Title: Buffalo to Santiago cheap flights from $424 (BUF to SCL) - Expedia.com ![](https://images.trvl-media.com/place/178306/9fa58083-ea34-4b53-ba1b-a3b5d959bf28.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/178306/9fa58083-ea34-4b53-ba1b-a3b5d959bf28.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # $424 Cheap Flights from Buffalo (BUF) to Santiago (SCL) [View $424 flight on Tue, Mar 17, 2026](https://expedia.com/Flights-Search?trip=oneway&leg1=from:BUF,to:SCL,departure:3/17/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:423.25&airProductToken=AQqeAQoyCNWCARIDNTQzGIEtIK4cKNTthwMwzO6HAzhHQABYAWoHQ0xBU1NJQ3IIVExBNE9aMU4KMwjDmgESAzIyORiuHCDvxAEohvKHAzC_9IcDOFRAAVgBagdDTEFTU0lDcghUTEE0T1oxTgozCMOaARIDMjc3GO_EASDSWCj09IcDMPz3hwM4VEABWAFqB0NMQVNTSUNyCFRMQTRPWjFOEgoIARABGAEqAkNNGAEiBAgBEAEoAigDKAQwAQ) ## Popular airlines from Buffalo Niagara Intl. Airport (BUF) to Santiago Intl. Airport (SCL) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_LA.svg) LATAM Airlines Group [](https://www.expedia.com/Flights-Search?leg1=from:BUF,to:SCL,departure:3/24/2026TANYT&leg2=from:SCL,to:BUF,departure:3/31/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"LA"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_DL.svg) Delta [](https://www.expedia.com/Flights-Search?leg1=from:BUF,to:SCL,departure:3/24/2026TANYT&leg2=from:SCL,to:BUF,departure:3/31/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"DL"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AA.svg) American Airlines [](https://www.expedia.com/Flights-Search?leg1=from:BUF,to:SCL,departure:3/24/2026TANYT&leg2=from:SCL,to:BUF,departure:3/31/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AA"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_UA.svg) United [](https://www.expedia.com/Flights-Search?leg1=from:BUF,to:SCL,departure:3/24/2026TANYT&leg2=from:SCL,to:BUF,departure:3/31/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"UA"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AC.svg) Air Canada [](https://www.expedia.com/Flights-Search?leg1=from:BUF,to:SCL,departure:3/24/2026TANYT&leg2=from:SCL,to:BUF,departure:3/31/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AC"}}]) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 30% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our OneKeyCash [Learn about One Key](https://www.expedia.com/welcome-one-key) ## Cheap Flights from Buffalo to Santiago (BUF-SCL) Prices were available within the past 7 days and start at $424 for one-way flights and $880 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Tue, Oct 13 - Tue, Oct 27 BUF Buffalo SCL Santiago $880 Roundtrip found 3 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:BUF,to:SCL,departure:10/13/2026TANYT&leg2=from:SCL,to:BUF,departure:10/27/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:879.23&airProductToken=AQqYAQoxCMGCARIENDY2MxiBLSDLASj-qZoDMM6qmgM4QkAAWAFqBUJBU0lDcghRTFhaSUJCWgoxCMGCARIEMzA4OBjLASCMAiiwrZoDMOuumgM4QkABWAFqBUJBU0lDcghRTFhaSUJCWgowCMGCARIDOTU3GIwCINJYKMqvmgMwqrOaAzhCQAFYAWoFQkFTSUNyCFFMWFpJQkJaCpoBCjAIwYIBEgM5MTIY0lggjAIo_subAzCL0JsDOEJAAFgBagVCQVNJQ3IIUUxYWklCQloKMgjBggESBDEyOTkYjAIgo7EBKPfQmwMwu9KbAzhCQAFYAWoFQkFTSUNyCFFMWFpJQkJaCjIIwYIBEgQxNzI0GKOxASCBLSjv05sDMKXVmwM4QkABWAFqBUJBU0lDcghRTFhaSUJCWhIKCAEQARgBKgJBQRgBIgQIARABKAIoAygEMAs) ![Delta](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DL.gif) Tue, Oct 