$418 Cheap Flights from Buffalo (BUF) to Santiago (SCL)

View $418 flight on Sat, Mar 21, 2026Opens in a new window

Popular airlines from Buffalo Niagara Intl. Airport (BUF) to Santiago Intl. Airport (SCL)

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Cheap Flights from Buffalo to Santiago (BUF-SCL)

Prices were available within the past 7 days and start at $418 for one-way flights and $764 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Feb 10 - Mon, Feb 16
BUF
Buffalo
SCL
Santiago
$764 Roundtrip, found 3 hours ago
$764
Roundtrip
found 3 hours ago
Select Delta flight, departing Tue, Feb 10 from Buffalo to Santiago, returning Mon, Feb 16, priced at $764 found 3 hours ago
United
Thu, Mar 5 - Tue, Mar 17
BUF
Buffalo
SCL
Santiago
$769 Roundtrip, found 1 day ago
$769
Roundtrip
found 1 day ago
Select United flight, departing Thu, Mar 5 from Buffalo to Santiago, returning Tue, Mar 17, priced at $769 found 1 day ago
American Airlines
Wed, Feb 11 - Wed, Feb 18
BUF
Buffalo
SCL
Santiago
$769 Roundtrip, found 3 hours ago
$769
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Wed, Feb 11 from Buffalo to Santiago, returning Wed, Feb 18, priced at $769 found 3 hours ago
Delta
Sun, Jan 25 - Tue, Feb 3
BUF
Buffalo
SCL
Santiago
$771 Roundtrip, found 1 day ago
$771
Roundtrip
found 1 day ago
Select Delta flight, departing Sun, Jan 25 from Buffalo to Santiago, returning Tue, Feb 3, priced at $771 found 1 day ago
Delta
Sun, Dec 28 - Mon, Jan 19
BUF
Buffalo
SCL
Santiago
$773 Roundtrip, found 1 day ago
$773
Roundtrip
found 1 day ago
Select Delta flight, departing Sun, Dec 28 from Buffalo to Santiago, returning Mon, Jan 19, priced at $773 found 1 day ago
JetBlue Airways
Thu, Nov 27 - Thu, Dec 4
BUF
Buffalo
SCL
Santiago
$774 Roundtrip, found 3 hours ago
$774
Roundtrip
found 3 hours ago
Select JetBlue Airways flight, departing Thu, Nov 27 from Buffalo to Santiago, returning Thu, Dec 4, priced at $774 found 3 hours ago
JetBlue Airways
Thu, Nov 27 - Thu, Dec 4
BUF
Buffalo
SCL
Santiago
$779 Roundtrip, found 3 hours ago
$779
Roundtrip
found 3 hours ago
Select JetBlue Airways flight, departing Thu, Nov 27 from Buffalo to Santiago, returning Thu, Dec 4, priced at $779 found 3 hours ago
JetBlue Airways
Thu, Nov 27 - Thu, Dec 4
BUF
Buffalo
SCL
Santiago
$779 Roundtrip, found 3 hours ago
$779
Roundtrip
found 3 hours ago
Select JetBlue Airways flight, departing Thu, Nov 27 from Buffalo to Santiago, returning Thu, Dec 4, priced at $779 found 3 hours ago
Delta
Sun, Dec 14 - Tue, Dec 23
BUF
Buffalo
SCL
Santiago
$781 Roundtrip, found 1 day ago
$781
Roundtrip
found 1 day ago
Select Delta flight, departing Sun, Dec 14 from Buffalo to Santiago, returning Tue, Dec 23, priced at $781 found 1 day ago
LATAM Airlines Group
Thu, Nov 27 - Thu, Dec 4
BUF
Buffalo
SCL
Santiago
$784 Roundtrip, found 3 hours ago
$784
Roundtrip
found 3 hours ago
Select LATAM Airlines Group flight, departing Thu, Nov 27 from Buffalo to Santiago, returning Thu, Dec 4, priced at $784 found 3 hours ago

Alternative airports near Santiago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Arturo Merino Benitez SCL. Cheapest and Closest option available. Average driving time to city center is 17 minutes. Flights from $809
SCL
Arturo Merino Benitez
CheapestClosest
Average driving time to city center17 min
Flights from $809

Frequently asked questions

How much does a flight from Buffalo Niagara Intl. Airport (BUF) to Arturo Merino Benitez Airport (SCL) cost?
Grab a cheap one-way flight from $418 or cheap return flight from $764 from Buffalo Niagara Intl. Airport (BUF) to Arturo Merino Benitez Airport (SCL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Buffalo Niagara Intl. Airport (BUF) to Arturo Merino Benitez Airport (SCL)?
The cheapest month to fly from BUF to SCL is February, when demand is low. Off-peak season is usually when airlines offer lower prices between these airports.
What is the cheapest airline that flies from Buffalo Niagara Intl. Airport (BUF) to Arturo Merino Benitez Airport (SCL)?
To find the cheapest airline that'll fly you from BUF to SCL, use Expedia's filter tool. Customize your search based on what matters most to you, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to list the most affordable options first.
How many flights per day from Buffalo Niagara Intl. Airport (BUF) to Arturo Merino Benitez Airport (SCL)?
Direct flights from Buffalo Niagara Intl. Airport (BUF) to Arturo Merino Benitez Airport (SCL) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your travel details and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from BUF to SCL?
Usually you'll find the greatest selection of flight options on a Friday. Tuesdays tend to be the quietest.* However, this can vary based on the season, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Buffalo Niagara Intl. Airport (BUF) to Arturo Merino Benitez Airport (SCL)?
To avoid possible delays on the Buffalo Niagara Intl. Airport (BUF) to Arturo Merino Benitez Airport (SCL) route, aim to travel before 3 PM. Later flights are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Buffalo Niagara Intl. Airport (BUF) to Arturo Merino Benitez Airport (SCL) last-minute?
Booking your plane ticket from BUF to SCL shortly before your trip is generally more expensive. But if there's some wiggle room with your departure dates and times, you could score a cheap last-minute fare.
Is it cheaper to book a BUF to SCL flight and hotel package?
You'll typically save money by booking a BUF to SCL flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage it all in one convenient place. After selecting your ideal flights and accommodations, you can add extras such as car rentals, activities and tours.
Can I cancel or change the date of my flight from Buffalo Niagara Intl. Airport (BUF) to Arturo Merino Benitez Airport (SCL)?
Generally, it's possible to cancel or reschedule your BUF to SCL flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Origin airport
Buffalo Niagara Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Air Canada, American Airlines, Copa, Delta, LATAM Airlines Group, United
Roundtrip price
$764
Distance
5297 mi

Book with confidence

Buffalo to Santiago Flights

The cheapest times to fly from Buffalo to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Buffalo to Santiago are during the month of February. You can find some of the cheapest flights from Buffalo to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Buffalo to Santiago

Sunday is one of the best days to book for cheap flights from Buffalo to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Buffalo to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Buffalo to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $418 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Buffalo to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Buffalo to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Buffalo to Santiago Flights

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*Available to One Key members.