Roundtrip, found 2 days ago
$1,862
Roundtrip
found 2 days ago
Select United flight, departing Wed, Nov 5 from Orange County to São Tomé Island, returning Wed, Nov 19, priced at $1,862 found 2 days ago
United
Wed, Nov 5 - Wed, Nov 19
SNA
Orange County
TMS
São Tomé Island
$1,880 Roundtrip, found 2 days ago
$1,880
Roundtrip
found 2 days ago
Select United flight, departing Wed, Nov 5 from Orange County to São Tomé Island, returning Wed, Nov 19, priced at $1,880 found 2 days ago
United
Wed, Nov 5 - Wed, Nov 19
SNA
Orange County
TMS
São Tomé Island
$1,975 Roundtrip, found 2 days ago
$1,975
Roundtrip
found 2 days ago
Select United flight, departing Wed, Nov 5 from Orange County to São Tomé Island, returning Wed, Nov 19, priced at $1,975 found 2 days ago
United
Wed, Nov 5 - Wed, Nov 19
SNA
Orange County
TMS
São Tomé Island
$1,995 Roundtrip, found 2 days ago
$1,995
Roundtrip
found 2 days ago
Select United flight, departing Wed, Nov 5 from Orange County to São Tomé Island, returning Wed, Nov 19, priced at $1,995 found 2 days ago
United
Wed, Nov 5 - Wed, Nov 19
SNA
Orange County
TMS
São Tomé Island
$2,110 Roundtrip, found 2 days ago
$2,110
Roundtrip
found 2 days ago
Select United flight, departing Wed, Nov 5 from Orange County to São Tomé Island, returning Wed, Nov 19, priced at $2,110 found 2 days ago
United
Wed, Nov 5 - Wed, Nov 19
SNA
Orange County
TMS
São Tomé Island
$2,157 Roundtrip, found 2 days ago
$2,157
Roundtrip
found 2 days ago
Select United flight, departing Wed, Nov 5 from Orange County to São Tomé Island, returning Wed, Nov 19, priced at $2,157 found 2 days ago
United
Wed, Nov 5 - Wed, Nov 19
SNA
Orange County
TMS
São Tomé Island
$2,174 Roundtrip, found 2 days ago
$2,174
Roundtrip
found 2 days ago
Select United flight, departing Wed, Nov 5 from Orange County to São Tomé Island, returning Wed, Nov 19, priced at $2,174 found 2 days ago
United
Wed, Nov 5 - Wed, Nov 19
SNA
Orange County
TMS
São Tomé Island
$2,270 Roundtrip, found 2 days ago
$2,270
Roundtrip
found 2 days ago
Select United flight, departing Wed, Nov 5 from Orange County to São Tomé Island, returning Wed, Nov 19, priced at $2,270 found 2 days ago
United
Wed, Nov 5 - Wed, Nov 19
SNA
Orange County
TMS
São Tomé Island
$2,290 Roundtrip, found 2 days ago
$2,290
Roundtrip
found 2 days ago
Select United flight, departing Wed, Nov 5 from Orange County to São Tomé Island, returning Wed, Nov 19, priced at $2,290 found 2 days ago
United
Wed, Nov 5 - Wed, Nov 19
SNA
Orange County
TMS
São Tomé Island
$2,295 Roundtrip, found 2 days ago
$2,295
Roundtrip
found 2 days ago
Select United flight, departing Wed, Nov 5 from Orange County to São Tomé Island, returning Wed, Nov 19, priced at $2,295 found 2 days ago
Flights from Orange County (SNA) to São Tomé Island (TMS)
Origin airport
John Wayne
Destination airport
São Tomé Intl.
Roundtrip price
$1,862
Distance
8148 mi

Orange County to São Tomé Island Flights

The cheapest times to fly from Orange County to São Tomé Island

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Orange County to São Tomé Island are during the month of November. You can find some of the cheapest flights from Orange County to São Tomé Island with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Orange County to São Tomé Island

Sunday is one of the best days to book for cheap flights from Orange County to São Tomé Island: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Orange County to São Tomé Island

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Orange County to São Tomé Island in 2025. You can also book with separate airlines for your outbound and return journeys, from $1,024 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Orange County to São Tomé Island flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Orange County to São Tomé Island airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from John Wayne Airport (SNA) to Sao Tome Intl. Airport (TMS) cost?
Get a cheap one-way flight from $1,024 or cheap return flight from $1,862 from John Wayne Airport (SNA) to Sao Tome Intl. Airport (TMS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from John Wayne Airport (SNA) to Sao Tome Intl. Airport (TMS)?
The cheapest month to fly from SNA to TMS is November, when demand is low. Off-peak season is typically when airlines offer lower prices between these airports.
What is the cheapest airline that flies from John Wayne Airport (SNA) to Sao Tome Intl. Airport (TMS)?
To find the cheapest airline flying from SNA to TMS, use Expedia's filter tool. Customize your search based on what's important to you, such as preferred carriers and cabin class. You can then sort your results by "Price (lowest to highest)" to see the cheapest flights first.
How many flights per day from John Wayne Airport (SNA) to Sao Tome Intl. Airport (TMS)?
Nonstop flights from John Wayne Airport (SNA) to Sao Tome Intl. Airport (TMS) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your travel details and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from SNA to TMS?
Generally you'll find the largest variety of flight choices on a Friday. Tuesdays are often the quietest.* But this can vary based on the airline, season and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from John Wayne Airport (SNA) to Sao Tome Intl. Airport (TMS)?
To avoid possible delays on the John Wayne Airport (SNA) to Sao Tome Intl. Airport (TMS) route, travel before 3 PM. Departures after this hour are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from John Wayne Airport (SNA) to Sao Tome Intl. Airport (TMS) last-minute?
Booking your plane ticket from SNA to TMS right before your getaway is generally more expensive. But if you're flexible with your travel times and dates, you could land a cheap last-minute fare.
Is it cheaper to book a SNA to TMS flight and hotel package?
Securing a SNA to TMS flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels in one place. Choose from our impressive range of hotels and then add flights, activities and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from John Wayne Airport (SNA) to Sao Tome Intl. Airport (TMS)?
If you booked your SNA to TMS flight within the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more details.

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*Available to One Key members.