13 - Tue, Oct 27 BUF Buffalo SCL Santiago $885 Roundtrip found 3 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:BUF,to:SCL,departure:10/13/2026TANYT&leg2=from:SCL,to:BUF,departure:10/27/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:884.73&airProductToken=AQp5CjUIxJgBEgQ1Mjk2GIEtIKlRKKasmgMwhq2aAzhFQABYAWoJTUFJTkJBU0lDcghYTFhLN05CUApACMSYARIENjA2MRipUSDSWCivrpoDMO6ymgM4RUABWAFqCU1BSU5CQVNJQ3IIWExYSzdOQlB6CQjMggESAzUzMwptCjQIxJgBEgMxNDYY0lgg4Fwo4sybAzCm0ZsDOEVAAFgBaglNQUlOQkFTSUNyCFhMWEs3TkJQCjUIxJgBEgQyMjY2GOBcIIEtKPjTmwMw79SbAzhFQAFYAWoJTUFJTkJBU0lDcghYTFhLN05CUBIKCAEQARgBKgJETBgBIgQIARABKAIoAygEMAE) ![Delta](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DL.gif) Tue, Oct 13 - Tue, Oct 27 BUF Buffalo SCL Santiago $890 Roundtrip found 3 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:BUF,to:SCL,departure:10/13/2026TANYT&leg2=from:SCL,to:BUF,departure:10/27/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:889.23&airProductToken=AQptCjUIxJgBEgQyMjY2GIEtIOBcKM6smgMw2q2aAzhFQABYAWoJTUFJTkJBU0lDcghYTFhLN05CUAo0CMSYARIDMTQ3GOBcINJYKKKvmgMww7OaAzhFQAFYAWoJTUFJTkJBU0lDcghYTFhLN05CUAqmAQo0CMSYARIDMTQ2GNJYIOBcKOLMmwMwptGbAzhFQABYAWoJTUFJTkJBU0lDcghYTFhLN05CUAo2CMSYARIEMTI0MBjgXCDjtAEoy9KbAzDC05sDOEVAAVgBaglNQUlOQkFTSUNyCFhMWEs3TkJQCjYIxJgBEgQ0NjQyGOO0ASCBLSiY1JsDMODUmwM4RUABWAFqCU1BSU5CQVNJQ3IIWExYSzdOQlASCggBEAEYASoCREwYASIECAEQASgCKAMoBDAB) ![Delta](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DL.gif) Thu, Jan 14 - Sat, Jan 23 BUF Buffalo SCL Santiago $890 Roundtrip found 5 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:BUF,to:SCL,departure:1/14/2027TANYT&leg2=from:SCL,to:BUF,departure:1/23/2027TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:889.73&airProductToken=AQpuCjUIxJgBEgQ1Mjk2GIEtIKlRKIzDogMw7sOiAzhFQABYAWoJTUFJTkJBU0lDcghYTFhLN05CUAo1CMSYARIENjA2MRipUSDSWCiLxaIDMMrJogM4RUABWAFqCU1BSU5CQVNJQ3IIWExYSzdOQlAKpQEKNQjMggESBDI0NDQY0lggi2Io6qmjAzCRrKMDOFFAAFgBaglNQUlOQkFTSUNyCFhMWEs3TkJQCjUIxJgBEgQ2MDY2GItiIKlRKLG3owMwm7ujAzhFQAFYAWoJTUFJTkJBU0lDcghYTFhLN05CUAo1CMSYARIENDczMBipUSCBLSjAvKMDMJ29owM4RUABWAFqCU1BSU5CQVNJQ3IIWExYSzdOQlASDAgBEAEYASoCREwyABgBIgQIARABKAIoAygEMAE) ![Delta](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DL.gif) Tue, Oct 13 - Tue, Oct 27 BUF Buffalo SCL Santiago $900 Roundtrip found 3 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:BUF,to:SCL,departure:10/13/2026TANYT&leg2=from:SCL,to:BUF,departure:10/27/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:899.73&airProductToken=AQpfCi4IxJgBEgQ1Mjk2GIEtIKlRKKasmgMwhq2aAzhYQABYAWoCU0xyCE5MWFNMNTRYCi0IzIIBEgM1MzMYqVEg0lgor66aAzDuspoDOE5AAVgBagJTTHIITkxYU0w1NFgKdwo5CMyCARIENjM1OBjSWCDgXCjizJsDMKbRmwM4TkAAWAFqAlNMcghOTFhTTDU0WHoJCMSYARIDMTQ2CjoIzIIBEgQ3MTY4GOBcIIEtKLXVmwMwrdabAzhOQAFYAWoCU0xyCE5MWFNMNTRYegoIxJgBEgQyMDUwEgoIARABGAEqAkxBGAEiBAgBEAEoAigEKAYwAQ) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Tue, Oct 13 - Tue, Oct 27 BUF Buffalo SCL Santiago $905 Roundtrip found 3 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:BUF,to:SCL,departure:10/13/2026TANYT&leg2=from:SCL,to:BUF,departure:10/27/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:904.73&airProductToken=AQp3CjoIzIIBEgQ2Nzc5GIEtIOBcKM6smgMw2q2aAzhOQABYAWoCU0xyCE5MWFNMNTRYegoIxJgBEgQyMjY2CjkIzIIBEgQ2MzU3GOBcINJYKKKvmgMww7OaAzhOQAFYAWoCU0xyCE5MWFNMNTRYegkIxJgBEgMxNDcKdwo5CMyCARIENjM1OBjSWCDgXCjizJsDMKbRmwM4TkAAWAFqAlNMcghOTFhTTDU0WHoJCMSYARIDMTQ2CjoIzIIBEgQ2Nzc5GOBcIIEtKPjTmwMw79SbAzhOQAFYAWoCU0xyCE5MWFNMNTRYegoIxJgBEgQyMjY2EgoIARABGAEqAkxBGAEiBAgBEAEoAigEKAYwAQ) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Thu, Nov 12 - Thu, Nov 19 BUF Buffalo SCL Santiago $909 Roundtrip found 3 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:BUF,to:SCL,departure:11/12/2026TANYT&leg2=from:SCL,to:BUF,departure:11/19/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:908.83&airProductToken=AQp3CjoIzIIBEgQ2NzgwGIEtIOBcKNT5nAMw4fqcAzhOQABYAWoCU0xyCE5MWFNMNTRYegoIxJgBEgQyNjY0CjkIzIIBEgQ2MzU3GOBcINJYKLqAnQMw4ISdAzhOQAFYAWoCU0xyCE5MWFNMNTRYegkIxJgBEgMxNDcKXQotCMyCARIDNTMyGNJYIKlRKO_PnQMwptWdAzhOQABYAWoCU0xyCE5MWFNMNTRYCiwIwmwSAzEwMhipUSCBLSjO2p0DMKzbnQM4TUABWAFqAlNMcghOTFhTTDU0WBIKCAEQARgBKgJMQRgBIgQIARABKAIoBCgGMAE) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Thu, Nov 12 - Thu, Nov 19 BUF Buffalo SCL Santiago $910 Roundtrip found 3 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:BUF,to:SCL,departure:11/12/2026TANYT&leg2=from:SCL,to:BUF,departure:11/19/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:909.73&airProductToken=AQp3CjoIzIIBEgQ2NzQ2GIEtIOBcKMX8nAMwzv2cAzhOQABYAWoCU0xyCE5MWFNMNTRYegoIxJgBEgQxMzg0CjkIzIIBEgQ2MzU3GOBcINJYKLqAnQMw4ISdAzhOQAFYAWoCU0xyCE5MWFNMNTRYegkIxJgBEgMxNDcKmwEKLQjMggESAzY0MhjSWCCLYij9x50DMKTKnQM4TkAAWAFqAlNMcghOTFhTTDU0WAouCMyCARIEMjQ4MhiLYiDgXCicy50DMN7OnQM4TkABWAFqAlNMcghOTFhTTDU0WAo6CMyCARIENjc0NxjgXCCBLSjuz50DMOfQnQM4TkABWAFqAlNMcghOTFhTTDU0WHoKCMSYARIEMjMzNBIKCAEQARgBKgJMQRgBIgQIARABKAIoBCgGMAE) ![United](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/UA.gif) Sat, Mar 21 - Fri, Mar 27 BUF Buffalo SCL Santiago $913 Roundtrip found 3 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:BUF,to:SCL,departure:3/21/2026TANYT&leg2=from:SCL,to:BUF,departure:3/27/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:912.04&airProductToken=AQqfAQozCNWCARIENDkzNRiBLSCIGCionIgDMPuciAM4R0AAWAFqB0NMQVNTSUNyCFRMQTRPWjFOCjMIw5oBEgM0MDMYiBgg78QBKNqjiAMwgaaIAzhUQAFYAWoHQ0xBU1NJQ3IIVExBNE9aMU4KMwjDmgESAzM5NRjvxAEg0lgo0KiIAzDYq4gDOFRAAVgBagdDTEFTU0lDcghUTEE0T1oxTgqfAQozCMOaARIDMjc2GNJYIO_EASiB24gDMJTeiAM4VEAAWAFqB0NMQVNTSUNyCFRMQTRPWjFOCjMIw5oBEgMyMjgY78QBIK4cKIffiAMw1-GIAzhUQAFYAWoHQ0xBU1NJQ3IIVExBNE9aMU4KMwjVggESBDEzMzUYrhwggS0o6eOIAzDO5IgDOEdAAVgBagdDTEFTU0lDcghUTEE0T1oxThIKCAEQARgBKgJDTRgBIgQIARABKAIoAygEMAE) ![JetBlue Airways](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/b6.gif) Thu, Nov 12 - Thu, Nov 19 BUF Buffalo SCL Santiago $945 Roundtrip found 3 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:BUF,to:SCL,departure:11/12/2026TANYT&leg2=from:SCL,to:BUF,departure:11/19/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:944.73&airProductToken=AQpeCi0IwmwSBDIwMDEYgS0gqVEolfqcAzDv-pwDOE1AAFgBagJTTHIITkxYU0w1NFgKLQjMggESAzUzMxipUSDSWCirgJ0DMOqEnQM4TkABWAFqAlNMcghOTFhTTDU0WAqbAQotCMyCARIDNTIyGNJYIItiKPXNnQMwnNCdAzhOQABYAWoCU0xyCE5MV1NMNTRYCi4IzIIBEgQyNDY4GItiIKlRKPHQnQMw29SdAzhOQAFYAWoCU0xyCE5MV1NMNTRYCjoIzIIBEgQ2MjAxGKlRIIEtKIDWnQMw3dadAzhOQAFYAWoCU0xyCE5MV1NMNTRYegoIxJgBEgQ0NzMwEgoIARABGAEqAkxBGAEiBAgBEAEoAigEKAYwAQ) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=FTG_SPRING_PROMO_) ## Alternative airports near Santiago Prices were available within the past 7 days. Prices and availability are subject to change. [](https://www.expedia.com/Flights-Search?leg1=from:BUF,to:SCL,departure:3/24/2026TANYT&leg2=from:SCL,to:BUF,departure:3/28/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&sortOrder=INCREASING&sortType=PRICE) SCL Arturo Merino Benitez CheapestClosest 17 min [Flights from $1,267 ](https://www.expedia.com/Flights-Search?leg1=from:BUF,to:SCL,departure:3/24/2026TANYT&leg2=from:SCL,to:BUF,departure:3/28/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&sortOrder=INCREASING&sortType=PRICE) ## Frequently asked questions ### How much does a flight from Buffalo Niagara Intl. Airport (BUF) to Arturo Merino Benitez Airport (SCL) cost? ### What is the cheapest month to fly from Buffalo Niagara Intl. Airport (BUF) to Arturo Merino Benitez Airport (SCL)? ### What is the cheapest airline that flies from Buffalo Niagara Intl. Airport (BUF) to Arturo Merino Benitez Airport (SCL)? ### How many flights per day from Buffalo Niagara Intl. Airport (BUF) to Arturo Merino Benitez Airport (SCL)? ### What day of the week has the most flights from BUF to SCL? ### What is the best time to fly from Buffalo Niagara Intl. Airport (BUF) to Arturo Merino Benitez Airport (SCL)? ### Is it cheaper to buy a plane ticket from Buffalo Niagara Intl. Airport (BUF) to Arturo Merino Benitez Airport (SCL) last-minute? ### Is it cheaper to book a BUF to SCL flight and hotel package? ### Can I cancel or change the date of my flight from Buffalo Niagara Intl. Airport (BUF) to Arturo Merino Benitez Airport (SCL)? ## Travel information | Origin airport | Buffalo Niagara Intl. | | ------------------- | ------------------------------------------------------------------ | | Destination airport | Arturo Merino Benitez | | Airlines serving | Air Canada, American Airlines, Delta, LATAM Airlines Group, United | | Roundtrip price | $879 | | Distance | 5297 mi | ## Book with confidence # Buffalo to Santiago Flights The cheapest times to fly from Buffalo to Santiago On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Buffalo to Santiago are during the month of October. You can find some of the cheapest flights from Buffalo to Santiago with Expedia's search tool and vast selection of airlines. The best time to book a flight from Buffalo to Santiago Sunday is one of the best days to book for cheap flights from Buffalo to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance. How to find cheap round-trip tickets from Buffalo to Santiago Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Buffalo to Santiago in 2026\. You can also book with separate airlines for your outbound and return journeys, from $424 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference\*. This is available for a small fee, and is free to One Key Gold and Platinum tier members. Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Buffalo to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps. You could also save big by booking one of Expedia's [vacation packages](https://www.expedia.com/package-deals). Bundling together your Buffalo to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures. \*Terms apply. Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023\. The percentages you see are averages. \*Flight schedules are subject to change. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Other - [Hotels near Santa Teresa de Lo Ovalle ](https://www.expedia.com/Santa-Teresa-De-Lo-Ovalle-Santiago-Hotels.0-n178546-0.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Pudahuel ](https://www.expedia.com/Pudahuel-Santiago-Hotels-Luxury-Hotel.0-n553248633981689009-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Hotels near Pudahuel ](https://www.expedia.com/Pudahuel-Santiago-Hotels.0-n553248633981689009-0.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Pudahuel ](https://www.expedia.com/Pudahuel-Santiago-Hotels-Cheap-Hotels.0-n553248633981689009-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Hotels with Free Airport Shuttle in Pudahuel ](https://www.expedia.com/Pudahuel-Santiago-Hotels-Hotels-With-Free-Airport-Shuttle.0-n553248633981689009-0-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - [Hotels with a Pool in Pudahuel ](https://www.expedia.com/Pudahuel-Santiago-Hotels-Hotel-With-Pool.0-n553248633981689009-0-tHotelwithPool.Travel-Guide-Filter-Hotels) - [Barrancas Hotels ](https://www.expedia.com/Barrancas-Hotels.d178525.Travel-Guide-Hotels) - [Hotels near San Pablo Station ](https://www.expedia.com/San-Pablo-Station-Hotels.d6233597.Travel-Guide-Hotels) - [Hotels near Renca ](https://www.expedia.com/Renca-Santiago-Hotels.0-n178540-0.Travel-Guide-Filter-Hotels) - [Hotels near Quinta Normal ](https://www.expedia.com/Quinta-Normal-Santiago-Hotels.0-n178539-0.Travel-Guide-Filter-Hotels) - [Santa Elena del Gomero Hotels ](https://www.expedia.com/Santa-Elena-Del-Gomero-Hotels.d178544.Travel-Guide-Hotels) - [Hotels near Mall Plaza Norte ](https://www.expedia.com/Mall-Plaza-Norte-Hotels.0-l6230822-0.Travel-Guide-Filter-Hotels) - [Hotels near National Museum of Natural History ](https://www.expedia.com/National-Museum-Of-Natural-History-Hotels.0-l6072119-0.Travel-Guide-Filter-Hotels) - [Hotels near Santiago Bueras Station ](https://www.expedia.com/Santiago-Bueras-Station-Hotels.d6233772.Travel-Guide-Hotels) - [Hotels near Museum of Memory and Human Rights ](https://www.expedia.com/Museum-Of-Memory-And-Human-Rights-Hotels.0-l6237463-0.Travel-Guide-Filter-Hotels) - [Hotels near Hipodromo Chile ](https://www.expedia.com/Hipodromo-Chile-Hotels.0-l6219631-0.Travel-Guide-Filter-Hotels) - [Hotels near University of Santiago-Chile ](https://www.expedia.com/University-Of-Santiago-Chile-Hotels.0-l6071699-0.Travel-Guide-Filter-Hotels) - [Hostels in Santiago Central Station ](https://www.expedia.com/Santiago-Central-Station-Hostels.d6233917-aaHostels.Travel-Guide-Accommodation) - [Hotels near Latin American Union Station ](https://www.expedia.com/Latin-American-Union-Station-Hotels.d6233624.Travel-Guide-Hotels) - [Hotels near Santa Rosa de Huechuraba ](https://www.expedia.com/Santa-Rosa-De-Huechuraba-Santiago-Hotels.0-n178545-0.Travel-Guide-Filter-Hotels) - [Hotels near Barrio Brasil ](https://www.expedia.com/Barrio-Brasil-Santiago-Hotels.0-n6287905-0.Travel-Guide-Filter-Hotels) - [Hotels near Maipu ](https://www.expedia.com/Maipu-Santiago-Hotels.0-n178549-0.Travel-Guide-Filter-Hotels) - [Hotels near Mercado Central ](https://www.expedia.com/Mercado-Central-Hotels.0-l6072109-0.Travel-Guide-Filter-Hotels) - [Hotels near Torre Entel ](https://www.expedia.com/Torre-Entel-Hotels.0-l553248621562626189-0.Travel-Guide-Filter-Hotels) - [Hotels near Plaza de la Constitucion ](https://www.expedia.com/Plaza-De-La-Constitucion-Hotels.0-l6072129-0.Travel-Guide-Filter-Hotels) - [Hotels near Museo Chileno de Arte Precolombino ](https://www.expedia.com/Museo-Chileno-De-Arte-Precolombino-Hotels.0-l553248621532374867-0.Travel-Guide-Filter-Hotels) - [Hotels near Palacio de la Moneda ](https://www.expedia.com/Palacio-De-La-Moneda-Hotels.0-l6072099-0.Travel-Guide-Filter-Hotels) - [Hotels near Fantasilandia ](https://www.expedia.com/Fantasilandia-Hotels.0-l6219460-0.Travel-Guide-Filter-Hotels) - [Hotels near Santiago Town Square ](https://www.expedia.com/Santiago-Town-Square-Hotels.0-l6072087-0.Travel-Guide-Filter-Hotels) - [Historic Hotels in Santiago Metropolitan Region ](https://www.expedia.com/Destinations-In-Santiago-Metropolitan-Region-Historic-Hotel.0-0-d6236511-tHistoricHotel.Hotel-Filter-Destinations) - [Hotels near Plaza de Armas ](https://www.expedia.com/Plaza-De-Armas-Hotels.0-l553248621532374866-0.Travel-Guide-Filter-Hotels) - [Resorts & Hotels with Spas in Santiago Metropolitan Region ](https://www.expedia.com/Destinations-In-Santiago-Metropolitan-Region-Spa-Hotel.0-0-d6236511-tSpaHotel.Hotel-Filter-Destinations) - [Cabin Rentals in Santiago Metropolitan Region ](https://www.expedia.com/Santiago-Metropolitan-Region-Cabins.d6236511-aaCabins.Travel-Guide-Accommodation) - [Santiago Metropolitan Region Hotels ](https://www.expedia.com/Destinations-In-Santiago-Metropolitan-Region.d6236511.Hotel-Destinations) - [Lodges in Santiago Metropolitan Region ](https://www.expedia.com/Santiago-Metropolitan-Region-Lodges.d6236511-aaLodges.Travel-Guide-Accommodation) - [Casino Hotels in Santiago Metropolitan Region ](https://www.expedia.com/Destinations-In-Santiago-Metropolitan-Region-Casino-Hotel.0-0-d6236511-tCasinoHotel.Hotel-Filter-Destinations) - [Apartments in Santiago Metropolitan Region ](https://www.expedia.com/Santiago-Metropolitan-Region-Apartments.d6236511-aaApartments.Travel-Guide-Accommodation) - [Gay friendly Hotels in Santiago Metropolitan Region ](https://www.expedia.com/Destinations-In-Santiago-Metropolitan-Region-LGBT-Welcoming-Hotel.0-0-d6236511-tLGBTWelcomingHotel.Hotel-Filter-Destinations) - [Family Hotels in Santiago Metropolitan Region ](https://www.expedia.com/Destinations-In-Santiago-Metropolitan-Region-Family-Hotel.0-0-d6236511-tFamilyHotel.Hotel-Filter-Destinations) - [Hotels with Balconies in Santiago Metropolitan Region ](https://www.expedia.com/Destinations-In-Santiago-Metropolitan-Region-Hotels-With-Balconies.0-0-d6236511-tHotelswithBalconies.Hotel-Filter-Destinations) - [Cheap Hotels in Santiago Metropolitan Region ](https://www.expedia.com/Destinations-In-Santiago-Metropolitan-Region-Cheap-Hotels.0-0-d6236511-tCheapHotels.Hotel-Filter-Destinations) - [Hotels with Bars in Santiago Metropolitan Region ](https://www.expedia.com/Destinations-In-Santiago-Metropolitan-Region-Bar-Hotel.0-0-d6236511-tBarHotel.Hotel-Filter-Destinations) - [Resorts in Santiago Metropolitan Region ](https://www.expedia.com/Santiago-Metropolitan-Region-Resorts.d6236511-aaResorts.Travel-Guide-Accommodation) - [Hotels with Free Airport Shuttle in Santiago Metropolitan Region ](https://www.expedia.com/Destinations-In-Santiago-Metropolitan-Region-Hotels-With-Free-Airport-Shuttle.0-0-d6236511-tHotelswithFreeAirportShuttle.Hotel-Filter-Destinations) - [Gay friendly Hotels in Santiago Province ](https://www.expedia.com/Destinations-In-Santiago-Province-LGBT-Welcoming-Hotel.0-0-d553248635975749887-tLGBTWelcomingHotel.Hotel-Filter-Destinations) - [Hotel Wedding Venues Hotels in Santiago Metropolitan Region ](https://www.expedia.com/Destinations-In-Santiago-Metropolitan-Region-Wedding-Hotels.0-0-d6236511-tWeddingHotels.Hotel-Filter-Destinations) - [Hotels near Cousino Palace ](https://www.expedia.com/Cousino-Palace-Hotels.0-l6237502-0.Travel-Guide-Filter-Hotels) - [Hotels near Movistar Arena ](https://www.expedia.com/Movistar-Arena-Hotels.0-l6072097-0.Travel-Guide-Filter-Hotels) - [Flights to Barrancas ](https://www.expedia.com/Cheap-Flights-To-Barrancas.d178525.Travel-Guide-Flights) - [Visit Santa Teresa de Lo Ovalle ](https://www.expedia.com/Santiago-Santa-Teresa-De-Lo-Ovalle.dx178546) - [Visit Pudahuel ](https://www.expedia.com/Santiago-Pudahuel.dx553248633981689009) - [Visit Barrancas ](https://www.expedia.com/Barrancas.dx178525) - [Visit Lo Prado ](https://www.expedia.com/Santiago-Lo-Prado.dx178535) - [Visit Renca ](https://www.expedia.com/Santiago-Renca.dx178540) - [Renca Vacations ](https://www.expedia.com/Renca.d178540.Destination-Travel-Guides) - [Visit Quinta Normal ](https://www.expedia.com/Santiago-Quinta-Normal.dx178539) - [Quinta Normal Vacations ](https://www.expedia.com/Quinta-Normal.d178539.Destination-Travel-Guides) - [Visit Santa Elena del Gomero ](https://www.expedia.com/Santa-Elena-Del-Gomero.dx178544) - [Visit Lo Aranguiz ](https://www.expedia.com/Santiago-Lo-Aranguiz.dx178533) - [Parque Quinta Normal ](https://www.expedia.com/Parque-Quinta-Normal-Downtown-Santiago.d6072117.Vacation-Attraction) - [Visit Conchali ](https://www.expedia.com/Santiago-Conchali.dx178527) - [National Museum of Natural History ](https://www.expedia.com/National-Museum-Of-Natural-History-Downtown-Santiago.d6072119.Vacation-Attraction) - [Museum of Memory and Human Rights ](https://www.expedia.com/Museum-Of-Memory-And-Human-Rights-Downtown-Santiago.d6237463.Vacation-Attraction) - [Visit Santa Rosa de Huechuraba ](https://www.expedia.com/Santiago-Santa-Rosa-De-Huechuraba.dx178545) - [Plaza Brasil ](https://www.expedia.com/Plaza-Brasil-Downtown-Santiago.d6274772.Vacation-Attraction) - [Templo Votivo de Maipu ](https://www.expedia.com/Templo-Votivo-De-Maipu-Maipu.d553248621532463317.Vacation-Attraction) - [Visit Barrio Brasil ](https://www.expedia.com/Santiago-Barrio-Brasil.dx6287905) - [Visit Maipu ](https://www.expedia.com/Santiago-Maipu.dx178549) - [Basílica del Salvador ](https://www.expedia.com/Basilica-Del-Salvador-Downtown-Santiago.d553248621532374862.Vacation-Attraction) - [Mapocho Cultural Center ](https://www.expedia.com/Mapocho-Cultural-Center-Downtown-Santiago.d553248621532373106.Vacation-Attraction) - [Mercado Central ](https://www.expedia.com/Mercado-Central-Downtown-Santiago.d6072109.Vacation-Attraction) - [Former National Congress ](https://www.expedia.com/Former-National-Congress-Downtown-Santiago.d6072101.Vacation-Attraction) - [Torre Entel ](https://www.expedia.com/Torre-Entel-Downtown-Santiago.d553248621562626189.Vacation-Attraction) - [Museum of Chilean Precolombian Art ](https://www.expedia.com/Museum-Of-Chilean-Precolombian-Art-Downtown-Santiago.d6072093.Vacation-Attraction) - [Plaza de la Constitucion ](https://www.expedia.com/Plaza-De-La-Constitucion-Downtown-Santiago.d6072129.Vacation-Attraction) - [Palacio de la Moneda ](https://www.expedia.com/Palacio-De-La-Moneda-Downtown-Santiago.d6072099.Vacation-Attraction) - [Metropolitan Cathedral ](https://www.expedia.com/Metropolitan-Cathedral-Downtown-Santiago.d6072081.Vacation-Attraction) - [Fantasilandia ](https://www.expedia.com/Fantasilandia-Downtown-Santiago.d6219460.Vacation-Attraction) - [National History Museum ](https://www.expedia.com/National-History-Museum-Downtown-Santiago.d6072089.Vacation-Attraction) - [Plaza de Armas ](https://www.expedia.com/Plaza-De-Armas-Downtown-Santiago.d553248621532374866.Vacation-Attraction) - [Visit Santiago Metropolitan Region ](https://www.expedia.com/Santiago-Metropolitan-Region.dx6236511) - [Santiago Town Square ](https://www.expedia.com/Santiago-Town-Square-Downtown-Santiago.d6072087.Vacation-Attraction) - [Santiago Metropolitan Region Vacations ](https://www.expedia.com/Santiago-Metropolitan-Region.d6236511.Destination-Travel-Guides) - [Cousino Palace ](https://www.expedia.com/Cousino-Palace-Downtown-Santiago.d6237502.Vacation-Attraction) - [Stock Exchange ](https://www.expedia.com/Stock-Exchange-Downtown-Santiago.d553248621532463986.Vacation-Attraction) - [Paseo Ahumada ](https://www.expedia.com/Paseo-Ahumada-Downtown-Santiago.d553248635926197025.Vacation-Attraction) - [Movistar Arena ](https://www.expedia.com/Movistar-Arena-Downtown-Santiago.d6072097.Vacation-Attraction) - [Car rentals near Renca ](https://www.expedia.com/Car-Rentals-In-Renca.d178540.Car-Rental-Guide) - [Car rentals near Estación Central ](https://www.expedia.com/Car-Rentals-In-Estacion-Central.d553248635943692002.Car-Rental-Guide) - [Car rentals near Conchali ](https://www.expedia.com/Car-Rentals-In-Conchali.d178527.Car-Rental-Guide) - [Car rentals near University of Santiago-Chile ](https://www.expedia.com/Car-Rentals-In-University-Of-Santiago-Chile.d6071699.Car-Rental-Guide) - [Car rentals near Independencia ](https://www.expedia.com/Car-Rentals-In-Independencia.d553248635943692038.Car-Rental-Guide) - [Car rentals near Santa Rosa de Huechuraba ](https://www.expedia.com/Car-Rentals-In-Santa-Rosa-De-Huechuraba.d178545.Car-Rental-Guide) - [Car rentals near Maipu ](https://www.expedia.com/Car-Rentals-In-Maipu.d178549.Car-Rental-Guide) - [Car rentals near Cerrillos ](https://www.expedia.com/Car-Rentals-In-Cerrillos.d553248635943692256.Car-Rental-Guide) - [Car rentals near Huechuraba ](https://www.expedia.com/Car-Rentals-In-Huechuraba.d553248635943692131.Car-Rental-Guide) - [Car rentals near Movistar Arena ](https://www.expedia.com/Car-Rentals-In-Movistar-Arena.d6072097.Car-Rental-Guide) - [Things to do in Barrancas ](https://www.expedia.com/Things-To-Do-In-Barrancas.d178525.Travel-Guide-Activities) - [Things to do in Santiago Metropolitan Region ](https://www.expedia.com/Things-To-Do-In-Santiago-Metropolitan-Region.d6236511.Travel-Guide-Activities) \*Available to One Key members.